The effects of an acute psychological stressor on cardiovascular, endocrine, and cellular immune response: a prospective study of individuals high and low in heart rate reactivity.

Abstract:

:High and low reactors were preselected on the basis of their heart rate reactivity to a speech stressor in a prescreening session. In the main study, subjects were exposed to a mental arithmetic plus noise stressor. Cardiovascular activity was recorded during baseline and stressor, and blood was drawn prior to and following the stressor for endocrine and immune assays. Results revealed that the stressor decreased the blastogenic response to concanavalin A and increased natural killer cell numbers and cytotoxicity, absolute numbers of CD8+ T-lymphocytes, norepinephrine and epinephrine levels, heart rate, and blood pressure responses. In addition, cortisol and natural killer cell cytotoxicity responses to the stressor differentiated individuals high versus low in heart rate reactivity. These results suggest that the interactions among the autonomic nervous system, endocrine system, and immune system are not only amenable to psychophysiological analysis but that such analyses may play an important role in illuminating underlying mechanisms.

journal_name

Psychophysiology

journal_title

Psychophysiology

authors

Sgoutas-Emch SA,Cacioppo JT,Uchino BN,Malarkey W,Pearl D,Kiecolt-Glaser JK,Glaser R

doi

10.1111/j.1469-8986.1994.tb02215.x

subject

Has Abstract

pub_date

1994-05-01 00:00:00

pages

264-71

issue

3

eissn

0048-5772

issn

1540-5958

journal_volume

31

pub_type

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