Abnormal T-cell subpopulation function in CLL: excessive suppressor (T gamma) and deficient helper (T mu) activity with respect to B-cell proliferation.

abstract：:Mutations in the SH2D1A gene have been described in most patients with the clinical syndrome of X-linked lymphoproliferative disease (XLP). The diagnosis of XLP is still difficult given its clinical heterogeneity and the lack of a readily available rapid diagnostic laboratory test, particularly in patients without a f...

journal_title：Blood

authors： Tabata Y,Villanueva J,Lee SM,Zhang K,Kanegane H,Miyawaki T,Sumegi J,Filipovich AH

更新日期：2005-04-15 00:00:00

abstract：:Recent advances in molecular biology have led to the identification of hematopoietic growth factors that support and influence the proliferation of hematopoietic progenitor cells in vitro and in vivo. Although these factors have been extensively studied, little is known of their role in the regulation of cell-cycling ...

journal_title：Blood

authors： Tanaka R,Katayama N,Ohishi K,Mahmud N,Itoh R,Tanaka Y,Komada Y,Minami N,Sakurai M,Shirakawa S

更新日期：1995-07-01 00:00:00

abstract：:The translocation t(8;14)(q24;q32) is the characteristic chromosomal aberration of Burkitt's-type lymphomas and leukemias (BLs). On the molecular level, the t(8;14) juxtaposes the c-myc gene in 8q24 next to the IgH locus in 14q32, resulting in overexpression of the transcription factor c-Myc. The detection of a t(8;14...

journal_title：Blood

authors： Siebert R,Matthiesen P,Harder S,Zhang Y,Borowski A,Zühlke-Jenisch R,Metzke S,Joos S,Weber-Matthiesen K,Grote W,Schlegelberger B

更新日期：1998-02-01 00:00:00

abstract：:Neonates respond suboptimally to many vaccines. The reasons for this defect are unclear, but suboptimal antigen presentation by dendritic cells has been suggested as one possibility. In this report we describe an in vitro system that allows the generation of large numbers of resting murine neonatal dendritic cells fac...

journal_title：Blood

authors： Kollmann TR,Way SS,Harowicz HL,Hajjar AM,Wilson CB

更新日期：2004-06-01 00:00:00

abstract：:We have shown previously that EM011, a synthetic compound, binds tubulin with a higher affinity than the founding compound, noscapine, without changing total microtubule polymer mass. Now we show that EM011 is potently effective against vinblastine-resistant human lymphoblastoid line CEM/VLB100 and its parental vinbla...

journal_title：Blood

authors： Aneja R,Zhou J,Vangapandu SN,Zhou B,Chandra R,Joshi HC

更新日期：2006-03-15 00:00:00

abstract：:The recruitment of phagocytic leukocytes to sites of vessel wall injury plays an important role in thrombus dissolution by proteases elaborated on their adhesion. However, leukocyte adhesion to the fibrin clot can be detrimental at the early stages of wound healing when hemostatic plug integrity is critical for preven...

journal_title：Blood

authors： Lishko VK,Burke T,Ugarova T

更新日期：2007-02-15 00:00:00

abstract：:The FAS receptor-FAS ligand system is a key apoptotic pathway for cells of the immune system. Ligation of the FAS-receptor (CD95) induces apoptosis by activation of pro-caspase-8 followed by downstream events, including an increase in reactive oxygen species (ROS) and the release of proapoptotic factors from the mitoc...

journal_title：Blood

authors： Perez-Cruz I,Carcamo JM,Golde DW

更新日期：2003-07-01 00:00:00

abstract：:The apparent simultaneous presence of surface markers characteristic of both B and T cells is a phenomenon being described with increasing frequency in patients with chronic lymphocytic leukemia (CLL). We describe a patient with CLL whose B lymphocytes possessed surface immunoglobulin reactive with neuraminidase-treat...

