当前位置： SCI文献检索 > TOXICOLOGY AND APPLIED PHARMACOLOGY期刊下所有文献 > Role of surfactant protein-A (SP-A) in lung injury in response to acute ozone exposure of SP-A deficient mice.

Role of surfactant protein-A (SP-A) in lung injury in response to acute ozone exposure of SP-A deficient mice.

Abstract：

:Millions are exposed to ozone levels above recommended limits, impairing lung function, causing epithelial damage and inflammation, and predisposing some individuals to pneumonia, asthma, and other lung conditions. Surfactant protein-A (SP-A) plays a role in host defense, the regulation of inflammation, and repair of tissue damage. We tested the hypothesis that the lungs of SP-A(-/-) (KO) mice are more susceptible to ozone-induced damage. We compared the effects of ozone on KO and wild type (WT) mice on the C57BL/6 genetic background by exposing them to 2 parts/million of ozone for 3 or 6 h and sacrificing them 0, 4, and 24 h later. Lungs were subject to bronchoalveolar lavage (BAL) or used to measure endpoints of oxidative stress and inflammation. Despite more total protein in BAL of KO mice after a 3 h ozone exposure, WT mice had increased oxidation of protein and had oxidized SP-A dimers. In KO mice there was epithelial damage as assessed by increased LDH activity and there was increased phospholipid content. In WT mice there were more BAL PMNs and elevated macrophage inflammatory protein (MIP)-2 and monocyte chemoattractant protein (MCP)-1. Changes in MIP-2 and MCP-1 were observed in both KO and WT, however mRNA levels differed. In KO mice MIP-2 mRNA levels changed little with ozone, but in WT levels they were significantly increased. In summary, several aspects of the inflammatory response differ between WT and KO mice. These in vivo findings appear to implicate SP-A in regulating inflammation and limiting epithelial damage in response to ozone exposure.

journal_name

Toxicol Appl Pharmacol

journal_title

Toxicology and applied pharmacology

authors

Haque R,Umstead TM,Ponnuru P,Guo X,Hawgood S,Phelps DS,Floros J

doi

10.1016/j.taap.2006.12.017

subject

Has Abstract

pub_date

2007-04-01 00:00:00

pages

72-82

issue

1

eissn

0041-008X

issn

1096-0333

pii

S0041-008X(06)00469-8

journal_volume

220

pub_type

杂志文章

相关文献

TOXICOLOGY AND APPLIED PHARMACOLOGY文献大全
  • Protective effect of beta-naphthoflavone against NO2 toxicity in mice with genetically inducible lung cytochrome P450.

    abstract：:The effects of the cytochrome P450 inducer beta-naphthoflavone (BNF) on NO2 toxicity were studied in two strains of mice. In one strain (C57B1/6J), cytochrome P450 could be induced by the aromatic hydrocarbon, while in the other strain (DBA/2J) cytochrome P450 was not inducible by this compound. Mice were treated with...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(88)90122-6

    authors： Azoulay-Dupuis E,Mansour H,Moreau J,Lachia L

    更新日期：1988-04-01 00:00:00

  • Comparative potency approach based on H2AX assay for estimating the genotoxicity of polycyclic aromatic hydrocarbons.

    abstract：:Polycyclic Aromatic Hydrocarbons (PAHs) constitute a family of over one hundred compounds and can generally be found in complex mixtures. PAHs metabolites cause DNA damage which can lead to the development of carcinogenesis. Toxicity assessment of PAH complex mixtures is currently expressed in terms of toxic equivalen...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2012.01.022

    authors： Audebert M,Zeman F,Beaudoin R,Péry A,Cravedi JP

    更新日期：2012-04-01 00:00:00

  • Impaired regulation of surfactant phospholipid metabolism in the isolated rat lung after nitrogen dioxide inhalation.

    abstract：:Various drugs have been shown to stimulate surfactant phospholipid metabolism. Particularly beta-adrenergic agonists play an important role under physiologic conditions. For the first time we have studied whether nitrogen dioxide (NO2) inhalation alters beta-adrenergic regulation of surfactant phospholipid metabolism ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1993.1105

    authors： Mengel RG,Bernhard W,Barth P,von Wichert P,Müller B

    更新日期：1993-06-01 00:00:00

  • Time- and concentration-dependent genomic responses of the rat airway to inhaled nickel subsulfide.

