An innovative digital imaging set-up allowing a low-dose approach to phase contrast applications in the medical field.

Abstract:

:Recently, new imaging modalities based on the detection of weak phase perturbations effects, among which are phase contrast and diffraction imaging, have been developed by several researchers. Due to their high sensitivity to weakly absorbing details, these techniques seem to be very promising for applications in the medical field. On the other hand, digital radiology is undergoing a wide diffusion, and its benefits are presently very well understood. Up to now, however, the strong pixel size constraints associated with phase contrast pattern detection limited the possibility of exploiting the advantages of phase contrast in digital radiology applications. In this paper, an innovative setup capable of removing the pixel size constraints, and thus opening the way to low dose digital phase contrast imaging, is described. Furthermore, we introduce an imaging technique based on the detection of radiation scattered at small angles: the information extracted from the sample is increased at no dose expense. We believe that several radiological fields, mammography being the first important example, may benefit from the herein described innovative imaging techniques.

journal_name

Med Phys

journal_title

Medical physics

authors

Olivo A,Arfelli F,Cantatore G,Longo R,Menk RH,Pani S,Prest M,Poropat P,Rigon L,Tromba G,Vallazza E,Castelli E

doi

10.1118/1.1388219

subject

Has Abstract

pub_date

2001-08-01 00:00:00

pages

1610-9

issue

8

eissn

0094-2405

issn

2473-4209

journal_volume

28

pub_type

杂志文章
  • Improvement of registration accuracy in accelerated partial breast irradiation using the point-based rigid-body registration algorithm for patients with implanted fiducial markers.

    abstract:PURPOSE:To investigate image-registration errors when using fiducial markers with a manual method and the point-based rigid-body registration (PRBR) algorithm in accelerated partial breast irradiation (APBI) patients, with accompanying fiducial deviations. METHODS:Twenty-two consecutive patients were enrolled in a pro...

    journal_title:Medical physics

    pub_type: 临床试验,杂志文章

    doi:10.1118/1.4915534

    authors: Inoue M,Yoshimura M,Sato S,Nakamura M,Yamada M,Hirata K,Sasaki M,Fujimoto T,Ogura M,Hiraoka M

    更新日期:2015-04-01 00:00:00

  • A novel approach to evaluate spatial resolution of MRI clinical images for optimization and standardization of breast screening protocols.

    abstract:PURPOSE:Stringent quality assurance is required in MRI breast screening to ensure that different scanners and imaging protocols reach similar diagnostic performance. The authors propose a methodology, based on power spectrum analysis (PSA), to evaluate spatial resolution in clinical images. To demonstrate this approach...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4966704

    authors: Borri M,Scurr ED,Richardson C,Usher M,Leach MO,Schmidt MA

    更新日期:2016-12-01 00:00:00

  • Validation for 2D/3D registration. I: A new gold standard data set.

    abstract:PURPOSE:In this article, the authors propose a new gold standard data set for the validation of two-dimensional/three-dimensional (2D/3D) and 3D/3D image registration algorithms. METHODS:A gold standard data set was produced using a fresh cadaver pig head with attached fiducial markers. The authors used several imagin...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3553402

    authors: Pawiro SA,Markelj P,Pernus F,Gendrin C,Figl M,Weber C,Kainberger F,Nöbauer-Huhmann I,Bergmeister H,Stock M,Georg D,Bergmann H,Birkfellner W

    更新日期:2011-03-01 00:00:00

  • Sparse and optimal acquisition design for diffusion MRI and beyond.

    abstract:PURPOSE:Diffusion magnetic resonance imaging (MRI) in combination with functional MRI promises a whole new vista for scientists to investigate noninvasively the structural and functional connectivity of the human brain-the human connectome, which had heretofore been out of reach. As with other imaging modalities, diffu...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3700166

    authors: Koay CG,Ozarslan E,Johnson KM,Meyerand ME

    更新日期:2012-05-01 00:00:00

  • Assessing radiation and light field congruence with a video based electronic portal imaging device.

    abstract::Projected light fields are used on treatment simulators and teletherapy treatment units to delineate the size and position of the radiation beam. Any discrepancy between these fields will lead to a systematic field placement error, with possibly serious implications with regard to the accuracy of the delivered dose di...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.597867

    authors: Luchka K,Chen D,Shalev S,Gluhchev G,Rajapakshe R

    更新日期:1996-07-01 00:00:00

  • The effects of motion on quantitative vessel measurements.

