Abstract：
STUDY OBJECTIVE:To study patients' requirement for propofol dosages during the course of repeated deep sedation for electroconvulsive therapy (ECT). DESIGN:Prospective study. SETTING:Outpatient psychiatric clinic in a tertiary-care, university-affiliated, 1100-bed metropolitan hospital. PATIENTS:30 patients undergoing 5-day successive ECT for depression over a 1-month period. INTERVENTIONS:Propofol and subsequently succinylcholine were injected intravenously (i.v.) to obtain deep sedation and relaxation followed by a 60 +/- 5 (SD) joules-ECT. MEASUREMENTS:The dosage that was required to deeply sedate the patients, the duration of the ECT, and interval of time to full wakefulness and coherent response were measured. MAIN RESULTS:13 of 30 patients 1) required >100% increase in the dose of propofol to achieve the same pharmacological prerequisite sedative endpoint, starting from their third treatment onward; 2) there was a 35% abbreviated duration of the convulsive activity; and 3) there was a 21% shortened interval of time to full wakefulness and coherent communication, starting at the fourth propofol injection. CONCLUSIONS:Repeated injections of propofol in patients undergoing ECT under deep sedation can induce a tolerance-like reaction to the drug.
journal_name
J Clin Anesthjournal_title
Journal of clinical anesthesiaauthors
Cohen Y,Feldinger E,Ogorek D,Weinbroum AAdoi
10.1016/j.jclinane.2003.09.009subject
Has Abstractpub_date
2004-06-01 00:00:00pages
282-5issue
4eissn
0952-8180issn
1873-4529pii
S0952818004000546journal_volume
16pub_type
临床试验,杂志文章abstract：STUDY OBJECTIVE:Dexmedetomidine, a highly selective α2-receptor agonist, has been widely used for protection against ischemia-reperfusion (IR) injury. We hypothesized that dexmedetomidine might exert a protective effect on IR injury after hepatectomy. DESIGN:A prospective, randomized, single-blind study was conducted ...
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journal_title：Journal of clinical anesthesia
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pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Journal of clinical anesthesia
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