Fast cerebral functional signal in the 100-ms range detected in the visual cortex by frequency-domain near-infrared spectrophotometry.

Abstract:

:Brain activity is associated with physiological changes, which alter the optical properties of the tissue in the near-infrared part of the spectrum. Two major types of optical signals following functional brain activation can be distinguished: a slow signal due to hemodynamic changes and a fast signal, which is directly related to neuronal activity. The fast signal is small and therefore difficult to detect. We used a specially noise-optimized frequency-domain near-infrared spectrometer with a pi-sensor, which was expected to be particularly sensitive to deeper tissue layers, to investigate the human visual cortex during visual stimulation generated by a checkerboard. We were able to detect significant fast signals in single light bundles, but not in pi-signals. The fast signals were mostly collocated with strong slow hemodynamic signals, but showed a higher degree of localization than the latter. The latencies of 40 +/- 16 ms of the fast signals were similar between locations. Our results also indicate that the brain responds differently to a single and double (forth and back) reversal of the checkerboard, with a stronger reaction upon the double reversal.

journal_name

Psychophysiology

journal_title

Psychophysiology

authors

Wolf M,Wolf U,Choi JH,Toronov V,Paunescu LA,Michalos A,Gratton E

doi

10.1111/1469-8986.00054

subject

Has Abstract

pub_date

2003-07-01 00:00:00

pages

521-8

issue

4

eissn

0048-5772

issn

1540-5958

journal_volume

40

pub_type

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