Acute changes in carbon dioxide levels alter the electroencephalogram without affecting cognitive function.

Abstract:

:The partial pressure of carbon dioxide in the arterial blood (PaCO2) is usually tightly regulated, yet it varies among healthy people at rest (range approximately 32-44 mmHg) as well as within an individual during many natural life situations. The present study examined whether modest changes in end-tidal PCO2 (PETCO2; a noninvasive measure of PaCO2) affect electroencephalographic (EEG) activity, cognitive function, and vigilance. Nine adults were ventilated mechanically using a mouthpiece; respiratory rate and breath size were held constant while PETCO2 was set to levels that produced minimal discomfort. Despite discrete changes in EEG, neither acute PETCO2 increases (mean = 47 mmHg) nor decreases (mean = 30 mmHg) from resting levels (mean = 38 mmHg) affected performance on cognitive tasks, latency or amplitude of the N1, P2, or P3 event-related potential, or alertness. Modest changes in PETCO2 may cause significant alterations in the EEG without disturbing cognitive function.

journal_name

Psychophysiology

journal_title

Psychophysiology

authors

Bloch-Salisbury E,Lansing R,Shea SA

subject

Has Abstract

pub_date

2000-07-01 00:00:00

pages

418-26

issue

4

eissn

0048-5772

issn

1540-5958

journal_volume

37

pub_type

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