Effect of rofecoxib, a cyclo-oxygenase-2 inhibitor, on various biochemical parameters of brain associated with pentylenetetrazol-induced chemical kindling in mice.

abstract：:In the present study, contractile responses and [3H]-noradrenaline overflow evoked by electrical field stimulation were assessed, respectively, in the small mesenteric artery and in tail artery removed from rats pre-treated with either saline or lipopolysaccharide (LPS). In small mesenteric arteries, LPS treatment did...

journal_title：Fundamental & clinical pharmacology

authors： Ohlmann P,Martínez MC,Bucher B,Andriantsitohaina R,Muller B,Schneider F,Stoclet JC

更新日期：2000-11-01 00:00:00

abstract：:Acetylcholinesterase (AChE, EC 3.1.1.7) and butyrylcholinesterase (BChE, EC 3.1.1.8) activities were detected in bronchial and bronchial epithelial cell homogenates of the pig. In the bronchial homogenates, the maximal upstroke velocity (Vmax) of AChE and the maximal velocity after second substrate fixation (Vss) of B...

journal_title：Fundamental & clinical pharmacology

authors： Taisne C,Norel X,Walch L,Labat C,Verriest C,Mazmanian GM,Brink C

更新日期：1997-01-01 00:00:00

abstract：:This paper reports data on the effect of a new antioxidant, U-83836E, on the lipid peroxidation and antioxidant status of liver, red blood cells (RBCs) and blood serum of rats intoxicated with methanol (3.0 g/kg body weight). Methanol administration slightly increased the levels of peroxidation products in the liver, ...

journal_title：Fundamental & clinical pharmacology

authors： Skrzydlewska E,Farbiszewski R

更新日期：1997-01-01 00:00:00

abstract：:The effect known as the GTP-shift refers to the complete conversion of receptors from the high- to the low agonist-affinity state in the presence of an excess of GTP or one of its analogs. 5'-Guanylylimidodiphosphate (GppNHp) was able to fully suppress the high (-)-isoproterenol-affinity of beta-adrenoceptors (beta AR...

journal_title：Fundamental & clinical pharmacology

authors： Garnier V,Zini R,Tillement JP

更新日期：1999-01-01 00:00:00

abstract：:Endocannabinoid system has attracted the researchers to investigate into its ever fascinating roles governing many of the physiological functions in the human body. The prime endogenous cannabinoids are arachidonoylethanolamide also called anandamide and 2-arachidonoylglycerol. Recent pharmacological advances point ou...

journal_title：Fundamental & clinical pharmacology

authors： Smita K,Sushil Kumar V,Premendran JS

更新日期：2007-02-01 00:00:00

abstract：:Suriclone is a novel cyclopyrrolone exhibiting anxiolytic activity. Twelve healthy Caucasian male volunteers participated in the study. A single dose of suriclone 0.4 mg, imipramine 75 mg, suriclone 0.4 mg + imipramine 75 mg, or placebo was given according to a 4 x 4 Latin-square design in order to assess the effect o...

journal_title：Fundamental & clinical pharmacology

authors： Perault MC,Chapelle G,Bouquet S,Chevalier P,Montay G,Gaillot J,Chakroun H,Guillet P,Vandel B

更新日期：1994-01-01 00:00:00

abstract：:Methodology used for the development of anti-Alzheimer's disease (AD) drugs raises specific problems which are rarely examined in the literature. While the general development scheme is similar to that required for most drugs, some specific aspects must be analyzed, highly dominated by the dual goal of pharmacology, i...

journal_title：Fundamental & clinical pharmacology

authors： Allain H,Bentué-Ferrer D,Zekri O,Schück S,Lebreton S,Reymann JM

更新日期：1998-01-01 00:00:00

abstract：:Studies have shown that diterpenes have anti-inflammatory and redox-protective pharmacological activities. The present study aimed to investigate the anti-inflammatory properties of phytol, a diterpene alcohol, in a mouse model of acute inflammation, and phytol effect on leukocyte recruitment, cytokines levels, and ox...

journal_title：Fundamental & clinical pharmacology

authors： Silva RO,Sousa FB,Damasceno SR,Carvalho NS,Silva VG,Oliveira FR,Sousa DP,Aragão KS,Barbosa AL,Freitas RM,Medeiros JV

更新日期：2014-08-01 00:00:00

abstract：:The insulin secreting B cell is fitted with the two types of purinergic receptors: P2 (for ATP and/or ADP) and P1 (for adenosine). The activation of P2 purinoceptors by ATP or ADP evokes a biphasic stimulation of insulin secretion from isolated perfused rat pancreas; this stimulation is dose-dependent between 10(-6) a...

journal_title：Fundamental & clinical pharmacology

authors： Hillaire-Buys D,Chapal J,Bertrand G,Petit P,Loubatières-Mariani MM

更新日期：1994-01-01 00:00:00

abstract：:The present study examined 15 patients previously resistant to conventional antihistamines, in which doxepin at doses in the range of 50-75 mg/day was shown to be effective in treatment of chronic urticaria and without significant adverse side effects. However, some controversy remains about its mechanism of action in...

