Abstract:
:The integrated effect of the cholesterol and CYP46 genotypes on the risk of cognitive decline needs to be determined. Using the Cognitive Abilities Screening Instrument (CASI), 145 mentally healthy middle-aged and older adults were recruited to investigate the influence of cholesterol and CYP46 genotypes on cognitive event-related potentials (ERPs). The subjects with a high low-density lipoprotein cholesterol (LDL-C) level displayed significantly lower amplitude ERPs, although the CASI scores showed no difference. There was no association between the CYP46 genotypes, CASI scores, cholesterol levels, and measures of ERPs. No interaction between LDL-C level and CYP46 genotypes was noted. The LDL-C level is an independent predictor of low P300 amplitude. Prevention and treatment of high cholesterol may be of potential benefit in reducing cognitive impairment.
journal_name
Psychophysiologyjournal_title
Psychophysiologyauthors
Lai CL,Hsu CY,Liou LM,Hsieh HY,Hsieh YH,Liu CKdoi
10.1111/j.1469-8986.2011.01221.xsubject
Has Abstractpub_date
2011-11-01 00:00:00pages
1572-1577issue
11eissn
0048-5772issn
1540-5958journal_volume
48pub_type
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