The complement system in systemic lupus erythematosus: an update.

Abstract:

:The complement system plays a major role in the autoimmune disease, systemic lupus erythematosus (SLE). However, the role of complement in SLE is complex since it may both prevent and exacerbate the disease. In this review, we explore the latest findings in complement-focused research in SLE. C1q deficiency is the strongest genetic risk factor for SLE, although such deficiency is very rare. Various recently discovered genetic associations include mutations in the complement receptors 2 and 3 as well as complement inhibitors, the latter related to earlier onset of nephritis. Further, autoantibodies are a distinct feature of SLE that are produced as the result of an adaptive immune response and how complement can affect that response is also being reviewed. SLE generates numerous disease manifestations involving contributions from complement such as glomerulonephritis and the increased risk of thrombosis. Furthermore, since most of the complement system is present in plasma, complement is very accessible and may be suitable as biomarker for diagnosis or monitoring of disease activity. This review highlights the many roles of complement for SLE pathogenesis and how research has progressed during recent years.

journal_name

Ann Rheum Dis

authors

Leffler J,Bengtsson AA,Blom AM

doi

10.1136/annrheumdis-2014-205287

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

1601-6

issue

9

eissn

0003-4967

issn

1468-2060

pii

annrheumdis-2014-205287

journal_volume

73

pub_type

杂志文章,评审
  • Intranasal calcitonin for the prevention of bone erosion and bone loss in rheumatoid arthritis.

    abstract::The effect of intranasal salmon calcitonin on pain, erosion progression, and bone loss in 40 women with rheumatoid arthritis was investigated. The study design was double blind, placebo controlled for the first four months and open for the next 36 months, allowing for cross over to active drug treatment or to the cont...

    journal_title:Annals of the rheumatic diseases

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/ard.51.6.761

    authors: Sileghem A,Geusens P,Dequeker J

    更新日期:1992-06-01 00:00:00

  • European League Against Rheumatism recommendations for monitoring patients with systemic lupus erythematosus in clinical practice and in observational studies.

    abstract:OBJECTIVES:To develop recommendations for monitoring patients with systemic lupus erythematosus (SLE) in clinical practice and observational studies and to develop a standardised core set of variables to monitor SLE. METHODS:We followed the European League Against Rheumatism (EULAR) standardised procedures for guideli...

    journal_title:Annals of the rheumatic diseases

    pub_type: 共识发展会议,杂志文章,实务指引

    doi:10.1136/ard.2009.117200

    authors: Mosca M,Tani C,Aringer M,Bombardieri S,Boumpas D,Brey R,Cervera R,Doria A,Jayne D,Khamashta MA,Kuhn A,Gordon C,Petri M,Rekvig OP,Schneider M,Sherer Y,Shoenfeld Y,Smolen JS,Talarico R,Tincani A,van Vollenhoven RF,

    更新日期:2010-07-01 00:00:00

  • Hip replacement surgery in patients with ankylosing spondylitis.

    abstract:OBJECTIVES:Although TNF-α inhibitors' striking effect on clinical symptoms have revolutionised the treatment of ankylosing spondylitis (AS), no certain influence on the development of spinal ankylosis and joint destruction has been documented. We wished to investigate whether improved treatment has affected the use of ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2013-203963

    authors: Nystad TW,Furnes O,Havelin LI,Skredderstuen AK,Lie SA,Fevang BT

    更新日期:2014-06-01 00:00:00

  • Anti-cyclic citrullinated peptide positivity in non-rheumatoid arthritis disease samples: citrulline-dependent or not?

    abstract:BACKGROUND:Antibodies directed against citrullinated proteins (eg anti-cyclic citrullinated peptide (CCP)) have excellent diagnostic and good prognostic potential for rheumatoid arthritis. Type 1 autoimmune hepatitis (AIH-1) is a chronic liver disease characterised by a variety of serum autoantibodies. Recently, in a l...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.2006.058933

    authors: Vannini A,Cheung K,Fusconi M,Stammen-Vogelzangs J,Drenth JP,Dall'Aglio AC,Bianchi FB,Bakker-Jonges LE,van Venrooij WJ,Pruijn GJ,Zendman AJ

