Acuros CTS: A fast, linear Boltzmann transport equation solver for computed tomography scatter - Part I: Core algorithms and validation.

Abstract:

PURPOSE:To describe Acuros® CTS, a new software tool for rapidly and accurately estimating scatter in x-ray projection images by deterministically solving the linear Boltzmann transport equation (LBTE). METHODS:The LBTE describes the behavior of particles as they interact with an object across spatial, energy, and directional (propagation) domains. Acuros CTS deterministically solves the LBTE by modeling photon transport associated with an x-ray projection in three main steps: (a) Ray tracing photons from the x-ray source into the object where they experience their first scattering event and form scattering sources. (b) Propagating photons from their first scattering sources across the object in all directions to form second scattering sources, then repeating this process until all high-order scattering sources are computed using the source iteration method. (c) Ray-tracing photons from scattering sources within the object to the detector, accounting for the detector's energy and anti-scatter grid responses. To make this process computationally tractable, a combination of analytical and discrete methods is applied. The three domains are discretized using the Linear Discontinuous Finite Elements, Multigroup, and Discrete Ordinates methods, respectively, which confer the ability to maintain the accuracy of a continuous solution. Furthermore, through the implementation in CUDA, we sought to exploit the parallel computing capabilities of graphics processing units (GPUs) to achieve the speeds required for clinical utilization. Acuros CTS was validated against Geant4 Monte Carlo simulations using two digital phantoms: (a) a water phantom containing lung, air, and bone inserts (WLAB phantom) and (b) a pelvis phantom derived from a clinical CT dataset. For these studies, we modeled the TrueBeam® (Varian Medical Systems, Palo Alto, CA) kV imaging system with a source energy of 125 kVp. The imager comprised a 600 μm-thick Cesium Iodide (CsI) scintillator and a 10:1 one-dimensional anti-scatter grid. For the WLAB studies, the full-fan geometry without a bowtie filter was used (with and without the anti-scatter grid). For the pelvis phantom studies, a half-fan geometry with bowtie was used (with the anti-scatter grid). Scattered and primary photon fluences and energies deposited in the detector were recorded. RESULTS:The Acuros CTS and Monte Carlo results demonstrated excellent agreement. For the WLAB studies, the average percent difference between the Monte Carlo- and Acuros-generated scattered photon fluences at the face of the detector was -0.7%. After including the detector response, the average percent differences between the Monte Carlo- and Acuros-generated scatter fractions (SF) were -0.1% without the grid and 0.6% with the grid. For the digital pelvis simulation, the Monte Carlo- and Acuros-generated SFs agreed to within 0.1% on average, despite the scatter-to-primary ratios (SPRs) being as high as 5.5. The Acuros CTS computation time for each scatter image was ~1 s using a single GPU. CONCLUSIONS:Acuros CTS enables a fast and accurate calculation of scatter images by deterministically solving the LBTE thus offering a computationally attractive alternative to Monte Carlo methods. Part II describes the application of Acuros CTS to scatter correction of CBCT scans on the TrueBeam system.

journal_name

Med Phys

journal_title

Medical physics

authors

Maslowski A,Wang A,Sun M,Wareing T,Davis I,Star-Lack J

doi

10.1002/mp.12850

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

1899-1913

issue

5

eissn

0094-2405

issn

2473-4209

journal_volume

45

pub_type

杂志文章
  • SU-E-J-160: 4D Dynamic Arc of Non-Modulated Variable-Dose-Rate Fields for Lung SBRT: A Feasibility Study.

    abstract:PURPOSE:Conformal SBRT plans for Lung cancer with static gantry angles are ideal candidates for applying motion tracking because of: (1) better dosimetric conformity with reduced target margin and (2) easier and more faithful target tracking without intensity modulation. This work is to demonstrate that by delivering t...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4734998

    authors: Yi B,Yang X,Niu Y,Yu C

    更新日期:2012-06-01 00:00:00

  • DMLC tracking and gating can improve dose coverage for prostate VMAT.

