Abstract：
:Total activity of creatine kinase (CK), lactate dehydrogenase (LD), aldolase (Ald), glutamico-oxaloacetic transaminase (GOT), and LD-isoenzyme distribution was studied in serum and muscle biopsies from normal persons and 117 patients with different types of muscular dystrophy: 82 Duchenne type (DMD), 12 BEcker type, 7 facioscapulohumeral (FSHMD), and 16 limb girdle (LGMD). Total enzyme activity in sera and muscle homogenates was determined by spectrophotometric assays. LD isoenzymes were separated by electrophoresis on agarose gel plates in barbital buffer (pH 8.6), scanned and quantitated. The amounts of the 2 types (M and H) of LD isoenzymes were calculated and the ratio of M/H in serum and muscle was used as an index to differentiate among the types of muscular dystrophy. Serum enzyme activity was elevated to variable degrees reflecting a corresponding decrease in muscle enzymes in the different muscular dystrophies. Patterns of LD isoenzymes in serum and muscle were specific to each type of muscle disease. Increase in serum LD5 (the muscle LD fraction) was a common feature in muscle damage. Changes in the amounts of M and H types in the subunits of LD correlated to the existence and severity of muscle damage. The mean muscle M/H ratio was 6.4 in controls, 1.8 in early DMD, 0.1 in late DMD, 3.0 in Becker type, 3.8 in FSHMD and 3.9 in LGMD. The muscle LD isoenzyme distribution in DMD showed a shift toward a more aerobic fetal muscle pattern. This is a result of the gradual disappearance of the mature anaerobic LD-type (M) and the increase in synthesis of the aerobic fetal LD-type (H) during the progression of the disease. This report provides a comparative study of the LD isoenzyme patterns in muscular dystrophies which may help in differential diagnosis.
journal_name
Arch Phys Med Rehabiljournal_title
Archives of physical medicine and rehabilitationauthors
Ibrahim GA,Zweber BA,Awad EAsubject
Has Abstractpub_date
1981-06-01 00:00:00pages
265-9issue
6eissn
0003-9993issn
1532-821Xjournal_volume
62pub_type
杂志文章abstract：OBJECTIVE:To estimate, for persons with multiple sclerosis (MS), the extent to which peak oxygen consumption (Vo(2)peak) can be predicted by the results on submaximal tests. DESIGN:Cross-sectional study. SETTING:Three MS clinics in the Greater Montreal region, Canada. PARTICIPANTS:A center-stratified random sample o...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章,多中心研究
doi：10.1016/j.apmr.2010.06.005
更新日期：2010-09-01 00:00:00
abstract：:This study on patients who had strokes investigates the relevance of a patient's age, sex, and the side of any symptoms in association with prestroke status, initial signs, initial disability, and recovery during the first six months. Disability was assessed using the Barthel activities of daily living (ADL) index; no...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：
更新日期：1986-08-01 00:00:00
abstract：OBJECTIVE:To describe the types, intensities, and average duration of leisure time physical activities (LTPAs) performed by people with chronic spinal cord injury (SCI). DESIGN:Cross-sectional telephone survey. SETTING:General community. PARTICIPANTS:Men and women with SCI (N=347) who reported engaging in LTPA over ...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/j.apmr.2009.12.028
更新日期：2010-05-01 00:00:00
abstract：:This self-directed learning module highlights advances in the management of pain. It is part of the chapter on physiatric therapeutics for the Self-Directed Medical Knowledge Program Study Guide for practitioners and trainees in physical medicine and rehabilitation. This section discusses neuroanatomy and neurophysiol...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：
更新日期：1990-03-01 00:00:00
abstract：:Impaired hand function is a problem for children with spastic quadriparetic cerebral palsy. When combined with decreased visual acuity and visuoperceptual loss the problem is compounded. A joystick switch control, which is easy to use and provides a visual cue for attracting attention to the switch, is described. ...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：
更新日期：1990-08-01 00:00:00
abstract：OBJECTIVE:To estimate the proportion of patients with ischemic stroke who fall within and above the total outpatient rehabilitation caps before and after the Balanced Budget Act of 1997 took effect; and to estimate the cost of poststroke outpatient rehabilitation cost and resource utilization in these patients before a...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/j.apmr.2015.07.008
更新日期：2015-11-01 00:00:00
abstract：:The symptoms of urinary incontinence, ataxia, and mental confusion are an integral part of the clinical presentation of normal pressure hydrocephalus (NPH). They are also common presentations in the rehabilitation setting of patients who have had a cerebral vascular accident. The concurrence of these entities challeng...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/s0003-9993(97)90069-1
