Abstract：
STUDY OBJECTIVE:To determine the cerebrospinal fluid (CSF): total plasma concentration ratio of ketorolac tromethamine following a single intramuscular (IM) dose. DESIGN:Open, single-dose, IM-administration study. SETTING:General operating theaters of a medical school hospital. PATIENTS:29 ASA physical status I and II patients scheduled to undergo elective surgery with spinal anesthesia. INTERVENTIONS:Patients were premedicated with ketorolac 90 mg IM formulated as 3 ml of a 3% solution. Between 1 and 4 1/2 hours later, an intravenous infusion of 500 ml of compound sodium lactate was begun. Lumbar puncture was then performed, and 2 ml of CSF was collected prior to administration of the spinal anesthetic. In addition, a 5 ml sample of venous blood was taken within 5 minutes of the CSF sample. MEASUREMENTS AND MAIN RESULTS:Simultaneous plasma and CSF concentrations of ketorolac were measured between 62 and 277 minutes following IM administration in 29 patients undergoing spinal anesthesia. The CSF concentrations were on the order of 1,000 times less than the total plasma concentrations; free concentrations of ketorolac in plasma were estimated to be about 10 times more than those in CSF. There appeared to be no constant time factor relating the appearance of ketorolac in the CSF to its plasma concentration following IM administration. CONCLUSION:Although the sensitivity of central prostaglandin synthetase systems to inhibition is unknown, it is unlikely from this pharmacokinetic data that there is a major central mechanism of analgesia for ketorolac.
journal_name
J Clin Anesthjournal_title
Journal of clinical anesthesiaauthors
Rice AS,Lloyd J,Bullingham RE,O'Sullivan Gdoi
10.1016/0952-8180(93)90061-isubject
Has Abstractpub_date
1993-11-01 00:00:00pages
459-62issue
6eissn
0952-8180issn
1873-4529pii
0952-8180(93)90061-Ijournal_volume
5pub_type
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journal_title：Journal of clinical anesthesia
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journal_title：Journal of clinical anesthesia
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journal_title：Journal of clinical anesthesia
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abstract：STUDY OBJECTIVE:To study the development and implementation of a hospital-wide protocol regarding preoperative beta-blocker therapy. DESIGN:Prospective, observational clinical study. SETTING:Preoperative test center at a university hospital. PATIENTS:1,000 consecutive patients presenting for a preoperative visit and...
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abstract：STUDY OBJECTIVE:To compare 4 different anesthesia induction protocols, in a simulated model of rapid-sequence induction, in controlled hypertensive patients. DESIGN:Prospective, randomized, double-blind, clinical investigation. SETTING:Large metropolitan university hospital. PATIENTS:120 ASA II-III adult hypertensiv...
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abstract：STUDY OBJECTIVE:Obesity has detrimental effects on general health and respiratory function. This study aimed to evaluate respiratory muscle strength in the morbidly obese population, before and after bariatric surgery, and to compare these estimates with the predictive values using different mathematical equations avai...
journal_title：Journal of clinical anesthesia
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journal_title：Journal of clinical anesthesia
pub_type： 杂志文章,多中心研究
doi：10.1016/0952-8180(95)00027-f
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abstract：STUDY OBJECTIVE:To evaluate patient satisfaction and patient reported anaesthesia related outcome parameters after outpatient surgery. DESIGN:A three-year (2013-2016) observational study. SETTING:A surgical day care centre embedded in a tertiary care, university hospital. PATIENTS:Adult Dutch-speaking patients who u...
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journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
doi：10.1016/j.jclinane.2007.11.002
更新日期：2008-06-01 00:00:00
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journal_title：Journal of clinical anesthesia
pub_type： 历史文章,杂志文章
doi：10.1016/0952-8180(92)90226-q
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journal_title：Journal of clinical anesthesia
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journal_title：Journal of clinical anesthesia
pub_type： 杂志文章,随机对照试验
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更新日期：2009-03-01 00:00:00
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journal_title：Journal of clinical anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2001-08-01 00:00:00
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journal_title：Journal of clinical anesthesia
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更新日期：1997-11-01 00:00:00
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journal_title：Journal of clinical anesthesia
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期：1997-03-01 00:00:00
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journal_title：Journal of clinical anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2001-09-01 00:00:00
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journal_title：Journal of clinical anesthesia
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更新日期：2016-12-01 00:00:00
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journal_title：Journal of clinical anesthesia
pub_type： 信件
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更新日期：2017-11-01 00:00:00
