当前位置： SCI文献检索 > ANNALS OF HEMATOLOGY期刊下所有文献 > Interleukin-6 (IL-6) levels in febrile children during maximal aplasia after bone marrow transplantation (BMT) are similar to those in children with normal hematopoiesis.

Interleukin-6 (IL-6) levels in febrile children during maximal aplasia after bone marrow transplantation (BMT) are similar to those in children with normal hematopoiesis.

Abstract：

:Interleukin-6 (IL-6) has been shown to be an inducer of the acute-phase response (APR) and to be involved in the pathogenesis of several disease states, including graft-versus-host disease (GvHD) following allogeneic bone marrow transplantation (BMT). As blood cells of the monocyte lineage are known to be major producers of this cytokine, we wondered whether extreme peripheral leukopenia following total ablation of hematopoiesis could compromise IL-6 production during the first days after allogeneic or autologous BMT. In the absence of detectable circulating leukocytes we measured elevated IL-6 levels in six children having fever (> or = 38 degrees C) of presumed infectious origin with an average of 74 +/- 60 units/ml (range 19-309 units/ml). IL-6 levels in febrile children having a normal hematopoiesis (118 +/- 254 units/ml, range 17-1213 units/ml) were not significantly higher than those found in the febrile BMT group (p > 0.05). Moreover, there was a clear association between elevated IL-6 levels and the presence of fever. C-reactive protein (CRP) was also elevated (> or = 1 mg/dl), whereas tumor-necrosis factor alpha (TNF) was undetectable (< 1 pg/ml). Two transplanted patients without fever during the period of total aplasia had neither detectable CRP nor IL-6, thus demonstrating that the transplant procedure itself does not induce an APR. Our data obtained during maximal leukopenia following BMT show that a functional hematopoietic system is not necessary for regular production of IL-6, which is associated with fever. Cells of nonhematopoietic origin may contribute to this production.

journal_name

Ann Hematol

journal_title

Annals of hematology

authors

Pechumer H,Wilhelm M,Ziegler-Heitbrock HW

doi

10.1007/BF01696617

subject

Has Abstract

pub_date

1995-06-01 00:00:00

pages

309-12

issue

6

eissn

0939-5555

issn

1432-0584

journal_volume

70

pub_type

杂志文章

相关文献

ANNALS OF HEMATOLOGY文献大全
  • Modified BEAM with triple autologous stem cell transplantation for patients with relapsed aggressive non-Hodgkin lymphoma.

    abstract：:Treatment of relapse and primary progression in aggressive lymphoma remains unsatisfactory; outcome is still poor. Better treatment strategies are much needed for this patient population. The R1 study is a prospective multi-center phase I/II study evaluating a dose finding approach with a triple transplant regimen in ...

    journal_title：Annals of hematology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00277-016-2671-5

    authors： Hohloch K,Zeynalova S,Chapuy B,Pfreundschuh M,Loeffler M,Ziepert M,Feller AC,Trümper L,Hasenclever D,Wulf G,Schmitz N

    更新日期：2016-06-01 00:00:00

  • Sudden onset of EDTA-dependent pseudothrombocytopenia after therapy with the glycoprotein IIb/IIIa antagonist c7E3 Fab.

    abstract：:The development of thrombocytopenia following exposure to the platelet glycoprotein (GP) IIb/ IIIa receptor antagonist abciximab (c7E3 Fab, ReoPro) is associated with adverse clinical outcome and excessive bleeding. Pseudothrombocytopenia is an important differential diagnosis in sudden onset of thrombocytopenia in a ...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s002770050573

    authors： Stiegler H,Fischer Y,Steiner S,Strauer BE,Reinauer H

    更新日期：2000-03-01 00:00:00

  • Plasma clot properties in patients with a mild-to-moderate bleeding tendency of unknown cause.

    abstract：:In a large proportion of patients with mild bleeding disorders (MBDs) no diagnosis can be established by routine coagulation tests. We investigated whether alterations in plasma clot properties account for MBDs of unknown cause. Ninety-five patients with MBDs of unknown origin and 98 age- and sex-matched healthy contr...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-015-2399-7

    authors： Gebhart J,Laczkovics C,Posch F,Ay C,Reitter-Pfoertner SE,Haslacher H,Muszbek L,Wolberg AS,Pabinger I

    更新日期：2015-08-01 00:00:00

  • DSMM XI study: dose definition for intravenous cyclophosphamide in combination with bortezomib/dexamethasone for remission induction in patients with newly diagnosed myeloma.

    abstract：:A clinical trial was initiated to evaluate the recommended dose of cyclophosphamide in combination with bortezomib and dexamethasone as induction treatment before stem cell transplantation for younger patients with newly diagnosed multiple myeloma (MM). Thirty patients were treated with three 21-day cycles of bortezom...

    journal_title：Annals of hematology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1007/s00277-009-0726-6

    authors： Kropff M,Liebisch P,Knop S,Weisel K,Wand H,Gann CN,Berdel WE,Einsele H,Deutsche Studiengruppe Multiples Myelom, DSMM.

