Severity of symptom flare after moderate exercise is linked to cytokine activity in chronic fatigue syndrome.

Abstract:

:Chronic fatigue syndrome (CFS) patients often report symptom flare (SF) for >24 h after moderate exercise (post-ex). We hypothesized that SF is linked to increases in circulating cytokines and CD40 Ligand (CD40L). In 19 CFS patients and 17 controls, mental and physical fatigue and pain symptom ratings were obtained together with serum for 11 cytokines and CD40L before and at 0.5, 8, 24, and 48 h post-ex. Before exercise, CFS had lower CD40L (p<.05) but similar cytokines versus controls. In subgroups based on SF at 48 h, high SF patients (n=11) increased in IL-1beta, IL-12, IL-6, IL-8, IL-10, and IL-13 (p<.05) 8 h post-ex. Low SF patients (n=8) showed post-ex decreases in IL-10, IL-13, and CD40L, and controls decreased in IL-10, CD40L, and TNFalpha (p<.05). Thus, in CFS, cytokine activity may vary directly with SF, which may explain prior inconsistent findings.

journal_name

Psychophysiology

journal_title

Psychophysiology

authors

White AT,Light AR,Hughen RW,Bateman L,Martins TB,Hill HR,Light KC

doi

10.1111/j.1469-8986.2010.00978.x

subject

Has Abstract

pub_date

2010-07-01 00:00:00

pages

615-24

issue

4

eissn

0048-5772

issn

1540-5958

pii

PSYP978

journal_volume

47

pub_type

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