Abstract:
BACKGROUND/AIM:Liver stellate cells play an important role in hepatic fibrosis, and its progression to cirrhosis. These cells show immunoreactivity with different monoclonal antibodies amongst which the commonest are alpha-smooth muscle actin (alpha-SMA) and glial fibrillary acid protein (GFAP). The aim of this study was to analyze stellate cell immunoreactivity for alpha-SMA and GFAP in tissue sections showing the signs of chronic viral B-hepatitis and compare it with those without histopathological changes. METHODS:We included 12 tissue samples showing chronic viral B hepatitis in the different stages of fibrosis and 7 tissue samples showing no histopathological changes. Immunohistochemical staining was performed using the streptavidin-biotin method. RESULTS:There was a regular presence of alpha-SMA immunoreactivity in tissue sections without histopathological changes in the portal tracts and also in liver parenchyma, while GFAP expression was noted in the periportal cavity. Tissue sections with the signs of chronic viral B hepatitis displayed very strong alpha-SMA expression in the portal tracts. A statistical analysis showed a positive correlation between the degree of liver fibrosis and alpha-SMA expression along the fibrous septa, whereas a negative correlation between the degree of liver fibrosis and alpha-SMA expression was present in the portal zone. CONCLUSION:This study showed the existance of two different stellate cell subpopulations in liver tissue. Differentiation between them was possible on the basis of SMA/GFAP expression.
journal_name
Vojnosanit Pregljournal_title
Vojnosanitetski pregledauthors
Tomanović N,Boricić I,Brasanac Ddoi
10.2298/vsp0606553tsubject
Has Abstractpub_date
2006-06-01 00:00:00pages
553-7issue
6eissn
0042-8450issn
2406-0720journal_volume
63pub_type
杂志文章abstract:BACKGROUND/AIM:Numerous studies have provided clear and convincing evidence that psychosocial factors contribute to the pathogenesis and expression of coronary heart disease (CHD). These factors have been related to the following psychosocial domains: personality factors and character traits, depression, anxiety, socia...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0602153j
更新日期:2006-02-01 00:00:00
abstract::We have followed up the course of the facial reconstruction in a 12 year old boy with totally destroyed middle and lower third of the face when the fuse for initial mine activation exploded in his mouth. The boy has undergone more than 20 operations within the 7-year period and his rehabilitation has not been complete...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND/AIM:A school teacher's occupation is one of the most vocal demanding professions. Vocal tiredness affects acoustic characteristics of voice, leads to the change in acoustic quality during vocal production. The aim of this study was to examine the influence of vocal tiredness on voice acoustic characteristics...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1103209p
更新日期:2011-03-01 00:00:00
abstract:INTRODUCTION:Intermediate syndrome (IMS) was described a few decades ago, however, there is still a controversy regard ing its exact etiology, risk factors, diagnostic parameters and required therapy. Considering that acute poisonings are treated in different types of medical institutions this serious complication of o...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp120229037v
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:To evaluate how infection of extremity after war wound influenced the possibilities and immediate effects of a physical therapy. METHODS:The retrospective clinical investigation comparing two groups: group A (n = 86) with infection, group B (n = 87) without infection. Main indicators for possibilities of the...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1997-11-01 00:00:00
abstract:BACKGROUND/AIM:Analysis of organophosphosphorus compounds and their metabolites in a biological material includes the use of numerous methods, covering both preparation of samples for analysis and their identification that is considered to be very complex. Low concentrations monitoring requires implementation of highly...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1009717z
更新日期:2010-09-01 00:00:00
abstract::The aim of this study was to investigate the influence of the corticosteroid therapy on the development and prognosis of proststreptococcal glomerulonephritis (PSGN) in the period of five years. The investigation included a group of 54 patients who were in the acute phase of poststreptococcal glomerulonephritis (PSGN)...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2001-03-01 00:00:00
abstract:BACKGROUND/AIM:World Health Organization (WHO) studies on the global level have shown that one of the major problems of the public health is hypertension. Blood pressure level greater than 140/90 mmHg is directly and predictively linked to other cardiovascular diseases. The aim of this research was to determine the pre...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章,多中心研究
doi:10.2298/vsp120423057m
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND/AIM:Splenomegaly is a frequent finding in patients with liver cirrhosis and portal hypertension and may cause hypersplenism. The occurrence of thrombocytopenia in those patients can be considered as an event with multiple etiologies. Two mechanisms may act alone or synergistically with splenic sequestration....
