Abstract：
STUDY OBJECTIVE:Some outpatient procedures are performed under sedation with dexmedetomidine, although the effect of dexmedetomidine on cognitive function remains unclear. This study investigated the effect of dexmedetomidine on cognitive function in healthy volunteers. DESIGN:Observation study in volunteers. SETTING:University-affiliated teaching hospital. PATIENTS:Six healthy volunteers. INTERVENTIONS:After infusion of a 6-μg/kg per hour loading dose of dexmedetomidine for 10 minutes, a maintenance infusion of 0.4 μg/kg per hour was administered for 4 hours. MEASUREMENTS:Cognitive function was evaluated before infusion (baseline) and at 2, 4, 6, and 8 hours after infusion. Cognitive function, response speed, accuracy, and consistency were measured by CogHealth. Depth of sedation was evaluated at 1-hour intervals by evaluating the Bispectral Index. Data are presented as the change from baseline. MAIN RESULTS:The Bispectral Index value was significantly lower from 10 minutes to 6 hours after infusion versus the pre-infusion value. Response speed was also significantly lower at 2 hours and 4 hours after infusion (92 ± 8%, P< .0001; 93 ± 6%, P< .0001), as was consistency (96 ± 7%, P= .0009; 96 ± 5%, P= .0003). Response accuracy was unaltered by the infusion. CONCLUSIONS:Dexmedetomidine slightly reduced response speed and consistency, but did not affect response accuracy. Cognitive function was restored to pre-administration values 2 hours after the infusion of dexmedetomidine was discontinued.
journal_name
J Clin Anesthjournal_title
Journal of clinical anesthesiaauthors
Yatabe T,Tamura T,Yamashita K,Yokoyama Mdoi
10.1016/j.jclinane.2016.03.017subject
Has Abstractpub_date
2016-09-01 00:00:00pages
92-6eissn
0952-8180issn
1873-4529pii
S0952-8180(16)30029-0journal_volume
33pub_type
杂志文章abstract：STUDY OBJECTIVES:To examine the possible pharmacodynamic interaction of propofol and sufentanil with respect to the induction of loss of consciousness. DESIGN:Prospective, randomized, double-blinded study. SETTING:University hospital. PATIENTS:30 female, ASA physical status I and II patients undergoing elective gyne...
journal_title：Journal of clinical anesthesia
pub_type： 临床试验,杂志文章,随机对照试验
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abstract：:During transplant surgery, clot formation resulting in life-threatening thromboembolic phenomena or graft loss may be a consequence unless close monitoring of coagulation and anticoagulation treatment is instituted in a timely manner. Three cases with a hypercoagulable state, as determined by thrombelastography at the...
journal_title：Journal of clinical anesthesia
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journal_title：Journal of clinical anesthesia
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abstract：:Insertion of drug-eluting stents is one of the strategies for treating patients with coronary artery disease. These patients can be a perioperative challenge in management as they need to be maintained on antiplatelet therapy to prevent stent thrombosis, which puts them at an increased risk for surgical bleeding. Rece...
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journal_title：Journal of clinical anesthesia
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journal_title：Journal of clinical anesthesia
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更新日期：2017-02-01 00:00:00
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更新日期：2002-02-01 00:00:00
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journal_title：Journal of clinical anesthesia
pub_type： 杂志文章,评审
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journal_title：Journal of clinical anesthesia
pub_type： 临床试验,杂志文章
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更新日期：1996-05-01 00:00:00
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journal_title：Journal of clinical anesthesia
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更新日期：2016-08-01 00:00:00
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pub_type： 杂志文章,评审
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