更新日期：1997-09-01 00:00:00
abstract：OBJECTIVE:To describe the neurologic outcomes of 29 spinal epidural abscess (SEA) patients after rehabilitation compared with a case-controlled traumatic spinal cord injury (TSCI) cohort. DESIGN:Five-year retrospective chart review. SETTING:University-affiliated surgical spine unit and inpatient rehabilitation progra...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/j.apmr.2008.09.567
更新日期：2009-03-01 00:00:00
abstract：:Despite long-standing claims that the conditioning method of treating enuresis is based on the classic conditioning paradigm, research explicitly investigating this claim has been limited. This study compares two conditioning methods of treating enuresis, both using the bell and pad, one in a classic conditioning para...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1984-02-01 00:00:00
abstract：OBJECTIVE:To summarize empirical studies on the effectiveness of psychological interventions in long-term rehabilitation after an acquired brain injury (ABI) in reducing depressive symptoms. DATA SOURCES:A systematic literature search was conducted on MEDLINE, PsycINFO, Embase, and CINAHL to identify articles publishe...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.apmr.2013.02.013
更新日期：2013-07-01 00:00:00
abstract：:Piriformis syndrome (PS) is defined by a loose cluster of symptoms arising from entrapment of one or both divisions of the sciatic nerve as they pass the sciatic notch. This paper presents a method of using the H-reflex as an aid in the diagnosis of PS. Forcible pressure from the piriformis muscle on the sciatic nerve...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/0003-9993(92)90010-t
更新日期：1992-04-01 00:00:00
abstract：OBJECTIVE:To evaluate the relationship between caregiver nature and availability, and rehabilitation outcomes in subacute stroke. DESIGN:Retrospective cohort study. SETTING:Four community rehabilitation hospitals. PARTICIPANTS:Patients with subacute, first-time stroke (N=4042; 48.5% men; mean age ± SD, 70.12±10.4y; ...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/j.apmr.2017.02.021
更新日期：2017-10-01 00:00:00
abstract：OBJECTIVE:To compare resource use of, and outcomes for, rehabilitation for severe stroke before and after the implementation of the Casemix and Rehabilitation Funding Tree case-mix-based funding model. DESIGN:Prospective, observational cohort study. SETTING:Eight inpatient rehabilitation centers in Australia. PARTIC...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章,多中心研究
doi：10.1016/j.apmr.2007.04.001
更新日期：2007-07-01 00:00:00
abstract：OBJECTIVE:To compare the prevalence and intensity of shoulder pain experienced during daily functional activities in individuals with tetraplegia and individuals with paraplegia who use manual wheelchairs. DESIGN:Self-report survey. SETTING:General community. PARTICIPANTS:Fifty-five women and 140 men, 92 subjects wi...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/s0003-9993(99)90285-x
更新日期：1999-04-01 00:00:00
abstract：:This self-directed learning module highlights new advances in this topic area. It is part of the chapter on rehabilitation in joint and connective tissue diseases in the Self-Directed Physiatric Education Program for practitioners and trainees in physical medicine and rehabilitation. This article discusses the followi...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章,评审
doi：10.1016/s0003-9993(95)80599-0
更新日期：1995-05-01 00:00:00
abstract：OBJECTIVE:To determine the reliability, validity, and responsiveness of the modified Kapandji index (MKI). DESIGN:Prospective study. A cohort of patients planned for surgery of the wrist and/or fingers was evaluated within 48 hours before surgery and at least 6 months after surgery. SETTING:Patients were in hospitali...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/s0003-9993(03)00128-x
更新日期：2003-07-01 00:00:00
abstract：OBJECTIVE:To investigate the task dependence of elbow weakness in patients with hemiparesis. DESIGN:Descriptive study based on interlimb comparisons of maximum voluntary torques (MVTs) generated isometrically in elbow flexion and extension under four task conditions: without explicit control of the torques at adjacent...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/s0003-9993(99)90225-3
更新日期：1999-07-01 00:00:00
abstract：OBJECTIVES:To measure the changes in the total and regional body fat mass, and assess the clinical usefulness of the body mass index (BMI) in detecting overweight subjects with sequelae of poliomyelitis. DESIGN:Prospective, cross-sectional study. SETTING:General community. PARTICIPANTS:Subjects with poliomyelitis (n...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/j.apmr.2011.01.019
更新日期：2011-07-01 00:00:00
abstract：OBJECTIVES:To describe the prevalence of greater trochanteric pain syndrome (GTPS); to determine whether GTPS is associated with iliotibial band (ITB) tenderness, knee osteoarthritis (OA), body mass index (BMI), or low back pain (LBP); and to assess whether GTPS is associated with reduced hip internal rotation, physica...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章,多中心研究