    abstract：OBJECTIVE:To provide insights into the mode of action for Ni3S2 lung carcinogenicity by examining gene expression changes in target cells after inhalation exposure. METHODS:Gene expression changes were determined in micro-dissected lung broncho-alveolar cells from Fischer 344 rats following inhalation of Ni3S2 at 0.0,...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2014.06.007

    authors： Efremenko AY,Campbell JL Jr,Dodd DE,Oller AR,Clewell HJ 3rd

    更新日期：2014-09-15 00:00:00

  • Distribution, teratogenicity, and embryonic delivered dose of retinoid Ro 23-9223.

    abstract：:Ro 23-9223 is a highly lipophilic aromatic retinoid with antiproliferative and sebum supressive effects in preclinical disease models of acne. To investigate the relation between Ro 23-9223 developmental toxicity, drug distribution, and transplacental transfer, groups of pregnant hamsters were given oral doses of 50-5...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1999.8866

    authors： Willhite CC,Lovey A,Eckhoff C

    更新日期：2000-04-15 00:00:00

  • Glycyrrhetinic acid attenuates lipopolysaccharide-induced fulminant hepatic failure in d-galactosamine-sensitized mice by up-regulating expression of interleukin-1 receptor-associated kinase-M.

    abstract：:Glycyrrhetinic acid (GA), the main active ingredient of licorice, reportedly has anti-inflammatory and hepatoprotective properties, but its molecular mechanisms remain be elusive. In the present study, Balb/c mice were pretreated with GA (10, 30, or 100mg/kg) 1h before lipopolysaccharide (LPS)/d-galactosamine (D-GalN)...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2017.02.011

    authors： Yin X,Gong X,Zhang L,Jiang R,Kuang G,Wang B,Chen X,Wan J

    更新日期：2017-04-01 00:00:00

  • Reversal of advanced colchicine toxicity in mice with goat colchicine-specific antibodies.

    abstract：:Colchicine-specific antibody (IgG(C] was tested in mice for reversal of colchicine toxicity. The mouse model was chosen because it reflects human pathophysiology in colchicine poisoning. IgG(C) was administered when at least 85% of colchicine was distributed in tissues. It resulted in a dramatic decrease in lethality ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(90)90172-q

    authors： Terrien N,Urtizberea M,Scherrmann JM

    更新日期：1990-07-01 00:00:00

  • Sex-specific modulation of hepatic covalent DNA modifications (I-compounds) by the cytochrome P450 inducer, pregnenolone-16 alpha-carbonitrile.

    abstract：:I-compounds are recently discovered, age-dependent covalent DNA modifications, which are detectable by 32P-postlabeling assay for DNA adducts. The effects of the catatoxic antiglucocorticoid, pregnenolone-16 alpha-carbonitrile (PCN), on hepatic and renal I-compound levels have been studied in male and female Sprague-D...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(92)90117-b

    authors： Moorthy B,van Golen KL,Randerath K

    更新日期：1992-04-01 00:00:00

  • Benzoquinone inhibits the voltage-dependent induction of the mitochondrial permeability transition caused by redox-cycling naphthoquinones.

    abstract：:The mitochondrial permeability pore is subject to regulation by a thiol-dependent voltage sensor (Petronilli, V., Costantini, P., Scorrano, L., Colonna, R., Passamonti, S., and Bernardi, P., J. Biol. Chem. 269, 16638-16642, 1994); thiol oxidation increases the gating potential, which increases the probability of pore ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1996.8099

    authors： Palmeira CM,Wallace KB

    更新日期：1997-04-01 00:00:00

  • Combining an in silico proarrhythmic risk assay with a tPKPD model to predict QTc interval prolongation in the anesthetized guinea pig assay.

