Abstract:
STUDY OBJECTIVE:To compare a total intravenous (IV) anesthetic technique based on propofol and alfentanil with a commonly used anesthetic technique for craniotomy. DESIGN:Open-label, randomized, clinical study. SETTING:Neurosurgical clinic at a university hospital. PATIENTS:Forty patients, aged 18 to 55 years, scheduled for brain tumor surgery. INTERVENTIONS:In 20 patients, anesthesia was induced with fentanyl and thiopental sodium and maintained with fentanyl, dehydrobenzperidol, isoflurane, nitrous oxide (N2O), and a thiopental sodium infusion. Twenty patients were anesthetized with a propofol loading infusion followed by a maintenance infusion at a fixed rate. In addition, alfentanil was administered as a loading bolus, followed by a variable-rate infusion, with additional doses as necessary to maintain hemodynamic stability. MEASUREMENTS AND MAIN RESULTS:A decrease in blood pressure (BP) after induction with thiopental sodium was followed by a significant increase in BP and heart rate (HR) during intubation. BP and HR did not change during the propofol loading infusion. However, the administration of alfentanil was followed by a similar decrease in BP with a return to baseline values during the intubation period. Return of normal orientation (7 +/- 5 minutes vs 27 +/- 23 minutes) and concentration (12 +/- 12 minutes vs 35 +/- 37 minutes) was shorter and more predictable for the propofol-alfentanil-treated patients than for the thiopental sodium patients. Maintenance propofol concentration (nine patients) was between 3 +/- 0.69 micrograms/ml and 3.36 +/- 1.17 micrograms/ml, while the concentration at awakening was 1.09 microgram/ml. Alfentanil concentration at extubation (nine patients) was 79 +/- 34 ng/ml. CONCLUSION:A total IV anesthetic technique with propofol and alfentanil is a valuable alternative to a more commonly used technique based on thiopental sodium, N2O, fentanyl, and isoflurane.
journal_name
J Clin Anesthjournal_title
Journal of clinical anesthesiaauthors
Van Hemelrijck J,Van Aken H,Merckx L,Mulier Jdoi
10.1016/0952-8180(91)90010-ksubject
Has Abstractpub_date
1991-03-01 00:00:00pages
131-6issue
2eissn
0952-8180issn
1873-4529pii
0952-8180(91)90010-Kjournal_volume
3pub_type
临床试验,杂志文章,随机对照试验abstract:STUDY OBJECTIVE:To establish a useful ultrasonic approach to the epidural space so as to optimize pre-puncture diagnostics. DESIGN:Prospective study. SETTING:University clinic. PATIENTS:60 participants (19 to 34 years of age), 40 healthy volunteers (20 male, 20 female) and 20 parturients. INTERVENTIONS:Ultrasound s...
journal_title:Journal of clinical anesthesia
pub_type: 临床试验,杂志文章
doi:10.1016/s0952-8180(01)00245-8
更新日期:2001-05-01 00:00:00
abstract:STUDY OBJECTIVE:To assess the impact of intraoperative hemodynamics in the development of perioperative myocardial infarction (MI) and myocardial ischemia after noncardiac surgery. DESIGN:Single-center retrospective cohort study of surgical patients from 2007 to 2012. SETTING:Postanesthesia care unit, intensive care ...
journal_title:Journal of clinical anesthesia
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doi:10.1016/j.jclinane.2016.05.009
更新日期:2016-11-01 00:00:00
abstract:STUDY OBJECTIVE:To develop a rapid online test of graft liver function during liver transplantation. DESIGN:Prospective, observational study. SETTING:University hospital transplant unit. PATIENTS:17 adult patients with end-stage liver disease who underwent liver transplantation surgery. INTERVENTIONS:Rocuronium inf...
journal_title:Journal of clinical anesthesia
pub_type: 临床试验,杂志文章
doi:10.1016/s0952-8180(03)00061-8
更新日期:2003-06-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the immediate effect of epidural blood patch (EBP) on the hearing loss that can accompany postdural puncture headache (PDPH). DESIGN:Prospective open study. SETTING:Anesthetic and otolaryngologic departments at a university hospital. SUBJECTS:16 patients who developed severe PDPH followi...
