Abstract:
AIM:To estimate a diagnostic value of antibodies to cyclic citrullinized peptide (CCP) in rheumatoid arthritis (RA). MATERIAL AND METHODS:The study was made of 85 RA patients. Of them, 48 patients had early RA, i.e. of 8 month and less duration. The control group consisted of 35 patients with non-differentiated arthritis (NDA) and 8 healthy donors. Concentrations of CCP antibodies, rheumatoid factor (RF) IgM and RF IgA were measured with enzyme immunoassay (EIA). RESULTS:The level of CCP antibodies in RA patients (76.3 +/- 43.8; median 100.0 U/ml) was significantly higher than in NDA patients (25.1 +/- 43.9; median 0.8 U/ml; p < 0.05) or in donors (0.38 +/- 0.36; median 0.2 U/ml; p < 0.05). A correlation was found between the CCP antibodies level and that of RF IgM (chi2 = 15.4; p = 0.001) and RF IgA (chi2 = 10.3; p = 0.001). Sensitivity (82%) and specificity (90%) of CCP antibodies in RA diagnosis was higher than these parameters for RF IgM and IgA (78%, 86% and 72%, 83%, respectively). Simultaneous tests for CCP antibodies, RF IgM and RF IgA led to a 93% specificity. CCP antibodies were detected in 50% patients seronegative by RF IgM and in 62% patients seronegative by IgA. Detection of CCP antibodies was closely associated with early RA (chi2 = 30.8; p = 0.0001). CONCLUSION:The EIA for CCP antibodies is a sensitive and specific serological test for early RA diagnosis.
journal_name
Ter Arkhjournal_title
Terapevticheskii arkhivauthors
Aleksandrova EN,Chemeris NA,Karateev DE,Novikov AA,Brodetskaia KA,Nasonov ELsubject
Has Abstractpub_date
2004-01-01 00:00:00pages
64-8issue
12eissn
0040-3660issn
2309-5342journal_volume
76pub_type
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
更新日期:1989-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
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journal_title:Terapevticheskii arkhiv
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journal_title:Terapevticheskii arkhiv
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journal_title:Terapevticheskii arkhiv
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更新日期:1986-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
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journal_title:Terapevticheskii arkhiv
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journal_title:Terapevticheskii arkhiv
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更新日期:1987-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
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更新日期:2001-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
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doi:
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journal_title:Terapevticheskii arkhiv
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pub_type: 临床试验,杂志文章
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journal_title:Terapevticheskii arkhiv
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journal_title:Terapevticheskii arkhiv
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更新日期:1997-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
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journal_title:Terapevticheskii arkhiv
pub_type: 临床试验,杂志文章
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更新日期:2001-01-01 00:00:00
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
doi:
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journal_title:Terapevticheskii arkhiv
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journal_title:Terapevticheskii arkhiv
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journal_title:Terapevticheskii arkhiv
pub_type: 杂志文章
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