journal_title：Blood

authors： Mills LE,O'Donnell JF,Guyre PM,LeMarbre PJ,Miller JD,Bernier GM

更新日期：1985-02-01 00:00:00

abstract：:In this issue of Blood, Lu et al describe the cooperation between an orally bioavailable mouse double minute 2 (MDM2) antagonist (RG7112) and the pegylated interferon α (Peg-IFNα 2a) to target JAK2V617F hematopoietic progenitors and stem cells. Their work provides a rationale for the treatment of patients suffering fr...

journal_title：Blood

authors： Plo I

更新日期：2014-07-31 00:00:00

abstract：:Identification of a novel therapy for prevention of sudden death by ischemic cardiac infarction is an area of intensive investigation. We here report that the mortality due to an experimental acute myocardial infarction (AMI) was markedly increased in mice deficient in alpha2-antiplasmin (alpha2-AP(-/-) mice) but not ...

journal_title：Blood

authors： Matsuno H,Kozawa O,Yoshimi N,Akamatsu S,Hara A,Mori H,Okada K,Ueshima S,Matsuo O,Uematsu T

更新日期：2002-10-01 00:00:00

abstract：:Epigenetic events that are essential drivers of lymphocyte transformation remain incompletely characterized. We used models of Epstein-Barr virus (EBV)-induced B-cell transformation to document the relevance of protein arginine methyltransferase 5 (PRMT5) to regulation of epigenetic-repressive marks during lymphomagen...

journal_title：Blood

authors： Alinari L,Mahasenan KV,Yan F,Karkhanis V,Chung JH,Smith EM,Quinion C,Smith PL,Kim L,Patton JT,Lapalombella R,Yu B,Wu Y,Roy S,De Leo A,Pileri S,Agostinelli C,Ayers L,Bradner JE,Chen-Kiang S,Elemento O,Motiwala T

更新日期：2015-04-16 00:00:00

abstract：:Immune function has been restored in 9 of 10 children with X-linked severe combined immunodeficiency by gamma c gene transfer in CD34+ cells. The distribution of both T-cell receptor (TCR) V beta family usage and TCR V beta complementarity-determining region 3 (CDR3) length revealed a broadly diversified T-cell repert...

journal_title：Blood

authors： Schmidt M,Hacein-Bey-Abina S,Wissler M,Carlier F,Lim A,Prinz C,Glimm H,Andre-Schmutz I,Hue C,Garrigue A,Le Deist F,Lagresle C,Fischer A,Cavazzana-Calvo M,von Kalle C

更新日期：2005-04-01 00:00:00

abstract：:Myelofibrosis (MF) is a BCR-ABL1-negative myeloproliferative neoplasm characterized by clonal myeloproliferation, dysregulated kinase signaling, and release of abnormal cytokines. In recent years, important progress has been made in the knowledge of the molecular biology and the prognostic assessment of MF. Convention...

journal_title：Blood

authors： Cervantes F

更新日期：2014-10-23 00:00:00

abstract：:Coagulation factor XIII (FXIII) is the main stabilizer of the fibrin clot. It circulates in plasma as a tetramer of two A-subunits and two B-subunits. Under physiological conditions, FXIII-A exists as a dimer (FXIII-A2). The interactions between the FXIII-A-subunits that stabilize the FXIII-A2 dimer are not fully unde...

journal_title：Blood

authors： Li B,Kohler HP,Schroeder V

更新日期：2020-01-09 00:00:00

abstract：:We evaluated the ability of 2 human mAbs directed against TRAILR1 (HGS-ETR1) and TRAILR2 (HGS-ETR2) to kill human myeloma cells. HGS-ETR1 and HGS-ETR2 mAbs killed 15 and 9 human myeloma cell lines (HMCLs; n = 22), respectively. IL-6, the major survival and growth factor for these HMCLs, did not prevent their killing. ...

journal_title：Blood

authors： Menoret E,Gomez-Bougie P,Geffroy-Luseau A,Daniels S,Moreau P,Le Gouill S,Harousseau JL,Bataille R,Amiot M,Pellat-Deceunynck C