doi：10.1016/j.apmr.2007.04.014
更新日期：2007-08-01 00:00:00
abstract：OBJECTIVES:To develop the Pain Assessment Instrument for Cerebral Palsy (PAICP) and to study its test-retest reproducibility and construct validity. DESIGN:Cross-sectional validation study. SETTING:Homes for severely handicapped. PARTICIPANTS:A total of 164 adults with severe cerebral palsy (CP), caregivers, and phy...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/j.apmr.2003.06.029
更新日期：2004-05-01 00:00:00
abstract：OBJECTIVE:To develop and evaluate energy expenditure (EE) estimation models for a physical activity monitoring system (PAMS) in manual wheelchair users with spinal cord injury (SCI). DESIGN:Cross-sectional study. SETTING:University-based laboratory environment, a semistructured environment at the National Veterans Wh...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/j.apmr.2016.02.016
更新日期：2016-07-01 00:00:00
abstract：OBJECTIVES:To determine the effects of 1.0 mg/kg nitro-L-arginine methyl ester (L-NAME) on orthostatic mean arterial pressure (MAP), serum aldosterone, and plasma renin concentrations in persons with chronic tetraplegia compared with nonspinal cord-injured controls. DESIGN:Prospective placebo-controlled intervention s...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/j.apmr.2009.02.004
更新日期：2009-08-01 00:00:00
abstract：:Fifty-six shoulders in 50 patients with adhesive capsulitis were divided into 2 groups, using different treatment programs. Group A comprised 28 shoulders in 26 patients. These were treated by therapeutic heating modalities followed by therapeutic exercises and gentle rhythmic stabilization manipulation. Group B total...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：
更新日期：1983-01-01 00:00:00
abstract：OBJECTIVE:To determine whether racial and ethnic effects on bounce-back risk (ie, movement to settings of higher care intensity within 30 d of hospital discharge) in acute stroke patients vary depending on initial posthospital discharge destination. DESIGN:Retrospective analysis of administrative data. SETTING:Four h...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/j.apmr.2009.10.015
更新日期：2010-02-01 00:00:00
abstract：OBJECTIVES:The primary aim of this study was to assess the intrarater reliability of ultrasonographic measurements of acromion-greater tuberosity (AGT) distance in patients with stroke using portable ultrasound. A secondary aim was to determine the discriminant validity of the ultrasonographic technique by comparison o...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/j.apmr.2010.10.018
更新日期：2011-05-01 00:00:00
abstract：OBJECTIVE:To compare the impacts of Tai Chi, a standard balance exercise program, and a video game balance board program on postural control and perceived falls risk. DESIGN:Randomized controlled trial. SETTING:Research laboratory. PARTICIPANTS:Independent seniors (N=40; 72.5±8.40) began the training, 27 completed. ...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.apmr.2012.01.023
更新日期：2012-07-01 00:00:00
abstract：OBJECTIVE:To demonstrate that after spinal cord injury (SCI) suppression of the parathyroid-vitamin D axis is associated with the degree of neurologic impairment and not the level of injury. DESIGN:A retrospective analysis of clinical and biochemical data obtained from hospital records of patients with SCI compared to...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/s0003-9993(97)90075-7
更新日期：1997-07-01 00:00:00
abstract：OBJECTIVE:Summarize the psychometric properties of functional, ambulatory, and quality of life instruments among adult lower limb amputees, highlighting evidence deemed generalizable to the United States Medicare population. DATA SOURCES:Six databases and existing systematic reviews through October 30, 2017. Searches ...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/j.apmr.2019.02.015
更新日期：2019-12-01 00:00:00
abstract：OBJECTIVE:To investigate the effectiveness of neuromuscular electrical stimulation (NMES) with or without other interventions in improving lower limb activity after chronic stroke. DATA SOURCES:Electronic databases, including PubMed, EMBase, Cochrane Library, PEDro (Physiotherapy Evidence Database), and PsycINFO, were...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 杂志文章
doi：10.1016/j.apmr.2017.12.019
更新日期：2018-05-01 00:00:00
abstract：OBJECTIVE:To determine whether the administration of clenbuterol, a beta2-adrenergic agonist, prevents loss of muscle mass during a period of imposed inactivity. DESIGN:Randomized trial. SETTING:Basic laboratory research. ANIMALS:Thirty Fischer 344 Brown Norway F1 Hybrid rats, 12 and 30 months of age. INTERVENTIONS...
journal_title：Archives of physical medicine and rehabilitation
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1053/apmr.2001.23756
更新日期：2001-07-01 00:00:00
