Mechanisms of depressed delayed-type hypersensitivity in rheumatoid arthritis: the role of protein energy malnutrition.

abstract：OBJECTIVE:Sacroiliitis is a hallmark of the spondyloarthropathies (SpA). The degree of inflammation can be quantified by magnetic resonance imaging (MRI). The aim of this study was to further elucidate the pathogenesis of SpA by quantitative cellular analysis of immunostained sacroiliac biopsy specimens and to compare ...

journal_title：Annals of the rheumatic diseases

authors： Bollow M,Fischer T,Reisshauer H,Backhaus M,Sieper J,Hamm B,Braun J

更新日期：2000-02-01 00:00:00

abstract：OBJECTIVES:In salivary glands from patients with Sjögren syndrome, overexpression of laminins 1 and 5 and disorganisation of the acinar basal lamina have been reported. Laminin 5 mediates association of the basal lamina with epithelial cells by forming adhesion complexes upon interaction with alpha6beta4 integrin. In t...

journal_title：Annals of the rheumatic diseases

authors： Velozo J,Aguilera S,Alliende C,Ewert P,Molina C,Pérez P,Leyton L,Quest A,Brito M,González S,Leyton C,Hermoso M,Romo R,González MJ

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVES:To evaluate the rate of tuberculosis (TB) in biologic users for rheumatic diseases in South Africa, the effectiveness of our latent TB infection (LTBI) programme, risk factors and outcome. METHODS:TB cases were collected from the South African Biologics Registry (SABIO), rheumatologists and pharmaceutical c...

journal_title：Annals of the rheumatic diseases

authors： Pettipher C,Benitha R

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:To compare the performance of the American-European Consensus Group (AECG) and the newly proposed American College of Rheumatology (ACR) classification criteria for Sjögren's Syndrome (SS) in a well-characterised sicca cohort, given ongoing efforts to resolve discrepancies and weaknesses in the systems. METH...

journal_title：Annals of the rheumatic diseases

authors： Rasmussen A,Ice JA,Li H,Grundahl K,Kelly JA,Radfar L,Stone DU,Hefner KS,Anaya JM,Rohrer M,Gopalakrishnan R,Houston GD,Lewis DM,Chodosh J,Harley JB,Hughes P,Maier-Moore JS,Montgomery CG,Rhodus NL,Farris AD,Segal BM

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:The Fc receptor-like 3 (FCRL3) gene -169T>C single nucleotide polymorphism (SNP) has been reported to be associated with several autoimmune diseases (AIDs) in Japanese populations. However, association results in other populations have been conflicting. Therefore, we investigated this SNP in a...

journal_title：Annals of the rheumatic diseases

authors： Eike MC,Nordang GB,Karlsen TH,Boberg KM,Vatn MH,IBSEN study group.,Dahl-Jørgensen K,Rønningen KS,Joner G,Flatø B,Bergquist A,Thorsby E,Førre O,Kvien TK,Undlien DE,Lie BA

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the genetic influence of PvuII and XbaI polymorphisms of oestrogen receptor alpha (ORalpha) in patients with systemic lupus erythematosus (SLE) in Korea. METHODS:Genomic DNA from 268 female controls and 137 female SLE patients (41 childhood onset and 96 adult onset) were analysed using PvuII and ...

journal_title：Annals of the rheumatic diseases

authors： Lee YJ,Shin KS,Kang SW,Lee CK,Yoo B,Cha HS,Koh EM,Yoon SJ,Lee J

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Anti-citrullinated protein antibodies (ACPA) are the most predictive factor for the development of rheumatoid arthritis (RA). OBJECTIVE:To investigate whether the recognition of citrullinated epitopes changes during disease onset or progression, by studying the fine specificity of ACPA in serum samples coll...

journal_title：Annals of the rheumatic diseases

authors： van der Woude D,Rantapää-Dahlqvist S,Ioan-Facsinay A,Onnekink C,Schwarte CM,Verpoort KN,Drijfhout JW,Huizinga TW,Toes RE,Pruijn GJ

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy and safety of combining monthly intravenous methotrexate (IV MTX) with monthly IV cyclophosphamide (CYTX; given on the same day) for the treatment of children who develop recurrent diffuse proliferative glomerulonephritis secondary to systemic lupus erythematosus during or after the s...

journal_title：Annals of the rheumatic diseases

authors： Lehman TJ,Edelheit BS,Onel KB

更新日期：2004-03-01 00:00:00

abstract：:No consensus has previously been formed regarding the types and presentations of infectious pathogens to be considered as 'opportunistic infections' (OIs) within the setting of biologic therapy. We systematically reviewed published literature reporting OIs in the setting of biologic therapy for inflammatory diseases. ...

journal_title：Annals of the rheumatic diseases

authors： Winthrop KL,Novosad SA,Baddley JW,Calabrese L,Chiller T,Polgreen P,Bartalesi F,Lipman M,Mariette X,Lortholary O,Weinblatt ME,Saag M,Smolen J

