Reversal of advanced colchicine toxicity in mice with goat colchicine-specific antibodies.

abstract：:Aromatase inhibitors like anastrozole play an undisputed key role in the treatment of breast cancer, but on the other hand, various side effects like osteoporosis and increased risk of bone fracture accompany the chronic administration of these drugs. Here we show for the first time that selenium nanoparticles, when g...

journal_title：Toxicology and applied pharmacology

authors： Vekariya KK,Kaur J,Tikoo K

更新日期：2013-04-15 00:00:00

abstract：:This study was conducted to evaluate UDP-glucuronosyl-transferase (UDP-GT) activity, UDP-glucuronic acid (UDP-GA) concentration, and UDP-glucose (UDPG) concentration in the rat intestine and liver following oral administration of butylated hydroxyanisole (BHA), benzo[a]pyrene (BaP), 3-methylcholanthrene (3MC), phenoba...

journal_title：Toxicology and applied pharmacology

authors： Goon D,Klaassen CD

更新日期：1992-08-01 00:00:00

abstract：:Biodistribution of cocaine in female rats before and after delivery of litters was studied in order to provide an explanation for the observed differences in cocaine-induced toxicity in pregnant and postpartum rats. Cocaine (20 mg/kg, ip) given to female rats at 16 days of gestation or 20 days of gestation did not hav...

journal_title：Toxicology and applied pharmacology

authors： Dwivedi C,Engineer FN,Vaughan SL

更新日期：1993-01-01 00:00:00

abstract：:Lead (Pb) depresses growth in infants and young children. Our earlier studies using a weanling rat model of Pb exposure suggest that this Pb effect is due to depression of appetite. In the present study we examined whether this depression of appetite is consistent with a down-regulation of the appetite "set point" as ...

journal_title：Toxicology and applied pharmacology

authors： Hammond PB,Minnema DJ,Shulka R

更新日期：1990-10-01 00:00:00

abstract：:Nodularin is a natural toxin with multiple features, including inhibitor of protein phosphatases 1 and 2A as well as tumor initiator and promoter. One unique feature of nodularin is that this chemical is a hepatotoxin. It can accumulate into the liver after contact and lead to severe damage to hepatocyte, such as apop...

journal_title：Toxicology and applied pharmacology

authors： Feng G,Li Y,Bai Y

更新日期：2011-03-15 00:00:00

abstract：:Drinking water contaminated with arsenic, a human carcinogen, is a worldwide health issue. An understanding of cellular signaling events in response to arsenic exposure and rational designing of strategies to reduce arsenic damages by modulating signaling events are important to fight against arsenic-induced diseases....

journal_title：Toxicology and applied pharmacology

authors： Wang XJ,Sun Z,Chen W,Li Y,Villeneuve NF,Zhang DD

更新日期：2008-08-01 00:00:00

abstract：:Combretastatin A-4 (CA-4) has already entered clinical trials of solid tumors over ten years. However, the limited anticancer activity and dose-dependent toxicity restrict its clinical application. Here, we offered convincing evidence that CA-4 induced autophagy in various cancer cells, which was demonstrated by acrid...

journal_title：Toxicology and applied pharmacology

authors： Li Y,Luo P,Wang J,Dai J,Yang X,Wu H,Yang B,He Q

更新日期：2014-01-15 00:00:00

abstract：:Homocysteine is increased during pathological conditions, endangering vascular and cognitive functions, and elevated homocysteine during pregnancy may be correlated with an increased incidence of schizophrenia in the offspring. This study showed that millimolar homocysteine concentrations in saline medium cause phosph...

journal_title：Toxicology and applied pharmacology

authors： Gu L,Hu X,Xue Z,Yang J,Wan L,Ren Y,Hertz L,Peng L

更新日期：2010-01-15 00:00:00

abstract：:While the physiologic and molecular effects of capsaicinoids have been extensively studied in various model systems by a variety of administration routes, little is known about the uptake and elimination kinetic profiles in human skin following topical exposure. The present study evaluated the uptake and elimination k...

journal_title：Toxicology and applied pharmacology

authors： Pershing LK,Reilly CA,Corlett JL,Crouch DJ

更新日期：2004-10-01 00:00:00

abstract：:Nickel (Ni) carcinogenesis is thought to involve gene chip silencing by epigenetic mechanisms. Serpina3g, a member of the mouse serpin family, was among the most down-regulated genes (32-fold) in response to Ni exposure of mouse cells based on the Affymetrix gene chip. Serpina3g down-regulation was controlled by a hyp...

journal_title：Toxicology and applied pharmacology

authors： Zhao J,Yan Y,Salnikow K,Kluz T,Costa M

更新日期：2004-01-01 00:00:00

abstract：:The hypothesis that 7,12-dimethyl-benz[a]anthracene (DMBA) suppresses immune function in mice via an inhibition of lymphocyte activation was examined in these studies. Daily exposure of B6C3F1 mice to DMBA (cumulative doses of 1.4 to 140 mg/kg) via the oral route for 14 days was found to inhibit phytohemagglutinin (PH...