    abstract:PURPOSE:To assess and compare the dosimetric impact of dynamic multileaf collimator (DMLC) tracking and gating as motion correction strategies to account for intrafraction motion during conventionally fractionated prostate radiotherapy. METHODS:A dose reconstruction method was used to retrospectively assess the dose d...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4892605

    authors: Colvill E,Poulsen PR,Booth JT,O'Brien RT,Ng JA,Keall PJ

    更新日期:2014-09-01 00:00:00

  • Assessment of image registration accuracy in three-dimensional transrectal ultrasound guided prostate biopsy.

    abstract:PURPOSE:Prostate biopsy, performed using two-dimensional (2D) transrectal ultrasound (TRUS) guidance, is the clinical standard for a definitive diagnosis of prostate cancer. Histological analysis of the biopsies can reveal cancerous, noncancerous, or suspicious, possibly precancerous, tissue. During subsequent biopsy s...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3298010

    authors: Karnik VV,Fenster A,Bax J,Cool DW,Gardi L,Gyacskov I,Romagnoli C,Ward AD

    更新日期:2010-02-01 00:00:00

  • Lung morphometry using hyperpolarized 129 Xe multi-b diffusion MRI with compressed sensing in healthy subjects and patients with COPD.

    abstract:PURPOSE:To demonstrate the feasibility of compressed sensing (CS) to accelerate the acquisition of hyperpolarized (HP) 129 Xe multi-b diffusion MRI for quantitative assessments of lung microstructural morphometry. METHODS:Six healthy subjects and six chronic obstructive pulmonary disease (COPD) subjects underwent HP 1...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.12944

    authors: Zhang H,Xie J,Xiao S,Zhao X,Zhang M,Shi L,Wang K,Wu G,Sun X,Ye C,Zhou X

    更新日期:2018-07-01 00:00:00

  • Comparison of exposure standards in the mammography x-ray region.

    abstract::Direct comparisons of the National Institute of Standards and Technology's (NIST) Ritz 20 kV to 100 kV standard free-air ionization chamber and a portable variable-length free-air ionization chamber designed by the University of Wisconsin-Madison Accredited Dosimetry Calibration Laboratory (UW-ADCL) were made on NISTs...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.598148

    authors: Coletti JG,Pearson DW,DeWerd LA,O'Brien CM,Lamperti PJ

    更新日期:1997-08-01 00:00:00

  • The prediction of breast cancer biopsy outcomes using two CAD approaches that both emphasize an intelligible decision process.

    abstract::Mammography is the most effective method for breast cancer screening available today. However, the low positive predictive value of breast biopsy resulting from mammogram interpretation leads to approximately 70% unnecessary biopsies with benign outcomes. To reduce the high number of unnecessary breast biopsies, sever...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2786864

    authors: Elter M,Schulz-Wendtland R,Wittenberg T

    更新日期:2007-11-01 00:00:00

  • Upgrade and benchmarking of a 4D treatment planning system for scanned ion beam therapy.

    abstract:PURPOSE:Upgrade and benchmarking of a research 4D treatment planning system (4DTPS) suitable for realistic patient treatment planning and treatment simulations taking into account specific requirements for scanned ion beam therapy, i.e., modeling of dose heterogeneities due to interplay effects and range changes caused...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4800802

    authors: Richter D,Schwarzkopf A,Trautmann J,Krämer M,Durante M,Jäkel O,Bert C

    更新日期:2013-05-01 00:00:00

  • Techniques to alleviate the effects of view aliasing artifacts in computed tomography.

    abstract::Due to practical limitations in data acquisition, 3-D computed tomography systems must attempt to provide rapid reconstructions of acceptable quality from a limited number of views. The use of convolution backprojection (CBP) for image reconstruction from an inadequate number of projections, results in view aliasing a...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.598606

    authors: Galigekere RR,Wiesent K,Holdsworth DW

    更新日期:1999-06-01 00:00:00

  • An experimentally validated couch and MLC tracking simulator used to investigate hybrid couch-MLC tracking.

