Abstract：
STUDY OBJECTIVES:To evaluate the efficacy and safety of granisetron-droperidol combination for the prevention of postoperative nausea and vomiting (PONV) after middle ear surgery. DESIGN:Prospective, randomized, double-blind study. SETTING:University hospital. PATIENTS:150 ASA physical status I patients (108 females, 42 males) scheduled for elective middle ear surgery. INTERVENTIONS:Patients received granisetron 40 micrograms/kg (n = 50), droperidol 20 micrograms/kg (n = 50), or granisetron 40 micrograms/kg plus droperidol 20 micrograms/kg (n = 50) intravenously immediately before induction of anesthesia. MEASUREMENTS AND MAIN RESULTS:A standard general anesthetic technique and postoperative analgesia were used throughout the study. A complete response, defined as no PONV and no need for another rescue antiemetic, from 0 to 3 hours after anesthesia occurred in 78%, 56%, and 94% of patients who had received granisetron, droperidol, and granisetron plus droperidol, respectively. The corresponding incidence between 3 and 24 hours after anesthesia was 80%, 52% and 94%. Thus, a complete response within the first 24-hour postanesthetic period was greater in patients receiving granisetron-droperidol combination than in those receiving granisetron alone or droperidol alone (p < 0.05). No clinically adverse events were observed in any of the groups. CONCLUSIONS:A combination of granisetron and droperidol is more effective than droperidol or granisetron alone for the prevention of PONV after middle ear surgery.
journal_name
J Clin Anesthjournal_title
Journal of clinical anesthesiaauthors
Fujii Y,Saitoh Y,Tanaka H,Toyooka Hdoi
10.1016/s0952-8180(99)00011-2subject
Has Abstractpub_date
1999-03-01 00:00:00pages
108-12issue
2eissn
0952-8180issn
1873-4529pii
S0952818099000112journal_volume
11pub_type
临床试验,杂志文章,随机对照试验,收录出版abstract：STUDY OBJECTIVE:To ascertain the optimal dose of trimethaphan camsylate administered by intravenous (i.v.) bolus injection for the control of hypertension and tachycardia during electroconvulsive therapy (ECT). DESIGN:Prospective, double blind, within-subject study. SETTING:Treating room of the psychiatric unit of th...
journal_title：Journal of clinical anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0952-8180(95)00192-1
更新日期：1996-03-01 00:00:00
abstract：:The anesthetic management of a parturient with a circulating lupus anticoagulant and an anticardiolipin antibody presenting to the obstetric suite taking heparin and aspirin is discussed. Issues concerning placement of a regional anesthetic with recent aspirin ingestion and heparin therapy are discussed. Documentation...
journal_title：Journal of clinical anesthesia
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更新日期：1996-02-01 00:00:00
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journal_title：Journal of clinical anesthesia
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doi：10.1016/0952-8180(95)00159-x
更新日期：1995-11-01 00:00:00
abstract：STUDY OBJECTIVE:To determine risk factors associated with reintubations in adult patients with soft tissue infections. DESIGN:A retrospective case-control design. SETTING:Operating room and postoperative recovery area. PATIENTS:There were 39 patients who presented for surgical intervention of their soft tissue infec...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
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更新日期：2016-11-01 00:00:00
abstract：STUDY OBJECTIVE:To study patients' requirement for propofol dosages during the course of repeated deep sedation for electroconvulsive therapy (ECT). DESIGN:Prospective study. SETTING:Outpatient psychiatric clinic in a tertiary-care, university-affiliated, 1100-bed metropolitan hospital. PATIENTS:30 patients undergoi...
journal_title：Journal of clinical anesthesia
pub_type： 临床试验,杂志文章
doi：10.1016/j.jclinane.2003.09.009
更新日期：2004-06-01 00:00:00
abstract：:Oxymetazoline nasal spray is a potent alpha 1-adrenergic agonist commonly used to vasoconstrict blood vessels in the nasal mucosa. In this incident, oxymetazoline nasal spray 0.025% was administered to a 2-year-old patient during general anesthesia for nasal endoscopy. Severe hypertension with reflex bradycardia progr...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
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更新日期：1995-09-01 00:00:00
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journal_title：Journal of clinical anesthesia
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更新日期：2020-06-01 00:00:00
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journal_title：Journal of clinical anesthesia
pub_type： 杂志文章,随机对照试验
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更新日期：2016-09-01 00:00:00
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journal_title：Journal of clinical anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s0952-8180(96)00171-7
更新日期：1996-12-01 00:00:00
abstract：BACKGROUND:Postoperative nausea and vomiting (PONV) is one of the common complications in patients who have undergone surgery with general anesthesia. The association of intraoperative use of remifentanil with PONV has remained controversial. The aim of the current study was to determine the association of dose of intr...
journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
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更新日期：2016-11-01 00:00:00
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journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
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更新日期：2015-06-01 00:00:00
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journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
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更新日期：1992-05-01 00:00:00
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journal_title：Journal of clinical anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1992-07-01 00:00:00
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journal_title：Journal of clinical anesthesia
pub_type： 杂志文章
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更新日期：2016-12-01 00:00:00
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journal_title：Journal of clinical anesthesia
pub_type： 临床试验,杂志文章
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更新日期：1997-06-01 00:00:00
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更新日期：2014-12-01 00:00:00
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journal_title：Journal of clinical anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Journal of clinical anesthesia
pub_type： 临床试验,杂志文章
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更新日期：2006-08-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Journal of clinical anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1997-09-01 00:00:00
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journal_title：Journal of clinical anesthesia
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更新日期：2014-05-01 00:00:00
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journal_title：Journal of clinical anesthesia
pub_type： 杂志文章,评审
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更新日期：1997-09-01 00:00:00
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journal_title：Journal of clinical anesthesia
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更新日期：2016-08-01 00:00:00
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journal_title：Journal of clinical anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1996-11-01 00:00:00
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journal_title：Journal of clinical anesthesia
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更新日期：1996-08-01 00:00:00
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journal_title：Journal of clinical anesthesia
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更新日期：2005-12-01 00:00:00
