Abstract：
:Intrathecal cytokine levels and blood-cerebrospinal fluid (CSF) barrier function were studied in 91 Trypanosoma brucei rhodesiense-infected patients. The CSF concentration of the cellular immune activation marker neopterin and the cytokines IL-6 and IL-10 were increased over control and post-treatment levels in all patients, with maximal levels observed in late-stage (meningoencephalitic) individuals. Analysis of CSF/serum concentration quotients indicated that IL-10 and neopterin were derived from central nervous system synthesis in at least 25% of the patients. Blood-CSF barrier dysfunction occurred in 64% of late-stage patients but not in early-stage patients. While the high level of neopterin observed in the late-stage patient CSF is indicative of widespread cellular activation, the increased levels of IL-6 and IL-10 suggest that counter-inflammatory cellular responses may be important in the regulation of neuropathogenesis in late-stage human African trypanosomiasis.
journal_name
Trans R Soc Trop Med Hygauthors
Maclean L,Odiit M,Sternberg JMdoi
10.1016/j.trstmh.2005.03.013subject
Has Abstractpub_date
2006-03-01 00:00:00pages
270-5issue
3eissn
0035-9203issn
1878-3503pii
S0035-9203(05)00326-3journal_volume
100pub_type
杂志文章abstract：:368 strains of Shigella were recovered from stool specimens in the Department of Medical Microbiology, Ahmadu Bello University Teaching Hospital, Zaria, during the period January 1980 to December 1984. S. flexneri was found to be the most common (60%) followed by S. boydii (20.7%), S. dysenteriae (14.1%) and S. sonnei...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(87)90383-x
更新日期：1987-01-01 00:00:00
abstract：:Countries around the world are facing an enormous challenge due to the COVID-19 pandemic. The pressure that the pandemic inflicts on health systems could certainly impact on the care, control, and elimination of neglected tropical diseases (NTDs). From mid-January 2020, Ethiopia started to prepare for the prevention a...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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更新日期：2020-10-05 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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更新日期：1995-11-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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更新日期：1983-01-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(87)90037-x
更新日期：1987-01-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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更新日期：2001-09-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/j.trstmh.2007.02.023
更新日期：2007-07-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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更新日期：2009-06-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(94)90228-3
更新日期：1994-11-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(94)90103-1
更新日期：1994-05-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
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更新日期：1999-11-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
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更新日期：1992-05-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章,评审
doi：10.1093/trstmh/trw025
更新日期：2016-05-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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更新日期：1981-01-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章,评审
doi：10.1016/j.trstmh.2007.09.018
更新日期：2008-02-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章,评审
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更新日期：2013-12-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章,多中心研究
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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更新日期：1981-01-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
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更新日期：1985-01-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(88)90419-1
更新日期：1988-01-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 社论
doi：10.1016/j.trstmh.2006.03.001
更新日期：2006-07-01 00:00:00
abstract：:Plasmodium falciparum in Thailand is highly resistant to available antimalarial drugs. Artemether, a derivative of artemisinin, is a promising compound currently used to cope with this situation but the course of treatment has to be at least 5 d. An effective short treatment course of this drug is possible when used i...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1995-05-01 00:00:00
abstract：:Neutralizing antibodies against poliovirus have been studied in 265 persons in Monrovia (Liberia). 34% of the individuals studied possessed antibodies against the three polioviruses, 23% against two, 26% against one; the remaining 17% showed none. The three poliovirus antibodies were evenly distributed amongst the pop...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(77)90075-x
更新日期：1977-01-01 00:00:00
abstract：:Blood pressure, heart rate and electrocardiographic responses to exercise were compared in a group of 125 subjects with antibodies to Trypanosoma cruzi and in 153 seronegative subjects, randomly selected from persons with no evidence of heart disease in a resting electrocardiogram during a cross-sectional survey among...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(90)90081-o
更新日期：1990-11-01 00:00:00
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journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(81)90202-9
更新日期：1981-01-01 00:00:00
abstract：:We report the results of a short study of the epidemiology of Leishmania tropica in the Sheikh Maksoud District of Aleppo, Syria. The present and past status of infection in a community of about 100,000 people are assessed from prevalence and incidence data obtained by active and passive case detection, and from a ski...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(93)90111-3
更新日期：1993-05-01 00:00:00
abstract：:The effects of levamisole, isoprinosine and Corynebacterium parvum on Trypanosoma cruzi (Y strain) experimental infection of mice were studied. In prophylactic treatment these drugs reduced the peak of parasitaemia, and had no apparent effect on mortality rate or on histopathological and electrocardiographic findings....
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(88)90268-4
更新日期：1988-01-01 00:00:00
abstract：:The possible depression of cell-mediated immunity by long-term Brugia malayi infection in jirds (Meriones unguiculatus) was investigated. Different groups of infected jirds were sensitized with dinitrofluorobenzene, sheep red blood cells, Dirofilaria immitis adult antigens and B. malayi adult antigens. The 24-hour del...
journal_title：Transactions of the Royal Society of Tropical Medicine and Hygiene
pub_type： 杂志文章
doi：10.1016/0035-9203(80)90070-x
更新日期：1980-01-01 00:00:00
