The anatomical and functional relationship between the P3 and autonomic components of the orienting response.

Abstract:

:Many psychophysiologists have noted the striking similarities between the antecedent conditions for the P3 component of the event-related potential and the orienting response: both are typically elicited by salient, unexpected, novel, task-relevant, and other motivationally significant stimuli. Although the close coupling of the P3 and orienting response has been well documented, the neural basis and functional role of this relationship is still poorly understood. Here we propose that the simultaneous occurrence of the P3 and autonomic components of the orienting response reflects the co-activation of the locus coeruleus-norepinephrine system and the peripheral sympathetic nervous system by their common major afferent: the rostral ventrolateral medulla, a key sympathoexcitatory region. A comparison of the functional significance of the locus coeruleus-norepinephrine system and the peripheral sympathetic nervous system suggests that the P3 and orienting response reflect complementary cognitive and physical contributions to the mobilization for action following motivationally significant stimuli.

journal_name

Psychophysiology

journal_title

Psychophysiology

authors

Nieuwenhuis S,De Geus EJ,Aston-Jones G

doi

10.1111/j.1469-8986.2010.01057.x

subject

Has Abstract

pub_date

2011-02-01 00:00:00

pages

162-75

issue

2

eissn

0048-5772

issn

1540-5958

pii

PSYP1057

journal_volume

48

pub_type

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