    abstract：:Human-based in silico models are emerging as important tools to study the effects of integrating inward and outward ion channel currents to predict clinical proarrhythmic risk. The aims of this study were 2-fold: 1) Evaluate the capacity of an in silico model to predict QTc interval prolongation in the in vivo anesthe...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2020.114883

    authors： Morissette P,Polak S,Chain A,Zhai J,Imredy JP,Wildey MJ,Travis J,Fitzgerald K,Fanelli P,Passini E,Rodriguez B,Sannajust F,Regan C

    更新日期：2020-03-01 00:00:00

  • In vivo distribution of organophosphate antidotes: autoradiography of [14C]HI-6 in the rat.

    abstract：:In order to visualize the distribution of HI-6 in the rat after iv administration, autoradiographic experiments were carried out with [14C]HI-6, labeled at the carbon of the carboxamide moiety. Autoradiography clearly confirms penetration of HI-6 into the central nervous system. Considerable radioactivity was found in...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(88)90392-4

    authors： Ligtenstein DA,Moes GW,Kossen SP

    更新日期：1988-02-01 00:00:00

  • Reaction between metabolically activated acetaminophen and phosphorothioate oligonucleotides.

    abstract：:Assessment of toxic or mutagenic risks associated with phosphorothioate oligonucleotides (PTO) is important. In vitro and in vivo data have shown that PTOs are nontoxic and nonmutagenic. However, these studies do not address interactions between PTOs and other compounds. The sulfur on PTOs may provide a novel reactive...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1995.1126

    authors： Copple BL,Gmeiner WM,Iversen PL

    更新日期：1995-07-01 00:00:00

  • Evaluation of Aroclor 1260 exposure in a mouse model of diet-induced obesity and non-alcoholic fatty liver disease.

    abstract：:Polychlorinated biphenyls (PCBs) are persistent organic pollutants associated with non-alcoholic fatty liver disease (NAFLD) in epidemiologic studies. The purpose of this study was to evaluate the hepatic effects of a PCB mixture, Aroclor 1260, whose composition mimics human bioaccumulation patterns, in a mouse model ...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2014.06.019

    authors： Wahlang B,Song M,Beier JI,Cameron Falkner K,Al-Eryani L,Clair HB,Prough RA,Osborne TS,Malarkey DE,States JC,Cave MC

    更新日期：2014-09-15 00:00:00

  • Suppression of fibroblast cell cycle progression in G1 phase by N-acetylcysteine.

    abstract：:The antioxidant N-acetyl-L-cysteine (NAC) has been increasingly used as an experimental tool to assess involvement of reactive oxygen species in cell signaling and is being evaluated as a preventive and therapeutic agent for cancer and pulmonary diseases related to inflammation and oxidative stress. However, a detaile...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1997.8361

    authors： Sekharam M,Trotti A,Cunnick JM,Wu J

    更新日期：1998-04-01 00:00:00

  • Acute nephropathy induced by gold sodium thiomalate: alterations in renal heme metabolism and morphology.

    abstract：:Gold compounds are used clinically in rheumatoid arthritis therapy. Acute renal toxicity is observed in some patients receiving chrysotherapy. The present study addresses morphofunctional and biochemical changes in rat kidneys during the first 8 days following a single ip injection of gold sodium thiomalate (AuTM), on...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(87)90100-1

    authors： Eiseman JL,Ribas JL,Knight E,Alvares AP

    更新日期：1987-11-01 00:00:00

  • Gypenoside XLIX, a naturally occurring gynosaponin, PPAR-alpha dependently inhibits LPS-induced tissue factor expression and activity in human THP-1 monocytic cells.

    abstract：:Tissue factor (TF) is involved not only in the progression of atherosclerosis and other cardiovascular diseases, but is also associated with tumor growth, metastasis, and angiogenesis and hence may be an attractive target for directed cancer therapeutics. Gynostemma pentaphyllum (GP) is widely used in the treatment of...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2006.10.013

    authors： Huang TH,Tran VH,Roufogalis BD,Li Y

    更新日期：2007-01-01 00:00:00

  • Correlation of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced apoptotic cell death in the embryonic vasculature with embryotoxicity.

