Abstract：
:Bioluminescent imaging (BLI) of luciferase-expressing cells in live small animals is a powerful technique for investigating tumor growth, metastasis, and specific biological molecular events. Three-dimensional imaging would greatly enhance applications in biomedicine since light emitting cell populations could be unambiguously associated with specific organs or tissues. Any imaging approach must account for the main optical properties of biological tissue because light emission from a distribution of sources at depth is strongly attenuated due to optical absorption and scattering in tissue. Our image reconstruction method for interior sources is based on the deblurring expectation maximization method and takes into account both of these effects. To determine the boundary of the object we use the standard iterative algorithm-maximum likelihood reconstruction method with an external source of diffuse light. Depth-dependent corrections were included in the reconstruction procedure to obtain a quantitative measure of light intensity by using the diffusion equation for light transport in semi-infinite turbid media with extrapolated boundary conditions.
journal_name
Med Physjournal_title
Medical physicsauthors
Slavine NV,Lewis MA,Richer E,Antich PPdoi
10.1118/1.2138007subject
Has Abstractpub_date
2006-01-01 00:00:00pages
61-8issue
1eissn
0094-2405issn
2473-4209journal_volume
33pub_type
杂志文章相关文献
MEDICAL PHYSICS文献大全abstract：:A simple noninvasive method is described for determining the backscatter to a monitor chamber of a medical accelerator based on the measurement of charge deposited in the target. This method is compared quantitatively to the more elaborate telescopic method for photon beams of 6 MV and 15 MV on linear accelerators hav...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1118/1.598203
更新日期：1998-03-01 00:00:00
abstract：:Attention is given to means of sensing ultrasonic energy distributions over an area. Under the restraints appropiate to real-time imaging of deep body organs, piezoelectric arrays offer the most promising method. Adaptation of integrated circuit techniques to array assembly permits very large arrays of small elements ...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1118/1.594247
更新日期：1976-09-01 00:00:00
abstract：:A spread-out Bragg peak (SOBP) is used in proton beam therapy to create a longitudinal conformality of the required dose to the target. In order to create this effect in a passive beam scattering system, a variety of components must operate in conjunction to produce the desired beam parameters. We will describe how th...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1118/1.2776255
更新日期：2007-10-01 00:00:00
abstract：PURPOSE:The biologically effective dose (BED) of temporary brachytherapy treatments is a function of both chosen radionuclide (R) and implant duration (T). This study endeavored to evaluate BED delivered to the tumor volume and surrounding ocular structures as a function of plaque position (P), prescription dose, R, an...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1118/1.4735548
更新日期：2012-06-01 00:00:00
abstract：:Deformable image registration is an important tool for image-guided radiotherapy. Physics-model-based deformable image registration using finite element analysis is one of the methods currently being investigated. The calculation accuracy of finite element analysis is dependent on given boundary conditions, which are ...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1118/1.1774131
更新日期：2004-09-01 00:00:00
abstract：:A theoretical analysis of the x-ray phase contrast imaging and its validation via synchrotron radiation imaging is here presented. Two different mathematical models have been followed: the simpler ray-optical approach and the more rigorous Fresnel-Kirchoff diffraction theory. Subsequently, the conditions upon which th...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1118/1.2126207
更新日期：2005-12-01 00:00:00
abstract：PURPOSE:A joint working group was created by the American Association of Physicists in Medicine (AAPM), the European Society for Radiotherapy and Oncology (ESTRO), and the Australasian Brachytherapy Group (ABG) with the charge, among others, to develop a set of well-defined test case plans and perform calculations and ...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1002/mp.12459
更新日期：2017-11-01 00:00:00
abstract：:A scintillation dosemeter is calibrated for 90Sr/90Y beta rays from an ophthalmic applicator, using an extrapolation ionization chamber as a reference instrument. The calibration factor for the scintillation dosemeter agrees with that given by the manufacturer of the dosemeter within ca. 2%. The estimated overall unce...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1118/1.1709490
