Abstract：
:The purpose of study was to analyze own clinical experience and assess the effectiveness in treatment of severe very poorly controlled allergic asthma patients with omalizumab. The effectiveness of biologic treatment with omalizumab was analyzed in 10 patients with severe very poorly controlled allergic asthma. It has been shown that indication of anti-IgE therapy in case of severe allergic asthma resulted in decrease of day and night asthma symptoms, symptoms of allergic rhinitis, dose of other anti - inflammatory asthma medications, discontinuation of systemic corticosteroids which led to good and partial control of the disease. Anti-IgE therapy is a highly effective treatment in asthma patients with atopic phenotype. :Эффективность таргетной биологической терапии у больных тяжелой атопической бронхиальной астмой В статье представлен анализ собственного клинического опыта проведения терапии омализумабом с оценкой ее эффективности у пациентов с тяжелой неконтролируемой атопической бронхиальной астмой (АБА). Проанализирована эффективность биологической терапии омализумабом у 10 пациентов с АБА тяжелого течения. Включение в базисную терапию АБА тяжелого течения анти-IgE-терапии позволило существенно снизить кратность дневных и ночных симптомов БА, признаков аллергического ринита, отказаться от применения системных глюкокортикостероидов, уменьшить объем других препаратов эмпирической терапии и, таким образом, достичь частичного или полного контроля заболевания. Таргетная биологическая терапия омализумабом является высокоэффективным методом лечения у больных с атопическим фенотипом БА.
journal_name
Ter Arkhjournal_title
Terapevticheskii arkhivauthors
Skorokhodkina OV,Valeeva AR,Luntsov AV,Pozdnyak VAdoi
10.26442/00403660.2019.12.000451subject
Has Abstractpub_date
2019-12-15 00:00:00pages
57-62issue
12eissn
0040-3660issn
2309-5342journal_volume
91pub_type
杂志文章abstract：:A study was made of the possibilities of an individual approach to intraarticular administration of protease inhibitors, cytostatics and orgoteine in patients with rheumatoid arthritis (RA). The activity of hyaluronidase, superoxide dismutase, the level of rheumatoid factor and the phagocyte count in synovial fluid we...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:The aim of study was to evaluate the morphological and immunohystochemical characteristics of aspirated thrombi in patients with ST-elevation myocardial infarction undergoing precutaneous coronary intervention to find the possible platelet activation and inflammatory cell involvement in coronary thrombi. MATERIALS AN...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：10.26442/00403660.2019.09.000199
更新日期：2019-09-15 00:00:00
abstract：:The analysis is presented of clinical picture, running, therapy and prognosis of infectious endocarditis in 67 patients over 60. They appeared to develop progressive cardiac failure, frequent thromboembolism of the cerebral vessels. The disease is often associated with other age-related disorders, proved difficult for...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
abstract：:Overall 16 patients with chronic renal failure on regular hemodialysis were examined. Of these, 8 received recombinant human erythropoietin (rhERP). A study was made of platelet aggregation and the level of some prostanoids in the blood of these patients. As the time of the treatment with rhERP was increased, the hemo...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:A study was made of the impact of a single intake of nifedipine, intal, sodium thiosulfate and essentiale on respiratory function, the blood content of ionized calcium, total calcium, hydroperoxides, total and non-protein thiol groups, and prostaglandins in bronchial asthma patients. All the drugs exerted an antioxida...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:The authors provide the data on comparative efficacy of different non-steroidal anti-inflammatory agents (220 studies), psychotropic drugs (32 cases) and combined therapy (58 cases). All the studies were made by the double blind method with the use of placebo (38 cases). As for the psychotropic drugs, use was made of ...