    abstract:PURPOSE/OBJECTIVE:Couch and MLC tracking are two novel techniques to mitigate intrafractional tumor motion on a conventional linear accelerator, but both techniques still have residual dosimetric errors. Here, we first propose and experimentally validate a software tool to simulate couch and MLC tracking, and then use ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.12104

    authors: Toftegaard J,Hansen R,Ravkilde T,Macek K,Poulsen PR

    更新日期:2017-03-01 00:00:00

  • Absolute x-ray dosimetry on a synchrotron medical beam line with a graphite calorimeter.

    abstract:PURPOSE:The absolute dose rate of the Imaging and Medical Beamline (IMBL) on the Australian Synchrotron was measured with a graphite calorimeter. The calorimetry results were compared to measurements from the existing free-air chamber, to provide a robust determination of the absolute dose in the synchrotron beam and p...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4870387

    authors: Harty PD,Lye JE,Ramanathan G,Butler DJ,Hall CJ,Stevenson AW,Johnston PN

    更新日期:2014-05-01 00:00:00

  • X-ray imaging with amorphous selenium: optimal spectra for digital mammography.

    abstract::The optimum x-ray spectra for acquisition of digital mammographic images using an amorphous selenium (a-Se) photoconductor are investigated. The recorded images consist of latent charge distributions on the surface of an a-Se plate, which are then read out using two methods, laser discharge, or flat panel recharge. Th...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.597688

    authors: Fahrig R,Rowlands JA,Yaffe MJ

    更新日期:1996-04-01 00:00:00

  • A compensative model for the angle-dependence of motion estimates in noninvasive vascular elastography.

    abstract:PURPOSE:Atherosclerosis of peripheral cerebral arteries can lead to stroke either by stenosis formation or plaque rupture. This pathology is initiated by the alteration of arterial wall mechanical properties shown to be assessable by ultrasound elastography. Recently, noninvasive vascular elastography (NIVE) was introd...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3539701

    authors: Mercure E,Deprez JF,Fromageau J,Basset O,Soulez G,Cloutier G,Maurice RL

    更新日期:2011-02-01 00:00:00

  • In vivo cancer diagnosis with optical spectroscopy and acoustically induced blood stasis using a murine MCa35 model.

    abstract::Ultrasound-induced blood stasis has been observed for more than 30 years. Most of the literature has been focused on the health risks associated with this phenomenon and methods employed to prevent stasis from occurring during ultrasound imaging. To date, experimental observations have been either in vitro or invasive...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2198196

    authors: Winey BA,Misic V,Liao L,Parker K,Fenton BM,Yu Y

    更新日期:2006-06-01 00:00:00

  • Reference standard and statistical model for intersite and temporal comparisons of CT attenuation in a multicenter quantitative lung study.

    abstract:PURPOSE:The purpose of this study was to detect and analyze anomalies between a large number of computed tomography (CT) scanners, tracked over time, utilized to collect human pulmonary CT data for a national multicenter study: chronic obstructive pulmonary disease genetic epidemiology study (COPDGene). METHODS:A cust...

    journal_title:Medical physics

    pub_type: 杂志文章,多中心研究

    doi:10.1118/1.4747342

    authors: Sieren JP,Newell JD,Judy PF,Lynch DA,Chan KS,Guo J,Hoffman EA

    更新日期:2012-09-01 00:00:00

  • Technical Note: Spot characteristic stability for proton pencil beam scanning.

    abstract:PURPOSE:The spot characteristics for proton pencil beam scanning (PBS) were measured and analyzed over a 16 month period, which included one major site configuration update and six cyclotron interventions. The results provide a reference to establish the quality assurance (QA) frequency and tolerance for proton pencil ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4939663

    authors: Chen CC,Chang C,Moyers MF,Gao M,Mah D

    更新日期:2016-02-01 00:00:00

  • The thermal characteristics of different diodes on in vivo patient dosimetry.