    更新日期:2007-04-01 00:00:00

  • Prevalence of rheumatoid arthritis in France: 2001.

    abstract:BACKGROUND:Prevalence estimates of rheumatoid arthritis (RA) vary across Europe. Recent estimates in southern European countries showed a lower prevalence than in northern countries. OBJECTIVES:To estimate the prevalence of RA in France in a multiregional representative sample in the year 2001. METHODS:A two stage ra...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.2004.029199

    authors: Guillemin F,Saraux A,Guggenbuhl P,Roux CH,Fardellone P,Le Bihan E,Cantagrel A,Chary-Valckenaere I,Euller-Ziegler L,Flipo RM,Juvin R,Behier JM,Fautrel B,Masson C,Coste J

    更新日期:2005-10-01 00:00:00

  • Pregnancy in patients with rheumatic disease: anti-inflammatory cytokines increase in pregnancy and decrease post partum.

    abstract:OBJECTIVE:To investigate changes in the levels of circulating cytokines with a focus on the Th1/Th2 balance during and after pregnancy in patients with rheumatoid arthritis (RA), juvenile idiopathic arthritis (JIA), and ankylosing spondylitis (AS). METHODS:Plasma and serum samples of 34 pregnant patients, 19 with RA, ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.2004.029538

    authors: Østensen M,Förger F,Nelson JL,Schuhmacher A,Hebisch G,Villiger PM

    更新日期:2005-06-01 00:00:00

  • Clinical value of gallium-67 scintigraphy in assessment of disease activity in Wegener's granulomatosis.

    abstract:BACKGROUND:Diagnosis of active pulmonary and paranasal involvement in patients with Wegener's granulomatosis (WG) can be difficult. The diagnostic value of gallium-67 scintigraphy in WG is unclear. OBJECTIVE:To evaluate the added diagnostic value of gallium-67 scintigraphy in patients with WG with suspected granulomat...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.62.7.659

    authors: Slart RH,Jager PL,Poot L,Piers DA,Tervaert JW,Stegeman CA

    更新日期:2003-07-01 00:00:00

  • Various rheumatic syndromes in adult patients associated with high antistreptolysin O titres and their differential diagnosis with rheumatic fever.

    abstract:OBJECTIVES:The purpose of this study was to analyse retrospectively adult patients with acute joint or muscle symptoms and a high antistreptolysin O (ASO) titre to find out which syndromes of clinical arthritis are associated with serological evidence of streptococcal infection. METHODS:Seventy six adult patients with...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.52.7.527

    authors: Valtonen JM,Koskimies S,Miettinen A,Valtonen VV

    更新日期:1993-07-01 00:00:00

  • Suppression of inflammation reduces endothelial microparticles in active systemic lupus erythematosus.

    abstract:BACKGROUND:In a prospective observational study, we investigated whether patients with active systemic lupus erythematosus (SLE) had higher indices of endothelial damage and dysfunction than healthy controls and whether improved disease control was associated with improvement in these indices. METHODS:Twenty-seven pat...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2012-203028

    authors: Parker B,Al-Husain A,Pemberton P,Yates AP,Ho P,Gorodkin R,Teh LS,Alexander MY,Bruce IN

    更新日期:2014-06-01 00:00:00

  • Haemophilus influenzae tenosynovitis.

    abstract::A case is reported of polytenosynovitis in a 31-year-old male during the course of a severe bacteraemic illness caused by Haemophilus influenzae type b. The clinical presentation was similar to tenosynovitis caused by bacterial or viral agents. As the management of the H. influenzae tenosynovitis would differ from tha...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.38.6.561

    authors: Bansal S,Magnussen CR,Napodano RJ

    更新日期:1979-12-01 00:00:00

  • Conventional treatments for ankylosing spondylitis.

    abstract::Management of ankylosing spondylitis (AS) is challenged by the progressive nature of the disease. To date, no intervention is available that alters the underlying mechanism of inflammation in AS. Currently available conventional treatments are palliative at best, and often fail to control symptoms in the long term. Cu...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,评审

    doi:10.1136/ard.61.suppl_3.iii40

    authors: Dougados M,Dijkmans B,Khan M,Maksymowych W,van der Linden S,Brandt J

    更新日期:2002-12-01 00:00:00

  • Assessing progression of patellofemoral osteoarthritis: a comparison between two radiographic methods.

