Genetic evidence that RI chloroquine resistance of Plasmodium falciparum is caused by recrudescence of resistant parasites.

Abstract:

:Isolates of Plasmodium falciparum from patients in a Sudanese village exhibiting RI resistance to chloroquine have been typed for allelic variants of 2 merozoite surface antigens, MSP1 and MSP2. Blood forms were taken from each patient before chloroquine was administered, and after parasites had reappeared following treatment. Each patient was found to be infected with genetically different parasites. However, in each patient the parasites of the recrudescent infections possessed the same alleles of each gene as those of the primary infection. The results show that the parasites which reappeared after chloroquine were a genuine recrudescence of the primary forms, and not derived from a new infection.

authors

Babiker H,Ranford-Cartwright L,Sultan A,Satti G,Walliker D

doi

10.1016/0035-9203(94)90103-1

subject

Has Abstract

pub_date

1994-05-01 00:00:00

pages

328-31

issue

3

eissn

0035-9203

issn

1878-3503

journal_volume

88

pub_type

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