Abstract：
:The anticonvulsant effect of compounds that inhibit peptidyl-dipeptidase (PDP) on bicuculline (BIC)- and strychnine (STRYC)-induced seizures was assessed after intracerebroventricular (ICV) or intraperitoneal (IP) administration in Swiss albino mice. STRYC-induced seizures were delayed by ICV injections and high IP doses of captopril, but not by ICV or IP injections of enalapril or by lower doses of captopril (0.1 mg/kg and 1 mg/kg IP). BIC-induced seizures were not suppressed by ICV or IP injections of either compound; on the contrary, captopril and enalapril exhibited proconvulsant effects when given IP or ICV by shortening the time of onset of tonic seizures and death. Results indicate that the anticonvulsant effect of captopril against STRYC-induced seizures is not mediated by central gamma-aminobutyric acid (GABA) receptors or by the inhibition of PDP.
journal_name
Fundam Clin Pharmacoljournal_title
Fundamental & clinical pharmacologyauthors
Miñano FJ,Serrano JS,Sancibrián M,Serrano MIdoi
10.1111/j.1472-8206.1987.tb00547.xsubject
Has Abstractpub_date
1987-01-01 00:00:00pages
77-83issue
2eissn
0767-3981issn
1472-8206journal_volume
1pub_type
杂志文章abstract：:The aim of this review is to comment the results described in the literature concerning the possible pharmacodynamic mechanisms involved in the improvement of quality of life of angiotensin converting enzyme inhibitors that is just a working hypothesis. These drugs, widely used in the treatment of hypertension, preven...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章,评审
doi：10.1111/j.1472-8206.1996.tb00592.x
更新日期：1996-01-01 00:00:00
abstract：:Macrophage inflammatory protein (MIP)-1beta and RANTES (regulated on activation, normal T-cells expressed and secreted) are members of the CC-family of chemokines. Although these two peptides are structurally and functionally related to one another, each exhibits distinct features, which allows it to independently reg...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1472-8206.2003.00227.x
更新日期：2004-04-01 00:00:00
abstract：:Cyclo-oxygenase (COX) has been reported to play a significant role in neurodegeneration and other brain-related disorders. Recent studies have reported that COX plays a significant role in the pathophysiology of brain-related disorders and COX-2 inhibitors could be useful drug therapy in neurodegenerative disorders. T...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1472-8206.2006.00398.x
更新日期：2006-06-01 00:00:00
abstract：:Erythropoietin (EPO), the principal hematopoietic cytokine produced by the kidney and the liver in fetuses, regulates mammalian erythropoiesis and exhibits diverse cellular effects in non-hematopoietic tissues. The introduction of recombinant human EPO (rhEPO) has marked a significant advance in the management of anem...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章,评审
doi：10.1111/j.1472-8206.2005.00347.x
更新日期：2005-08-01 00:00:00
abstract：:Alizapride is a new antidopaminergic-related benzamide with specific antiemetic properties. Pharmacokinetics at a high repetitive dose (16 mg/kg) shows a biexponential plasma decay with T1/2 alpha of 8.33 +/- 2.47 min and T1/2 beta 2.8 +/- 0.7 hr. Large Vdss and high total body clearance are apparent. We demonstrate a...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1472-8206.1987.tb00559.x
更新日期：1987-01-01 00:00:00
abstract：:The off-label and unlicensed use of drugs to treat children is a common practice that occurs either in hospital or in the community. This derives from the fact that research for establishing drug efficacy and safety in children has not been carried out due to ethical problems, logistical difficulties, financial and le...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章,评审
doi：10.1046/j.1472-8206.2003.00123.x
更新日期：2003-02-01 00:00:00
abstract：:Over the past 10 years, more than 40 potentially oncogenic genes, termed protooncogenes, have been identified in the human genome. Little is known of the physiological role of the proteins encoded by these genes, but they seem to be involved in the reception and transmission of hormonal and other environmental informa...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章,评审
doi：10.1111/j.1472-8206.1990.tb00694.x
更新日期：1990-01-01 00:00:00
abstract：:The impact of an acute coronary syndrome (ACS) event, such as an acute myocardial infarction (MI), is not limited to the acute management phase; patients face an elevated risk of residual atherothrombotic events that commonly requires chronic management for months or even years. Significant advances have been made in ...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章,评审