journal_title：Terapevticheskii arkhiv
pub_type： 临床试验,杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:The central hemodynamics and myocardial contractility were studied in 40 normal untrained men by tetrapolar chest rheography. The response to exercise was studied and compared in subjects with eu- and hypokinetic circulatory types. It was revealed that marked differences in the SI, CI, SPR recorded at rest lessen with...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：AIM:To study heart rate variability (HRV) according to 24-h Holter monitoring of ECG in patients with ischemic heart disease (IHD) and to examine effects of tianeptine on HRV. MATERIAL AND METHODS:Twenty eight patients with IHD (17 males and 11 females aged 40-70 years) with a verified IHD diagnosis and atherosclerosi...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2006-01-01 00:00:00
abstract：AIM:To study efficacy of the myocardial cytoprotector trimethasidine MB and metabolic drug 3-(2,2,2-trimethylhydrasine) propionate dihydrate (3-TMHP) in the treatment of chronic cardiac failure (CCF). MATERIAL AND METHODS:Sixty-five patients with CCF after myocardial infarction (> 6 months) with left ventricular eject...
journal_title：Terapevticheskii arkhiv
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2007-01-01 00:00:00
abstract：AIM:To design Markov's model of decision making to study the role of order in the use of most usable basic antirheumatic drugs (methotrexate-MT, parenteral gold--PG and sulfasalasine--SS) in terms of the course duration and cost. MATERIAL AND METHODS:The model was based on metaanalysis made in 2000. The program TreeAg...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:To investigate sex- and age-specific features of radiographic abnormalities in rheumatoid arthritis (RA) patients, radiographic signs in hands and feet were assessed using Steinbroker criteria. A score system from 0 to 3 was also introduced to evaluate every radiographic feature: osteoporosis, cysts, joint space narro...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1994-01-01 00:00:00
abstract：AIM:To evaluate the impact of hyperglycemia concurrent with obstructive sleep apnea syndrome (OSAS) on endothelial function (EF) and vessel remodeling in patients with Grade 1-2 hypertension. MATERIAL AND METHODS:A total of 101 patients with Grade 1-2 hypertension were examined. A study group (SG) consisted of 74 hype...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：10.17116/terarkh2015871026-30
更新日期：2015-01-01 00:00:00
abstract：AIM:To study immune disorders in cell immunity and cytokine profile in integument lupus erythematosus (ILE) and systemic lupus erythematosus (SLE). MATERIAL AND METHODS:Lymphocyte phenotype, oxygen-dependent and non-oxygen-dependent functions of circulating neutrophils and monocytes, serum levels of circulating immune...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2009-01-01 00:00:00
abstract：AIM:To evaluate the efficacy of the enterokinetic prucalopride (resolor) in patients with chronic constipation. SUBJECTS:The effect of treatment with prucalopride (resolor) in 109 patients with chronic constipation was analyzed. RESULTS:The effect was noted in 82% of the patients; 61 patients were fully satisfied wit...
journal_title：Terapevticheskii arkhiv
pub_type： 临床试验,杂志文章
doi：
更新日期：2013-01-01 00:00:00
abstract：:A study was made of a vasodilating effect of nifedipine on the hemodynamics of 30 patients with chronic postinfarction left ventricular aneurysm, with chronic cardiovascular insufficiency of the II-III degree according to NYHA. A mean value of the acontractile segment on ventriculograms was 32.5 +/- 1.7%. The main par...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:Left and right ventricular diastolic function was investigated at doppler echocardiography in patients with myocardiodystrophy exposed to organic aromatic solvents (30 female house painters). The control group consisted of healthy females and females with autonomic-dyshormonal myocardiodystrophy. The study group exhib...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：AIM:To study prognostic implications of a focal mature cell lesion of the bone marrow (BM) in patients with diffuse large B cell lymphosarcoma (DBLCL). MATERIAL AND METHODS:54 patients with histologically confirmed DBLCL were given first-line CHOP and CHOP-like courses from 1996 to 2003. B-cell nature of the tumor was...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：:A study of 186 coronary patients with rhythm disturbance has shown that early incorporation of the elements of physical rehabilitation in combined treatment improves functioning of all the links of the blood circulation system, helps to raise cardiac rhythm stability and reduces the period of patients' stay in hospita...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：AIM:To study effects of long-term administration of ACE inhibitor ramipril (hartil) on renin-angiotensin-aldosteron system (RAAS), dynamics of clinical symptoms of the disease and structural-functional indices of the right and left ventricle (RV, LI) in patients with chronic obstructive pulmonary disease (COPD) with de...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2008-01-01 00:00:00
