Mutation induction by cross-links in DNA of Deinococcus radiodurans.

abstract：:The potential antiatherogenic actions of the angiotensin II receptor antagonist, losartan were investigated in apolipoprotein (apo) E deficient mice, an animal model with severe hypercholesterolemia and extensive atherosclerosis. In these animals accelerated atherosclerosis is associated with increased lipid peroxidat...

journal_title：Biochemical and biophysical research communications

authors： Keidar S,Attias J,Smith J,Breslow JL,Hayek T

更新日期：1997-07-30 00:00:00

abstract：:We investigated the role of tyrosine phosphorylation of FAK in the stretch-induced MAPKs (extracellular signal-regulated kinase (ERK), p38MAPK) activation in mutant FAK-transfected fibroblasts. In response to uniaxial cyclic stretch (1 Hz, 120% in length), the levels of tyrosine phosphorylation of the Tyr-397 and Tyr-...

journal_title：Biochemical and biophysical research communications

authors： Wang JG,Miyazu M,Matsushita E,Sokabe M,Naruse K

更新日期：2001-10-26 00:00:00

abstract：:Reactive oxygen species (ROS) generated during inflammation and aging contribute to the resorption of articular cartilage. Low antioxidant levels are a risk factor for arthritis because they protect cartilage from ROS. N-Acetylcysteine (NAC) is a ROS scavenger and, depending upon the concentration, an anti-inflammator...

journal_title：Biochemical and biophysical research communications

authors： Li WQ,Dehnade F,Zafarullah M

更新日期：2000-09-07 00:00:00

abstract：:1alpha,25-Dihydroxyvitamin D3 (1alpha,25(OH)2D3) increases the binding of transforming growth factor beta1(TGF beta1) via TGF beta receptors to the surface of human osteoblasts. The increase in TGF beta receptors induced by 1alpha,25(OH)2D3 is dependent on increases in TGF beta secretion induced by 1alpha,25(OH)2D3, s...

journal_title：Biochemical and biophysical research communications

authors： Nagel D,Kumar R

更新日期：2002-02-08 00:00:00

abstract：:The highly reactive electrophile, methylglyoxal (MG), a break down product of carbohydrates, is a major environmental mutagen having potential genotoxic effects. Previous studies have suggested the reaction of MG with free amino groups of proteins forming advanced glycation end products (AGEs). This results in the gen...

journal_title：Biochemical and biophysical research communications

authors： Ahmad S,Moinuddin,Dixit K,Shahab U,Alam K,Ali A

更新日期：2011-04-15 00:00:00

abstract：:The apical ectodermal ridge (AER) controls limb outgrowth and patterning, such that its removal causes changes in mesodermal gene expression, cell death and limb truncation. Fibroblast growth factor (FGF) family members are expressed in the AER and can rescue limb bud outgrowth after AER removal. Cells localized under...

journal_title：Biochemical and biophysical research communications

authors： Pascoal S,Andrade RP,Bajanca F,Palmeirim I

更新日期：2007-01-05 00:00:00

abstract：:The WNT genes encode a large family of secreted glycoprotein signalling molecules important from the earliest stages of development through to the adult. We have identified a novel isoform of the recently described WNT family member, Wnt16, following analysis of chromosome 7q31 genomic sequence. We find differential o...

journal_title：Biochemical and biophysical research communications

authors： Fear MW,Kelsell DP,Spurr NK,Barnes MR

更新日期：2000-11-30 00:00:00

abstract：:Cell to cell interaction in bone marrow is crucial for differentiation of hematopoietic cells. We have shown that EphB4 receptor is expressed in erythroid progenitor and its activation accelerates erythroid differentiation. To elucidate the role of EphB4 activation in erythropoiesis, we analyzed effects of EphB4 on ce...

journal_title：Biochemical and biophysical research communications

authors： Sakamoto H,Zhang XQ,Suenobu S,Ohbo K,Ogawa M,Suda T

更新日期：2004-08-27 00:00:00

abstract：:Serotype conversion (O-antigen glucosylation) in Shigella flexneri is mediated by temperate bacteriophages, which encode a three-gene cluster that contains gtrA, gtrB, and gtr([type]). Sequence analysis has revealed that gtrA and gtrB are conserved and readily interchangeable between serotypes. The gtr([type]) is uniq...

journal_title：Biochemical and biophysical research communications

authors： Korres H,Mavris M,Morona R,Manning PA,Verma NK

更新日期：2005-03-25 00:00:00

abstract：:The structure of intracellular third loop peptide (betaIII-2: RRSSKFCLKEKKALK) was studied by CD and NMR spectroscopy. According to the CD study, this peptide forms a helix in the TFE solution. The three-dimensional molecular structure in TFE was determined by the 2D (1)H NMR spectroscopy. The structure consists of a ...

