Effect of cholesterol and CYP46 polymorphism on cognitive event-related potentials.

Abstract:

:The integrated effect of the cholesterol and CYP46 genotypes on the risk of cognitive decline needs to be determined. Using the Cognitive Abilities Screening Instrument (CASI), 145 mentally healthy middle-aged and older adults were recruited to investigate the influence of cholesterol and CYP46 genotypes on cognitive event-related potentials (ERPs). The subjects with a high low-density lipoprotein cholesterol (LDL-C) level displayed significantly lower amplitude ERPs, although the CASI scores showed no difference. There was no association between the CYP46 genotypes, CASI scores, cholesterol levels, and measures of ERPs. No interaction between LDL-C level and CYP46 genotypes was noted. The LDL-C level is an independent predictor of low P300 amplitude. Prevention and treatment of high cholesterol may be of potential benefit in reducing cognitive impairment.

journal_name

Psychophysiology

journal_title

Psychophysiology

authors

Lai CL,Hsu CY,Liou LM,Hsieh HY,Hsieh YH,Liu CK

doi

10.1111/j.1469-8986.2011.01221.x

subject

Has Abstract

pub_date

2011-11-01 00:00:00

pages

1572-1577

issue

11

eissn

0048-5772

issn

1540-5958

journal_volume

48

pub_type

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