更新日期：2004-05-01 00:00:00
abstract：PURPOSE:The authors have developed a system that monitors intrafractional target motion perpendicular to the treatment beam with the aid of radioopaque markers by means of separating kV image and megavoltage (MV) treatment field on a single flat-panel detector. METHODS:They equipped a research Siemens Artiste linear a...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1118/1.3665712
更新日期：2012-01-01 00:00:00
abstract：:Monte Carlo (MC) simulations were performed to estimate brachytherapy dose distributions for Collaborative Ocular Melanoma Study (COMS) eye plaques. Brachytherapy seed models 200, 6711, and CS-1 Rev2 carrying 103Pd, 125I, and 131Cs radionuclides, respectively, were modeled and benchmarked against previously published ...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1118/1.2940604
更新日期：2008-07-01 00:00:00
abstract：:Respiratory motion can introduce significant errors in radiotherapy. Conventional CT scans as commonly used for treatment planning can include severe motion artifacts that result from interplay effects between the advancing scan plane and object motion. To explicitly include organ/target motion in treatment planning a...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1118/1.1869852
更新日期：2005-04-01 00:00:00
abstract：PURPOSE:In this article, the authors propose a new gold standard data set for the validation of two-dimensional/three-dimensional (2D/3D) and 3D/3D image registration algorithms. METHODS:A gold standard data set was produced using a fresh cadaver pig head with attached fiducial markers. The authors used several imagin...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1118/1.3553402
更新日期：2011-03-01 00:00:00
abstract：PURPOSE:The most common metric for comparing measured to calculated dose, such as for pretreatment quality assurance of intensity-modulated photon fields, is a pass rate (%) generated using percent difference (%Diff), distance-to-agreement (DTA), or some combination of the two (e.g., gamma evaluation). For many dosimet...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1118/1.3651695
更新日期：2011-11-01 00:00:00
abstract：:A double-mirror multilayer monochromator was developed for the purpose of irradiating live cell cultures at the Synchrotron Radiation Center, University of Wisconsin-Madison. The monochromator is designed for the soft x-ray region with photon energies between 270 and 2400 eV. Multilayer mirrors with 55 bilayers of W/C...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1118/1.598259
更新日期：1998-05-01 00:00:00
abstract：PURPOSE:Hybrid Photon Counting (HPC) detectors profoundly improved x-ray diffraction experiments at third generation synchrotron facilities. Enabling the simultaneous measurement of x-ray intensities in multiple energy bins, they also have many potential applications in the field of medical imaging. A prerequisite for ...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1002/mp.12323
更新日期：2017-09-01 00:00:00
abstract：:A PTW Riga diamond detector and LiF TLDs have been evaluated for use in proton beam dosimetry by comparing results of proton beam calibration with those obtained using thimble ionization chambers. The thimble ionization chambers were calibrated in terms of exposure while the TLDs and diamond detector were calibrated i...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1118/1.597608
更新日期：1995-04-01 00:00:00
abstract：PURPOSE:To balance dose reduction and image registration accuracy in breast setup imaging. In particular, the authors demonstrate the relationship between scan angle and dose delivery for cone beam tomosynthesis (CBTS) when employed for setup verification of breast cancer patients with surgical clips. METHODS:The dose...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1118/1.3464716
更新日期：2010-08-01 00:00:00
abstract：:Recently, new imaging modalities based on the detection of weak phase perturbations effects, among which are phase contrast and diffraction imaging, have been developed by several researchers. Due to their high sensitivity to weakly absorbing details, these techniques seem to be very promising for applications in the ...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1118/1.1388219
更新日期：2001-08-01 00:00:00
abstract：:Stereo x-ray radiography attracts increasing attention in major clinical applications. The purpose of this paper is to analyze the 3D localization error for breast biopsy procedures and provide guidelines for improving its accuracy. Our prototype is a CCD based digital stereo x-ray imaging system. The mathematical mod...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1118/1.598953