journal_title：Biochemical and biophysical research communications

authors： Okuda A,Matsumoto O,Akaji M,Taga T,Ohkubo T,Kobayashi Y

更新日期：2002-03-15 00:00:00

abstract：:RNA extracts from the isthmus of laying hen oviduct contain truncated 5S RNA molecules that were found to be shorter at their 5' terminus as compared to native 5S RNA I and II. Moreover one of the truncated species differs from 5S RNA I by the absence of the 3' end nucleotide. The truncated forms increase of about 70%...

journal_title：Biochemical and biophysical research communications

authors： Keith G,Nys Y,Fix C,Heyman T

更新日期：1986-08-14 00:00:00

abstract：:Members of the dynamin superfamily are implicated in vesicle trafficking. Using human glycogen synthase kinase 3 beta (Gsk-3 beta) as bait in the yeast two-hybrid system, we identified a novel human dynamin-like protein IV (HdynIV). When the full-length cDNA of HdynIV was sequenced, it showed that HdynIV's carboxyl te...

journal_title：Biochemical and biophysical research communications

authors： Hong YR,Chen CH,Cheng DS,Howng SL,Chow CC

更新日期：1998-08-28 00:00:00

abstract：:Polyribosomes were isolated without the use of detergents, irradiated with ultraviolet light and labelled in the presence of (gamma-32P) adenosine 5'-triphosphate. Poly(A)+RNA-protein structures separated by chromatography on oligo (dT)-cellulose contained up to 1o crosslinked proteins as shown by SDS-polyacrylamide g...

journal_title：Biochemical and biophysical research communications

authors： Schweiger A,Kostka G,Weiss E

更新日期：1986-04-14 00:00:00

abstract：:The perichromosomal layer (PCL) is a structure that surrounds mitotic chromosomes, found in both animal and plant cells. It comprises various proteins and RNAs, mainly derived from the nucleolus. Several functions for the PCL have been suggested; however, the mechanism of PCL organization during mitosis remains unclea...

journal_title：Biochemical and biophysical research communications

authors： Hayashi Y,Kato K,Kimura K

更新日期：2017-11-18 00:00:00

abstract：:Galectins (gal), a family of soluble beta-galactoside-binding proteins present at the cell surface, are involved in cancer progression and metastasis. Here we investigated the expression of several galectins in normal (PrEC), benign (BPH-1), and malignant (LNCaP) prostate epithelial cells and found that all galectins,...

journal_title：Biochemical and biophysical research communications

authors： Ahmed H,Banerjee PP,Vasta GR

更新日期：2007-06-22 00:00:00

abstract：:Intracellular transport and storage of retinoids were shown to be conducted by fatty acid-binding protein (FABP). When rat liver cytosol was gel filtrated, retinyl palmitate-binding activity was mainly eluted in the fraction with a Mr. of around 14,000, in which both FABP and cellular retinol-binding protein (CRBP) co...

journal_title：Biochemical and biophysical research communications

authors： Fukai F,Kase T,Shidotani T,Nagai T,Katayama T

更新日期：1987-09-30 00:00:00

abstract：:We previously showed that beta-defensin-1 (BD-1), an anti-microbial peptide, is up-regulated during progressive hyperglycemia in the kidneys of the GK rat [R.A. Page, C.A. Morris, J.D. Williams, C.J. von Ruhland, A.N. Malik, Isolation of diabetes-associated kidney genes using differential display, Biochem. Biophys. Re...

journal_title：Biochemical and biophysical research communications

authors： Malik AN,Al-Kafaji G

更新日期：2007-02-09 00:00:00

abstract：:A secondary structure has been predicted for the hemorrhagic metalloproteases using a method developed in Zurich that extracts structural information from patterns of conservation and variation in homologous protein sequences. This prediction tests the limits of the method when applied to a small number of homologous ...

journal_title：Biochemical and biophysical research communications

authors： Gerloff DL,Jenny TF,Knecht LJ,Benner SA

更新日期：1993-07-15 00:00:00

abstract：:Genomic alterations and abnormal expression of the fragile histidine triad (FHIT) gene in gastric carcinomas were examined to determine whether the FHIT gene is actually a frequent target for alteration during gastric carcinogenesis. To correlate DNA and RNA lesions of the FHIT gene with the effect on FHIT protein exp...

journal_title：Biochemical and biophysical research communications

authors： Lee SH,Kim WH,Kim HK,Woo KM,Nam HS,Kim HS,Kim JG,Cho MH

更新日期：2001-06-15 00:00:00

abstract：:Linkage-specific polyubiquitination regulates many cellular processes. The N-terminal fragment of Rabex-5 (Rabex-5(9-73)) contains tandem ubiquitin binding domains: A20_ZF and MIU. The A20_ZF-MIU of Rabex-5 is known to bind monoubiquitin but molecular details of polyubiquitin binding affinity and linkage selectivity b...