abstract：AIM:Assessment of leukocyte activity with spontaneous NBT-test in influenza patients regarding the disease stage, severity, complication and concomitant diseases. MATERIAL AND METHODS:107 influenza patients aged 16-84 years were studied. 70 patients had no complications, 11 patients had early influenzal pneumonia, 26 ...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:A total of 108 patients with peptic ulcer were entered into the study. Examination of the microcirculation in the eye conjunctiva and microvessels of biopsy specimens of the mucous membrane taken from ulcerous areas revealed that disease relapses were marked by pronounced disorders of the end blood flow. The extent of...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1986-01-01 00:00:00
abstract：:The effects of strophanthin treatment given in courses on the central hemodynamics, pulmonary, intrahepatic circulation and myocardial contractility were studied in 97 patients with decompensated chronic cor pulmonale depending on the hemodynamic type of circulation. In patients with CNPD and circulatory failure havin...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：:The conception on fungal origin of sergentella-like elements in peripheral blood proposed by A. N. Dekhkan-Khodzhaeva et al. is discussed. According to the author, these elements are rather twisted coats of hemolyzed red cells. There is a close relationship between sergentellas and hemolysis activation in stress. It i...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章,评审
doi：
更新日期：1995-01-01 00:00:00
abstract：:Mono- and multifactorial discriminant analyses aided by computer were used in 106 patients with coronary disease to compare the clinical and angiographic findings common to different manifestations of angina pectoris. The relationship was discovered between the clinical form of angina pectoris and the gravity of lesio...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：AIM:To study effects of carvedilol and atenolol and their combination with fosinopril on heart rhythm variability (HRV, clinicofunctional status and quality of life in postmyocardial infarction patients with moderate chronic cardiac failure (CCF). MATERIAL AND METHODS:An 8-week randomized open study enrolled 50 male p...
journal_title：Terapevticheskii arkhiv
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2004-01-01 00:00:00
abstract：:A total of 65 patients with infection-dependent bronchial asthma (BA) in the phase of exacerbation were examined for eosinophil number in the peripheral blood, forced expiration volume within the first second (FEV1), systolic pressure in the pulmonary artery (SPPA), the content of endogenous hydrocortisone and IgE, an...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1989-01-01 00:00:00
abstract：:The results of programmed therapy of acute lymphoblastic leukemia (ALL) in 31 adult patients were analyzed. Ph-positive ALL were marked in 5 patients. Low hemosuppressive induction, heavy consolidation and multidrug maintenance therapy was used. Complete remissions were obtained in 18 patients, their median time was 1...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：AIM:To assess clinical efficacy of mineral water and perindopril in convalescents after hemorrhagic fever with renal syndrome (HFRS) in outpatient setting. MATERIAL AND METHODS:The study covered 113 HFRS convalescents. HFRS was confirmed serologically. The patients were divided into three groups: group 1 (n = 50) rece...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：
更新日期：2004-01-01 00:00:00
abstract：AIM:To study the prevalence of metabolic syndrome (MS) and its components in a 25-45-year-old Novosibirsk population. SUBJECTS AND METHODS:The Novosibirsk Research Institute of Internal and Preventive Medicine conducted a cross-sectional population-based survey in one of the typical districts of Novosibirsk in 2013-20...
journal_title：Terapevticheskii arkhiv
pub_type： 杂志文章
doi：10.17116/terarkh2016881051-56
更新日期：2016-01-01 00:00:00
abstract：AIM:To study effects of laser therapy in combined treatment of pneumonia on external respiration function, membrane permeability, microcirculation and serum trace elements. MATERIAL AND METHODS:142 pneumonia patients were randomly divided into two groups: 96 patients treated with drugs and laser radiation (the study g...
journal_title：Terapevticheskii arkhiv
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2002-01-01 00:00:00
