Influence of the menstrual cycle on the incidence of nausea and vomiting after laparoscopic gynecological surgery: a pilot study.

Abstract:

STUDY OBJECTIVE:To investigate whether the phase of menstrual cycle influences the incidence of postoperative nausea and vomiting (PONV) in women undergoing general anesthesia for elective laparoscopic gynecological surgery. DESIGN:Prospective, observational, blinded study. SETTING:General hospital, Postanesthesia Care Unit, and gynecologic floor room. PATIENTS:111 ASA physical status 1 and 2 women, aged 18 to 53 years. INTERVENTIONS:Patients were classified into three groups according to the phase of menstrual cycle at the time of anesthesia: Group F1: follicular phase (menstrual days 1-8; n = 34); Group O2: ovulatory phase (days 9-15; n = 40); and Group L3: luteal phase (days 16 to end of cycle; n = 37). Anesthetic, postoperative pain management, and antiemetic regimens were standardized. MEASUREMENTS:Frequency of nausea, vomiting, or both were assessed for early (0-2 hrs). Late PONV (2-24 hrs) along with the use of rescue antiemetic, severity of nausea, and pain. MAIN RESULTS:In the follicular (n = 34), ovulatory (n = 40) and luteal phase (n = 37) groups, the frequencies of PONV over 24 hours were 35%, 38%, and 14% (P = 0.04), respectively. This was due to differences in the early postoperative period where the frequencies were 21%, 25%, and 3% (P = 0.02), respectively, as frequencies were similar in the late period (15%, 20% and 14%, P = 0.71), respectively. Nausea scores, rescue antiemetic usage, pain scores, and opioid consumption were similar in the groups. CONCLUSION:Patients in the luteal phase of their menstrual cycle may have a decreased risk of PONV after laparoscopic gynecological surgery in the early postoperative period.

journal_name

J Clin Anesth

authors

Šimurina T,Mraovic B,Skitarelić N,Andabaka T,Sonicki Z

doi

10.1016/j.jclinane.2011.07.011

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

185-92

issue

3

eissn

0952-8180

issn

1873-4529

pii

S0952-8180(12)00070-0

journal_volume

24

pub_type

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