Abstract:
:The time course of the schizophrenia auditory gating deficit may provide clues to mechanisms of impaired cognition. Magnetoencephalography was recorded during a standard paired-click paradigm. Using source strength of the M50 and M100 components for each click, calculated from dipole locations identified as underlying each component for the first click, a ratio of the second divided by the first was used to measure gating. Patients showed a left-hemisphere gating deficit in M50 and a bilateral gating deficit in M100. Hypothesizing that an early deficit may affect later processing, hierarchical regression was used to examine variance shared between the components. A left-hemisphere M100 gating deficit was coupled with the left M50 gating deficit. In contrast, a right-hemisphere M100 gating deficit was unrelated to M50 gating in either hemisphere. Investigations of interhemisphere gating relations may clarify group differences in regional connectivity and their role in gating.
journal_name
Psychophysiologyjournal_title
Psychophysiologyauthors
Hanlon FM,Miller GA,Thoma RJ,Irwin J,Jones A,Moses SN,Huang M,Weisend MP,Paulson KM,Edgar JC,Adler LE,Cañive JMdoi
10.1111/j.1469-8986.2005.00299.xsubject
Has Abstractpub_date
2005-07-01 00:00:00pages
417-27issue
4eissn
0048-5772issn
1540-5958pii
PSYP299journal_volume
42pub_type
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