    更新日期：2009-11-01 00:00:00

  • Reprogramming of human peripheral blood monocytes to erythroid lineage by blocking of the PU-1 gene expression.

    abstract：:In hematopoietic system development, PU.1 and GATA-1 as lineage-specific transcription factors (TF) are expressed in common myeloid progenitors. The cross antagonism between them ascertains gene expression programs of monocytic and erythroid cells, respectively. This concept in transdifferentiation approaches has not ...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-015-2583-9

    authors： Nouri M,Deezagi A,Ebrahimi M

    更新日期：2016-03-01 00:00:00

  • Decreased expression of indoleamine 2,3-dioxygenase 1 in dendritic cells contributes to impaired regulatory T cell development in immune thrombocytopenia.

    abstract：:Along with their immunogenic role, dendritic cells (DCs) are also critical in maintaining tolerance to self-antigens by inducing regulatory T cells (Tregs) via the expression of the immunomodulatory enzyme indoleamine 2,3-dioxygenase 1 (IDO1). In turn, Tregs modulate the maturation and/or function of DCs. In immune th...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-012-1556-5

    authors： Catani L,Sollazzo D,Trabanelli S,Curti A,Evangelisti C,Polverelli N,Palandri F,Baccarani M,Vianelli N,Lemoli RM

    更新日期：2013-01-01 00:00:00

  • Stroke prevention in the young child with sickle cell anaemia.

    abstract：:Cerebrovascular disease resulting in stroke is a serious and preventable complication of sickle cell anaemia (SCA). Children at high risk of preventable stroke can be identified by transcranial Doppler ultrasound (TCD). Current guidelines in the UK recommend annual TCD screening from 3 years, although studies suggest ...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-009-0757-z

    authors： Roberts L,O'Driscoll S,Dick MC,Height SE,Deane C,Goss DE,Pohl K,Rees DC

    更新日期：2009-10-01 00:00:00

  • Polyclonal IgG4 hypergammaglobulinemia associated with plasmacytic lymphadenopathy, anemia and nephropathy.

    abstract：:Marked polyclonal immunoglobulin (Ig)G4 hypergammaglobulinemia has exceptionally been reported. Here we report on two Algerian patients who presented a syndrome characterized by anemia, plasmacytic lymphadenopathy, renal manifestations, and a marked polyclonal IgG4 hypergammaglobulinemia leading to a hyperviscosity sy...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-006-0158-5

    authors： Boulanger E,Fuentes V,Meignin V,Mougenot B,Labaume S,Gouilleux-Gruart V,Cogné M,Aucouturier P,Clauvel JP,Ronco P,Lassoued K

    更新日期：2006-12-01 00:00:00

  • Meis1 is critical to the maintenance of human acute myeloid leukemia cells independent of MLL rearrangements.

    abstract：:Although the outcome of patients with acute myeloid leukemia (AML) has improved by optimized chemotherapy regimens and bone marrow transplantation, leukemia relapse remains one of the most challenging problems during therapy. Sustained existence of AML blasts is a fundamental determinant for the development of leukemi...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-016-2913-6

    authors： Liu J,Qin YZ,Yang S,Wang Y,Chang YJ,Zhao T,Jiang Q,Huang XJ

    更新日期：2017-04-01 00:00:00

  • Relapsing bloodstream infections during treatment of acute leukemia.

    abstract：:Acute leukemia (AL) patients may experience more than one episode of bloodstream infection (BSI) caused by the same pathogen during the entire chemotherapy program. In order to identify factors influencing BSI recurrence (R-BSI) during subsequent phases of treatment, we analyzed all BSIs occurring to consecutively tre...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-013-1965-0

    authors： Cattaneo C,Antoniazzi F,Tumbarello M,Skert C,Borlenghi E,Schieppati F,Cerqui E,Pagani C,Petullà M,Re A,Rossi G

    更新日期：2014-05-01 00:00:00

  • Interim PET-CT-guided therapy in elderly patients with Hodgkin lymphoma-a retrospective national multi-center study.