    abstract::Diode sensitivity variations with temperature (SVWT) have been reported to vary from small negative values up to 0.6% per degrees C. Thus it is possible for diode calibration factors established at room temperature (approximately 20 degrees C) to yield errors in the range of -1% to +9% when diodes are placed on a pati...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1367862

    authors: Welsh KT,Reinstein LE

    更新日期:2001-05-01 00:00:00

  • Comparison of transperineal ultrasound image guidance technique to transabdominal technique for prostate radiation therapy.

    abstract:INTRODUCTION:Ultrasound (US) guidance of the prostate has long been conducted using a transabdominal (TA) approach. More recently, a transperineal (TP) approach has been made available for image guidance. Our aim was to determine if both methods produced similar alignments within the same patients. MATERIALS AND METHO...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.14522

    authors: Szegedi M,Boehm C,Paxton A,Rassiah-Szegedi P,Sarkar V,Zhao H,Su F,Kokeny KE,Lloyd S,Tward J,Salter BJ

    更新日期:2020-12-01 00:00:00

  • Fast contour propagation for MR-guided prostate radiotherapy using convolutional neural networks.

    abstract:PURPOSE:To quickly and automatically propagate organ contours from pretreatment to fraction images in magnetic resonance (MR)-guided prostate external-beam radiotherapy. METHODS:Five prostate cancer patients underwent 20 fractions of image-guided external-beam radiotherapy on a 1.5 T MR-Linac system. For each patient,...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.13994

    authors: Eppenhof KAJ,Maspero M,Savenije MHF,de Boer JCJ,van der Voort van Zyp JRN,Raaymakers BW,Raaijmakers AJE,Veta M,van den Berg CAT,Pluim JPW

    更新日期:2020-03-01 00:00:00

  • Scattered photons produced by beam-modifying filters.

    abstract::When a beam-modifying filter such as a wedge or a compensator is placed in an x-ray beam, scattered photons are generated in the filter material. The magnitude of the dose contribution from these photons for a 4-MV x-ray beam was measured. At a distance of 30 cm from the filter, a copper sheet of 1-cm thickness produc...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.595923

    authors: Huang PH,Chin LM,Bjärngard BE

    更新日期:1986-01-01 00:00:00

  • Use of 48Ca as a stable isotope tracer analyzed by proton activation.

    abstract::The use of the stable isotope 48Ca as a tracer in biological systems has been studied. Determination of 48Ca concentrations in samples was accomplished by proton activation via the (p,n) reaction with subsequent measurement of gamma-ray spectra from 44-h 48Sc and 4-h 44Sc. With protons of about 5.5 MeV and a Ge(Li) ga...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.594303

    authors: Edwards FM,Kraushaar JJ,Ristinen RA,Rudolph H

    更新日期:1977-01-01 00:00:00

  • Penetration quality measurement for standardization of radiographic image quality.

    abstract::Interchange or transfer of radiographic techniques through measurement of penetration quality is discussed. The usefulness of this achievement is verified using an aluminum step wedge. Also, the procedure described provides a method for performance evaluation of kVp compensation on diagnostic x-ray installations. ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.594156

    authors: Lin PJ

    更新日期:1975-01-01 00:00:00

  • Verification of treatment parameter transfer by means of electronic portal dosimetry.

    abstract::Electronic portal imaging devices (EPIDs) are mainly used for patient setup verification during treatment but other geometric properties like block shape and leaf positions are also determined. Electronic portal dosimetry allows dosimetric treatment verification. By combining geometric and dosimetric information, the ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1640972

    authors: Nijsten SM,Minken AW,Lambin P,Bruinvis IA

    更新日期:2004-02-01 00:00:00

  • Future of medical physics: Real-time MRI-guided proton therapy.

    abstract::With the recent clinical implementation of real-time MRI-guided x-ray beam therapy (MRXT), attention is turning to the concept of combining real-time MRI guidance with proton beam therapy; MRI-guided proton beam therapy (MRPT). MRI guidance for proton beam therapy is expected to offer a compelling improvement to the c...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.12371

    authors: Oborn BM,Dowdell S,Metcalfe PE,Crozier S,Mohan R,Keall PJ

    更新日期:2017-08-01 00:00:00

  • SU-E-T-04: Repair Kinetics of Sublethal Damage in Rat Cervical Spinal Cord - Application of the GLQ Model Incorporating Reciprocal Time Pattern.