更新日期：2000-05-01 00:00:00
abstract：PURPOSE:A critical step in adaptive radiotherapy (ART) workflow is deformably registering the simulation CT with the daily or weekly volumetric imaging. Quantifying the deformable image registration accuracy under these circumstances is a complex task due to the lack of known ground-truth landmark correspondences betwe...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1002/mp.12321
更新日期：2017-08-01 00:00:00
abstract：PURPOSE:The spatial and temporal tracking performance of a commercially available 3D optical surface imaging system is evaluated for its potential use in frameless stereotactic radiosurgery head tracking applications. METHODS:Both 3D surface and infrared (IR) marker tracking were performed simultaneously on a head pha...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1118/1.4823757
更新日期：2013-11-01 00:00:00
abstract：:The minimum margins required to compensate for random geometric uncertainties in the delivery of radiotherapy treatment were determined for a spherical Clinical Target Volume, using an analytic model for the cumulative dose. Margins were calculated such that the minimum dose in the target would be no less than 95% of ...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1118/1.1809991
更新日期：2004-11-01 00:00:00
abstract：PURPOSE:In using flat panel detectors (FPD) for cone beam computed tomography (CBCT), pixel gain variations may lead to structured nonuniformities in projections and ring artifacts in CBCT images. Such gain variations can be caused by change in detector entrance exposure levels or beam hardening, and they are not accou...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1118/1.4893278
更新日期：2014-09-01 00:00:00
abstract：PURPOSE:In fractionated radiation therapy, image guidance with daily tomographic imaging becomes more and more clinical routine. In principle, this allows for daily computation of the delivered dose and for accumulation of these daily dose distributions to determine the actually delivered total dose to the patient. How...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1118/1.3697524
更新日期：2012-04-01 00:00:00
abstract：:Part III (oral exam) is the final part of ABR board exam for Diagnostic Medical Physics. In this exam, each of five oral examiners questions the candidate in each of five question categories. Oral exam has unique challenges to the candidate compared with the written exams. The candidate is expected to have not only ad...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1118/1.4736136
更新日期：2012-06-01 00:00:00
abstract：PURPOSE:A high resolution, water equivalent, optical and passive x-ray dosimeter has been constructed using plastic scintillator and optical fiber. This dosimeter has a peak edge-on spatial resolution of 100 μm in one dimension, with a 10 μm resolution dosimeter under investigation. The dosimeter design has a potential...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1002/mp.12209
更新日期：2017-05-01 00:00:00
abstract：PURPOSE:Plastic scintillation detectors are used for dosimetry in small radiation fields with high dose gradients, e.g., provided by β-emitting sources like 106 Ru/106 Rh eye plaques. A drawback is a background signal caused by Cerenkov radiation generated by electrons passing the optical fibers (light guides) of this ...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1002/mp.12374
更新日期：2017-09-01 00:00:00
abstract：PURPOSE:The availability of accurate and simple models for the estimation of x-ray spectra is of great importance for system simulation, optimization, or inclusion of photon energy information into data processing. There is a variety of publicly available tools for estimation of x-ray spectra in radiology and mammograp...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1118/1.4837220
更新日期：2014-01-01 00:00:00
abstract：:Techniques have been developed for reducing motion blurring artifacts by using respiratory gated computed tomography (CT) in sinogram space and quantitatively evaluating the artifact reduction. A synthetic sinogram was built from multiple scans intercepting a respiratory gating window. A gated CT image was then recons...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1118/1.2074187
更新日期：2005-11-01 00:00:00
abstract：PURPOSE:To evaluate the performance and efficacy for intensity inhomogeneity correction of various sequences of the human brain in 7T MRI using the extended version of the unified segmentation algorithm. MATERIALS:Ten healthy volunteers were scanned with four different sequences (2D spin echo [SE], 3D fast SE, 2D fast...
journal_title：Medical physics
pub_type： 杂志文章
doi：10.1118/1.4860954
更新日期：2014-02-01 00:00:00
