Abstract:
OBJECTIVE:To determine whether the administration of clenbuterol, a beta2-adrenergic agonist, prevents loss of muscle mass during a period of imposed inactivity. DESIGN:Randomized trial. SETTING:Basic laboratory research. ANIMALS:Thirty Fischer 344 Brown Norway F1 Hybrid rats, 12 and 30 months of age. INTERVENTIONS:The rats were randomly assigned to a control group, or to 1 of 2 experimental groups: hindlimb unweighted for 2 weeks (HU-2), or hindlimb unweighted with daily injections of clenbuterol for 2 weeks (HU-2Cl). MAIN OUTCOME MEASURES:Muscle mass weighed in milligrams and single fiber cross-sectional area histochemically evaluated. RESULTS:In both age groups, the HU-2 animals had greater muscle atrophy (decrease in muscle mass) in the soleus muscle than the extensor digitorum longus (EDL) muscle. In the HU-2Cl groups, the decline in muscle mass of both the soleus and EDL muscles was attenuated by about 4% to 20%. In the HU-2 group, single fiber cross-sectional area decreased for both fiber types (type I, 20%-40%; type II, 37%-50%) in both age groups. Clenbuterol retarded the inactivity-induced decline in single fiber cross-sectional area by 12% to 50%. In the EDL muscles of the HU-2Cl group, we found hypertrophy in both fiber types in the 30-month-old animals and in type I fibers in the 12-month-old animals. CONCLUSIONS:Clenbuterol attenuated the decrease in muscle mass and single fiber cross-sectional area in both age groups. By preventing the loss of muscle mass, clenbuterol administered early in rehabilitation may benefit severely debilitated patients imposed by inactivity. The attenuated muscle atrophy found with clenbuterol in the present study provides cellular evidence for the reported change in muscle strength after its administration after knee surgery. Thus, the administration of clenbuterol may lead to a more rapid rate of rehabilitation.
journal_name
Arch Phys Med Rehabiljournal_title
Archives of physical medicine and rehabilitationauthors
Herrera NM Jr,Zimmerman AN,Dykstra DD,Thompson LVdoi
10.1053/apmr.2001.23756subject
Has Abstractpub_date
2001-07-01 00:00:00pages
930-4issue
7eissn
0003-9993issn
1532-821Xpii
S0003-9993(01)37788-2journal_volume
82pub_type
临床试验,杂志文章,随机对照试验abstract:OBJECTIVES:To examine the safety, feasibility, and balance performance effects of a 4-week home-based balance therapy program using a commercially available videogame system. DESIGN:A pilot study involving a preintervention and postintervention design was conducted with measurements taken at baseline, immediately post...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2011.08.031
更新日期:2012-02-01 00:00:00
abstract::This case report describes a 2-year treatment course of a 6-year-old with spastic paraparesis due to human immunodeficiency virus (HIV) encephalopathy. She continued to develop worsening musculoskeletal problems and a decline in mobility despite aggressive antispasticity interventions. In addition to meeting the usual...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2006.03.015
更新日期:2006-07-01 00:00:00
abstract::Establishing treatment effectiveness is a high priority for rehabilitation research. The use of traditional quantitative null hypotheses to achieve this priority is reviewed. Three problems are identified in the analysis and interpretation of investigations based on statistical testing of hypotheses: (1) confusion of ...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/s0003-9993(95)80021-2
更新日期:1995-02-01 00:00:00
abstract:OBJECTIVES:To determine the intra- and interrater reliability of the Action Research Arm (ARA) test, to assess its ability to detect a minimal clinically important difference (MCID) of 5.7 points, and to identify less reliable test items. DESIGN:Intrarater reliability of the sum scores and of individual items was asse...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1053/apmr.2001.18668
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the validity of the Prosthetic Upper Extremity Functional Index (PUFI), a parent- and older child-report measure that evaluates the extent of Prosthetic limb use, ease of task performance with and without the prosthesis, and its usefulness. DESIGN:Evaluation of discriminant validity (the PUFI's a...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1053/ampr.2003.50127
更新日期:2003-04-01 00:00:00
abstract::This study on patients who had strokes investigates the relevance of a patient's age, sex, and the side of any symptoms in association with prestroke status, initial signs, initial disability, and recovery during the first six months. Disability was assessed using the Barthel activities of daily living (ADL) index; no...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:
更新日期:1986-08-01 00:00:00
abstract:OBJECTIVES:To describe the development of the Amputee Mobility Predictor (AMP) instrument designed to measure ambulatory potential of lower-limb amputees with (AMPPRO) and without (AMPnoPRO) the use of a prosthesis, and to test its reliability and validity. DESIGN:Measurement study using known groups method and concur...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1053/ampr.2002.32309