更新日期：2006-08-15 00:00:00

abstract：:Although W/Wv mutant mice are profoundly deficient in tissue mast cells, these mice do have cells with similar features of mast cells that develop from their bone marrow cells as efficiently as those from congenic +/+ mice in pokeweed mitogen-stimulated spleen cell-conditioned medium (PWM-SCM). With cultured mast cell...

journal_title：Blood

authors： Fujita J,Nakayama H,Onoue H,Ebi Y,Kanakura Y,Kuriu A,Kitamura Y

更新日期：1988-08-01 00:00:00

abstract：:Agammaglobulinemia is the most profound primary antibody deficiency that can occur due to an early termination of B-cell development. We here investigated 3 novel patients, including the first known adult, from unrelated families with agammaglobulinemia, recurrent infections, and hypertrophic cardiomyopathy (HCM). Two...

journal_title：Blood

authors： Saettini F,Poli C,Vengoechea J,Bonanomi S,Orellana JC,Fazio G,Rodriguez FH,Noguera LP,Booth CA,Jarur-Chamy V,Shams M,Iascone M,Vukic M,Gasperini S,Quadri M,Barroeta Seijas AB,Rivers E,Mauri M,Badolato R,Cazzaniga G

更新日期：2020-09-09 00:00:00

abstract：:Proteasome inhibition is an effective treatment strategy for multiple myeloma. With improving survival, attention is increasingly focusing on ease of administration and toxicity profile. Ixazomib is an investigational, orally bioavailable 20S proteasome inhibitor. Sixty patients with relapsed and/or refractory multipl...

journal_title：Blood

authors： Kumar SK,Bensinger WI,Zimmerman TM,Reeder CB,Berenson JR,Berg D,Hui AM,Gupta N,Di Bacco A,Yu J,Shou Y,Niesvizky R

更新日期：2014-08-14 00:00:00

abstract：:Burkitt lymphoma (BL) is a highly aggressive B-cell neoplasm harboring chromosomal rearrangements of the c-myc oncogene. BL cells frequently resist apoptosis induction by chemotherapeutic agents; however, the mechanism of unresponsiveness has not been elucidated. Here, we show that cytochrome c fails to stimulate apop...

journal_title：Blood

authors： Sun Y,Orrenius S,Pervaiz S,Fadeel B

更新日期：2005-05-15 00:00:00

abstract：:The combination of imatinib with chemotherapy has been recently reported as very promising in patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL). During 2004 and 2005, 45 patients with newly diagnosed Ph+ ALL were treated in the Group for Research on Adult Acute Lymphoblastic Leuke...

journal_title：Blood

authors： de Labarthe A,Rousselot P,Huguet-Rigal F,Delabesse E,Witz F,Maury S,Réa D,Cayuela JM,Vekemans MC,Reman O,Buzyn A,Pigneux A,Escoffre M,Chalandon Y,MacIntyre E,Lhéritier V,Vernant JP,Thomas X,Ifrah N,Dombret H,Group

更新日期：2007-02-15 00:00:00

abstract：:The bcr-abl chimeric messenger RNA is frequently detected in chronic myeloid leukemia (CML) patients after bone marrow transplantation. It was previously reported that the relapse risk of bcr-abl detection 6 to 12 months after transplantation was greater than 40%. This risk decreased as the time between transplantatio...

journal_title：Blood

authors： Radich JP,Gooley T,Bryant E,Chauncey T,Clift R,Beppu L,Edmands S,Flowers ME,Kerkof K,Nelson R,Appelbaum FR

更新日期：2001-09-15 00:00:00

abstract：:High-pressure liquid chromatography analysis of polyamines in bone narrow from leukemic and nonleukemic subjects demonstrated increased concentrations of putrescine, spermidine, and spermine associated with increased cellularity. The most striking abnormality was the marked elevation of putrescine. Bone marrow polyami...

