Abstract:
STUDY OBJECTIVE:To develop a rapid online test of graft liver function during liver transplantation. DESIGN:Prospective, observational study. SETTING:University hospital transplant unit. PATIENTS:17 adult patients with end-stage liver disease who underwent liver transplantation surgery. INTERVENTIONS:Rocuronium infusion dose requirements and plasma concentrations to maintain constant levels of neuromuscular paralysis during three phases of liver transplantation and their relationship with early postoperative liver function tests were studied. MEASUREMENTS:Infusion dose requirements of rocuronium, assay of rocuronium plasma concentrations using gas chromatography-mass spectrometry, and intensity of neuromuscular blockade were measured. MAIN RESULTS:A 24% decrease in rocuronium infusion requirements was observed during the an-hepatic phase. Rocuronium requirement during the neohepatic phase was increased only modestly or remained unchanged in 14 of the 16 patients who had normal graft function in the immediate postoperative period. Rocuronium plasma concentrations for maintaining constant levels of paralysis were significantly lower during the neohepatic phase than during the paleohepatic and anhepatic phases, indicating that there is likely to be a change in pharmacodynamics during this phase. Significant reduction in rocuronium infusion requirements during the neohepatic phase was observed in the only patient who had poor graft function in the early postoperative stage, suggesting that the reduced infusion requirement to maintain a constant neuromuscular paralysis may be related to the functional state of the graft liver after reperfusion. CONCLUSIONS:A significant reduction in rocuronium infusion requirement during the neohepatic phase may be suggestive of impaired organ function after reperfusion of the graft liver. Rocuronium may serve as a potential online indicator of graft liver function during liver transplantation by measurement of its infusion requirements during transplantation.
journal_name
J Clin Anesthjournal_title
Journal of clinical anesthesiaauthors
Gao L,Ramzan I,Baker Bdoi
10.1016/s0952-8180(03)00061-8subject
Has Abstractpub_date
2003-06-01 00:00:00pages
257-66issue
4eissn
0952-8180issn
1873-4529pii
S0952818003000618journal_volume
15pub_type
临床试验,杂志文章abstract:STUDY OBJECTIVE:To investigate the effects of intravenous (IV) versus oral clonidine on alterations of heart rate (HR), mean arterial pressure (MAP), cardiac output (CO), and plasma-catecholamines due to endotracheal intubation. DESIGN:Randomized, double-blind, placebo-controlled study. SETTING:University hospital su...
journal_title:Journal of clinical anesthesia
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/S0952-8180(97)00239-0
更新日期:1997-03-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the effect-site target concentration (C(et)) of remifentanil that provides optimal conditions for patients and operators during cataract surgery during monitored anesthesia care using a target controlled infusion (TCI) of propofol and remifentanil. DESIGN:Prospective, randomized, double-bl...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jclinane.2010.02.007
更新日期:2010-11-01 00:00:00
abstract::The acceptance of new and increasingly expensive technologies is a major component of the rising costs of health care. While the practice of anesthesia has been relatively immune from the effects of cost containment, it is inevitable that practitioners will have to justify costly practices. Available pharmacoeconomic ...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/s0952-8180(05)80008-x
更新日期:1994-09-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the risk factors of perioperative complications and the impact of intrathecal morphine (ITM) in major vascular surgery. DESIGN:Retrospective analysis of a prospective cohort. SETTINGS:Operating room, intensive care unit, and Postanesthesia Care Unit of a university hospital. MEASUREMENTS...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2013.01.009
更新日期:2013-06-01 00:00:00
abstract:STUDY OBJECTIVE:To report the occurrence of pseudo-hypotension during posterior osteotomy for correction of kyphosis in patients with ankylosing spondylitis. DESIGN:Retrospective case series. SETTING:University-affiliated hospital. MEASUREMENTS:The records of 36 patients with ankylosing spondylitis, who had severe t...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2012.05.001
更新日期:2013-02-01 00:00:00
abstract:STUDY OBJECTIVES:To assess whether the year of residency in anesthesiology is associated with residents' overall perceptions of the learning environment and to evaluate the association between year of residency and each of the five domains of the Dundee Ready Education Environment Measure (DREEM) survey. DESIGN:Cross-...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2016.09.017
更新日期:2016-12-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate and compare cardiovascular responses to a new method of orotracheal intubation incorporating TV monitoring, with conventional orotracheal intubation via rigid blade laryngoscopy. DESIGN:Prospective single-blind study. SETTING:Operating room of a medical college hospital. PATIENTS:90 ASA p...