    abstract:OBJECTIVE:To compare two plain radiographic methods for sensitivity to detect progression of patellofemoral osteoarthritis. METHODS:Two sets of paired skyline and lateral knee radiographs from 54 hospital referred patients (108 knees) with knee osteoarthritis were taken an average of 31 months apart (range 12-40). Fil...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.55.12.875

    authors: Lanyon P,Jones A,Doherty M

    更新日期:1996-12-01 00:00:00

  • Non-steroidal anti-inflammatory drugs and risk of cardiovascular disease in patients with rheumatoid arthritis: a nationwide cohort study.

    abstract::OBJECTIVE: To examine the risk of major cardiovascular disease associated with non-steroidal anti-inflammatory drugs (NSAIDs) in a large 'real-world' contemporary rheumatoid arthritis (RA) cohort. METHODS: A longitudinal cohort study was conducted with use of Danish nationwide individual-level registry data on inpat...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2012-203137

    authors: Lindhardsen J,Gislason GH,Jacobsen S,Ahlehoff O,Olsen AM,Madsen OR,Torp-Pedersen C,Hansen PR

    更新日期:2014-08-01 00:00:00

  • Association between radiographic severity of rheumatoid arthritis and shared epitope alleles: differing mechanisms of susceptibility and protection.

    abstract:OBJECTIVE:To investigate the association of a recently described classification of Human leukocyte antigen (HLA)-DRB1 shared epitope alleles with rheumatoid factors (RF) and anti-cyclic citrullinated peptide (CCP) production and radiological severity in rheumatoid arthritis (RA). METHODS:Patients with RA (n = 962) wer...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.2007.075382

    authors: Mewar D,Marinou I,Coote AL,Moore DJ,Akil M,Smillie D,Dickson MC,Binks MH,Montgomery DS,Wilson AG

    更新日期:2008-07-01 00:00:00

  • Blood-based test for diagnosis and functional subtyping of familial Mediterranean fever.

    abstract:BACKGROUND AND OBJECTIVE:Familial Mediterranean fever (FMF) is the most common monogenic autoinflammatory disease (AID) worldwide. The disease is caused by mutations in the MEFV gene encoding the inflammasome sensor Pyrin. Clinical diagnosis of FMF is complicated by overlap in symptoms with other diseases, and interpre...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2019-216701

    authors: Van Gorp H,Huang L,Saavedra P,Vuylsteke M,Asaoka T,Prencipe G,Insalaco A,Ogunjimi B,Jeyaratnam J,Cataldo I,Jacques P,Vermaelen K,Dullaers M,Joos R,Sabato V,Stella A,Frenkel J,De Benedetti F,Dehoorne J,Haerynck F,C

    更新日期:2020-07-01 00:00:00

  • Interferon beta stimulates interleukin 1 receptor antagonist production in human articular chondrocytes and synovial fibroblasts.

    abstract:BACKGROUND:Interferon (IFN) beta displays anti-inflammatory and immunosuppressive activity and has been considered for the treatment of rheumatoid arthritis (RA). Information about the effects of this molecule on joint cells is scarce, however. OBJECTIVE:To investigate the effects of IFNbeta on the production of inter...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.2002.005546

    authors: Palmer G,Mezin F,Juge-Aubry CE,Plater-Zyberk C,Gabay C,Guerne PA

    更新日期:2004-01-01 00:00:00

  • Detection, scoring and volume assessment of bone erosions by ultrasonography in rheumatoid arthritis: comparison with CT.

    abstract:OBJECTIVES:To determine the accuracy of ultrasonography (US) for bone erosion detection in different areas of rheumatoid arthritis (RA) metacarpophalangeal (MCP) joints with multislice CT as the reference method. Second, to establish the necessary bone volume loss on CT for US to reliably detect it as an erosion, and f...