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVES:To identify differences in health factors, neuromuscular attributes, and performance-based mobility among community-dwelling older adults with symptomatic lumbar spinal stenosis; and to determine which neuromuscular attributes are associated with performance-based measures of mobility. DESIGN:Cross-sectiona...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2017.02.028
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:To examine racial differences in employment status and occupational status 1 year after a traumatic brain injury (TBI). DESIGN:Retrospective study. SETTING:Longitudinal dataset of the Traumatic Brain Injury Model Systems national database. PARTICIPANTS:Subjects with primarily moderate to severe TBI (3468 w...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章,多中心研究
doi:10.1016/j.apmr.2008.02.012
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:To assess the effects of guidance force (GF) and gait speed (GS) on cardiorespiratory responses and energy cost in subacute dependent ambulatory patients with stroke. DESIGN:Cross-sectional study. SETTING:University rehabilitation hospital. PARTICIPANTS:Patients with subacute stroke (N=10; mean age, 64.50±...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2016.10.021
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:To investigate walking ability and quality of life of osseointegrated leg prostheses compared with socket prostheses. DESIGN:Prospective case-control study. SETTING:University medical center. PARTICIPANTS:Subjects (N=22) with transfemoral amputation (1 bilateral) referred to our center because of socket-re...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2013.05.020
更新日期:2013-11-01 00:00:00
abstract:OBJECTIVES:To identify cancer patients' symptoms at admission and on discharge from an acute rehabilitation unit, to document the discharge medications used for symptom management, and to assess how symptoms affect lengths of stay (LOS). DESIGN:Retrospective chart review. SETTING:Acute inpatient rehabilitation unit w...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2007.03.032
更新日期:2007-07-01 00:00:00
abstract::The authors' philosophy and regimen of treatment, based on experience with 103 pressure ulcers in 75 patients, are presented. This experience illustrates that the problem of pressure ulcers can be managed well by the application of sound surgical principles in a community hospital with a rehabilitation unit. With some...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:
更新日期:1978-04-01 00:00:00
abstract:OBJECTIVE:To compare postural balance between patients who have had either a large diameter head total hip arthroplasty or surface replacement arthroplasty. DESIGN:Observational study. SETTING:Outpatient biomechanical laboratory. PARTICIPANTS:Two groups of 14 patients with surface replacement or large diameter head ...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2009.01.033
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:To assess the effectiveness of serial casting in the treatment of pressure ulcers caused by severe spasticity. DESIGN:Case series. SETTING:A clinic for the rehabilitation of persons with neurologic disorders. PATIENTS:Nine patients with 11 pressure ulcers resulting from severe cerebral spasticity, the ulce...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1053/apmr.2002.27474
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:To evaluate whether early neuropsychologic testing is useful in predicting long-term productivity outcome after traumatic brain injury (TBI). DESIGN:Validation cohort prediction study. SETTING:Four inpatient brain injury rehabilitation programs participating in the Traumatic Brain Injury Model Systems proje...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章,多中心研究
doi:10.1053/apmr.2001.23753
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVE:To examine the impact of comorbid obstructive sleep apnea (OSA) on the cognitive functioning of traumatic brain injury (TBI) patients. DESIGN:A case-control study. Neuropsychologic test performances of TBI patients with OSA were compared with those who did not have OSA. The diagnosis of OSA was based on stan...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章,多中心研究
doi:10.1016/j.apmr.2007.07.012
更新日期:2007-10-01 00:00:00
abstract::Power wheelchair (PWC) users depend on their equipment to reliably transport them throughout daily activities and allow them to participate fully in community life. However, as reported by Worobey and colleagues, PWCs frequently require repairs and cause users a variety of problems, which can range from annoying to ca...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 评论,杂志文章
doi:10.1016/j.apmr.2014.01.002