    abstract：:Hodgkin lymphoma (HL), a disease of mostly young patients, also peaks in the elderly. Despite the profound improvement in the outcome of young patients, in the elderly, 5-year progression-free survival (PFS) rates are under 70%. Interim PET-CT (iPET) is known to be highly predictive for PFS in young HL patients, but i...

    journal_title：Annals of hematology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1007/s00277-019-03686-y

    authors： Bentur OS,Dann EJ,Paran E,Lavie D,Nachmias B,Ron Y,Dally N,Gutwein O,Herishanu Y,Sarid N,Avivi I,Perry C

    更新日期：2019-07-01 00:00:00

  • Treatment of primary mediastinal large B cell lymphoma with an alternating chemotherapy regimen based on high-dose methotrexate.

    abstract：:Primary mediastinal large B cell lymphomas (MLCL) differ from other diffuse large cell lymphomas, leading to a description as a separate entity in the current World Health Organization classification. Dose intensification improves long-term results, but no standard therapy has been established so far. We investigated ...

    journal_title：Annals of hematology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1007/s00277-008-0625-2

    authors： Fietz T,Knauf WU,Hänel M,Franke A,Freund M,Thiel E,East German Study Group on Hematology and Oncology-OSHO.

    更新日期：2009-05-01 00:00:00

  • Upfront autologous stem cell transplantation for untreated diffuse large B cell lymphoma patients in rituximab era: a systematic review and meta-analysis.

    abstract：:To assess the survival outcomes and adverse events (AEs) of high-intermediate- or high-risk patients with diffuse large B cell lymphoma (DLBCL) who underwent conventional chemotherapy plus rituximab with or without first-line autologous stem cell transplantation (ASCT). Related studies published on Medline, Embase, Co...

    journal_title：Annals of hematology

    pub_type： 杂志文章,meta分析

    doi：10.1007/s00277-020-04016-3

    authors： Ma SY,Tian XP,Cai J,Zhong GZ,Chen X,Huang HQ,Lin TY,Li ZM,Cai QQ

    更新日期：2020-06-01 00:00:00

  • Predictors of clinical responses to hypomethylating agents in acute myeloid leukemia or myelodysplastic syndromes.

    abstract：:Azacitidine and decitabine, two hypomethylating agents, are known to be effective in the treatment of high-risk myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) patients who cannot endure intensive cytotoxic chemotherapy or are not eligible for transplantation. However, the treatment response rate is l...

    journal_title：Annals of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s00277-018-3464-9

    authors： Wang H,Li Y,Lv N,Li Y,Wang L,Yu L

    更新日期：2018-11-01 00:00:00

  • D816 mutation of the KIT gene in core binding factor acute myeloid leukemia is associated with poorer prognosis than other KIT gene mutations.

    abstract：:The clinical impact of KIT mutations in core binding factor acute myeloid leukemia (CBF-AML) is still unclear. In the present study, we analyzed the prognostic significance of each KIT mutation (D816, N822K, and other mutations) in Japanese patients with CBF-AML. We retrospectively analyzed 136 cases of CBF-AML that h...

    journal_title：Annals of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00277-017-3074-y

    authors： Yui S,Kurosawa S,Yamaguchi H,Kanamori H,Ueki T,Uoshima N,Mizuno I,Shono K,Usuki K,Chiba S,Nakamura Y,Yanada M,Kanda J,Tajika K,Gomi S,Fukunaga K,Wakita S,Ryotokuji T,Fukuda T,Inokuchi K

    更新日期：2017-10-01 00:00:00

  • Aberrant germinal center formation, follicular T-helper cells, and germinal center B-cells were involved in chronic graft-versus-host disease.

    abstract：:Chronic graft-versus-host disease (cGVHD) is an important complication after allogeneic hematopoietic stem cell transplantation (HSCT). To define the roles of T-cells and B-cells in cGVHD, a murine minor histocompatibility complex-mismatched HSCT model was used. Depletion of donor splenocyte CD4(+) T-cells and B220(+)...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-015-2394-z

    authors： Shao L,Lie AK,Zhang Y,Wong CH,Kwong YL

    更新日期：2015-09-01 00:00:00

  • Clinicopathological characteristics and outcomes of light chain deposition disease: an analysis of 48 patients in a single Chinese center.

    abstract：:To explore the clinicopathological characteristics and outcomes of light chain deposition disease (LCDD) in a Chinese population, we retrospectively studied the clinicopathological data, treatment, and outcomes of 48 patients with biopsy-proven LCDD from a single center. Among the patients, there were 29 males and 19 ...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-016-2659-1

    authors： Li XM,Rui HC,Liang DD,Xu F,Liang SS,Zhu XD,Huang XH,Liu ZH,Zeng CH

    更新日期：2016-05-01 00:00:00

  • Immunomagnetic enrichment of CD138 positive cells from weakly infiltrated myeloma patients samples enables the determination of the tumor clone specific IgH rearrangement.

