In vivo assessment of arsenic bioavailability in rice and its significance for human health risk assessment.

abstract：:Studies of structure-activity relationships and molecular mechanisms of action are fundamental to our understanding of the harmful effects of chemicals on the environment and their more direct effects on human health. It is important to identify factors that determine toxicological effects of foreign chemicals in biol...

journal_title：Environmental health perspectives

authors： McKinney JD

更新日期：1985-09-01 00:00:00

abstract：:The major aspects that must be considered in studies of the health effects of environmental pollutants are: the direct damage due to the exposure, the role of pre-existing disease, and effects of the exposure on the response to secondary stresses. In experimental studies at concentrations of air pollutants found in ur...

journal_title：Environmental health perspectives

authors： Ehrlich R

更新日期：1980-04-01 00:00:00

abstract：:Fish and shellfish caught in polluted waters contain potentially dangerous amounts of toxic and carcinogenic chemicals. Public concern was heightened when a large percentage of winter flounder taken from Boston Harbor was found to have visible cancer of the liver; winter flounder outside the estuary area had no liver ...

journal_title：Environmental health perspectives

authors： Huff J,Bucher J,Yang R

更新日期：1991-01-01 00:00:00

abstract：:The clinical use of polymeric materials in the body to repair and restore damaged or diseased tissues and organs is substantially increasing on an annual basis. Concomitant with this use is an increase in materials related research on medically used polymers. Information on the historical and current clinical use of p...

journal_title：Environmental health perspectives

authors： King RN,Lyman DJ

更新日期：1975-06-01 00:00:00

abstract：:This article provides an overview of the problem of genetic susceptibility to childhood cancer with a particular emphasis on problems with ascertaining inherited cancer risk and the role of tumor-suppressor gene mutations in cancer predispositions. The association between neurofibromatosis type 1 and childhood leukemi...

journal_title：Environmental health perspectives

authors： Shannon K

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Previous studies have suggested an effect of high arsenic concentration on cognitive and neurobehavioral function in humans. OBJECTIVE:Our goal was to identify demographic and nutritional factors that are associated with As exposure and the influence of this exposure on cognitive function in school-age chil...

journal_title：Environmental health perspectives

authors： Rosado JL,Ronquillo D,Kordas K,Rojas O,Alatorre J,Lopez P,Garcia-Vargas G,Del Carmen Caamaño M,Cebrián ME,Stoltzfus RJ

更新日期：2007-09-01 00:00:00

abstract：:The steroids trenbolone acetate (TbA) and melengestrol acetate (MGA) are licensed as growth promoters for farm animals in several meat-exporting countries. Although many studies have explored their safety for both animals and consumers, little is known about their fate after excretion by the animal. Our study aimed to...

journal_title：Environmental health perspectives

authors： Schiffer B,Daxenberger A,Meyer K,Meyer HH

更新日期：2001-11-01 00:00:00

abstract：:Low-dose extrapolation model selection for evaluating the health effects of environmental pollutants is a key component of the risk assessment process. At a workshop held in Baltimore, Maryland, on 23-24 April 2007, sponsored by U.S. Environmental Protection Agency and Johns Hopkins Risk Sciences and Public Policy Ins...

journal_title：Environmental health perspectives

authors： White RH,Cote I,Zeise L,Fox M,Dominici F,Burke TA,White PD,Hattis DB,Samet JM

更新日期：2009-02-01 00:00:00

abstract：:Soil ingestion estimates play an important role in risk assessment of contaminated sites, and estimates of soil ingestion in children are of special interest. Current estimates of soil ingestion are trace-element specific and vary widely among elements. Although expressed as daily estimates, the actual estimates have ...

journal_title：Environmental health perspectives

authors： Stanek EJ 3rd,Calabrese EJ

更新日期：1995-03-01 00:00:00

abstract：BACKGROUND:Particulate matter (PM) in outdoor air pollution was recently designated a Group I carcinogen by the International Agency for Research on Cancer (IARC). This determination was based on the evidence regarding the relationship of PM2.5 and PM10 to lung cancer risk; however, the IARC evaluation did not include ...

journal_title：Environmental health perspectives

authors： Hamra GB,Guha N,Cohen A,Laden F,Raaschou-Nielsen O,Samet JM,Vineis P,Forastiere F,Saldiva P,Yorifuji T,Loomis D