journal_title：Fundamental & clinical pharmacology

authors： Figueiredo A,Ribeiro CA,Gonçalo M,Almeida L,Poiares-Baptista A,Teixeira F

更新日期：1990-01-01 00:00:00

abstract：:Torsades de pointes is the most typical ventricular tachycardia involving QT-interval prolongation. It is a rather unusual but potentially lethal ventricular tachycardia with a distinctive morphology favored by bradycardia, antiarrhythmic drugs and hypokalemia and requires specific treatment. Torsades de pointes has b...

journal_title：Fundamental & clinical pharmacology

authors： Weissenburger J,Davy JM,Chézalviel F

更新日期：1993-01-01 00:00:00

abstract：:Some combinations of antihypertensive agents were shown to reduce proteinuria in patients with renal failure. However, preventive effects of such combinations on renal structure and function are presently unknown when treatment is administered before the onset of renal abnormalities. We thus investigated the long-term...

journal_title：Fundamental & clinical pharmacology

authors： Renaud IM,Chainey A,Belair MF,Mandet C,Michel O,Myara I,Chevalier J,Plante GE

更新日期：2004-08-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a common infectious disease in the world. Two percent of the patients with chronic HBV infection will develop cirrhosis each year, and will die prematurely from cirrhosis or hepatocellular carcinoma. So far interferon alfa and lamivudine are the only effective drugs. Interf...

journal_title：Fundamental & clinical pharmacology

authors： Ormeci N

更新日期：2003-12-01 00:00:00

abstract：:An antagonism between cholecystokinin (CCK) peptides and benzodiazepines (BZD) has been described in various paradigms. We sought to determine whether CCK and BZD are also antagonistic in their effects on brain neurotransmitter levels in the rat. No effect on the noradrenergic system was induced in any brain area by C...

journal_title：Fundamental & clinical pharmacology

authors： Rybarczyk MC,Orosco M,Rouch C,Jacquot C,Cohen Y

更新日期：1990-01-01 00:00:00

abstract：:Vanadium pharmacokinetic parameters and oral bioavailability were determined after administration of vanadyl sulfate, an antidiabetic agent, to male Wistar rats. An optimal sampling design was used over a 21-day period; vanadium was measured in blood by atomic absorption spectrophotometry (AAS). After i.v. bolus injec...

journal_title：Fundamental & clinical pharmacology

authors： Azay J,Brès J,Krosniak M,Teissedre PL,Cabanis JC,Serrano JJ,Cros G

更新日期：2001-10-01 00:00:00

abstract：:Dapsone-induced agranulocytosis is a rare but potentially fatal adverse drug reaction (ADR). A 45-year-old male Caucasian patient developed agranulocytosis caused by dapsone (diamino-diphenyl sulfone), which he was prescribed for leukocytoclastic vasculitis. Patient's treatment consisted of termination of dapsone, ant...

journal_title：Fundamental & clinical pharmacology

authors： Potočnjak I,Likić R,Šimić I,Juričić Nahal D,Čegec I,Ganoci L,Božina N

更新日期：2017-10-01 00:00:00

abstract：:Amitriptyline significantly inhibited alcohol, aspirin, indomethacin and cold-restraint stress-induced ulceration. Secretory studies conducted in pyloric-ligated rats revealed that the drug, at the doses employed, significantly reduced total acidity and protein content. However, significant reductions of the gastric v...

journal_title：Fundamental & clinical pharmacology

authors： Sen T,Abdulsalam CA,Pal S,Sen S,Karmakar S,Saravanan KS,Chaudhuri AK

更新日期：2002-08-01 00:00:00

abstract：:Vitamin K1 injection induces severe dose-related anaphylactoid reactions and overdose for the treatment of vitamin K deficiency. We aimed to find an optimal and small dose of vitamin K1 injection to treat vitamin K deficiency and avoid anaphylactoid reactions in animal. Rats were administered a vitamin K-deficient die...

journal_title：Fundamental & clinical pharmacology

authors： Mi YN,Ping NN,Li B,Xiao X,Zhu YB,Cao L,Ren JK,Cao YX

更新日期：2017-10-01 00:00:00

abstract：:Mycophenolate mofetil (MMF) is a new immunosuppressive drug used to reduce acute rejection after heart transplantation. As with other immunosuppressive drugs, MMF therapy is associated with several adverse effects. However, the direct effects of MMF on myocardial tissue has not been yet evaluated. The aim of the work ...

journal_title：Fundamental & clinical pharmacology

authors： Bès S,Tatou E,Vandroux D,Tissier C,Rochette L,Athias P

更新日期：2004-06-01 00:00:00

abstract：:The effects of a new transdermal delivery system for clonidine (M-5041T) on hypotensive effect, urine volume, plasma renin activity (PRA) and antidiuretic hormone (ADH) in spontaneously hypertensive rats (SHRs) were compared to the effects of the continuous infusion of clonidine. Both M-5041T (1.5 and 4.5 mg/kg) and t...

