Abstract：
STUDY OBJECTIVE:To define the optimal dose of lidocaine to be added to propofol to reduce the incidence of pain during its injection. DESIGN:Double-blind, randomized, placebo-controlled study. SETTING:Medical center operating rooms. PATIENTS:135 ASA I and II female patients undergoing minor outpatient surgery. INTERVENTIONS:Patients were randomly allocated to one of five groups: Group A (control), no lidocaine: Group B, lidocaine 10 mg: Group C, lidocaine 20 mg; Group D, lidocaine 30 mg; Group F, lidocaine 40 mg. For each patient, pain during injection of the propofol solution was graded as none, mild, moderate, or severe. MEASUREMENTS AND MAIN RESULTS:The incidence of pain in the control group was 85%. All treatment groups receiving lidocaine had a significantly lower incidence of pain compared with the control group (P < 0.001). The lidocaine 30 mg and 40 mg groups both had a 7% incidence of pain, which was significantly less than a 33% incidence in the lidocaine 10 mg group (P < 0.05). CONCLUSIONS:Within this dose range and in this patient population, 30 mg of lidocaine is optimal for reducing the pain during injection of propofol.
journal_name
J Clin Anesthjournal_title
Journal of clinical anesthesiaauthors
Gajraj NM,Nathanson MHdoi
10.1016/s0952-8180(96)00133-xsubject
Has Abstractpub_date
1996-11-01 00:00:00pages
575-7issue
7eissn
0952-8180issn
1873-4529pii
S0952-8180(96)00133-Xjournal_volume
8pub_type
临床试验,杂志文章,随机对照试验abstract：:During surgical removal of tumors of the skull base or cerebellopontine angle with brainstem compression, the vagus nerve is at a high risk for injury that can result in permanent or transient swallowing and speech dysfunction. Intramuscular recording of cricothyroid muscle can be used for vagal nerve mapping during i...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/j.jclinane.2015.01.002
更新日期：2015-05-01 00:00:00
abstract：STUDY OBJECTIVE:To ascertain the optimal dose of trimethaphan camsylate administered by intravenous (i.v.) bolus injection for the control of hypertension and tachycardia during electroconvulsive therapy (ECT). DESIGN:Prospective, double blind, within-subject study. SETTING:Treating room of the psychiatric unit of th...
journal_title：Journal of clinical anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0952-8180(95)00192-1
更新日期：1996-03-01 00:00:00
abstract：:This study examines whether epidural anesthesia is more effective than general anesthesia using an inhalation agent in controlling cardiovascular responses during femoral-popliteal bypass surgery. Nineteen patients were randomized into two groups: general anesthesia (n = 10) and epidural anesthesia (n = 9). The patien...
journal_title：Journal of clinical anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0952-8180(90)90056-9
更新日期：1990-03-01 00:00:00
abstract：STUDY OBJECTIVE:To examine and compare the mechanism of injury, diagnostic findings, initial methods of airway management, and outcome of patients who had upper airway injuries. DESIGN:A retrospective review of hospital records. SETTING:A large metropolitan, university-affiliated trauma center. PATIENTS:Forty-six ca...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/0952-8180(91)90003-6
更新日期：1991-03-01 00:00:00
abstract：STUDY OBJECTIVE:To confirm the relationship between bevel orientation, catheter direction, and radiopaque contrast spread in the lumbar region. DESIGN:Pilot cadaver study. SETTING:Anatomy laboratory of a university hospital. MEASUREMENTS:Cadavers were randomized to two groups of 4 cadavers each. In Group 1, needle b...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/j.jclinane.2014.04.004
更新日期：2014-12-01 00:00:00
abstract：:Tracheobronchopathia osteochondroplastica is a rare disorder characterized by cartilaginous or ossified submucosal nodules that project into the tracheobronchial lumen. It is typically discovered in the evaluation of chronic upper respiratory symptoms. A case of a completely asymptomatic man diagnosed with extensive d...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/j.jclinane.2013.05.010
更新日期：2013-12-01 00:00:00
abstract：:Opioids decrease the sympathetic and somatic responses to noxious stimulation and can be given in high doses without negative inotropic effects, even in patients with impaired cardiac function. With currently available opioids, precise titration of dose to effect is difficult, and high doses result in drug accumulatio...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章,评审
doi：10.1016/s0952-8180(96)00179-1
更新日期：1996-12-01 00:00:00
abstract：:In December 2001, the United States Food and Drug Administration (FDA) added a "black box" warning to the labeling for droperidol stating that all doses, even those typically used for postoperative nausea and vomiting, were potentially associated with malignant ventricular dysrhythmias, including torsade de pointes. T...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/s0952-8180(02)00445-2
更新日期：2002-12-01 00:00:00
abstract：STUDY OBJECTIVE:To provide a contemporary medicolegal analysis of claims brought against anesthesia providers in the United States related to neuraxial blocks for surgery and obstetrics. DESIGN:In this retrospective analysis, we analyzed closed claims data from the Controlled Risk Insurance Company (CRICO) Comparative...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/j.jclinane.2019.03.013
更新日期：2019-11-01 00:00:00
abstract：STUDY OBJECTIVE:To determine the effect of intravenous administration of prostaglandin E1 (PGE1) in inducing controlled hypotension during general anesthesia. DESIGN:Randomized, prospective study. SETTING:Inpatient surgery at a university hospital. PATIENTS:57 ASA physical status I and II patients scheduled for tota...