更新日期：2015-12-01 00:00:00

abstract：:Of 29 524 hospitalised medical patients monitored in a drug surveillance programme 1835 (6.2%) received the xanthine oxidase inhibitor allopurinol. After the exclusion of skin reactions adverse effects were attributed to this drug in 33 (1.8%) patients, the most frequent being haematological abnormalities (11 patients...

journal_title：Annals of the rheumatic diseases

authors： McInnes GT,Lawson DH,Jick H

更新日期：1981-06-01 00:00:00

abstract：OBJECTIVES:To assess the interobserver agreement on the diagnostic classification of shoulder disorders, based on history taking and physical examination, and to identify the determinants of diagnostic disagreement. METHODS:Consecutive eligible patients with shoulder pain were recruited in various health care settings...

journal_title：Annals of the rheumatic diseases

authors： de Winter AF,Jans MP,Scholten RJ,Devillé W,van Schaardenburg D,Bouter LM

更新日期：1999-05-01 00:00:00

abstract：:The complement system plays a major role in the autoimmune disease, systemic lupus erythematosus (SLE). However, the role of complement in SLE is complex since it may both prevent and exacerbate the disease. In this review, we explore the latest findings in complement-focused research in SLE. C1q deficiency is the str...

journal_title：Annals of the rheumatic diseases

authors： Leffler J,Bengtsson AA,Blom AM

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:Antiphospholipid antibody (aPL) specificity for aPL-related events was evaluated in systemic lupus erythematosus (SLE). METHODS:A study was carried out on 105 patients affected with SLE comparing the prevalence of lupus anticoagulant (LA) and IgG and IgM anticardiolipin antibodies (aCL) between patients with...

journal_title：Annals of the rheumatic diseases

authors： Ghirardello A,Doria A,Ruffatti A,Rigoli AM,Vesco P,Calligaro A,Gambari PF

更新日期：1994-02-01 00:00:00

abstract：:Symptomatic osteonecrosis occurred in 8 out of 68 patients with systemic lupus erythematosus. Multiple joints were involved in 3 patients, and weight-bearing joints were most frequently affected. Osteonecrosis tended to occur early in the disease, and the patients had all received corticosteroids. Symptoms tended to o...

journal_title：Annals of the rheumatic diseases

authors： Griffiths ID,Maini RN,Scott JT

更新日期：1979-10-01 00:00:00

abstract：BACKGROUND:The heteropolymer technology was developed to remove pathogens from the circulation. OBJECTIVES:To evaluate the safety and tolerability of a single administration and to establish proof of principle for ETI-104 in normal healthy volunteers (NHV) and patients with systemic lupus erythematosus (SLE) METHODS: ...

journal_title：Annals of the rheumatic diseases

authors： Iking-Konert C,Stocks S,Weinsberg F,Engelbrecht R,Bleck E,Perniok A,Fischer-Betz R,Pincus S,Nardone L,Schneider M

更新日期：2004-09-01 00:00:00

abstract：BACKGROUND:Tumour necrosis factor alpha (TNFalpha) blockade using infliximab, a chimeric anti-TNFalpha antibody, is an effective treatment for both psoriasis and psoriatic arthritis (PsA). OBJECTIVE:To analyse the early effects of infliximab treatment on serial skin and synovial tissue biopsy samples. METHODS:Twelve ...

journal_title：Annals of the rheumatic diseases

authors： Goedkoop AY,Kraan MC,Teunissen MB,Picavet DI,de Rie MA,Bos JD,Tak PP

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVES:Prior studies have suggested a potential link between nasal microbes and granulomatosis with polyangiitis (GPA; Wegener's), but these studies relied on culture-dependent methods. This study comprehensively examined the entire community of nasal microbiota (bacteria and fungi) in participants with GPA compare...

journal_title：Annals of the rheumatic diseases

authors： Rhee RL,Sreih AG,Najem CE,Grayson PC,Zhao C,Bittinger K,Collman RG,Merkel PA

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Systemic sclerosis (SSc) is an autoimmune disease characterised by fibrosis of the skin and the internal organs. Except for anticentromere, antitopoisomerase I and antipolymerase III antibodies, there are no reliable circulating markers predicting susceptibility and internal organ complications. This study h...

journal_title：Annals of the rheumatic diseases

authors： van Bon L,Cossu M,Loof A,Gohar F,Wittkowski H,Vonk M,Roth J,van den Berg W,van Heerde W,Broen JC,Radstake TR

更新日期：2014-08-01 00:00:00

abstract：:Autonomic function assessed by tests of cardiovascular reflexes was studied in 25 patients with systemic sclerosis and 10 patients with primary Raynaud's phenomenon. A comparison was made with 13 normal healthy subjects. Significant abnormalities in the cardiovascular reflexes were found in systemic sclerosis, both in...

journal_title：Annals of the rheumatic diseases

authors： Klimiuk PS,Taylor L,Baker RD,Jayson MI

更新日期：1988-07-01 00:00:00

abstract：BACKGROUND:Human leucocyte antigen (HLA) genes predict disease severity in psoriasis (HLA-Cw6) and rheumatoid arthritis (shared epitope (SE)), but the situation is unclear for psoriatic arthritis (PsA). AIM:To determine the association of the HLA-Cw6 and HLA-DRB1 gene with disease severity in a large UK cohort with Ps...