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1002166d
更新日期:2010-02-01 00:00:00
abstract:INTRODUCTION:Sinus pericranii is a rare vascular anomaly. It is characterized by abnormal communication between the extracranial and intracranial venous system, usually involving the superior sagittal sinus and occasionally the transverse sinus. Off the midline lesions are extremely rare. Multiplicity, associated venou...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp140416065i
更新日期:2015-09-01 00:00:00
abstract::The stability of an efficacious antidote in the treatment of organophosphorous poisoning--HI-6 has been examined in aqueous solutions of eye drops by accelerated stability tests. Disintegration kinetics has been examined at the increased temperatures and pH value of isotonic solution of 25 mg/ml concentration in ampul...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1989-11-01 00:00:00
abstract:INTRODUCTION:Solitary fibrous tumors are rare soft tissue tumors of submesothelial origin and variable malignant potential. The most common localization is pleural, whereas only 0.6% are of extrapleural localization. Solitary fibrous tumor of the peritoneum, especially of gastric serosa is an extremely rare form of thi...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp140131098b
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND/AIM:Dystonia is considered to be a prolonged involuntary contractions of the muscles leading to twisting, repetitive movements or irregular postures. Etiologically, it could be classified as primary and secondary dystonia. Dopa-responsive dystonia (DRD) belongs to a group of primary dystonia. The aim of this...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0901029d
更新日期:2009-01-01 00:00:00
abstract:INTRODUCTION:Dental injuries in immature permanent teeth often result in endodontic complications. Apexification technique using calcium hydroxide is associated with certain flaws, such as long treatment time, the possibility of tooth fracture and incomplete calcification. The use of an apical plug employing mineral tr...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1308781c
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND/AIM:The modification of implant surfaces could affect mechanical implant stability as well as dynamics and quality of peri-implant bone healing. The aim of this 3-month experimental study in dogs was to investigate implant stability, marginal bone levels and bone tissue response to zirconia dental implants w...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp121003034d
更新日期:2014-05-01 00:00:00
abstract::In retrospective, non-randomized study were analyzed 45 patients with local recurrences of rectal carcinoma treated by combined external beam radiotherapy (EBRT) and "High dose rate (HDR) remote afterloading" brachytherapy in the period from January 1st, 1988 to May 1st, 1988. Depending on the localization of the loca...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1998-11-01 00:00:00
abstract:BACKGROUND:Meckel's diverticulum (MD) is a congenital anomaly of the small intestine. It results from incomplete obliteration and resorption of the proximal omphaloenteric duct connecting yolk sac with primitive gut in the fetal period. CASE REPORT:A case of 20-year old female with ectopic pancreatic rests in a MD was...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1012021p
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND/AIM:Interest in dental esthetics has increased rapidly during the last few decades among both patients and dentists, and the creation of a natural dental appearance has become an important task in all fields of dentistry, especially in prosthodontics and restorative dentistry. The aim of this research was to...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND/AIM:Enlargement of optical zone (OZ) diameter during laser in situ keratomileusis (LASIK) correction of myopia postoperatively improves the optical outcome, however, it also leads to the increased stroma tissue consumption--progressive corneal thinning. The aim of this investigation was to present the possib...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp140627029m
更新日期:2016-06-01 00:00:00
abstract::The aim of this study was to determine the resistance of Enterococcus faecalis (E. faecalis) and Enterococcus faecium (E. faecium) to penicillin, ampicillin, vancomycin, teicoplanin, gentamicin (high level), streptomycin (high level), oxytetracycline, chloramphenicol, rifampin, erythromycin, ciprofloxacin, norfloxacin...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0205499m
更新日期:2002-09-01 00:00:00
abstract:INTRODUCTION:Psychiatric symptoms are not rare manifestations of brain tumors. Brain tumors presented by symptoms of raised intracranial pressure, focal neurological signs, or convulsions are usually first seen by the neurologist or less frequently by the neurosurgeon in routine diagnostic procedures. On the other hand...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1109809i
更新日期:2011-09-01 00:00:00
abstract::The Clinic for Rheumatology and Clinical Immunology of the Military Medical Academy, with the participation of the hosts and experts from eminent Yugoslav institutions, in April 1997 organized the symposium on two current and trendy subjects from clinical immunology: "Antiphospholipid syndrome" and "The use of polyval...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章,评审
doi:
更新日期:1998-03-01 00:00:00
abstract::Incidence of the epicondylitis humeri lateralis in a sample of 48 patients was analyzed according to age groups. The highest incidence was found in the age group of 21-30 that corresponds to the etiologic factor of more intensive work with extended arm and clenched hand, practiced by tennis players, bricklayers, house...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:
更新日期:1994-03-01 00:00:00
abstract:BACKGROUND:Although relatively rare, gastric vascular anomalies can be recognized as a source of both chronic and acute blood loss, most often presenting as long term iron deficiency anemia, rarely as severe acute gastrointestinal bleeding. CASE REPORT:We present five patients with various gastric vascular anomalies, ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0809710g
更新日期:2008-09-01 00:00:00
abstract:BACKGROUND/AIM:Obesity is the most common disease of nutrition and is the consequence of reduced movement. Unfortunately, this problem is increasingly present in juvenile age, so that the pediatric outpatient offices are dominated by obese young people. The aim of this study was to evaluate and quantify the effects of ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1201009s
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Central nervous system hemangioblastomas (HBs) are uncommon, highly vascularized tumors that are predominantly found in the cerebellum. They occur sporadically or in association with von Hippel-Lindau (VHL) disease. HBs are of unknown histogenesis, and the origin of stromal cells is still a subject of debate...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0403273t
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND/AIM:Bone allografts are frequently used in orthopedic reconstructive procedures carrying a high risk for recipients. To assess the nature and frequency of allograft contamination and associated surgical infection the case records from our institutional bone bank were reviewed. METHODS:We retrospectively ana...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1505427s
更新日期:2015-05-01 00:00:00
abstract:INTRODUCTION:Behcet's disease is multisystemic vasculitis which affects vein and artery blood vessels. Intestinal perforation rarely occurs as clinic manifestation in as little as 1% of patients. The transverse colon is the most infrequent site of perforation. We presented a patient diagnosed with Behcet's disease who ...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp1111992t
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND/AIM:There are few tests for evaluation of functional abilities of patients surgically treated for hip fractures or osteoarthritis during early rehabilition period. The aim of this study was to investigate reliability (interobserver reproducibility and internal consistency) of the A-test, an original test for...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp130118042v
更新日期:2014-07-01 00:00:00
abstract:AIM:To establish the risk factors for complications and fatal outcome after the operative occlusion of cerebral aneurysms. METHODS:Retrospective study on 91 (lethality rate) and on 72 operated patients (complications). For survived and dead patients, as well as for patients with and without complications, following pa...
journal_title:Vojnosanitetski pregled
pub_type: 杂志文章
doi:10.2298/vsp0204355r
更新日期:2002-07-01 00:00:00