    abstract::Optimal visualization of moving structures such as the heart and coronary arteries using digital radiographic imaging systems is a difficult problem that can involve tradeoffs between temporal, spatial, and density resolution. The motion dependence of four angiographic measures of vessel dimensions is given and demons...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.595651

    authors: Parker DL,Clayton PD,Gustafson DE

    更新日期:1985-11-01 00:00:00

  • ARPM-net: A novel CNN-based adversarial method with Markov random field enhancement for prostate and organs at risk segmentation in pelvic CT images.

    abstract:PURPOSE:The research is to develop a novel CNN-based adversarial deep learning method to improve and expedite the multi-organ semantic segmentation of CT images and to generate accurate contours on pelvic CT images. METHODS:Planning CT and structure datasets for 120 patients with intact prostate cancer were retrospect...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.14580

    authors: Zhang Z,Zhao T,Gay H,Zhang W,Sun B

    更新日期:2020-11-05 00:00:00

  • Cascaded systems analysis of the 3D noise transfer characteristics of flat-panel cone-beam CT.

    abstract::The physical factors that govern 2D and 3D imaging performance may be understood from quantitative analysis of the spatial-frequency-dependent signal and noise transfer characteristics [e.g., modulation transfer function (MTF), noise-power spectrum (NPS), detective quantum efficiency (DQE), and noise-equivalent quanta...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3002414

    authors: Tward DJ,Siewerdsen JH

    更新日期:2008-12-01 00:00:00

  • Acuros CTS: A fast, linear Boltzmann transport equation solver for computed tomography scatter - Part I: Core algorithms and validation.

    abstract:PURPOSE:To describe Acuros® CTS, a new software tool for rapidly and accurately estimating scatter in x-ray projection images by deterministically solving the linear Boltzmann transport equation (LBTE). METHODS:The LBTE describes the behavior of particles as they interact with an object across spatial, energy, and dir...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.12850

    authors: Maslowski A,Wang A,Sun M,Wareing T,Davis I,Star-Lack J

    更新日期:2018-05-01 00:00:00

  • First Measurements of Ionization Cluster-Size Distributions with a Compact Nanodosimeter.

    abstract:PURPOSE:A nanodosimeter is a type of detector which measures single ionizations in a small gaseous volume in order to obtain ionization cluster size probability distributions for characterization of radiation types. Working nanodosimeter detectors are usually bulky machines which require a lot of space. In this work, t...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.14738

    authors: Vasi F,Schneider U

    更新日期:2021-01-28 00:00:00

  • Effect of phantom voxelization in CT simulations.

    abstract::In computer simulations of x-ray CT systems one can either use continuous geometrical descriptions for phantoms or a voxelized representation. The voxelized approach allows arbitrary phantoms to be defined without being confined to geometrical shapes. The disadvantage of the voxelized approach is that inherent errors ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1461841

    authors: Goertzen AL,Beekman FJ,Cherry SR

    更新日期:2002-04-01 00:00:00

  • Technical Note: Experimental verification of magnetic field-induced beam deflection and Bragg peak displacement for MR-integrated proton therapy.

    abstract:PURPOSE:Given its sensitivity to anatomical variations, proton therapy is expected to benefit greatly from integration with magnetic resonance imaging for online anatomy monitoring during irradiation. Such an integration raises several challenges, as both systems mutually interact. The proton beam will experience quasi...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.12961

    authors: Schellhammer SM,Gantz S,Lühr A,Oborn BM,Bussmann M,Hoffmann AL

    更新日期:2018-07-01 00:00:00

  • Response of an implantable MOSFET dosimeter to 192Ir HDR radiation.

    abstract::New in vivo dosimetry methods would be useful for clinical HDR brachytherapy. An implantable MOSFET Dose Verification System designed by Sicel Technologies, Inc. was examined for use with 192Ir HDR applications. This investigation demonstrated that varying the dose rate from 22 to 84 cGy/min did not change detector re...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3013574

    authors: Fagerstrom JM,Micka JA,DeWerd LA

    更新日期:2008-12-01 00:00:00

  • Comparison of secondary neutron dose in proton therapy resulting from the use of a tungsten alloy MLC or a brass collimator system.