更新日期：2014-09-01 00:00:00

abstract：:Gene expression is a unique way of characterizing how cells and organisms adapt to changes in the external environment. The measurements of gene expression levels upon exposure to a chemical can be used both to provide information about the mechanism of action of the toxicant and to form a sort of "genetic signature" ...

journal_title：Environmental health perspectives

authors： Lettieri T

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Preterm birth (PTB), a leading cause of infant mortality and morbidity, has a complex etiology with a multitude of interacting causes and risk factors. The role of environmental contaminants, particularly bisphenol A (BPA), is understudied with regard to PTB. OBJECTIVES:In the present study we examined the ...

journal_title：Environmental health perspectives

authors： Cantonwine DE,Ferguson KK,Mukherjee B,McElrath TF,Meeker JD

更新日期：2015-09-01 00:00:00

abstract：:For decades, a number of guinea pig tests have been used to identify human contact allergens in workplace and consumer products, but these tests have limitations. In addition to using large numbers of test animals, they also provide only subjective measurements, because the allergic activity is measured by watching th...

journal_title：Environmental health perspectives

authors： Clay R

更新日期：1998-10-01 00:00:00

abstract：:The 11 September 2001 terrorist attack on New York City's World Trade Center (WTC) caused an unprecedented environmental emergency. The collapse of the towers sent a tremendous cloud of crushed building materials and other pollutants into the air of lower Manhattan. In response to the calamity, federal, state, and cit...

journal_title：Environmental health perspectives

authors： Gavett SH

更新日期：2003-06-01 00:00:00

abstract：:The N-oxidation of carcinogenic arylamines to form N-hydroxy arylamines has long been regarded as a necessary metabolic step for conversion to proximate carcinogenic derivatives. In contrast, arylamine ring-oxidation has been generally considered to be an important detoxification mechanism. Both enzymatic reactions ar...

journal_title：Environmental health perspectives

authors： Kadlubar FF,Fu PP,Jung H,Shaikh AU,Beland FA

更新日期：1990-07-01 00:00:00

abstract：:Human milk is a repository for certain classes of long-lived, fat-soluble environmental contaminant chemicals. Some members of this class, such as the chlorinated pesticides and the chlorinated biphenyls, can be expected to be present at chemical waste disposal sites. Analysis of samples of breast milk obtained from w...

journal_title：Environmental health perspectives

authors： Rogan W,Gladen B

更新日期：1983-02-01 00:00:00

abstract：:Germ-line mutations of the mouse have for years comprised one class of biological markers for mammalian reproductive and developmental toxicology. Understanding the molecular nature of mutations and the mechanisms by which mutations are translated into specific (and often complex) phenotypes, however, still looms as a...

journal_title：Environmental health perspectives

authors： Rinchik EM

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND:Exposure to air pollution has been associated with higher C-reactive protein (CRP) levels, suggesting an inflammatory response. Not much is known about this association in pregnancy. OBJECTIVES:We investigated the associations of air pollution exposure during pregnancy with maternal and fetal CRP levels in ...

journal_title：Environmental health perspectives

authors： van den Hooven EH,de Kluizenaar Y,Pierik FH,Hofman A,van Ratingen SW,Zandveld PY,Lindemans J,Russcher H,Steegers EA,Miedema HM,Jaddoe VW

更新日期：2012-05-01 00:00:00

abstract：:Serious problems emerge when evaluating evidence on lead neurotoxicity in children. The extent of these problems and ways to control them were explored in a study of 1291 children from the first class in the schools of Aarhus municipality, Denmark. The lead retention in circumpulpal dentin in shed deciduous teeth was ...

journal_title：Environmental health perspectives

authors： Grandjean P,Lyngbye T,Hansen ON

更新日期：1991-08-01 00:00:00

abstract：:Environmental chemicals that function as estrogens have been suggested to be associated with an increase in disease and dysfunctions in animals and humans. To characterize chemicals that may act as estrogens in humans, we have compared three in vitro assays which measure aspects of human estrogen receptor (hER)-mediat...

journal_title：Environmental health perspectives

authors： Klotz DM,Beckman BS,Hill SM,McLachlan JA,Walters MR,Arnold SF

更新日期：1996-10-01 00:00:00

abstract：BACKGROUND:Dozens of studies link acute exposure to particulate matter (PM) air pollution with premature mortality and morbidity, but questions remain about which species and sources in the vast PM mixture are responsible for the observed health effects. Although a few studies exist on the effects of species and source...

