Ion transport processes in corn mitochondria : I. Effect of the local anesthetic dibucaine.

Abstract:

:The local anesthetic dibucaine inhibited respiration-dependent contraction mediated by the K(+)/H(+) antiport system of isolated corn mitochondria. Respiration declined concurrently. Nigericin, an exogenous K(+)/H(+) exchanger, restored ion efflux in dibucaine-blocked corn mitochondria. It was concluded that dibucaine inhibited ion efflux via blockage of the K(+)/H(+) antiport. Further experiments determined that dibucaine also inhibited proton influx facilitated by protonophores and by the ATPase complex during state III respiration. These results are discussed in relation to the mechanism by which dibucaine inhibits proton translocation across the inner mitochondrial membrane.

journal_name

Plant Physiol

journal_title

Plant physiology

authors

Klein RR,Koeppe DE

doi

10.1104/pp.77.4.909

subject

Has Abstract

pub_date

1985-04-01 00:00:00

pages

909-11

issue

4

eissn

0032-0889

issn

1532-2548

journal_volume

77

pub_type

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