    abstract：:In multiple myeloma, the polymerase chain reaction (PCR) of the Ig heavy chain with allele-specific oligonucleotide (ASO) primers is a common and well-described method of identifying the tumor clone in peripheral blood (PB), bone marrow (BM) or leukapheresis products (LA). A factor which is crucial to the detection of...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s002770000245

    authors： Draube A,Pfister R,Vockerodt M,Schuster S,Kube D,Diehl V,Tesch H

    更新日期：2001-02-01 00:00:00

  • Multiple myeloma in elderly patients-a Portuguese multicentric real-life study.

    abstract：:Patients older than 75 years old with multiple myeloma (MM) have shorter survival and are usually treated differently from what features in clinical trials. In this study, the authors characterized the Portuguese population of MM patients above 75 years old, treated between 2009 and 2016. We compared the outcomes obta...

    journal_title：Annals of hematology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1007/s00277-019-03640-y

    authors： João C,Bergantim R,Neves M,Chacim S,Afonso C,Barradas J,Bernardo M,Coelho H,Esteves G,Fraga C,Geraldes C,Gonçalves C,Jorge A,Macedo A,Mendonça T,Moreira A,Roque A,Sarmento AB,Trigo F,Vitória H,Esteves S,Lúcio P

    更新日期：2019-07-01 00:00:00

  • Role of 18FDG-PET/CT in detecting relapse during follow-up of patients with Hodgkin's lymphoma.

    abstract：:The role of 18FDG-PET/CT during follow-up of patients affected by Hodgkin's lymphoma (HL) in complete remission after treatment is not fully elucidated, since a wide use of 18F fluorodeoxyglucose positron emission tomography/computed tomography (18FDG-PET/CT) in this setting could be limited by a relative high rate of...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-009-0752-4

    authors： Crocchiolo R,Fallanca F,Giovacchini G,Ferreri AJ,Assanelli A,Verona C,Pescarollo A,Bregni M,Ponzoni M,Gianolli L,Fazio F,Ciceri F

    更新日期：2009-12-01 00:00:00

  • Treatment of late-onset hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation: the role of corticosteroids.

    abstract：:We aimed to evaluate the treatments, particularly the role of corticosteroids, in patients with late-onset hemorrhagic cystitis (LOHC) after allogeneic hematopoietic stem cell transplantation (allo-HSCT). One hundred and sixty-three consecutive patients who underwent non-T-cell-depleted allo-HSCT and met the criterion...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-018-3290-0

    authors： Mo XD,Zhang XH,Xu LP,Wang Y,Yan CH,Chen H,Chen YH,Han W,Wang FR,Wang JZ,Liu KY,Huang XJ

    更新日期：2018-07-01 00:00:00

  • Chemotherapy-induced mesenchymal stem cell damage in patients with hematological malignancy.

    abstract：:Hematopoietic recovery after high-dose chemotherapy (HDC) in the treatment of hematological diseases may be slow and/or incomplete. This is generally attributed to progressive hematopoietic stem cell failure, although defective hematopoiesis may be in part due to poor stromal function. Chemotherapy is known to damage ...

    journal_title：Annals of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00277-009-0896-2

    authors： Kemp K,Morse R,Wexler S,Cox C,Mallam E,Hows J,Donaldson C

    更新日期：2010-07-01 00:00:00

  • Next-generation sequencing for JAK2 mutation testing: advantages and pitfalls.

    abstract：:The JAK2V617F mutation is part of the major criteria for diagnosis of myeloproliferative neoplasms (MPN). Allele-specific quantitative PCR (qPCR) is the most prevalent method used in laboratories but with the advent of next-generation sequencing (NGS) techniques, we felt necessary to evaluate this approach for JAK2 mu...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-018-3499-y

    authors： Maslah N,Verger E,Schlageter MH,Miclea JM,Kiladjian JJ,Giraudier S,Chomienne C,Cassinat B

    更新日期：2019-01-01 00:00:00

  • Acute lymphoblastic leukemia in elderly: the Polish Adult Leukemia Group (PALG) experience.

    abstract：:This is a retrospective, multicenter study to evaluate biological features and outcome of elderly patients diagnosed with acute lymphoblastic leukemia (ALL) during the last 10 years in ten hematological centers in Poland. Eighty-seven patients aged 60 years or older were studied. To our knowledge, this is one of the l...