journal_title：Environmental health perspectives

authors： Ostro B,Tobias A,Querol X,Alastuey A,Amato F,Pey J,Pérez N,Sunyer J

更新日期：2011-12-01 00:00:00

abstract：:The activities of plants and plant/microbial associations may offer a viable means of accomplishing the in situ remediation of contaminated soils. Two uses of plants for phytoremediation are reported here. In one set of studies, the ability of plants to foster degradative microorganisms was investigated. Results indic...

journal_title：Environmental health perspectives

authors： Shann JR

更新日期：1995-06-01 00:00:00

abstract：:During a 2-year chronic inhalation study on methylene chloride (2000 or 0 ppm; 6 hr/day, 5 days/week), gas-uptake pharmacokinetic studies and tissue partition coefficient determinations were conducted on female B6C3F1, mice after 1 day, 1 month, 1 year, and 2 years of exposure. Using physiologically based pharmacokine...

journal_title：Environmental health perspectives

authors： Thomas RS,Yang RS,Morgan DG,Moorman MP,Kermani HR,Sloane RA,O'Connor RW,Adkins B Jr,Gargas ML,Andersen ME

更新日期：1996-08-01 00:00:00

abstract：:A review and summary is given of analytical, biochemical, and immunological studies made following an immunodiagnostic investigation which revealed significant decreases in the numbers, and changes in the functional integrity, of both T-and B-lymphocytes in a group of Michigan dairy farmers exposed to polybrominated b...

journal_title：Environmental health perspectives

authors： Roboz J,Greaves J,Bekesi JG

更新日期：1985-05-01 00:00:00

abstract：BACKGROUND:Mercury is a pervasive environmental pollutant whose toxic effects have not been studied in sea turtles in spite of their threatened status and evidence of immunosuppression in diseased populations. OBJECTIVES:In the present study we investigate mercury toxicity in loggerhead sea turtles (Caretta caretta) b...

journal_title：Environmental health perspectives

authors： Day RD,Segars AL,Arendt MD,Lee AM,Peden-Adams MM

更新日期：2007-10-01 00:00:00

abstract：:High-performance liquid chromatography (HPLC) methods are described which permit the rapid isolation of multiple target macromolecules from the tissues of animals exposed to chemical mutagens. DNA and selected chromosomal proteins are isolated in a simple two step separation scheme. Isolated nuclei are dissolved in 3 ...

journal_title：Environmental health perspectives

authors： Balhorn R,Mazrimas JA,Corzett M

更新日期：1985-10-01 00:00:00

abstract：:Fluorescence in situ hybridization with chromosome-specific composite DNA probes (chromosome painting) is a reliable and efficient method for detecting structural chromosome aberrations. Painting is now being used to quantify chromosome damage in many human populations. In one such study we evaluated 91 unexposed peop...

journal_title：Environmental health perspectives

authors： Tucker JD,Moore DH 2nd

更新日期：1996-05-01 00:00:00

abstract：BACKGROUND:Childhood lead exposure has been associated with growth delay. However, the association between blood lead levels (BLLs) and insulin-like growth factor 1 (IGF-1) has not been characterized in a large cohort with low-level lead exposure. METHODS:We recruited 394 boys 8-9 years of age from an industrial Russi...

journal_title：Environmental health perspectives

authors： Fleisch AF,Burns JS,Williams PL,Lee MM,Sergeyev O,Korrick SA,Hauser R

更新日期：2013-07-01 00:00:00

abstract：:[35S]t-Butylbicyclophosphorothionate or [35S]TBPS is an improved radioligand for the picrotoxinin binding site in rat brain synaptic membranes. The toxic isomers of the hexachlorocyclohexanes, polychlorobornanes, and chlorinated cyclodienes displace [35S]TBPS with a stereospecificity and potency generally correlated w...

journal_title：Environmental health perspectives

authors： Casida JE,Lawrence LJ

更新日期：1985-09-01 00:00:00

abstract：:Environmental pollution with the nephrotoxic metal cadmium is considered a potential health risk for the general population. In 1976 it was reported that the cadmium concentration in human kidney cortex in Sweden had increased in parallel with increasing levels in soil and grain during the twentieth century. Since the...

journal_title：Environmental health perspectives

authors： Friis L,Petersson L,Edling C

更新日期：1998-04-01 00:00:00