    abstract：:Vertebrate embryos are particularly sensitive to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Identification of tissues that are susceptible to the adverse effects of TCDD is requisite for understanding the embryo toxic effects of TCDD. The objective of the present study was to quantitate the temporal appearance of and...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1997.8309

    authors： Cantrell SM,Joy-Schlezinger J,Stegeman JJ,Tillitt DE,Hannink M

    更新日期：1998-01-01 00:00:00

  • Physiologically based pharmacokinetic toolkit to evaluate environmental exposures: Applications of the dioxin model to study real life exposures.

    abstract：:Chlorinated dibenzo-p-dioxins (CDDs) are a series of mono- to octa-chlorinated homologous chemicals commonly referred to as polychlorinated dioxins. One of the most potent, well-known, and persistent member of this family is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). As part of translational research to make computer...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2016.12.007

    authors： Emond C,Ruiz P,Mumtaz M

    更新日期：2017-01-15 00:00:00

  • Protective role of dietary butylated hydroxyanisole against chemical-induced acute liver damage in mice.

    abstract：:Prior consumption of a diet containing the food antioxidant, butylated hydroxyanisole (BHA), by female mice prevented the development of or minimized the acute liver damage caused by monocrotaline, acetaminophen, or bromobenzene. In contrast, neither the incidence nor the severity of carbon tetrachloride-induced hepat...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(83)90121-7

    authors： Miranda CL,Henderson MC,Schmitz JA,Buhler DR

    更新日期：1983-06-15 00:00:00

  • Cyclooxygenase-2 mediates interleukin-6 upregulation by vomitoxin (deoxynivalenol) in vitro and in vivo.

    abstract：:Interleukin-6 (IL-6) is a central mediator of immunotoxicity that is associated with exposure to the trichothecene vomitoxin (VT). The purpose of this investigation was to test the hypothesis that the inducible cyclooxygenase-2 (COX-2) and its metabolites contribute to VT-induced IL-6 upregulation. VT at 100 to 250 ng...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/s0041-008x(02)00033-9

    authors： Moon Y,Pestka JJ

    更新日期：2003-03-01 00:00:00

  • Environmental hormone disruptors: evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites.

    abstract：:Recent studies with vinclozolin, a dicarboximide fungicide, demonstrate that perinatal exposure to 100 mg vinclozolin/kg/day from Gestational Day 14 through Postnatal Day 3 inhibits morphological sex differentiation. At 1 year, treated male rats exhibited hypospadias, cleft phallus, suprainguinal ectopic testes, a vag...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1994.1117

    authors： Kelce WR,Monosson E,Gamcsik MP,Laws SC,Gray LE Jr

    更新日期：1994-06-01 00:00:00

  • Human and experimental studies on renal eicosanoid response to long-term cadmium exposure.

    abstract：:In order to assess the effects of long-term exposure to cadmium (Cd) on the renal metabolism of eicosanoids, the urinary excretion of 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), prostaglandin E2 (PGE2), prostaglandin F2 alpha (PGF2 alpha), and thromboxane B2 (TXB2) was determined in 37 workers exposed to Cd and...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(92)90294-3

    authors： Cárdenas A,Ramis I,Hotter G,Roselló J,Gelpí E,Roels H,Bernard A,Lauwerys R

    更新日期：1992-10-01 00:00:00

  • Human exposure to bisphenol A by biomonitoring: methods, results and assessment of environmental exposures.

    abstract：:Human exposure to bisphenol A is controversially discussed. This review critically assesses methods for biomonitoring of bisphenol A exposures and reported concentrations of bisphenol A in blood and urine of non-occupationally ("environmentally") exposed humans. From the many methods published to assess bisphenol A co...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.taap.2007.12.008

    authors： Dekant W,Völkel W

    更新日期：2008-04-01 00:00:00

  • The enhanced value of combining conventional and "omics" analyses in early assessment of drug-induced hepatobiliary injury.

    abstract：:The InnoMed PredTox consortium was formed to evaluate whether conventional preclinical safety assessment can be significantly enhanced by incorporation of molecular profiling ("omics") technologies. In short-term toxicological studies in rats, transcriptomics, proteomics and metabolomics data were collected and analyz...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2010.09.022

    authors： Ellinger-Ziegelbauer H,Adler M,Amberg A,Brandenburg A,Callanan JJ,Connor S,Fountoulakis M,Gmuender H,Gruhler A,Hewitt P,Hodson M,Matheis KA,McCarthy D,Raschke M,Riefke B,Schmitt CS,Sieber M,Sposny A,Suter L,Sweatman

