Insulin allergy treated with human insulin (recombinant DNA).

Abstract:

:Two insulin-dependent diabetic subjects treated with pork and beef insulin during a period of 6 mo developed severe local reactions. Both patients had an important allergic history (asthma, urticaria, drug reactions, rhinitis). Skin-testing revealed type I allergy to beef and pork insulin. Specific IgE-insulin binding was demonstrated with both insulins. After negative skin testing with NPH Lilly human insulin (recombinant DNA), treatment was started with this compound and remained successful during a period of 6-9 mo. In one patient a local reaction occurred when regular human insulin (recombinant DNA) was added to NPH in order to obtain better control. Skin testing with regular human insulin was positive, but not with NPH human insulin alone. The mechanism of this phenomenon remains unsolved.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

De Leeuw I,Delvigne C,Bekaert J

doi

10.2337/diacare.5.2.s168

subject

Has Abstract

pub_date

1982-11-01 00:00:00

pages

168-70

eissn

0149-5992

issn

1935-5548

journal_volume

5 Suppl 2

pub_type

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