journal_title：Annals of the rheumatic diseases

authors： Ho PY,Barton A,Worthington J,Thomson W,Silman AJ,Bruce IN

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:An imbalance in cytokine homoeostasis is thought to have a key role in the neuropsychiatric syndromes of systemic lupus erythematosus (NPSLE), and recently, a role for chemokines has been noted. OBJECTIVE:To compare concentrations of monocyte chemotactic protein-1 (MCP-1)/CCL2 in cerebral spinal fluid (CSF)...

journal_title：Annals of the rheumatic diseases

authors： Iikuni N,Okamoto H,Yoshio T,Sato E,Kamitsuji S,Iwamoto T,Momohara S,Taniguchi A,Yamanaka H,Minota S,Kamatani N

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Whether preradiographic lesions in knees at risk for osteoarthritis are incidental versus disease is unclear. We hypothesised, in persons without but at higher risk for knee osteoarthritis, that: 12-48 month MRI lesion status worsening is associated with 12-48 month incident radiographic osteoarthritis (obje...

journal_title：Annals of the rheumatic diseases

authors： Sharma L,Nevitt M,Hochberg M,Guermazi A,Roemer FW,Crema M,Eaton C,Jackson R,Kwoh K,Cauley J,Almagor O,Chmiel JS

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:To compare familial inflammatory inclusion body myositis (IBM) with hereditary inclusion body myopathies and sporadic IBM. PATIENTS AND METHODS:Clinical, biological, MRI, and histological data were analysed in two siblings with inflammatory IBM and compared with those of patients with sporadic and hereditary...

journal_title：Annals of the rheumatic diseases

authors： Ranque-Francois B,Maisonobe T,Dion E,Piette JC,Chauveheid MP,Amoura Z,Papo T

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:A great deal of evidence has shown that non-human leucocyte antigen (HLA)-B27 genes may play crucial roles in the aetiology of ankylosing spondylitis (AS), but there is little evidence of a relationship with tumour necrosis factor (TNF)alpha gene variation. One functional single-nucleotide polymorphism (SNP)...

journal_title：Annals of the rheumatic diseases

authors： Zhu X,Wang Y,Sun L,Song Y,Sun F,Tang L,Huo Z,Li J,Yang Z

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:To assess the effects of acute stress on inflammatory, haemostatic, rheological, and haemodynamic activity in patients with rheumatoid arthritis (RA) in comparison with patients with osteoarthritis (OA). METHODS:21 patients with RA and 10 with OA underwent a brief mental stress task while standing. Inflammat...

journal_title：Annals of the rheumatic diseases

authors： Veldhuijzen van Zanten JJ,Ring C,Carroll D,Kitas GD

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVES:Annual echocardiography screening is widely used in scleroderma, but the utility of longitudinal assessment is unknown. We evaluated whether change in right ventricular systolic pressure (RVSP) was a risk factor for mortality and development of pulmonary arterial hypertension (PAH) in a cohort of scleroderma...

journal_title：Annals of the rheumatic diseases

authors： Shah AA,Chung SE,Wigley FM,Wise RA,Hummers LK

更新日期：2013-07-01 00:00:00

abstract：:HLA types, especially HLA-DR3, are associated with the development of toxic reactions in patients with rheumatoid arthritis after treatment with gold or D-penicillamine. In this study, after treatment with sulphasalazine, leucopenia was observed in three patients, who all had a history of leucopenia after previous gol...

journal_title：Annals of the rheumatic diseases

authors： Bliddal H,Eiberg B,Helin P,Svejgaard A

更新日期：1989-07-01 00:00:00

abstract：OBJECTIVES:To examine the effect of reproductive history and use of hormonal therapies on the risk of hip and knee joint replacement for osteoarthritis. METHODS:A prospective study of 1.3 million women aged on average 56 years at recruitment and followed-up through linkage to routinely collected hospital admission rec...

journal_title：Annals of the rheumatic diseases

authors： Liu B,Balkwill A,Cooper C,Roddam A,Brown A,Beral V,Million Women Study Collaborators.

更新日期：2009-07-01 00:00:00

abstract：:Today, patients' functioning is a central issue in medicine. Concepts, classifications, and measurements of functioning and health, such as the International Classification of Functioning, Disability and Health (ICF) are of prime importance in clinical practice, teaching, and research. This report compares the content...

journal_title：Annals of the rheumatic diseases

authors： Stucki G,Cieza A

更新日期：2004-11-01 00:00:00

abstract：:Antibody production in response to the primary immunogen bacteriophage phi X174 was investigated in 14 patients with previous yersinia arthritis (YA) and in 15 controls. HLA-B27 occurred in 10 patients with YA and in three controls. After primary and secondary immunisation the antibody responses were essentially simil...

journal_title：Annals of the rheumatic diseases

authors： Bucknall R,Leirisalo-Repo M,Laitinen O,Jones JV

更新日期：1987-12-01 00:00:00