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Hemodynamic effects of 6% and 10% hydroxyethyl starch solutions versus 4% albumin solution in septic patients.

Abstract：

STUDY OBJECTIVE:To compare the hemodynamic effects of two different concentrations of pentastarch hydroxyethyl starch (HES; 200/0.5) solutions with a 4% human albumin solution for fluid resuscitation. DESIGN:Open-label, randomized, controlled study. SETTING:Medical-surgical intensive care unit. PATIENTS:34 consecutive, hemodynamically stable, adult patients with sepsis and suspected hypovolemia. INTERVENTIONS:Patients received a 400 mL infusion of either 10% HES (n = 11), 6% HES (n = 10), or 4% albumin (n = 13) over 40 minutes. MEASUREMENTS:Hemodynamic and blood data were collected 40, 70, 100, and 160 minutes after the start of the fluid challenge. MAIN RESULTS:Cardiac index, stroke volume index, and left ventricular stroke work index increased more in the 10% HES group than the 6% HES or albumin groups (P < 0.05). Oxygen delivery increased only in the 10% HES group. A decrease in hemoglobin concentration occurred in all three groups but was greatest in the 10% HES group. CONCLUSIONS:HES is as effective as albumin for volume resuscitation in septic patients.

journal_name

J Clin Anesth

journal_title

Journal of clinical anesthesia

authors

Friedman G,Jankowski S,Shahla M,Gomez J,Vincent JL

doi

10.1016/j.jclinane.2008.05.022

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

528-33

issue

7

eissn

0952-8180

issn

1873-4529

pii

S0952-8180(08)00281-X

journal_volume

20

pub_type

杂志文章,随机对照试验

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