Abstract:
STUDY OBJECTIVE:To establish the analgesic effective doses as defined as a visual analog pain scale (VAS) of at least 10 for 95% of parturients (ED95) receiving either epidural fentanyl or sufentanil with bupivacaine 0.125% for labor analgesia. DESIGN:Double-blind, randomized controlled study. SETTING:Two tertiary-care teaching hospitals. PATIENTS:100 female patients, at full-term pregnancy, in active early labor (< 5 cm cervical dilation) and requesting obstetric anesthesia services for labor analgesia. INTERVENTIONS:Patients were randomized and equally distributed to receive one of ten epidural dosing regimens of bupivacaine 0.125% alone or with either fentanyl 25, 50, 75, or 100 micrograms or sufentanil 5, 10, 15, 20, or 25 micrograms in a 10-ml bolus after a 3-ml test dose of bupivacaine 0.25%. MEASUREMENTS AND MAIN RESULTS:VAS scores were obtained from each parturient using a 10-cm plastic VAS slide rule at times 0, 1, 5, 10, 15, 20, 25, and 30 minutes, and then again when the patient requested additional analgesia. Analgesic duration and demographic and obstetric data also were obtained. Using a log-probit dose-response analysis, analgesic success as defined as a VAS of at least 10 with each opioid dose was plotted and an ED95 value of 8 micrograms and 50 micrograms was established for sufentanil and fentanyl, respectively, in bupivacaine 0.125%. No statistical difference was detected for analgesic duration or incidence of side effects between analgesic groups. CONCLUSIONS:Epidural analgesia with fentanyl and sufentanil in bupivacaine 0.125% behaves in a dose-response fashion allowing for the determination of equipotent dose of each.
journal_name
J Clin Anesthjournal_title
Journal of clinical anesthesiaauthors
Herman NL,Sheu KL,Van Decar TK,Rubin JD,Gadalla F,Koff HD,Reynolds JEdoi
10.1016/s0952-8180(98)00113-5subject
Has Abstractpub_date
1998-12-01 00:00:00pages
670-7issue
8eissn
0952-8180issn
1873-4529pii
S0952-8180(98)00113-5journal_volume
10pub_type
临床试验,杂志文章,随机对照试验abstract::With the advent of safety needles to prevent inadvertent needle sticks in the operating room (OR), a potentially new issue has arisen. These needles may result in coring, or the shaving off of fragments of the rubber stopper, when the needle is pierced through the rubber stopper of the medication vial. These fragments...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2013.10.007
更新日期:2014-03-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the onset time, success rate, and recovery profile of unilateral spinal anesthesia produced with 4 mg, 6 mg, and 8 mg of 0.5% hyperbaric bupivacaine. DESIGN:Prospective, randomized, blinded study. SETTING:Outpatient anesthesia unit at a University Hospital. PATIENTS:90 ASA physical status...
journal_title:Journal of clinical anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0952-8180(03)00078-3
更新日期:2003-08-01 00:00:00
abstract::We anesthesized a patient susceptible to malignant hyperthermia (MH) three different times by epidural anesthesia with different types of local anesthetics. His skinned fiber test showed a marked acceleration of calcium (Ca2+)-induced Ca2+ release (CICR). When ester type local anesthetic was used for ankle contracture...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/0952-8180(95)00204-9
更新日期:1996-03-01 00:00:00
abstract:STUDY OBJECTIVE:To compare spinal anesthesia and combined sciatic-femoral nerve block for outpatient knee arthroscopy. DESIGN:Prospective, randomized, controlled study. SETTING:Postoperative recovery area at a university-affiliated medical center. PATIENTS:50 ASA physical status I and II adult outpatients undergoing...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jclinane.2008.04.003
更新日期:2008-09-01 00:00:00
abstract:STUDY OBJECTIVE:To investigate whether the phase of menstrual cycle influences the incidence of postoperative nausea and vomiting (PONV) in women undergoing general anesthesia for elective laparoscopic gynecological surgery. DESIGN:Prospective, observational, blinded study. SETTING:General hospital, Postanesthesia Ca...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2011.07.011
更新日期:2012-05-01 00:00:00
abstract:STUDY OBJECTIVE:Perioperative fasting guidelines differ in their approaches to chewing gum in the preoperative period. Current recommendations range from canceling the surgery to proceeding with it. Given this lack of consensus, we performed gastric ultrasound assessments in healthy volunteers before and after a standa...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2019.01.021
更新日期:2019-09-01 00:00:00
abstract:STUDY OBJECTIVE:To determine whether postoperative wound infiltration with local anesthetics combined with fentanyl improves analgesia following breast surgery; and to investigate awakening and postoperative nausea/vomiting. DESIGN:Prospectively randomized clinical study. SETTING:University hospital. PATIENTS:45 ASA...