    journal_title:Annals of the rheumatic diseases

    pub_type: 临床试验,杂志文章

    doi:10.1136/annrheumdis-2011-201114

    authors: Døhn UM,Terslev L,Szkudlarek M,Hansen MS,Hetland ML,Hansen A,Madsen OR,Hasselquist M,Møller J,Ostergaard M

    更新日期:2013-04-01 00:00:00

  • Screening for latent tuberculosis infection: performance of tuberculin skin test and interferon-γ release assays under real-life conditions.

    abstract:OBJECTIVES:To characterise optimal screening strategies for latent tuberculosis infection (LTBI) prior to the initiation of anti-tumour necrosis factor therapy. METHODS:Patients in 62 German rheumatology centres were evaluated for LTBI. Each patient was screened with a tuberculin skin test (TST) and one form of an int...

    journal_title:Annals of the rheumatic diseases

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1136/annrheumdis-2011-200941

    authors: Kleinert S,Tony HP,Krueger K,Detert J,Mielke F,Rockwitz K,Schwenke R,Burmester GR,Diel R,Feuchtenberger M,Kneitz C

    更新日期:2012-11-01 00:00:00

  • Evidence for treating rheumatoid arthritis to target: results of a systematic literature search update.

    abstract:OBJECTIVE:A systematic literature review (SLR; 2009-2014) to compare a target-oriented approach with routine management in the treatment of rheumatoid arthritis (RA) to allow an update of the treat-to-target recommendations. METHODS:Two SLRs focused on clinical trials employing a treatment approach targeting a specifi...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,评审

    doi:10.1136/annrheumdis-2015-207526

    authors: Stoffer MA,Schoels MM,Smolen JS,Aletaha D,Breedveld FC,Burmester G,Bykerk V,Dougados M,Emery P,Haraoui B,Gomez-Reino J,Kvien TK,Nash P,Navarro-Compán V,Scholte-Voshaar M,van Vollenhoven R,van der Heijde D,Stamm TA

    更新日期:2016-01-01 00:00:00

  • Incidence of arthro-osteitis in patients with pustulosis palmaris et plantaris.

    abstract::Arthro-osteitis at the anterior chest wall was found in 12 (9.4%) out of 128 consecutive patients with pustulosis palmaris et plantaris. This finding indicates that the concomitance of arthro-osteitis with PPP is not incidental but is based on some common aetiological factor. We propose a term ;pustulotic arthro-ostei...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.40.6.554

    authors: Sonozaki H,Kawashima M,Hongo O,Yaoita H,Ikeno M,Matsuura M,Okai K,Azuma A

    更新日期:1981-12-01 00:00:00

  • Absence of chromosome damage in human lymphocytes exposed to allopurinol and oxipurinol.

    abstract::The biochemical evidence against incorporation of the purine analogues, allopurinol and oxipurinol, into nucleic acids is reviewed. Cytological experiments have been carried out to investigate the possibility that chromosomal damage might result from exposure of human lymphocytes to these drugs. Lymphocytes from 19 pa...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.35.2.143

    authors: Stevenson AC,Silcock SR,Scott JT

    更新日期:1976-04-01 00:00:00

  • Immunoprotein deposition in synovial tissue in Reiter's syndrome.

    abstract::The aetiology of Reiter's syndrome (RS) is unknown. In order to evaluate the role of immunological mechanisms in this disease we performed synovial biopsies on 12 patients with RS looking for deposition of immunoglobulins and complement components in synovial tissue. By immunofluorescent techniques 11 synovia were fou...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.40.3.281

    authors: Baldassare AR,Weiss TD,Tsai CC,Arthur RE,Moore TL,Zuckner J

    更新日期:1981-06-01 00:00:00

  • Sequential studies on synovial lymphocyte stimulation by rubella antigen, and rubella virus isolation in an adult with persistent arthritis.

    abstract::The response of synovial lymphocytes from a 65-year-old lady with persistent polyarthritis, to rubella antigen and a number of other microbial agents was studied over a period of 11 months by [3H]thymidine incorporation. The results were correlated with the ability to isolate rubella virus from both peripheral blood a...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.44.8.564

    authors: Chantler JK,da Roza DM,Bonnie ME,Reid GD,Ford DK

    更新日期:1985-08-01 00:00:00

  • The arthritis sufferer and the community: a comparison of arthritis sufferers in rural and urban areas.