    abstract:PURPOSE:To apply the dual ionization chamber method for mixed radiation fields to an accurate comparison of the secondary neutron dose arising from the use of a tungsten alloy multileaf collimator (MLC) as opposed to a brass collimator system for defining the shape of a therapeutic proton field. METHODS:Hydrogenous an...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3656025

    authors: Diffenderfer ES,Ainsley CG,Kirk ML,McDonough JE,Maughan RL

    更新日期:2011-11-01 00:00:00

  • SU-E-J-63: Feasibility Study of Proton Digital Tomosynthesis in Proton Beam Therapy.

    abstract:PURPOSE:We investigated the feasibility of proton tomosynthesis as daily positioning of patients and compared the results with photon tomosynthesis as an alternative to conventional portal imaging or on-board cone-beam computed tomography. METHODS:Dedicated photon-like proton beam using the passively scattered proton ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4734898

    authors: Min B,Kwak J,Lee J,Cho S,Park S,Yoo S,Chung K,Cho S,Lim Y,Shin D,Lee S,Kim J

    更新日期:2012-06-01 00:00:00

  • The use of PET images for radiotherapy treatment planning: an error analysis using radiobiological endpoints.

    abstract:PURPOSE:There is significant current interest in the use of biological image guidance in radiotherapy planning. In lung-cancer treatment, tumor motion due to respiration is known to be a limitation. This is particularly true in PET, where image data are collected over a number of minutes. An in-house-developed 4D PET a...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3276776

    authors: Perrin R,Evans PM,Webb S,Partridge M

    更新日期:2010-02-01 00:00:00

  • Monte Carlo assessment of computed tomography dose to tissue adjacent to the scanned volume.

    abstract::The assessment of the radiation dose to internal organs or to an embryo or fetus is required on occasion for risk assessment or for comparing imaging studies. Limited resources hinder the ability to accurately assess the radiation dose received to locations outside the tissue volume actually scanned during computed to...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1312809

    authors: Boone JM,Cooper VN 3rd,Nemzek WR,McGahan JP,Seibert JA

    更新日期:2000-10-01 00:00:00

  • Radiofrequency penetration and absorption in the human body: limitations to high-field whole-body nuclear magnetic resonance imaging.

    abstract::This study presents experimental results about the effective depth of penetration and about the radiofrequency (rf) power absorption in humans as a function of frequency. The frequency range investigated covers 10 up to 220 MHz. For the main part, the results were derived from bench measurements of the quality factor ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.595995

    authors: Röschmann P

    更新日期:1987-11-01 00:00:00

  • Normalized dose data for upper gastrointestinal tract contrast studies performed to infants.

    abstract::The aim of the current study was to (a) provide normalized dose data for the estimation of the radiation dose from upper gastrointestinal tract contrast (UGIC) studies carried out to infants and (b) estimate the average patient dose and risks associated with radiation from UGIC examinations performed in our institutio...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2181297

    authors: Damilakis J,Stratakis J,Raissaki M,Perisinakis K,Kourbetis N,Gourtsoyiannis N

    更新日期:2006-04-01 00:00:00

  • Noise texture and signal detectability in propagation-based x-ray phase-contrast tomography.

    abstract:PURPOSE:X-ray phase-contrast tomography (PCT) is a rapidly emerging imaging modality for reconstructing estimates of an object's three-dimensional x-ray refractive index distribution. Unlike conventional x-ray computed tomography methods, the statistical properties of the reconstructed images in PCT remain unexplored. ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3267548

    authors: Chou CY,Anastasio MA

    更新日期:2010-01-01 00:00:00

  • The role of water desorption on optical clearing of biotissue: studied with near infrared reflectance spectroscopy.

    abstract::In order to understand the role of water desorption, i.e., the opposite of water adsorption, in optical clearing of biological tissue created by the application of hyperosmotic agents, dynamics of water loss in fresh porcine muscle tissue administrated with glycerol or ethylene glycol was investigated with the near-in...

    journal_title:Medical physics

    pub_type:

    doi:10.1118/1.1576228

    authors: Xu X,Wang RK

    更新日期:2003-06-01 00:00:00

  • Basic imaging properties of a computed radiographic system with photostimulable phosphors.