journal_title：Blood

authors： Rennert O,Miale T,Shukla J,Lawson D,Frias J

更新日期：1976-04-01 00:00:00

abstract：:The genetic diversity of the human immunodeficiency virus (HIV) isolated from transfusion-associated AIDS patients has been examined. Restriction enzyme mapping studies of integrated proviral DNA of donor and recipient origin demonstrated genomic variation between isolates. Analysis of the molecularly cloned viral gen...

journal_title：Blood

authors： Srinivasan A,York D,Ranganathan P,Ferguson R,Butler D Jr,Feorino P,Kalyanaraman V,Jaffe H,Curran J,Anand R

更新日期：1987-06-01 00:00:00

abstract：:Expression of the arterial marker molecule ephrinB2 in endothelial cells is a prerequisite for adequate remodeling processes of the developing or angiogenic vasculature. Although its role in these processes has been extensively studied, the impact of ephrinB2 on the remodeling of adult arteries is largely unknown. To ...

journal_title：Blood

authors： Korff T,Braun J,Pfaff D,Augustin HG,Hecker M

更新日期：2008-07-01 00:00:00

abstract：:Immunosenescence is the functional deterioration of the immune system during natural aging. Despite increased susceptibility to bacterial infections in older adults, age-associated changes to neutrophil responses are only partially understood, and neutrophil migration has not been characterized in detail. Here we desc...

journal_title：Blood

authors： Sapey E,Greenwood H,Walton G,Mann E,Love A,Aaronson N,Insall RH,Stockley RA,Lord JM

更新日期：2014-01-09 00:00:00

abstract：:We performed a longitudinal analysis of point mutations of the N-ras proto-oncogene in patients with myelodysplasia and a follow-up of at least 2.5 years after diagnosis. Point mutations at codons 12, 13, and 61 of the N-ras oncogene were analyzed after in vitro amplification of N-ras specific sequences followed by do...

journal_title：Blood

authors： van Kamp H,de Pijper C,Verlaan-de Vries M,Bos JL,Leeksma CH,Kerkhofs H,Willemze R,Fibbe WE,Landegent JE

更新日期：1992-03-01 00:00:00

abstract：:Studies in mice have shown that proinflammatory Th17 cells can cause acute graft-versus-host disease (aGVHD) related tissue damage; however, whether they play a role in human aGVHD remains unclear. In a prospective study, we measured the proportion of Th17 cells in the blood and skin of patients at the onset of aGVHD....

journal_title：Blood

authors： Broady R,Yu J,Chow V,Tantiworawit A,Kang C,Berg K,Martinka M,Ghoreishi M,Dutz J,Levings MK

更新日期：2010-12-16 00:00:00

abstract：:Myeloid leukemias in AKXD23 mice contain proviral insertions at Evi1, resulting in transcriptional activation. Although Evi1 is clearly involved in leukemia, gene transfer studies in mice with Evi1 fail to cause leukemia, arguing that cooperating events are necessary. We reanalyzed AKXD-23 tumors for cooperating provi...

journal_title：Blood

authors： Boyd KE,Xiao YY,Fan K,Poholek A,Copeland NG,Jenkins NA,Perkins AS

更新日期：2006-01-15 00:00:00

abstract：:We describe the membrane localization of a new platelet-specific alloantigen, designated Naka, that is involved in refractoriness to HLA-matched platelet transfusions. By indirect immunoprecipitation, anti-Naka antibody precipitated a single, radiolabeled platelet membrane protein with a molecular weight (mol wt) of 9...

journal_title：Blood

authors： Tomiyama Y,Take H,Ikeda H,Mitani T,Furubayashi T,Mizutani H,Yamamoto N,Tandon NN,Sekiguchi S,Jamieson GA

更新日期：1990-02-01 00:00:00

abstract：:Erythropoietin (Ep), insulin, and prostaglandins E1 and A1 (PGE1, PGA1) enhanced heme synthesis by mitochondria isolated from embryonic and adult mouse liver cells. The combination of Ep with PGE1 had an antagonistic effect, while that of Ep with PGA1 gave an additive result. The capability of isolated human platelet ...

journal_title：Blood

authors： Agam G,Djaldetti M

更新日期：1978-06-01 00:00:00