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Statins attenuate sepsis.

Abstract：

HYPOTHESIS:If (1) 3-hydroxy-3-methylglutaryl-coenzyme reductase inhibitors (statins) block the rate-limiting step in cholesterol synthesis and promote the expression of low-density lipoprotein receptors, (2) "Gram-negative sepsis" results from an abundant systemic response to bacterial lipopolysaccharide (endotoxin), (3) triglyceride-rich lipoproteins can bind endotoxin and low-density lipoprotein receptors enhance the uptake of both of these molecules, and (4) low-density lipoprotein receptor internalization of lipoproteins and endotoxin co-opts a common transcriptional regulatory system (NF-kappaB) that results in reduced cell vulnerability to inflammation, then statins, in addition to their lipid-lowering capacity, enhance endotoxin clearance from the circulation and attenuate the septic response.

journal_name

Surgery

journal_title

Surgery

authors

Spitzer AL,Harris HW

doi

10.1016/j.surg.2005.08.029

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

283-7

issue

3

eissn

0039-6060

issn

1532-7361

pii

S0039-6060(05)00551-9

journal_volume

139

pub_type

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