Abstract:
:The local anesthetic dibucaine inhibited respiration-dependent contraction mediated by the K(+)/H(+) antiport system of isolated corn mitochondria. Respiration declined concurrently. Nigericin, an exogenous K(+)/H(+) exchanger, restored ion efflux in dibucaine-blocked corn mitochondria. It was concluded that dibucaine inhibited ion efflux via blockage of the K(+)/H(+) antiport. Further experiments determined that dibucaine also inhibited proton influx facilitated by protonophores and by the ATPase complex during state III respiration. These results are discussed in relation to the mechanism by which dibucaine inhibits proton translocation across the inner mitochondrial membrane.
journal_name
Plant Physioljournal_title
Plant physiologyauthors
Klein RR,Koeppe DEdoi
10.1104/pp.77.4.909subject
Has Abstractpub_date
1985-04-01 00:00:00pages
909-11issue
4eissn
0032-0889issn
1532-2548journal_volume
77pub_type
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