Abstract:
:The interactions between rabbit corneal epithelium and endothelium were investigated in an organ culture model using scanning electron microscopy and correlative light microscopy. Following mechanical removal of corneal endothelium, corneal epithelium was observed to migrate across the cut surface of the corneal stroma and onto the denuded Descemet's membrane after 48 hours in organ culture. By 72 hours, a distinct line of contact between the migrated epithelium and endothelium was established. Following epithelial-endothelial contact, no cellular migration occurred. Corneal endothelial inhibition of epithelial migration may be a major factor in the prevention of surface epithelial invasion and proliferation following surgery and trauma.
journal_name
Ophthalmologyjournal_title
Ophthalmologyauthors
Sassani JW,John T,Cameron JD,Yanoff M,Eagle RC Jrdoi
10.1016/s0161-6420(84)34250-6subject
Has Abstractpub_date
1984-06-01 00:00:00pages
553-7issue
6eissn
0161-6420issn
1549-4713pii
S0161-6420(84)34250-6journal_volume
91pub_type
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