journal_title：Toxicology and applied pharmacology

authors： Burchiel SW,Davis DA,Gomez MP,Montano RM,Barton SL,Seamer LC

更新日期：1990-09-15 00:00:00

abstract：:Purified fetal bovine serum acetylcholinesterase (FBS AChE) and horse serum butyrylcholinesterase (BChE) were successfully used as single pretreatment drugs for the prevention of pinacolyl methylphosphonofluoridate (soman) toxicity in nonhuman primates. Eight rhesus monkeys, trained to perform Primate Equilibrium Plat...

journal_title：Toxicology and applied pharmacology

authors： Wolfe AD,Blick DW,Murphy MR,Miller SA,Gentry MK,Hartgraves SL,Doctor BP

更新日期：1992-12-01 00:00:00

abstract：:Exposure to the potent tumor promoter 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) or related agonists of the aryl hydrocarbon receptor (AhR) can result in hepatocarcinogenesis in rodents. Changes in the expression and/or the level of growth factors may be a critical event in TCDD-mediated hepatocarcinogenesis. In this...

journal_title：Toxicology and applied pharmacology

authors： Riebniger D,Schrenk D

更新日期：1998-09-01 00:00:00

abstract：:Metformin is a first-line drug for the treatment of type 2 diabetes (T2D) and is often prescribed in combination with other drugs to control a patient's blood glucose level and achieve their HbA1c goal. New treatment options for T2D will likely include fixed dose combinations with metformin, which may require preclini...

journal_title：Toxicology and applied pharmacology

authors： Quaile MP,Melich DH,Jordan HL,Nold JB,Chism JP,Polli JW,Smith GA,Rhodes MC

更新日期：2010-03-15 00:00:00

abstract：:Arsenic in drinking water is a worldwide health problem that is associated with cardiovascular disease, but the cause is currently unknown. Arsenic effects on platelets, which are important in development of cardiovascular disease, were examined in vitro and in a drinking water study using a rat animal model. Trivalen...

journal_title：Toxicology and applied pharmacology

authors： Lee MY,Bae ON,Chung SM,Kang KT,Lee JY,Chung JH

更新日期：2002-03-01 00:00:00

abstract：:Several studies have shown that ultrafine particles (UFPs) may pass from the lungs to the circulation because of their very small diameter, and induce lung oxidative stress with a resultant increase in lung epithelial permeability. The direct effects of UFPs on vascular endothelium remain unknown. We hypothesized that...

journal_title：Toxicology and applied pharmacology

authors： Mo Y,Wan R,Chien S,Tollerud DJ,Zhang Q

更新日期：2009-04-15 00:00:00

abstract：:The relative methemoglobin (MetHgb) forming ability of two metabolites of dapsone, dapsone hydroxylamine (DDS-NOH) and monoacetyldapsone hydroxylamine (MADDS-NOH), were compared in rat and human whole blood. Concentration-response curves for the two metabolites were generated in vitro in whole blood. Data were fit to ...

journal_title：Toxicology and applied pharmacology

authors： Vage C,Saab N,Woster PM,Svensson CK

更新日期：1994-12-01 00:00:00

abstract：:The Zrt/Irt-related protein 8 (ZIP8) encoded by slc39a8 is now emerging as an important zinc transporter involved in cellular cadmium incorporation. We have previously shown that mRNA and protein levels of ZIP8 were decreased in cadmium-resistant metallothionein-null (A7) cells, leading to a decrease in cadmium accumu...

journal_title：Toxicology and applied pharmacology

authors： Fujishiro H,Okugaki S,Yasumitsu S,Enomoto S,Himeno S

更新日期：2009-12-01 00:00:00

abstract：:To study the genotoxicity of valepotriates in vitro, the degree of DNA damage in human endothelial cell line ECV304 treated with 5-60 microg/mL of dichloromethane extracts of valerian (DEV) was analyzed by the Comet assay. No DNA damage was observed in ECV304 cells after culture for 48 h in the presence of 5,10, and 2...

journal_title：Toxicology and applied pharmacology

authors： Hui-lian W,Dong-fang Z,Zhao-feng L,Yang L,Qian-rong Li,Yu-zhen W

更新日期：2003-04-01 00:00:00

abstract：:In order to assess the effects of long-term exposure to cadmium (Cd) on the renal metabolism of eicosanoids, the urinary excretion of 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), prostaglandin E2 (PGE2), prostaglandin F2 alpha (PGF2 alpha), and thromboxane B2 (TXB2) was determined in 37 workers exposed to Cd and...

journal_title：Toxicology and applied pharmacology

authors： Cárdenas A,Ramis I,Hotter G,Roselló J,Gelpí E,Roels H,Bernard A,Lauwerys R