doi：10.1111/fcp.12063
更新日期：2014-08-01 00:00:00
abstract：:Neuropathic pain (NP) is difficult to treat and is associated with a decline in quality of life. NP aetiologies are numerous and a number of pathologies display neuropathic characteristics. Of the various N-methyl-d-aspartate antagonists that are alternatives to be recommended in first-line NP treatment, memantine has...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章,评审
doi：10.1111/fcp.12316
更新日期：2018-02-01 00:00:00
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journal_title：Fundamental & clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1046/j.0767-3981.2003.00208.x
更新日期：2004-02-01 00:00:00
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journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1472-8206.1996.tb00305.x
更新日期：1996-01-01 00:00:00
abstract：:Cyclosporine A (CsA) is an immunosuppressor, which is most frequently used in the transplant surgery and in the treatment of autoimmune diseases. It has been shown that CsA is able to generate reactive oxygen species and lipid peroxidation, which are directly involved in the CsA nephrotoxicity, hepatotoxicity and card...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1472-8206.2008.00609.x
更新日期：2008-08-01 00:00:00
abstract：:Clinical research in chronic heart failure has recently focused on the stimulated neuro-hormonal compensatory mechanisms that could contribute to auto-aggravation of the disease. On the basis of such a hypothesis, and apart from the inhibition of the renin angiotensin system, the antagonism of beta-receptors has evolv...
journal_title：Fundamental & clinical pharmacology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1997-01-01 00:00:00
abstract：:Overdose cardiac effects of imipramine are due to fast Na channel blockade and are clinically reversed by administration of sodium lactate which induces alkalosis (about pH 7.50) and hypernatremia (about 8 mM). The mechanisms of this beneficial effect of Na lactate were explored in vitro on guinea-pig ventricular myoc...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1472-8206.1992.tb00102.x
更新日期：1992-01-01 00:00:00
abstract：:Zinc is the authoritative metal which is present in our body, and reactive zinc metal is crucial for neuronal signaling and is largely distributed within presynaptic vesicles. Zinc also plays an important role in synaptic function. At cellular level, zinc is a modulator of synaptic activity and neuronal plasticity in ...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章,评审
doi：10.1111/fcp.12110
更新日期：2015-04-01 00:00:00
abstract：:The aim of the present study was the investigation of pretreatment effects with clonidine (0.06 mg/kg, intraperitoneal [i.p.]), lithium (1 mEq, i.p.) or quinine (0.5 mg/kg, i.p.) on the activities of various drugs acting on noradrenergic and/or serotonergic systems in the mouse tail suspension test. Drugs used in the ...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1472-8206.1997.tb00199.x
更新日期：1997-01-01 00:00:00
abstract：:The anti-anginal drug trimetazidine (TMZ) has been shown to increase the synthesis of phospholipids in ventricular myocytes, including phosphatidyl-inositol (PI). This study focused on the consequences of increasing PI metabolism on alpha-adrenergic signaling pathway in cultured rat cardiomyocytes. In the cells treate...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1046/j.1472-8206.2003.00146.x
更新日期：2003-02-01 00:00:00
abstract：:In epileptic patients cyproheptadine is frequently prescribed as an appetite stimulant for the treatment of anorexia associated with anti-epileptic drugs and for the management of 'serotonin syndrome' in depressed epileptic patients. However, the study of serotonergic and histaminergic pathway shows that the decreased...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1472-8206.2009.00797.x
更新日期：2010-08-01 00:00:00
abstract：:The cardioprotective effects of cariporide were investigated against myoglobin and troponin I elevation in a model of myocardial infarction in pig, and the possible relationship between these markers and myocardial infarct size. The left circumflex coronary artery was ligated for 60-min and then reperfused for 48-h. P...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1472-8206.2006.00394.x
更新日期：2006-04-01 00:00:00
abstract：:Interferon (IFN)-γ is known to downregulate expression of drug detoxifying proteins such as cytochromes P-450 (CYPs) in human hepatocytes. The present study was designed to determine whether IFN-γ may also impair expression of influx and efflux drug transporters, which constitute important determinants of the liver de...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1472-8206.2010.00822.x
