Abstract:
:Sleep disruption is an important aspect of major depressive disorder but lacks an objective and inexpensive means of assessment. We evaluated the utility of electrocardiogram (ECG)-based cardiopulmonary coupling analysis to quantify physiologic sleep stability in patients with major depression. Relative to controls, unmedicated depressed patients had a reduction in high-frequency coupling, an index of stable sleep, an increase in low-frequency coupling, an index of unstable sleep, and an increase in very-low-frequency coupling, an index of wakefulness/REM sleep. The medicated depressed group showed a restoration of stable sleep to a level comparable with that of the control group. ECG-based cardiopulmonary coupling analysis may provide a simple, cost-efficient point-of-care method to quantify sleep quality/stability and to objectively evaluate the severity of insomnia in patients with major depression.
journal_name
Psychophysiologyjournal_title
Psychophysiologyauthors
Yang AC,Yang CH,Hong CJ,Tsai SJ,Kuo CH,Peng CK,Mietus JE,Goldberger AL,Thomas RJdoi
10.1111/j.1469-8986.2010.01060.xsubject
Has Abstractpub_date
2011-02-01 00:00:00pages
285-91issue
2eissn
0048-5772issn
1540-5958pii
PSYP1060journal_volume
48pub_type
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