journal_title:Journal of clinical anesthesia
pub_type: 临床试验,杂志文章
doi:10.1016/0952-8180(95)00053-k
更新日期:1995-09-01 00:00:00
abstract:STUDY OBJECTIVE:To compare values for two whole blood viscoelastic coagulation tests, thromboelastography (TEG) and Sonoclot analysis (Sonoclot R Coagulation Analyzer, Sienco, Inc., Morrison, CO), between healthy parturients and nonparturients. DESIGN:Prospective study. SETTING:University hospital. PATIENTS:41 healt...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
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abstract:STUDY OBJECTIVES:To evaluate the efficacy and safety of granisetron-droperidol combination for the prevention of postoperative nausea and vomiting (PONV) after middle ear surgery. DESIGN:Prospective, randomized, double-blind study. SETTING:University hospital. PATIENTS:150 ASA physical status I patients (108 females...
journal_title:Journal of clinical anesthesia
pub_type: 临床试验,杂志文章,随机对照试验,收录出版
doi:10.1016/s0952-8180(99)00011-2
更新日期:1999-03-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the profile of molecular hemostatic markers in patients receiving either spinal or balanced general anesthesia for total hip arthroplasty. DESIGN:Open, randomized, observational study. SETTING:Orthopedic unit and central laboratory of a university hospital. PATIENTS:26 consenting ASA phys...
journal_title:Journal of clinical anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-09-01 00:00:00
abstract:STUDY OBJECTIVE:To assess bispectral index (BIS) monitoring on decision making during cardiac surgery with cardiopulmonary bypass (CPB) by measuring the number of preset standardized comments with and without knowing the BIS value and by classifying the interventions following the BIS data. DESIGN:Prospective, randomi...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jclinane.2004.12.018
更新日期:2005-11-01 00:00:00
abstract::The need for greater efficiency in OR management will become apparent as hospitals are forced to respond to a myriad of pressures imposed by the external environment. The most effective strategy in dealing with this challenge will be realized by adopting a "systems" approach to OR functions as opposed to the more trad...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/0952-8180(95)00159-x
更新日期:1995-11-01 00:00:00
abstract:STUDY OBJECTIVE:To confirm the relationship between bevel orientation, catheter direction, and radiopaque contrast spread in the lumbar region. DESIGN:Pilot cadaver study. SETTING:Anatomy laboratory of a university hospital. MEASUREMENTS:Cadavers were randomized to two groups of 4 cadavers each. In Group 1, needle b...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2014.04.004
更新日期:2014-12-01 00:00:00
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journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2013.01.009
更新日期:2013-06-01 00:00:00
abstract:STUDY OBJECTIVE:To determine if the use of ultrasound guidance (vs non-ultrasound techniques) improves the success rate of nerve blocks. DESIGN:Meta-analysis of randomized controlled trials (RCTs) in the published literature. SETTING:University medical center. MEASUREMENTS:16 RCTs of patients undergoing elective sur...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章,meta分析
doi:10.1016/j.jclinane.2010.12.005
更新日期:2011-03-01 00:00:00
abstract:STUDY OBJECTIVES:To study the effect of tracheal intubation or laryngeal mask airway (LMA) insertion on intraocular pressure (IOP) in strabismus patients undergoing balanced anesthesia with sevoflurane and remifentanil. DESIGN:Open, prospective, randomized study. SETTING:Tertiary care academic medical institution. P...
