Effects of isoproterenol on T-wave amplitude and heart rate: a dose-response study.

Abstract:

:This report examines the hypothesis that electrocardiographic T-wave amplitude is sensitive to graded increases in beta-sympathetic stimulation of the heart. Beta-adrenergic activity was manipulated pharmacologically in 9 healthy men by bolus infusion of isoproterenol in each of six doses: 0.1, 0.25, 0.5, 1.0, 2.0, and 4.0 micrograms. Results indicated that elevations in heart rate above placebo values increased as a linear function of isoproterenol dose. In contrast, the dose-response curve for T-wave amplitude was best described by a quadratic function: an initial reduction in T-wave amplitude at low levels of isoproterenol infusion was followed by a significant reversal of this effect at higher doses. Comparison of the heart rate and T-wave amplitude data points to limitations in the use of the latter as an index of beta-adrenergic activity. One of several possible explanations for the T-wave results would entail a mechanism that preserves ventricular function at high levels of beta-sympathetic stimulation.

journal_name

Psychophysiology

journal_title

Psychophysiology

authors

Contrada RJ,Dimsdale J,Levy L,Weiss T

doi

10.1111/j.1469-8986.1991.tb00731.x

subject

Has Abstract

pub_date

1991-07-01 00:00:00

pages

458-62

issue

4

eissn

0048-5772

issn

1540-5958

journal_volume

28

pub_type

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