Abstract:
:Two insulin-dependent diabetic subjects treated with pork and beef insulin during a period of 6 mo developed severe local reactions. Both patients had an important allergic history (asthma, urticaria, drug reactions, rhinitis). Skin-testing revealed type I allergy to beef and pork insulin. Specific IgE-insulin binding was demonstrated with both insulins. After negative skin testing with NPH Lilly human insulin (recombinant DNA), treatment was started with this compound and remained successful during a period of 6-9 mo. In one patient a local reaction occurred when regular human insulin (recombinant DNA) was added to NPH in order to obtain better control. Skin testing with regular human insulin was positive, but not with NPH human insulin alone. The mechanism of this phenomenon remains unsolved.
journal_name
Diabetes Carejournal_title
Diabetes careauthors
De Leeuw I,Delvigne C,Bekaert Jdoi
10.2337/diacare.5.2.s168subject
Has Abstractpub_date
1982-11-01 00:00:00pages
168-70eissn
0149-5992issn
1935-5548journal_volume
5 Suppl 2pub_type
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