    journal_title：Annals of hematology

    pub_type： 杂志文章,多中心研究

    doi：10.1007/s00277-003-0808-9

    authors： Robak T,Szmigielska-Kapłon A,Wrzesień-Kuś A,Wierzbowska A,Skotnicki AB,Piatkowska-Jakubas B,Kuliczkowski K,Mazur G,Zduńczyk A,Stella-Hołowiecka B,Hołowiecki J,Dwilewicz-Trojaczek J,Madry K,Dmoszyńska A,Cioch M

    更新日期：2004-04-01 00:00:00

  • Steady-state sVCAM-1 serum levels in adults with sickle cell disease.

    abstract：:Cytokines and adhesion molecules play an important role in the pathophysiology of vaso-occlusion in sickle cell disease (SCD), and their in vivo profiles are potential tools for assessing SCD severity. We compared steady-state soluble vascular cell adhesion molecule-1 (sVCAM-1) serum levels to clinical (painful crisis...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-003-0609-1

    authors： Schnog JB,Rojer RA,Mac Gillavry MR,Ten Cate H,Brandjes DPM,Duits AJ

    更新日期：2003-02-01 00:00:00

  • Long-term follow-up of allogeneic stem cell transplantation in patients with severe aplastic anemia after conditioning with cyclophosphamide plus antithymocyte globulin.

    abstract：:We investigated the efficacy of an antithymocyte globulin/cyclophosphamide preparative regimen prior to allogeneic stem cell transplantation from HLA-identical siblings in patients with severe aplastic anemia. Since 1990, 21 patients, 6 males and 15 females, with a median age of 25 years (range: 7-43) have been enroll...

    journal_title：Annals of hematology

    pub_type： 临床试验,杂志文章

    doi：10.1007/s00277-002-0566-0

    authors： Kröger N,Zabelina T,Renges H,Krüger W,Kordes U,Rischewski J,Schrum J,Horstmann M,Ayuk F,Erttmann R,Kabisch H,Zander AR

    更新日期：2002-11-01 00:00:00

  • Epidemiology of chronic myeloid leukaemia: an update.

    abstract：:National and regional population-based registries are, provided diagnostic accuracy and full coverage of the target population, indispensible tools for epidemiological research. Chronic myeloid leukaemia (CML) registries with more comprehensive reporting may also provide complementary data on treatment outcome to thos...

    journal_title：Annals of hematology

    pub_type： 杂志文章,评审

    doi：10.1007/s00277-015-2314-2

    authors： Höglund M,Sandin F,Simonsson B

    更新日期：2015-04-01 00:00:00

  • Comparison and evaluation of three screening tests of hereditary spherocytosis in Chinese patients.

    abstract：:The objective of this study is to compare and evaluate the diagnostic value of hereditary spherocytosis (HS) by three screening tests, comparing mean spherical corpuscular volume (MSCV) to mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), and flow cytometric osmotic fragility test. Perip...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-014-2270-2

    authors： Tao YF,Deng ZF,Liao L,Qiu YL,Chen WQ,Lin FQ

    更新日期：2015-05-01 00:00:00

  • CTLA-4 polymorphisms are associated with treatment outcomes of patients with multiple myeloma receiving bortezomib-based regimens.

    abstract：:Single-nucleotide polymorphisms (SNPs) of cytotoxic T lymphocyte antigen-4 (CTLA-4) are important risk factors associated with autoimmune diseases and malignancies. This study explored the association of CTLA-4SNPs with the development of myeloma and evaluated the outcome of patients receiving bortezomib-based regimen...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-017-3203-7

    authors： Qin XY,Lu J,Li GX,Wen L,Liu Y,Xu LP,Chang YJ,Liu KY,Jiang ZF,Huang XJ

    更新日期：2018-03-01 00:00:00

  • Modified expression of coagulation factor VIII by addition of a glycosylation site at the N terminus of the protein.

    abstract：:Recently, it was shown that glycoproteins with N-glycans close to the NH(2) terminus can directly enter the calnexin/calreticulin cycle and bypass BiP binding. This should allow efficient secretion of glycoproteins such as factor VIII (FVIII) whose secretion is negatively affected by BiP interaction. Examination of th...

    journal_title：Annals of hematology

    pub_type： 杂志文章

    doi：10.1007/s00277-007-0380-9

    authors： Srour MA,Grupp J,Aburubaiha Z,Albert T,Brondke H,Oldenburg J,Schwaab R

    更新日期：2008-02-01 00:00:00