    abstract::One hundred and two rural patients and 100 urban patients with rheumatoid arthritis and osteoarthrosis and 203 age and sex matched controls were visited in their homes to evaluate their problems, needs, and expectations. Although one would expect disability to affect the mobility of a person, it was found that rural p...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.47.2.150

    authors: Cornelissen PG,Rasker JJ,Valkenburg HA

    更新日期:1988-02-01 00:00:00

  • Comparative study of tibial (single) and tibiofemoral (double) osteotomy for osteoarthrosis and rheumatoid arthritis.

    abstract::Osteotomies on 101 knees in 79 patients were assessed either prospectively or retrospectively. High tibial osteotomy was performed in 54 knees (27 with rheumatoid arthritis (RA) and 27 with osteoarthrosis (OA)) and double (tibiofemoral) osteotomy in 47 knees (25 RA and 22 OA), and were assessed prospectively in 46 and...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.36.4.319

    authors: Iveson JM,Longton EB,Wright V

    更新日期:1977-08-01 00:00:00

  • Destructive arthritis associated with acne fulminans: a case report.

    abstract::Arthralgias have previously been reported in association with acne fulminans, but the following case in the first report of osseous lesions associated with this disease. The destructive bony lesion was rapid in onset but self-limited. ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.39.4.403

    authors: Hunter LY,Hensinger RN

    更新日期:1980-08-01 00:00:00

  • Mitogen activated protein kinase inhibitors: where are we now and where are we going?

    abstract::Orally bioavailable compounds that target key intracellular signalling molecules are receiving increasing attention for the treatment of rheumatic diseases. The mitogen activated protein (MAP) kinases are especially attractive because they regulate both cytokine production and cytokine action. The MAP kinases are expr...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章,评审

    doi:10.1136/ard.2006.058388

    authors: Sweeney SE,Firestein GS

    更新日期:2006-11-01 00:00:00

  • COL2A1 gene polymorphisms and susceptibility to osteoarthritis of the hand in Finnish women.

    abstract:OBJECTIVES:To study the role of two COL2A1 single nucleotide polymorphisms (rs3737548 and rs2276455) and their haplotypes in individual susceptibility to osteoarthritis (OA) of the hand in Finnish women. METHODS:Bilateral hand radiographs of 543 Finnish female dentists and teachers aged 45-63 years were examined and c...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.2008.094706

    authors: Hämäläinen S,Solovieva S,Hirvonen A,Vehmas T,Takala EP,Riihimäki H,Leino-Arjas P

    更新日期:2009-10-01 00:00:00

  • PKCδ null mutations in a mouse model of osteoarthritis alter osteoarthritic pain independently of joint pathology by augmenting NGF/TrkA-induced axonal outgrowth.

    abstract:OBJECTIVES:A key clinical paradox in osteoarthritis (OA), a prevalent age-related joint disorder characterised by cartilage degeneration and debilitating pain, is that the severity of joint pain does not strictly correlate with radiographic and histological defects in joint tissues. Here, we determined whether protein ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/annrheumdis-2015-208444

    authors: Kc R,Li X,Kroin JS,Liu Z,Chen D,Xiao G,Levine B,Li J,Hamilton JL,van Wijnen AJ,Piel M,Shelly DA,Brass D,Kolb E,Im HJ

    更新日期:2016-12-01 00:00:00

  • Pyogenic osteomyelitis presenting as an acute sterile arthropathy.

    abstract::We report two cases of osteomyelitis secondary to staphylococcal septicaemia, presenting with large sterile effusions in adjacent joints. In both cases the clinical features were suggestive of septic arthritis. Multiple joints were involved in each patient. Initial radiographs showed no abnormalities. ...

    journal_title:Annals of the rheumatic diseases

    pub_type: 杂志文章

    doi:10.1136/ard.43.4.607

    authors: Platt PN,Griffiths ID

    更新日期:1984-08-01 00:00:00