journal_title:Journal of clinical anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0952-8180(00)00196-3
更新日期:2000-11-01 00:00:00
abstract::A parturient presented at 35 weeks' gestation with worsening neurological symptoms caused by syringomyelia. She underwent urgent cesarean delivery. The etiology and anesthetic considerations for an obstetrical patient with syringomyelia are discussed. ...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2011.03.007
更新日期:2011-12-01 00:00:00
abstract::Approximately 2 million closed head injuries (CHIs) occur yearly in the United States. Twenty-five percent of these injuries require hospitalization, and 70,000 to 90,000 of those hospitalized suffer long-term disability. This case conference details one such case of CHI in which the patient ultimately died. Close att...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/s0952-8180(05)80020-0
更新日期:1994-09-01 00:00:00
abstract::Horner's syndrome is a complication of epidural analgesia and anesthesia, encountered more commonly in pregnant women than in other patients. Previous reports described the appearance of Horner's syndrome following epidural injection of concentrated local anesthetic solutions. We report unilateral Horner's syndrome oc...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/s0952-8180(03)00017-5
更新日期:2003-05-01 00:00:00
abstract:STUDY OBJECTIVE:To determine if open-access scheduling would reduce the cancellation rate for new patient evaluations in a chronic pain clinic by at least 50%. DESIGN:Retrospective, observational study using electronic health records. SETTING:Chronic pain clinic of an academic anesthesia department. PATIENTS:All pat...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2017.06.003
更新日期:2017-09-01 00:00:00
abstract:STUDY OBJECTIVE:To establish the analgesic effective doses as defined as a visual analog pain scale (VAS) of at least 10 for 95% of parturients (ED95) receiving either epidural fentanyl or sufentanil with bupivacaine 0.125% for labor analgesia. DESIGN:Double-blind, randomized controlled study. SETTING:Two tertiary-ca...
journal_title:Journal of clinical anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0952-8180(98)00113-5
更新日期:1998-12-01 00:00:00
abstract:STUDY OBJECTIVE:To define the optimal dose of lidocaine to be added to propofol to reduce the incidence of pain during its injection. DESIGN:Double-blind, randomized, placebo-controlled study. SETTING:Medical center operating rooms. PATIENTS:135 ASA I and II female patients undergoing minor outpatient surgery. INTE...
journal_title:Journal of clinical anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0952-8180(96)00133-x
更新日期:1996-11-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate patient acceptability of continued versus divided anesthetic care. DESIGN:Patient satisfaction ratings with continuous and divided anesthetic care were assessed by patient questionnaire. In addition, the effect of training anesthesia personnel in communication regarding divided anesthesia c...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2006.04.004
更新日期:2007-02-01 00:00:00
abstract:STUDY OBJECTIVE:The aim of this study is to compare the effects of intravenous single-dose dexketoprofen trometamol and diclofenac sodium 30 minutes before the end of the surgery on relief of postoperative pain in patients undergoing laparoscopic cholecystectomy. DESIGN:A randomized fashion. SETTING AND PATIENTS:Sixt...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jclinane.2016.02.020
更新日期:2016-08-01 00:00:00
abstract:STUDY OBJECTIVE:To investigate whether gender difference has an effect on an anesthesia resident's ability to perform successful mask ventilation. DESIGN:Cohort study. SETTING:Surgical operation theater of a university-affiliated hospital. PATIENTS:839 ASA physical status I, II, and III patients undergoing general a...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2008.06.037
更新日期:2009-05-01 00:00:00
abstract:STUDY OBJECTIVE:To compare turnover times for a series of elective cases with surgeons following themselves with turnover times for a series of previously scheduled elective procedures for which the succeeding surgeon differed from the preceding surgeon. DESIGN:Retrospective cohort study. SETTING:University-affiliate...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2014.02.008
更新日期:2014-08-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate patient satisfaction and patient reported anaesthesia related outcome parameters after outpatient surgery. DESIGN:A three-year (2013-2016) observational study. SETTING:A surgical day care centre embedded in a tertiary care, university hospital. PATIENTS:Adult Dutch-speaking patients who u...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2017.09.007
更新日期:2017-12-01 00:00:00
