Betamethasone in prevention of postoperative nausea and vomiting following breast surgery.

Abstract:

STUDY OBJECTIVE:To investigate whether betamethasone decreases the incidence of postoperative nausea/vomiting (PONV) and reduces postoperative pain following partial mastectomy. DESIGN:Prospective randomized, double-blinded study. SETTING:Operating room and Postanesthesia Care Unit of a university hospital. PATIENTS:80 ASA physical status 1 and 2 women scheduled for elective breast cancer surgery. INTERVENTIONS:Patients were randomly allocated to two groups in double-blinded fashion: Group B (betamethasone; 37 pts) and Group C (control; 38 pts). Group B received 8 mg of betamethasone intravenously before the start of surgery. MEASUREMENTS:The rate of PONV and pain were recorded using a numeric rating scale (NRS; 0-10), as well as rescue doses of antiemetics (ondansetron) and analgesics (ketobemidone). MAIN RESULTS:There was a significant lower incidence of postoperative nausea (PON) scoring NRS ≥ 1 in Group B in the 4 to 12-hour period compared with Group C (P = 0.02). The cumulative incidence of PON was 57% in Group B versus 68% in Group C (P = 0.27). The overall incidence of postoperative vomiting (POV) was 18% and 20% in Groups B and C, respectively. Postoperative pain was reduced by 40% in Group B in the 4 to 12-hour period, but the mean dose of postoperative rescue analgesic did not differ between the groups. CONCLUSIONS:Preoperative betamethasone reduces the severity of PONV and pain in patients undergoing elective breast surgery.

journal_name

J Clin Anesth

authors

Olanders KJ,Lundgren GA,Johansson AM

doi

10.1016/j.jclinane.2014.02.006

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

461-5

issue

6

eissn

0952-8180

issn

1873-4529

pii

S0952-8180(14)00118-4

journal_volume

26

pub_type

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