journal_title：Journal of clinical anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0952-8180(93)90125-x
更新日期：1993-07-01 00:00:00
abstract：:A 27-year-old parturient developed a severe headache after placement of a labor epidural catheter. A presumptive diagnosis of an occult postdural puncture headache (PDPH) was made, and the patient was treated with an intravenous (IV) infusion of 500 mg of caffeine sodium benzoate (CSB) to vasoconstrict dilated cerebra...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/0952-8180(92)90121-g
更新日期：1992-01-01 00:00:00
abstract：:Neuromuscular blocking agents are used in many surgical procedures and have enabled new surgical advances. The expanded landscape of neuromuscular blockade (NMB) reversal drugs allows for fast and complete NMB reversal and the reduction of postoperative complications from residual block. In the United States, neostigm...
journal_title：Journal of clinical anesthesia
pub_type： 信件
doi：10.1016/j.jclinane.2017.07.004
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Hybrid operating room suites with intraoperative magnetic resonance imaging enable image guided surgery in a fully functional operating room environment. While this environment creates challenges to anesthetic care, the effects on anesthetic adverse events and outcomes are largely unknown. This...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/j.jclinane.2018.10.022
更新日期：2019-05-01 00:00:00
abstract：STUDY OBJECT:To investigate the changes in hemodynamics and hypnotic levels during propofol infusion and tracheal intubation with and without fentanyl. DESIGN:Randomized, double-blinded study. SETTING:Teaching hospital. PATIENTS:40 ASA physical status I adult patients scheduled for elective surgery. INTERVENTIONS:P...
journal_title：Journal of clinical anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0952-8180(01)00375-0
更新日期：2002-03-01 00:00:00
abstract：:Posterior reversible encephalopathy syndrome refers to a neuroradiologic disorder in which seizure activity (multiple seizures are more common than single events) is commonly the initial presenting symptom. We describe a case of posterior reversible encephalopathy syndrome in a previously healthy parturient who presen...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/j.jclinane.2006.07.004
更新日期：2007-03-01 00:00:00
abstract：PURPOSE:The aim of this study was to evaluate the effect of neuraxial blocks on surgical blood losses and on the number of patients requiring blood transfusion. METHODS:A search of the American National Library of Medicine's PubMed up to November 12, 2004, was performed. Twenty-four studies could be kept for analysis....
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章,meta分析
doi：10.1016/j.jclinane.2005.08.013
更新日期：2006-03-01 00:00:00
abstract：:A 13-year-old girl with Goltz's (Goltz-Gorlin) syndrome (focal dermal hypoplasia) and cloacal exstrophy underwent day surgery cystoscopy. During the administration of inhalation anesthesia by mask, persistent partial upper airway obstruction was noted. Direct laryngoscopy unexpectedly showed variously sized verrucous ...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/0952-8180(91)90190-x
更新日期：1991-09-01 00:00:00
abstract：:The case of a patient with hereditary angioedema (HAE), a rare, life-threatening disorder caused by reduced activity of the C1 esterase inhibitor, and requiring off-pump coronary artery bypass graft (OP-CABG) surgery, is presented. Perioperative management of patients with HAE who undergo complex cardiac surgical proc...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/j.jclinane.2009.04.007
更新日期：2010-06-01 00:00:00
abstract：STUDY OBJECTIVE:To evaluate airway changes in patients undergoing surgery in the prone position. DESIGN:Single-arm observational study. PATIENTS:Patients between 18 to 65 years old, scheduled for prone spinal surgery; 74 patients were enrolled and 54 patients were analyzed. INTERVENTION:The initial airway examinatio...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/j.jclinane.2014.04.010
更新日期：2014-12-01 00:00:00
abstract：:We report the case of a 13 year old patient who received 3.0 mg of remifentanil during a 50-minute surgical procedure as a result of a dosage miscalculation. The patient failed to awaken at the conclusion of the procedure and showed signs of opioid overdose. She recovered spontaneously two hours later. ...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/j.jclinane.2010.07.005
更新日期：2011-06-01 00:00:00
abstract：STUDY OBJECTIVE:To compare a total intravenous (IV) anesthetic technique based on propofol and alfentanil with a commonly used anesthetic technique for craniotomy. DESIGN:Open-label, randomized, clinical study. SETTING:Neurosurgical clinic at a university hospital. PATIENTS:Forty patients, aged 18 to 55 years, sched...