journal_title:Journal of clinical anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0952-8180(02)00511-1
更新日期:2003-03-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the cerebrospinal fluid (CSF): total plasma concentration ratio of ketorolac tromethamine following a single intramuscular (IM) dose. DESIGN:Open, single-dose, IM-administration study. SETTING:General operating theaters of a medical school hospital. PATIENTS:29 ASA physical status I and ...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/0952-8180(93)90061-i
更新日期:1993-11-01 00:00:00
abstract:OBJECTIVE:To evaluate changes in cardiac troponin-I levels after major vascular surgery and their association with early and late postoperative cardiac complications. DESIGN:Prospective, observational investigation. SETTING:University teaching hospital. PATIENTS:75 consecutive patients undergoing major vascular surg...
journal_title:Journal of clinical anesthesia
pub_type: 临床试验,杂志文章
doi:10.1016/j.jclinane.2005.11.005
更新日期:2006-06-01 00:00:00
abstract::The American Society of Anesthesiologists, the Anesthesia Patient Safety Foundation, the Joint Commission on the Accreditation of Healthcare Organizations (JCAHO), and the Patient Safety and Quality Improvement Act of 2005 encourage anesthesiology departments to institute systematic improvements in patient safety, inc...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2008.09.010
更新日期:2009-08-01 00:00:00
abstract:STUDY OBJECTIVE:To compare emergence from anesthesia and the hemodynamic and respiratory depressant effects of thiopental sodium infusion plus sufentanil or fentanyl with those of isoflurane as the primary component of a balanced technique for neuroanesthesia. DESIGN:Randomized, double-blind, prospective study. SETTI...
journal_title:Journal of clinical anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0952-8180(92)90158-w
更新日期:1992-09-01 00:00:00
abstract:STUDY OBJECTIVE:To ascertain current anesthesia utilization of esophageal and precordial stethoscopes in U.S. anesthesia training programs. DESIGN:Prospective, single-blind, incidence study. SETTING:Operating rooms of three tertiary care hospitals with major academic anesthesiology departments. SUBJECTS:Anesthesia f...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章,多中心研究
doi:10.1016/0952-8180(95)00027-f
更新日期:1995-08-01 00:00:00
abstract:STUDY OBJECTIVES:To test the effect of stellate ganglion block on tympanic membrane temperatures. DESIGN:Prospective, observational study. SETTING:Department of Anesthesia, Yamanashi Medical University, Yamanashi, Japan. SUBJECTS:7 healthy male volunteers. INTERVENTIONS:Stellate ganglion block, 6 ml of 1% mepivacai...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/s0952-8180(98)00092-0
更新日期:1998-12-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the effect-site target concentration (C(et)) of remifentanil that provides optimal conditions for patients and operators during cataract surgery during monitored anesthesia care using a target controlled infusion (TCI) of propofol and remifentanil. DESIGN:Prospective, randomized, double-bl...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jclinane.2010.02.007
更新日期:2010-11-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the effects of alfentanil or lidocaine on the excitatory phenomena (myoclonus, cough, hiccough) caused by methohexital anesthesia and on the hemodynamic changes induced by retrobulbar block. DESIGN:Prospective, randomized, placebo-controlled, double-blind study. SETTING:University-affiliat...
journal_title:Journal of clinical anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0952-8180(98)00072-5
更新日期:1998-09-01 00:00:00
abstract:STUDY OBJECTIVE:To report the occurrence of pseudo-hypotension during posterior osteotomy for correction of kyphosis in patients with ankylosing spondylitis. DESIGN:Retrospective case series. SETTING:University-affiliated hospital. MEASUREMENTS:The records of 36 patients with ankylosing spondylitis, who had severe t...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2012.05.001
更新日期:2013-02-01 00:00:00
abstract:STUDY OBJECTIVE:To investigate associations of heart rate variability (HRV) measurements with postoperative atrial fibrillation (AF) in patients undergoing off-pump coronary surgery. DESIGN:Prospective, observational, exploratory study. SETTING:Large university-affiliated community medical center. PATIENTS:50 patien...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2010.12.016
更新日期:2011-09-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the immediate effect of epidural blood patch (EBP) on the hearing loss that can accompany postdural puncture headache (PDPH). DESIGN:Prospective open study. SETTING:Anesthetic and otolaryngologic departments at a university hospital. SUBJECTS:16 patients who developed severe PDPH followi...
journal_title:Journal of clinical anesthesia
pub_type: 临床试验,杂志文章
doi:10.1016/0952-8180(95)00053-k
更新日期:1995-09-01 00:00:00
abstract:STUDY OBJECTIVES:To examine whether epidural administration of neostigmine reduces the stress and inflammatory responses thereby improving postoperative pain status. DESIGN:Randomized, double-blinded clinical study. SETTING:Operating rooms and wards of a university hospital. PATIENTS:40 ASA physical status I patient...