更新日期：1992-10-01 00:00:00

abstract：:The anti-HIV drug 3'-azido-3'-deoxythymidine (AZT) is the drug of choice for preventing maternal-fetal HIV transmission during pregnancy. Our aim was to assess the cytotoxic effects of AZT on human placenta in vitro. The mechanisms of AZT-induced effects were investigated using JEG-3 choriocarcinoma cells and primary ...

journal_title：Toxicology and applied pharmacology

authors： Collier AC,Helliwell RJ,Keelan JA,Paxton JW,Mitchell MD,Tingle MD

更新日期：2003-10-15 00:00:00

abstract：:Arsenate (AsV) is a structural analogue of phosphate (P(i)), yet its toxic effect is likely due to its reduction to the more toxic arsenite (AsIII), the mechanism of which is still unclear. Since mitochondria take up AsV as they do P(i), they may reduce AsV to AsIII. To test this hypothesis isolated rat liver mitochon...

journal_title：Toxicology and applied pharmacology

authors： Németi B,Gregus Z

更新日期：2002-08-01 00:00:00

abstract：:The acaricide chlordimeform has been reported to have adverse effects in mammals that may be mediated by an interaction with alpha-adrenergic receptors. Since the hormonal signals involved in the regulation of reproductive function are themselves under hypothalamic adrenergic control, the present study was designed to...

journal_title：Toxicology and applied pharmacology

authors： Goldman JM,Cooper RL,Laws SC,Rehnberg GL,Edwards TL,McElroy WK,Hein JF

更新日期：1990-06-01 00:00:00

abstract：:The dosage-regimen-dependent teratogenicity as well as plasma and tissue levels of the antiepileptic drug valproic acid (VPA) were studied in the mouse by comparing various injection regimens and infusion of the drug via implanted osmotic minipumps. Concentrations of 225-248 micrograms VPA/ml maternal plasma (about 2X...

journal_title：Toxicology and applied pharmacology

authors： Nau H

更新日期：1985-09-15 00:00:00

abstract：:Dimethyl sulfoxide (DMSO) can protect the liver from injury produced by a variety of hepatotoxicants when administered prior to or concomitant with the toxicants. This protective action has previously been attributed to DMSO-induced inhibition of bioactivation of the compounds to toxic intermediates. In these studies,...

journal_title：Toxicology and applied pharmacology

authors： Lind RC,Gandolfi AJ

更新日期：1997-01-01 00:00:00

abstract：:Cigarette smoking, arsenic and occupational exposures are well-known risk factors for the development of urothelial carcinoma (UC). Therefore, the aim of this study is to investigate whether the effect of cigarette smoking, alcohol consumption, arsenic and occupational exposures on risk of UC could be modified by gene...

journal_title：Toxicology and applied pharmacology

authors： Wang YH,Yeh SD,Shen KH,Shen CH,Juang GD,Hsu LI,Chiou HY,Chen CJ

更新日期：2009-11-15 00:00:00

abstract：:The effects of toluene on the sensitivity to seizures induced by aminophylline were investigated. Mice were pretreated with an ip injection of corn oil or toluene (100-500 mg/kg) followed by a timed intravenous infusion of aminophylline at various time intervals to assess the seizure thresholds and lethal doses. Tolue...

journal_title：Toxicology and applied pharmacology

authors： Chan MH,Chen HH

更新日期：2003-12-01 00:00:00

abstract：:Inorganic arsenicals are clearly toxicants and carcinogens in humans. In mammals, including humans, inorganic arsenic often undergoes methylation, forming compounds such as monomethylarsonic acid (MMAs(V)) and dimethylarsinic acid (DMAs(V)). However, much less information is available on the in vitro toxic potential o...

journal_title：Toxicology and applied pharmacology

authors： Sakurai T,Kojima C,Ochiai M,Ohta T,Sakurai MH,Waalkes MP,Fujiwara K

更新日期：2004-03-01 00:00:00

abstract：:Occupational exposure to low molecular weight chemicals, like trimellitic anhydride (TMA), can result in occupational asthma. Alveolar macrophages (AMs) are among the first cells to encounter inhaled compounds. These cells can produce many different mediators that have a putative role in asthma. In this study, we exam...

journal_title：Toxicology and applied pharmacology

authors： Valstar DL,Schijf MA,Nijkamp FP,Storm G,Arts JH,Kuper CF,Bloksma N,Henricks PA

更新日期：2006-02-15 00:00:00

abstract：:Dietary consumption of phytoestrogens like genistein has been linked with lower incidence of prostate cancer. The estradiol-like benzopyran core of genistein confers estrogen receptor-β (ER-β) selectivity that imparts weak anti-proliferative activity against prostate cancer cells. DL-2-[4-(2-piperidinoethoxy)phenyl]-3...

journal_title：Toxicology and applied pharmacology

authors： Kumar R,Verma V,Sharma V,Jain A,Singh V,Sarswat A,Maikhuri JP,Sharma VL,Gupta G

更新日期：2015-03-15 00:00:00