    abstract:PURPOSE:The repair rate conventionally assumed to be constant during the entire radiation course. However, increasing evidences from animal studies show that the repair process may slow down with time and the experimental data does not fit an exponential pattern. To address this enigma, we presented a generalized linea...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4735058

    authors: Huang Z,Mayr NA,Lo SS,McLawhorn R,Gao M,Liu T,Yuh W

    更新日期:2012-06-01 00:00:00

  • Noise texture and signal detectability in propagation-based x-ray phase-contrast tomography.

    abstract:PURPOSE:X-ray phase-contrast tomography (PCT) is a rapidly emerging imaging modality for reconstructing estimates of an object's three-dimensional x-ray refractive index distribution. Unlike conventional x-ray computed tomography methods, the statistical properties of the reconstructed images in PCT remain unexplored. ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3267548

    authors: Chou CY,Anastasio MA

    更新日期:2010-01-01 00:00:00

  • Breast tumor segmentation in 3D automatic breast ultrasound using Mask scoring R-CNN.

    abstract:PURPOSE:Automatic breast ultrasound (ABUS) imaging has become an essential tool in breast cancer diagnosis since it provides complementary information to other imaging modalities. Lesion segmentation on ABUS is a prerequisite step of breast cancer computer-aided diagnosis (CAD). This work aims to develop a deep learnin...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.14569

    authors: Lei Y,He X,Yao J,Wang T,Wang L,Li W,Curran WJ,Liu T,Xu D,Yang X

    更新日期:2020-10-30 00:00:00

  • Attenuation-based estimation of patient size for the purpose of size specific dose estimation in CT. Part I. Development and validation of methods using the CT image.

    abstract:PURPOSE:For the purpose of size-specific dose estimation, information regarding patient attenuation is required. The purpose of this work is to describe a method for measuring patient attenuation and expressing the results in terms of a water cylinder, with cross sectional area A(w), which would absorb the same average...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4754303

    authors: Wang J,Duan X,Christner JA,Leng S,Yu L,McCollough CH

    更新日期:2012-11-01 00:00:00

  • Impact of calibration methods for color medical displays on interpreting brain SPECT images.

    abstract:PURPOSE:Color images are visualized on medical monitors that are adjusted by a grayscale standard display function (GSDF) or γ2.2. Although the GSDF is visually displayed as a linear graded grayscale, it does not specify how color medical images should be presented. On the other hand, the usual gamma setting for color ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.13532

    authors: Shibutani T,Onoguchi M,Yoneyama H,Nakajima K,Matsuo S,Bamba Y,Saito S

    更新日期:2019-06-01 00:00:00

  • A method for determining multileaf collimator transmission and scatter for dynamic intensity modulated radiotherapy.

    abstract::The main purpose of this work is to demonstrate a practical means of determining the leaf transmission and scatter characteristics of a multileaf collimator (MLC) pertinent to the commissioning of dynamic intensity modulated radiotherapy, especially for the sweeping window technique. The data are necessary for the con...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1312190

    authors: Arnfield MR,Siebers JV,Kim JO,Wu Q,Keall PJ,Mohan R

    更新日期:2000-10-01 00:00:00

  • Thermoluminescent dosimetry of the SourceTech Medical model STM1251 125I seed.

    abstract::Many new models of 125I seeds are being introduced, mainly due to the increase in prostate seed implants. We have evaluated the SourceTech Medical (STM), model STM1251, 125I seed using thermoluminescent dosimeters (TLDs) in a solid water phantom. TLD cubes, LiF TLD-100, with dimension 1 mm on each edge, were irradiate...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1577251

    authors: Chiu-Tsao ST,Duckworth TL,Hsiung CY,Li Z,Williamson J,Patel NS,Harrison LB

    更新日期:2003-07-01 00:00:00