journal_title:Journal of clinical anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.jclinane.2003.12.009
更新日期:2004-11-01 00:00:00
abstract::Vagus nerve stimulation (VNS) for medically refractory seizures has been an approved therapy by the Food and Drug Administration since 1997, with additional approval as an adjunct therapy for major depression granted in 2005. Potential applications for VNS therapy in obesity, neuropsychiatric disorders, and chronic pa...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章,评审
doi:10.1016/j.jclinane.2009.10.002
更新日期:2010-05-01 00:00:00
abstract:STUDY OBJECTIVE:Evaluate feasibility of 1-day OR management course for anesthesiology residents and determine if course content increases trust in OR management science. DESIGN:Pre- and post-course survey evaluations. SETTING:OR management course. PATIENTS:University of Florida anesthesiology residents. INTERVENTIO...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2018.12.045
更新日期:2019-08-01 00:00:00
abstract:STUDY OBJECTIVE:To compare the effects of Truview PCD™ video laryngoscopy (TVL) and Macintosh blade direct laryngoscopy (MDL) on hemodynamic responses observed during laryngoscopy and orotracheal intubation conditions in geriatric patients. DESIGN:Randomized prospective study. SETTING:Operating room. PATIENTS:One hu...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2016.09.010
更新日期:2016-12-01 00:00:00
abstract:STUDY OBJECTIVE:To evaluate the effect of clonidine when added to local anesthetics on duration of postoperative analgesia during retrobulbar block. DESIGN:Prospective, randomized controlled trial. SETTING:Operating room and Postanesthesia Care Unit of a university-affiliated hospital. SUBJECTS:80 ASA physical statu...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.jclinane.2010.12.014
更新日期:2011-08-01 00:00:00
abstract:STUDY OBJECTIVE:To assess intubating conditions without neuromuscular blocking drugs, to determine the relation between the dose of rocuronium and the probability of achieving excellent or at least good (good or excellent) intubating conditions with the intubating laryngeal mask airway (ILMA), and finally, to determine...
journal_title:Journal of clinical anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.jclinane.2004.06.009
更新日期:2005-05-01 00:00:00
abstract:STUDY OBJECTIVE:To determine the value of clinical history and preoperative coagulation tests. DESIGN:Prospective, multicenter clinical investigation. SETTING:Twenty-four centers over a one-year period. PATIENTS:1,706 children scheduled for tonsillectomy. In 1, 479 out of 1,706 children, studied age was ranged from ...
journal_title:Journal of clinical anesthesia
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1016/s0952-8180(00)00164-1
更新日期:2000-06-01 00:00:00
abstract::The benefits of cardiopulmonary exercise testing have been well established. Certain patient groups present challenges for conducting such a test. We were presented with a patient with a permanent tracheostomy at the preoperative assessment clinic. We describe our technique in overcoming the problem of connecting him ...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2016.04.019
更新日期:2016-11-01 00:00:00
abstract:STUDY OBJECTIVES:To investigate the hypothesis that the combination of ondansetron and droperidol would be more effective than droperidol alone in reducing nausea and vomiting. DESIGN:Randomized, doubleblind study. SETTING:Magee-Womens Hospital, Pittsburgh, Pennsylvania. PATIENTS:160 healthy, ASA physical status I a...
journal_title:Journal of clinical anesthesia
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/s0952-8180(97)00188-8
更新日期:1998-02-01 00:00:00
abstract::The neurologic implications of diabetic hyperglycemia depend on whether the ischemic insult is permanent or temporary. Laboratory studies show that following permanent focal ischemia, a situation analogous to stroke, diabetic hyperglycemia is protective in the penumbral region, whereas it may slightly increase infarct...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章,评审
doi:10.1016/s0952-8180(97)00021-4
更新日期:1997-06-01 00:00:00
abstract::The use of direct oral anticoagulants including apixaban, rivaroxaban, and dabigatran, which are approved for several therapeutic indications, can simplify perioperative and postoperative management of anticoagulation. Utilization of regional neuraxial anesthesia in patients receiving anticoagulants carries a relative...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章,评审
doi:10.1016/j.jclinane.2016.02.028
更新日期:2016-08-01 00:00:00
abstract:STUDY OBJECTIVE:To assess the clinical impact of paravertebral blocks (PVBs) on the immediate outcome of patients undergoing radical prostatectomy. DESIGN:Retrospective review. SETTING:Urology ward of a university medical center. MEASUREMENTS:Records of 100 consecutive patients who underwent a radical prostatectomy ...
journal_title:Journal of clinical anesthesia
pub_type: 杂志文章
doi:10.1016/j.jclinane.2006.12.003
更新日期:2007-06-01 00:00:00