    abstract::We measured the characteristic curve, modulation transfer function (MTF), and the Wiener spectrum of a commercially available computed radiographic (CR) system with photostimulable phosphor plate (imaging plate, IP). The characteristic curve (system response) obtained by an inverse-square x-ray sensitometry showed a w...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.596402

    authors: Fujita H,Ueda K,Morishita J,Fujikawa T,Ohtsuka A,Sai T

    更新日期:1989-01-01 00:00:00

  • The potential role of positron emission mammography for detection of breast cancer. A phantom study.

    abstract::Positron emission mammography (PEM) is a new, specialized imaging modality utilizing PET radiopharmaceuticals to detect breast cancer. The capabilities and limitations of PEM in detecting breast tumors were investigated with a series of phantom experiments. The PEM imager was mounted on a standard Lorad biopsy table (...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1287439

    authors: Raylman RR,Majewski S,Wojcik R,Weisenberger AG,Kross B,Popov V,Bishop HA

    更新日期:2000-08-01 00:00:00

  • The thermal characteristics of different diodes on in vivo patient dosimetry.

    abstract::Diode sensitivity variations with temperature (SVWT) have been reported to vary from small negative values up to 0.6% per degrees C. Thus it is possible for diode calibration factors established at room temperature (approximately 20 degrees C) to yield errors in the range of -1% to +9% when diodes are placed on a pati...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1367862

    authors: Welsh KT,Reinstein LE

    更新日期:2001-05-01 00:00:00

  • Evaluations of two solid water parallel-plate chambers in high-energy photon and electron beams.

    abstract::Using high-energy photon and electron beams, the response of two solid water parallel-plate chambers is evaluated against a PTW (Physicallsch-Technische Werkstatten) Farmer-type chamber. These two chambers are (1) a Memorial "Holt" chamber which was further modified by this author to take advantage of electrically con...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.597074

    authors: Kubo H

    更新日期:1993-03-01 00:00:00

  • Sensitivities in the production of spread-out Bragg peak dose distributions by passive scattering with beam current modulation.

    abstract::A spread-out Bragg peak (SOBP) is used in proton beam therapy to create a longitudinal conformality of the required dose to the target. In order to create this effect in a passive beam scattering system, a variety of components must operate in conjunction to produce the desired beam parameters. We will describe how th...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2776255

    authors: Lu HM,Brett R,Engelsman M,Slopsema R,Kooy H,Flanz J

    更新日期:2007-10-01 00:00:00

  • Automatic quantitative low contrast analysis of digital chest phantom radiographs.

    abstract::Up to the present, the majority of low contrast object evaluations performed on phantom images have been accomplished in a subjective fashion. This is mainly due to the time and effort required to manually measure each radiograph with a densitometer to obtain quantitative results. However, with the development of digi...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1543153

    authors: Kwan AL,Filipow LJ,Le LH

    更新日期:2003-03-01 00:00:00

  • Characteristics and quality assurance of a dedicated open 0.23 T MRI for radiation therapy simulation.

    abstract::A commercially available open MRI unit is under routine use for radiation therapy simulation. The effects of a gradient distortion correction (GDC) program used to post process the images were assessed by comparison with the known geometry of a phantom. The GDC reduced the magnitude of the distortions at the periphery...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1513991

    authors: Mah D,Steckner M,Palacio E,Mitra R,Richardson T,Hanks GE

    更新日期:2002-11-01 00:00:00

  • Parametrization of head-scatter factors for rectangular photon fields using an equivalent square formalism.

    abstract::Head-scatter factors of symmetric square and rectangular fields (field center on the central beam axis) defined by the upper (Y) and lower (X) jaws for 6 and 15 MV photon beams from 2300CD and 600C accelerators (Varian Associates, Inc., Palo Alto, CA) were measured, as well as those for fields shaped by the Y jaws and...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.597617

    authors: Yu MK,Murray B,Sloboda R

    更新日期:1995-08-01 00:00:00

  • Poster - Thurs Eve-31: Clinical implementation and experience with EPID-based precision isocentre localization.

    abstract::Modern linear accelerators contain multiple isocentres, defined by the mechanical motions of gantry, collimator and table. Isocentre localization for these motions has been performed using film and manual evaluations which have difficulty in relating the individual motions. To address these limitations, we have develo...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2965950

    authors: Heaton R,Smale J,Norrlinger B,Wang Y,van Prooijen M,Islam M

    更新日期:2008-07-01 00:00:00