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:Although fatigue is a common debilitating complaint in multiple sclerosis (MS), its relationship to the cardiopulmonary exercise response has yet to be defined. DESIGN:A patient with MS manifested primarily by profound fatigue undergoes complete pulmonary function testing and a maximal incremental cycle ergo...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/s0003-9993(95)80515-x
更新日期:1995-06-01 00:00:00
abstract:OBJECTIVE:To determine the predictive value of measurements of hand edema for the development of reflex sympathetic dystrophy (RSD). DESIGN:Cohort study. SETTING:Departments of rehabilitation medicine in 3 general hospitals and 1 rehabilitation hospital in Japan. PARTICIPANTS:Thirty-four stroke patients. INTERVENTI...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章,多中心研究
doi:10.1053/apmr.2002.34830
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVES:To determine whether a significant difference exists between musculoskeletal symptoms of polio survivors and those of older adults with no history of polio, and to determine if activity level and strength predict pain in either group. DESIGN:Matched research design. SETTING:A research laboratory in a rehab...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2004.01.041
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:To examine the effects of campus services on the health of veterans with traumatic injuries and comorbidities as they return from military service and enter college. DESIGN:Cross-sectional Internet survey using a mixed-methods analysis approach. SETTING:Four-year urban research university. PARTICIPANTS:Vet...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2017.10.008
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:To create upper-extremity and mobility subdomain scores from the Patient-Reported Outcomes Measurement Information System (PROMIS) physical functioning adult item bank. DESIGN:Expert reviews were used to identify upper-extremity and mobility items from the PROMIS item bank. Psychometric analyses were conduct...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2013.05.014
更新日期:2013-11-01 00:00:00
abstract::A series of patients with amputations were investigated to determine the effect on gait of increasing the mass of the prosthetic foot. Weights of 113.4 and 226.8 gm (4 and 8 oz) were added and gait parameters observed. No changes were noted as the result of the extra foot mass. ...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:
更新日期:1977-06-01 00:00:00
abstract::While participation is increasingly defined as the key outcome of rehabilitation, disagreements on and shortcomings in the definition, operationalization, and measurement of this concept abound and interfere with the progress of clinical services and research. This article explores a number of the major issues related...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章,评审
doi:10.1016/j.apmr.2009.10.036
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVES:To document the impact of age, age at injury, years postinjury, and injury severity on changes over time in selected physical and psychosocial outcomes of people aging with spinal cord injury (SCI), and to identify the best predictors of these outcomes. DESIGN:Retrospective cross-sectional and longitudinal ...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2004.03.017
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:To determine if a difference exists in the plantar soft tissue of patients with diabetes mellitus (DM) and peripheral neuropathy (PN) compared with age-matched controls. DESIGN:Case-control study with a parallel 3-element 1-dimensional viscoelastic model developed to characterize indentation data. SETTING:D...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1053/apmr.2002.35661
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVE:To measure with near-infrared spectroscopy (NIRS) the changes in cerebral hemodynamics and oxygenation in the prefrontal cortex of poststroke patients with hemiplegia performing several rehabilitation tasks and to analyze the different effects of the tasks. DESIGN:Case series pilot study. SETTING:Hospitals ...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1053/apmr.2000.9400
更新日期:2000-10-01 00:00:00
abstract:OBJECTIVE:To test the hypotheses that people with hemiplegia using arms and legs to propel their wheelchairs perform better backward than forward and prefer the backward direction. DESIGN:Within-participant cross-sectional design. PARTICIPANTS:Manual wheelchair users (N=18) with hemiplegia caused by stroke, a sample ...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:10.1016/j.apmr.2013.03.001
更新日期:2013-09-01 00:00:00
abstract::Patients with viable phrenic nerves and adequate diaphragm and lung function can be freed from mechanical ventilation by the use of phrenic nerve pacers. Four quadriplegic patients with phrenic nerve pacers were admitted to a rehabilitation facility between April 1981 and September 1986. These patients made significan...
journal_title:Archives of physical medicine and rehabilitation
pub_type: 杂志文章
doi:
更新日期:1989-07-01 00:00:00