abstract::Arterial misplacement of the Swan-Ganz catheter occurs occasionally and usually can be easily detected. However, in some special clinical settings, the problem may become more complicated. We report a case of chronic obstructive pulmonary disease in which, because of severe hypoxemia, systemic hypotension, and pulmona...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/0952-8180(95)00032-d
更新日期:1995-06-01 00:00:00
abstract:STUDY OBJECTIVE:To compare the postoperative analgesia of three different concentrations of levobupivacaine for ilioinguinal/iliohypogastric (II/IH) block in children undergoing inguinal hernia repair. DESIGN:Double-blind, prospective, randomized, controlled trial. SETTING:Operating room and postoperative recovery ar...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jclinane.2008.10.012
更新日期:2009-09-01 00:00:00
abstract:STUDY OBJECTIVE:To determine if practicing anesthesiologists recommend preoperative evaluations consistent with the 2007 ACC/AHA guidelines on perioperative care. DESIGN:Survey instrument. SETTING:Academic medical center. SUBJECTS:ASA membership. MEASUREMENTS:In this Web-based survey, participants were presented wi...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jclinane.2011.11.007
更新日期:2012-09-01 00:00:00
abstract:STUDY OBJECTIVE:To correlate tracheal width as measured by ultrasound with width measured by computed tomography (CT), and to evaluate the possible role of ultrasound in the selection of the proper size of left-sided double-lumen endotracheal tubes (LDLTs). DESIGN:Two independent, prospective, observational clinical s...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2007.11.002
更新日期:2008-06-01 00:00:00
abstract::Oxymetazoline nasal spray is a potent alpha 1-adrenergic agonist commonly used to vasoconstrict blood vessels in the nasal mucosa. In this incident, oxymetazoline nasal spray 0.025% was administered to a 2-year-old patient during general anesthesia for nasal endoscopy. Severe hypertension with reflex bradycardia progr...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/0952-8180(95)00060-u
更新日期:1995-09-01 00:00:00
abstract:STUDY OBJECTIVE:To test the hypothesis that the change of body and head position affects upper airway patency during midazolam sedation. DESIGN:Clinical study using 30 healthy subjects. SETTING:Research unit for sleep study. INTERVENTIONS:We used a pressure-flow relationship to evaluate critical closing pressure (Pc...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2005.08.010
更新日期:2006-05-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate whether alkalizing local anesthetic with sodium bicarbonate reduces pain related to infiltration of local anesthetic during dorsal penile nerve block for circumcision. DESIGN:Prospective, randomized, double-blind, controlled study. SETTING:E. Wolfson Medical Center, Holon, Israel. PATIENT...
journal_title:Journal of clinical anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0952-8180(99)00097-5
更新日期:1999-11-01 00:00:00
abstract::Multiple drugs are used to provide anesthesia. Volatile anesthetics are commonly combined with opioids. Several studies have demonstrated that small doses of opioid (i.e., within the analgesic range) result in a marked reduction in minimum alveolar concentration (MAC) of the volatile anesthetic that will prevent purpo...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章,评审
doi:10.1016/s0952-8180(97)00122-0
更新日期:1997-09-01 00:00:00
abstract:STUDY OBJECTIVES:To evaluate and compare cisatracurium-induced neuromuscular blockade and intubating conditions between immediate postpartum (PP) and nonpregnant (NP) patients. DESIGN:Prospective control study. SETTINGS:University Hospital Center. PATIENTS:44 ASA physical status I and II patients: 22 immediate postp...
journal_title:Journal of clinical anesthesia
pub_type: 临床试验,杂志文章
doi:10.1016/s0952-8180(01)00226-4
更新日期:2001-03-01 00:00:00
abstract:OBJECTIVE:To evaluate and compare the face mask (FM) and oral mask (OM) ventilation techniques during anesthesia emergence regarding tidal volume, leak volume, and difficult mask ventilation (DMV) incidence. DESIGN:Prospective, randomized, crossover study. SETTING:Operating room, training and research hospital. SUBJ...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jclinane.2015.12.008
更新日期:2016-06-01 00:00:00
abstract:STUDY OBJECTIVE:To confirm the relationship between bevel orientation, catheter direction, and radiopaque contrast spread in the lumbar region. DESIGN:Pilot cadaver study. SETTING:Anatomy laboratory of a university hospital. MEASUREMENTS:Cadavers were randomized to two groups of 4 cadavers each. In Group 1, needle b...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2014.04.004
更新日期:2014-12-01 00:00:00
abstract:STUDY OBJECTIVE:To survey graduates from our residency program to determine their involvement and their interest in becoming certified in neonatal resuscitation. DESIGN:Survey questionnaire. SETTING:Graduates from the University of Pennsylvania Anesthesia Program between 1989 and 1999. SUBJECTS:212 individuals compl...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/s0952-8180(01)00285-9
更新日期:2001-08-01 00:00:00