    更新日期：2011-04-15 00:00:00

  • Regulation of UDP glucuronosyltransferases in the gastrointestinal tract.

    abstract：:The UDP glucuronosyltransferases (UGT) of the gastrointestinal (GI) tract have a crucial role in protection against the toxic effects of lipophilic chemicals in the environment. UGTs such as UGT1A7, UGT1A8, and UGT1A10 are exclusively expressed in gastrointestinal tissues, each with a unique tissue distribution patter...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章,评审

    doi：10.1016/j.taap.2004.01.008

    authors： Gregory PA,Lewinsky RH,Gardner-Stephen DA,Mackenzie PI

    更新日期：2004-09-15 00:00:00

  • Fluoride-induced changes in renal papillary cyclic-AMP.

    abstract：:Studies were conducted which examined urinary excretion and papillary production of cyclic-AMP in the rat following vasopressin (ADH) stimulation in the presence or absence of inorganic fluoride ion (F). In one set of experiments, six anesthetized Fischer 344 rats were administered 5 munits arginine vasopressin during...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/0041-008x(83)90129-1

    authors： Maxwell JA,Caffrey JL,Yorio T,Sinclair RJ

    更新日期：1983-06-15 00:00:00

  • Reduced cytochrome P4501A activity and recovery from oxidative stress during subchronic benzo[a]pyrene and benzo[e]pyrene treatment of rainbow trout.

    abstract：:This study assessed the role of aryl hydrocarbon receptor (AHR) affinity, and cytochrome P4501A (CYP1A) protein and activity in polyaromatic hydrocarbon (PAH)-induced oxidative stress. In the 1-100nM concentration range benzo[a]pyrene (BaP) but not benzo[e]pyrene (BeP) competitively displaced 2nM [(3)H]2, 3, 7, 8-tetr...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2011.04.015

    authors： Curtis LR,Garzon CB,Arkoosh M,Collier T,Myers MS,Buzitis J,Hahn ME

    更新日期：2011-07-01 00:00:00

  • Rat testicular Src: normal distribution and involvement in ethylene glycol monomethyl ether-induced apoptosis.

    abstract：:Kinase activities were previously proposed to be central to germ cell apoptosis induced by ethylene glycol monomethyl ether (EGME) and its active metabolite methoxyacetic acid (MAA). We evaluated the role of tyrosine kinase pp60(c-src) in control and EGME-treated adult rat testis in vivo, as well as in vitro using cul...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1006/taap.1999.8870

    authors： Wang W,Wine RN,Chapin RE

    更新日期：2000-03-01 00:00:00

  • Reducing the antigen-independent toxicity of antibody-drug conjugates by minimizing their non-specific clearance through PEGylation.

    abstract：:Recently, we described a family of non-targeting monomethylauristatin E (MMAE) antibody-drug conjugates (ADCs) whose pharmacokinetics could be tuned through incorporation of a short polyethylene glycol (PEG) moiety of up to twelve units into a drug-linker to render the ADC surface more hydrophilic. That work demonstra...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章

    doi：10.1016/j.taap.2020.114932

    authors： Simmons JK,Burke PJ,Cochran JH,Pittman PG,Lyon RP

    更新日期：2020-04-01 00:00:00

  • Modulation of T-helper cell populations: potential mechanisms of respiratory hypersensitivity and immune suppression.

    abstract：:Information presented at this symposium indicates that modulation of Th cell responses is one means by which xenobiotics may cause immunotoxicity. A shift from Th1 to Th2 responses can enhance both infectious and allergic disease. Hence, in some cases, a common mechanism may be responsible for effects that are general...

    journal_title：Toxicology and applied pharmacology

    pub_type： 杂志文章,评审

    doi：10.1006/taap.1997.8142

    authors： Selgrade MK,Lawrence DA,Ullrich SE,Gilmour MI,Schuyler MR,Kimber I

    更新日期：1997-07-01 00:00:00