journal_title:Journal of clinical anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0952-8180(01)00259-8
更新日期:2001-06-01 00:00:00
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journal_title:Journal of clinical anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jclinane.2014.02.006
更新日期:2014-09-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the influence of temperature and duration of cardiopulmonary bypass (CPB) on blood loss and transfusion requirements. DESIGN:Retrospective chart review. SETTING:Tertiary care, academic medical institution. MEASUREMENTS AND MAIN RESULTS:The charts of 378 patients who had undergone primary...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/s0952-8180(98)00085-3
更新日期:1998-11-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the methods used to teach surgical airway management to residents. DESIGN:Electronic mail survey instrument. SETTING:Academic medical center. PARTICIPANTS:82 (of a possible 132) United States residency program directors. MEASUREMENTS:Data including whether instruction in surgical airway...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2010.10.002
更新日期:2011-06-01 00:00:00
abstract::Myotonic dystrophy (DM), though rare, can significantly complicate anesthesia due to muscular and extra-muscular involvement. When this condition is compounded by a pheochromocytoma, anesthetizing such patients becomes extra challenging. We present a case report of a 61-year-old lady with congenital DM, with the whole...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2016.03.035
更新日期:2016-11-01 00:00:00
abstract::The acceptance of new and increasingly expensive technologies is a major component of the rising costs of health care. While the practice of anesthesia has been relatively immune from the effects of cost containment, it is inevitable that practitioners will have to justify costly practices. Available pharmacoeconomic ...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/s0952-8180(05)80008-x
更新日期:1994-09-01 00:00:00
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journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/0952-8180(94)00015-v
更新日期:1995-02-01 00:00:00
abstract:STUDY OBJECTIVE:Medical residents working overnight call shifts experience sleep deprivation and circadian clock disruption. This leads to deficits in sensorimotor function and increases in workplace accidents. Using quick tablet-based tasks, we investigate whether measureable executive function differences exist follo...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2017.04.002
更新日期:2017-08-01 00:00:00
abstract::Kearns-Sayre syndrome (KSS) is a rare mitochondrial myopathy and often involves cardiac conduction abnormality and muscle weakness. We report a patient with KSS who had an implantable cardioverter-defibrillator (ICD) implanted during general anesthesia with propofol and nitrous oxide (N2O). These anesthetics did not s...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2004.08.002
更新日期:2004-11-01 00:00:00
abstract::The case of a patient with hereditary angioedema (HAE), a rare, life-threatening disorder caused by reduced activity of the C1 esterase inhibitor, and requiring off-pump coronary artery bypass graft (OP-CABG) surgery, is presented. Perioperative management of patients with HAE who undergo complex cardiac surgical proc...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
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更新日期:2010-06-01 00:00:00
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journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2010.05.002
更新日期:2010-12-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the onset time, success rate, and recovery profile of unilateral spinal anesthesia produced with 4 mg, 6 mg, and 8 mg of 0.5% hyperbaric bupivacaine. DESIGN:Prospective, randomized, blinded study. SETTING:Outpatient anesthesia unit at a University Hospital. PATIENTS:90 ASA physical status...
journal_title:Journal of clinical anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-08-01 00:00:00
abstract:STUDY OBJECTIVES:To examine the effect of timing of an intravenous (i.v.) dose (intraoperative vs. postoperative) of ketorolac tromethamine on pain scores and overall outcome after total abdominal hysterectomy (TAH) and myomectomy. DESIGN:Prospective, randomized, placebo-controlled study. PATIENTS:248 ASA physical st...
journal_title:Journal of clinical anesthesia
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:1997-08-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the effects of epinephrine (1:200,000) in the epidural space on the incidence of blood vessel injury by epidural catheter insertion for cesarean section. DESIGN:Prospective observational study. SETTING:University-affiliated teaching hospital. PATIENTS:Four hundred laboring women with sing...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jclinane.2014.09.004
更新日期:2015-02-01 00:00:00
abstract:STUDY OBJECTIVE:To develop categories of behavior that define an applicant's aptitude for anesthesia, and to attempt to determine the relative importance of these behaviors to successful residency performance. DESIGN:Prospective open study. SETTING:Anesthesia residencies at three midwest university teaching hospitals...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/s0952-8180(97)00195-5
更新日期:1997-12-01 00:00:00
abstract::This is a case of systemic ropivacaine toxicity from a sciatic nerve catheter. A 20-year-old patient after heart transplant with poor systemic perfusion on hemodialysis and multiple medications experienced local anesthetic systemic toxicity 72 hours after placement of a peripheral nerve catheter. The case demonstrates...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2015.03.021
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVE:To evaluate changes in cardiac troponin-I levels after major vascular surgery and their association with early and late postoperative cardiac complications. DESIGN:Prospective, observational investigation. SETTING:University teaching hospital. PATIENTS:75 consecutive patients undergoing major vascular surg...
journal_title:Journal of clinical anesthesia
pub_type: 临床试验,杂志文章
doi:10.1016/j.jclinane.2005.11.005
更新日期:2006-06-01 00:00:00
abstract::Recent pharmacologic evidence supports the importance of the integrity of the endothelium in modulating vascular reactivity. The endothelial cells produce one or more endothelium derived relaxing factor(s) or EDRF that cause relaxation of vascular smooth muscle cells through production of cyclic guanosine monophosphat...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章,评审
doi:10.1016/0952-8180(88)90033-5
更新日期:1988-01-01 00:00:00