更新日期：2011-02-01 00:00:00
abstract：:To assess the incidence of hospital admissions related to adverse drug reactions (ADRs) in France and the frequency of preventable ADRs in France, a prospective study was conducted among a representative randomly selected sample of medical wards in public hospitals between December 2006 and June 2007; all patients adm...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/fcp.12088
更新日期：2015-02-01 00:00:00
abstract：:The H1-histaminergic agonists 2-pyridylethylamine (2-PEA) and 2-methylhistamine relaxed potassium-constricted, perfused, rabbit middle cerebral arteries at low concentrations (3 x 10(-11) to 3 x 10(-8) M) and constricted them at high concentrations (3 x 10(-7) to 3 x 10(-4) M). The relaxation and the contraction were ...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1472-8206.1988.tb00648.x
更新日期：1988-01-01 00:00:00
abstract：:Anxiety following heart failure (HF) and/or myocardial infarction (MI) can impede recovery and constitute a major risk factor for further cardiac events. The present study was aimed to evaluate anxiety following doxorubicin (DOX)-induced cardiomyopathy, a rodent model for HF, in mice. Furthermore, the study investigat...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/j.1472-8206.2011.00925.x
更新日期：2012-06-01 00:00:00
abstract：:The present study investigated the effects of positive end-expiratory pressure (PEEP) on propofol concentrations in humans. Eleven patients undergoing elective surgery were enrolled in this study. Anesthesia was induced with propofol, then maintained using 60% nitrous oxide in oxygen, fentanyl 10-20 microg/kg and cont...
journal_title：Fundamental & clinical pharmacology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1472-8206.2006.00436.x
更新日期：2006-10-01 00:00:00
abstract：:Chelerythrine, a potent inhibitor of protein kinase C (PKC), was evaluated for its effect on inositol phosphate (IP) metabolism in newborn rat cardiomyocytes in culture. In a first step, we evaluated the effect of chelerythrine on IP accumulation in basal conditions. For a 10(-4) M dose, 5-phosphatase activity (which ...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1046/j.1472-8206.2002.00069.x
更新日期：2002-02-01 00:00:00
abstract：:This study aimed to investigate the modulation of nitric oxide/reactive oxygen species in sodium nitroprusside relaxation in mice aorta. Sodium nitroprusside induced relaxation in endothelium-intact (e+) and endothelium-denuded (e-) aortas with greater potency in e+ than in e-. The nitric oxide synthase inhibitor did ...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/fcp.12103
更新日期：2015-04-01 00:00:00
abstract：:Intracerebroventricular (i.c.v.) injections of dihydropyridine derivatives calcium channel agonist (BAY K8644) and antagonist (nifedipine, nicardipine, PN 200-110) induced opposite long-lasting changes in blood pressure (BP) in pentobarbital anesthetized spontaneously hypertensive rats (SMR). I.c.v. nifedipine (NIF), ...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章,评审
doi：10.1111/j.1472-8206.1989.tb00474.x
更新日期：1989-01-01 00:00:00
abstract：:Studies have shown that diterpenes have anti-inflammatory and redox-protective pharmacological activities. The present study aimed to investigate the anti-inflammatory properties of phytol, a diterpene alcohol, in a mouse model of acute inflammation, and phytol effect on leukocyte recruitment, cytokines levels, and ox...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/fcp.12049
更新日期：2014-08-01 00:00:00
abstract：:Cyclophosphamide given in association with corticosteroids has markedly improved the prognosis of systemic vasculitis. Little information has been reported on cyclophosphamide pharmacokinetics in these diseases and data evaluating its metabolite, 4-hydroxycyclophosphamide/aldophosphamide, pharmacokinetics and concentr...
journal_title：Fundamental & clinical pharmacology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1472-8206.2000.tb00424.x
更新日期：2000-07-01 00:00:00
abstract：:Vitamin K1 injection induces severe dose-related anaphylactoid reactions and overdose for the treatment of vitamin K deficiency. We aimed to find an optimal and small dose of vitamin K1 injection to treat vitamin K deficiency and avoid anaphylactoid reactions in animal. Rats were administered a vitamin K-deficient die...
journal_title：Fundamental & clinical pharmacology
pub_type： 杂志文章
doi：10.1111/fcp.12290
更新日期：2017-10-01 00:00:00