journal_title：Biochemical and biophysical research communications

authors： Shin D,Lee SY,Han S,Ren S,Kim S,Aikawa Y,Lee S

更新日期：2012-07-13 00:00:00

abstract：:Maximal stimulation of inositol 1,4,5 trisphosphate (IP3) production by epinephrine and carbachol in rat parotid cell aggregates is additive when the two agents are employed simultaneously. The additive response proceeds through both the alpha 1-adrenergic and muscarinic-cholinergic signal transduction pathways. It is...

journal_title：Biochemical and biophysical research communications

authors： Kowatch MA,Roth GS

更新日期：1991-05-15 00:00:00

abstract：:Akt is one of the critical mediators in cellular signaling, and overactivation of Akt related pathway frequently occurs in hepatocellular carcinoma (HCC). In this study, we presented that Akt was upregulated in HCC cell lines, and its active phosphorylated form was mainly located in the nucleus. Employing the laser co...

journal_title：Biochemical and biophysical research communications

authors： Zhu L,Hu C,Li J,Xue P,He X,Ge C,Qin W,Yao G,Gu J

更新日期：2007-05-18 00:00:00

abstract：:The cellular response to DNA damage induced by gamma-irradiation activates cell-cycle arrest to permit DNA repair and to prevent replication. Cyclin D1 is the key molecule for transition between the G1 and S phases of the cell-cycle, and amplification or overexpression of cyclin D1 plays pivotal roles in the developme...

journal_title：Biochemical and biophysical research communications

authors： Choo DW,Baek HJ,Motoyama N,Cho KH,Kim HS,Kim SS

更新日期：2009-01-23 00:00:00

abstract：:Unveiling the mechanism of the relapse of acute lymphoblastic leukemia (ALL) is the key to improve the prognosis of ALL and remains a huge challenge. Glycan-based interactions play a vital role in immune surveillance, cell-cell adhesion and cell-matrix interaction, contributing to treatment failure in tumor. However, ...

journal_title：Biochemical and biophysical research communications

authors： Yi L,Hu Q,Zhou J,Liu Z,Li H

更新日期：2019-02-26 00:00:00

abstract：:Angiogenesis is a key pathogenic event in hepatic fibrogenesis, which is mediated by activated hepatic stellate cells (HSCs). TNP-470 is a known anti-angiogenic agent in cancer, and in this study, we investigated the regulatory mechanisms of TNP-470 blockage of vascular endothelial growth factor (VEGF) synthesis in ac...

journal_title：Biochemical and biophysical research communications

authors： Wang YQ,Luk JM,Chu AC,Ikeda K,Man K,Kaneda K,Fan ST

更新日期：2006-03-03 00:00:00

abstract：:The 3'UTR of eukaryotic mRNA is an important regulation region, on which many trans factors act. In recent years, a series of 3'UTRs were shown to have tumor suppressor function, including the 3'UTR of the human nuclear factor for interleukin-6 (NF-IL6 3'UTR). To understand molecular basis for this function, we have t...

journal_title：Biochemical and biophysical research communications

authors： He YZ,Liu DG

更新日期：2000-09-16 00:00:00

abstract：:Patient-derived xenografts (PDXs) are widely recognised as a more physiologically relevant preclinical model than standard cell lines, but are expensive and low throughput, have low engraftment rate and take a long time to develop. Our newly developed conditional reprogramming (CR) technology addresses many PDX drawba...

journal_title：Biochemical and biophysical research communications

authors： Mondal AM,Ma AH,Li G,Krawczyk E,Yuan R,Lu J,Schlegel R,Stamatakis L,Kowalczyk KJ,Philips GK,Pan CX,Liu X

更新日期：2019-09-10 00:00:00

abstract：:Xenopus XmN-cadherin gene appears to have dual functions, since its mRNA is maternally provided in unfertilized eggs, once disappears almost completely during gastrula stage, then accumulates again specifically in neural tissues in later stage embryos. In the present experiment, we first followed the change in XmN-cad...

journal_title：Biochemical and biophysical research communications

authors： Hojyo T,Tooi O,Tashiro K,Shiokawa K

更新日期：1998-01-06 00:00:00

abstract：:Ugp1, UDP-glucose pyrophosphorylase, plays an important role in carbohydrate metabolism because it provides UDP-glucose that is a pivotal metabolite in several metabolic pathways in Saccharomyces cerevisiae. In this study, we show that a considerable reduction of glycogen and trehalose content in ugp1 knockdown cells ...

journal_title：Biochemical and biophysical research communications

authors： Yi DG,Huh WK

更新日期：2015-11-27 00:00:00

abstract：:We have investigated the possible presence of endothelin-metabolizing neutral endopeptidase (NEP, EC 3.4.24.11) on A10 cell membranes using [125I]-ET-1 binding and direct measurements of NEP. NEP activity of A10 cell membranes has been compared to that of solubilized rat kidney brush border membranes (KNEP). Specific ...

journal_title：Biochemical and biophysical research communications

authors： Dickinson KE,Tymiak AA,Cohen RB,Liu EC,Webb ML,Hedberg A

更新日期：1991-04-15 00:00:00