journal_title：Journal of clinical anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0952-8180(91)90010-k
更新日期：1991-03-01 00:00:00
abstract：STUDY OBJECTIVE:To document the effects of compromised respiratory function on oxygen saturation (SpO2) after cesarean section via the telemetric pulse oximetry network (TPON) for 24 continuous hours. DESIGN:Prospective study. SETTING:Postpartum ward of a university hospital. PATIENTS:ASA physical status I or II par...
journal_title：Journal of clinical anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0952-8180(94)90009-4
更新日期：1994-03-01 00:00:00
abstract：STUDY OBJECTIVE:To survey graduates from our residency program to determine their involvement and their interest in becoming certified in neonatal resuscitation. DESIGN:Survey questionnaire. SETTING:Graduates from the University of Pennsylvania Anesthesia Program between 1989 and 1999. SUBJECTS:212 individuals compl...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/s0952-8180(01)00285-9
更新日期：2001-08-01 00:00:00
abstract：:We describe the anesthetic management of a morbidly obese patient with obstructive sleep apnea who underwent awake craniotomy. The patient's personal continuous positive airway pressure (CPAP) machine was used to support ventilation intraoperatively. Dexmedetomidine was used as the primary sedative. During cortical ma...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/j.jclinane.2007.10.015
更新日期：2008-06-01 00:00:00
abstract：:Oxymetazoline nasal spray is a potent alpha 1-adrenergic agonist commonly used to vasoconstrict blood vessels in the nasal mucosa. In this incident, oxymetazoline nasal spray 0.025% was administered to a 2-year-old patient during general anesthesia for nasal endoscopy. Severe hypertension with reflex bradycardia progr...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/0952-8180(95)00060-u
更新日期：1995-09-01 00:00:00
abstract：:The neurologic implications of diabetic hyperglycemia depend on whether the ischemic insult is permanent or temporary. Laboratory studies show that following permanent focal ischemia, a situation analogous to stroke, diabetic hyperglycemia is protective in the penumbral region, whereas it may slightly increase infarct...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章,评审
doi：10.1016/s0952-8180(97)00021-4
更新日期：1997-06-01 00:00:00
abstract：:Recent pharmacologic evidence supports the importance of the integrity of the endothelium in modulating vascular reactivity. The endothelial cells produce one or more endothelium derived relaxing factor(s) or EDRF that cause relaxation of vascular smooth muscle cells through production of cyclic guanosine monophosphat...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章,评审
doi：10.1016/0952-8180(88)90033-5
更新日期：1988-01-01 00:00:00
abstract：:A case of new-onset atrial fibrillation subsequent to activation of neuraxial anesthesia is presented. The development of atrial fibrillation was temporally related to placement and dosing of an epidural catheter, and may have been triggered by a vagal response to dosing of the anesthetic or the resulting treatment wi...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章,评审
doi：10.1016/j.jclinane.2011.10.013
更新日期：2012-06-01 00:00:00
abstract：:We report an 11-year-old male with undiagnosed myopathy, who developed cardiac arrest secondary to severe rhabdomyolysis and hyperkalemia following succinylcholine administration. The patient required extracorporeal membrane oxygenation support from which he was eventually weaned successfully. He died eleven days afte...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/j.jclinane.2003.09.020
更新日期：2004-09-01 00:00:00
abstract：STUDY OBJECTIVE:To evaluate the reliability of assessments of nasal flow rate for improved nostril selection for nasotracheal intubation. DESIGN:Prospective, randomized, double-blinded study. SETTING:Operating room of a university-affiliated hospital. PATIENTS:118 ASA physical status 1 and 2 patients, aged 18-65 yea...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.jclinane.2011.08.006
更新日期：2012-06-01 00:00:00