journal_title：Fundamental & clinical pharmacology

authors： Naruse T,Ishida T,Ishii R,Tagawa T

更新日期：1996-01-01 00:00:00

abstract：:The third generation aromatase inhibitors are currently the drugs of choice for the treatment of early and advanced breast cancer in postmenopausal women. One of the significant limiting factor during therapy is their negative impact on bone health. In this study, we compared the effects of a nonsteroidal (letrozole) ...

journal_title：Fundamental & clinical pharmacology

authors： Kalam A,Talegaonkar S,Vohora D

更新日期：2016-10-01 00:00:00

abstract：:During the phase I trials, from the juridical point of view, the responsibilities are shared between the pharmaceutical company and the physician who manages the trial. The pharmaceutical company is responsible for the product, the choice of methodology and respect for the regulations. On the financial side, the compa...

journal_title：Fundamental & clinical pharmacology

authors： Rouzioux JM

更新日期：1990-01-01 00:00:00

abstract：:The cardioprotective effects of cariporide were investigated against myoglobin and troponin I elevation in a model of myocardial infarction in pig, and the possible relationship between these markers and myocardial infarct size. The left circumflex coronary artery was ligated for 60-min and then reperfused for 48-h. P...

journal_title：Fundamental & clinical pharmacology

authors： Létienne R,Bel L,Bessac AM,Denais D,Degryse AD,John GW,Le Grand B

更新日期：2006-04-01 00:00:00

abstract：:A survey was run on a sample of 134 French GPs from the Rhône-Alpes region, in an attempt to investigate the way they recollect important clinical trials that should have an impact on their practice. It was found that 1) most of them did not remember these trials (however, the awareness score did vary throughout the t...

journal_title：Fundamental & clinical pharmacology

authors： Reveilleau S,Boissel JP,Alamercery Y

更新日期：1991-01-01 00:00:00

abstract：:The monoterpene alcohol (-)-borneol has many biological effects such as sedative, anti-inflammatory, analgesic, anti-nociceptive, antithrombotic and vasorelaxant effects. Our objective in this study was to investigate the mechanism of action of (-)-borneol and determine its vasorelaxant effect. (-)-Borneol was tested ...

journal_title：Fundamental & clinical pharmacology

authors： Santos SE,Ribeiro FPRA,Menezes PMN,Duarte-Filho LAM,Quintans JSS,Quintans-Junior LJ,Silva FS,Ribeiro LAA

更新日期：2019-04-01 00:00:00

abstract：:We report 6 additional observations of a drug/hormone assay interaction between serum testosterone and phenylbutazone intake. This interaction had been described previously only once. We discuss its potential mechanisms, based upon our experimental findings, and its clinical implications. ...

journal_title：Fundamental & clinical pharmacology

authors： Uzzan B,Dumont-Fischer D,Lahlou N,Bihan H,Boissier MC,Alvarez JC,Perret GY,Cohen R

更新日期：2008-04-01 00:00:00

abstract：:Angiotensin II AT1 receptor blockade (AT1-) has been shown to prolong survival in post-myocardial infarction (MI) heart failure in rats. In this study, we investigated whether an early AT1-induced improvement in coronary vasodilatation reserve (CVR) might be involved in this beneficial effect. Wistar rats with MI were...

journal_title：Fundamental & clinical pharmacology

authors： Gervais M,Richer C,Fornes P,De Gasparo M,Giudicelli JF

更新日期：1999-01-01 00:00:00

abstract：:The anticonvulsant effect of compounds that inhibit peptidyl-dipeptidase (PDP) on bicuculline (BIC)- and strychnine (STRYC)-induced seizures was assessed after intracerebroventricular (ICV) or intraperitoneal (IP) administration in Swiss albino mice. STRYC-induced seizures were delayed by ICV injections and high IP do...

journal_title：Fundamental & clinical pharmacology

authors： Miñano FJ,Serrano JS,Sancibrián M,Serrano MI

更新日期：1987-01-01 00:00:00

abstract：:The effects of nifedipine and nicardipine, 2 dihydropyridines (DHP) used in the treatment of cardiovascular disorders, were compared in frog atrial fibers. Rapid photolysis of nifedipine with a single UV flash (1-ms duration) reversed the block, allowing comparison of effects of both drugs on the same preparation, and...

journal_title：Fundamental & clinical pharmacology

authors： Charnet P,Ouadid H,Richard S,Nargeot J

更新日期：1987-01-01 00:00:00

abstract：:Strong sero-epidemiologic, pathologic, and experimental evidence suggests that Chlamydophila pneumoniae (Cpn) infection may play a causative role in the development of atherosclerosis. Cpn is an obligate intracellular gram-negative bacterium that is responsible for 10% of cases of community-acquired pneumonia. In addi...

journal_title：Fundamental & clinical pharmacology

authors： Deniset JF,Pierce GN

更新日期：2010-10-01 00:00:00