Abstract:
AIMS:It is currently accepted that primary ovarian tumours rarely, if ever, give rise to mucinous ascites/pseudomyxoma peritonei (PMP) which most commonly results from the intra-abdominal spread of an appendiceal mucinous neoplasm. However, primary ovarian mucinous tumours of appendiceal type arising within mature cystic teratomas appear to represent an exception to this rule. In this report two further examples of this rare tumour are described, and the immunohistological phenotype including expression of MUC proteins is compared with secondary ovarian involvement by low-grade appendiceal mucinous neoplasm. METHODS:Two cases of ovarian mucinous tumour associated with mature cystic teratoma and PMP are described. The tumours were examined immunohistochemically for expression of cytokeratin (CK)7, CK20, carcinoembryonic antigen (CEA), CDX-2, MUC2, MUC5AC and MUC6. The results were compared with four cases of ovarian neoplasia secondary to primary appendiceal low-grade mucinous tumour. RESULTS:The ovarian mucinous tumours associated with mature cystic teratomas were morphologically similar to those secondary to appendiceal neoplasia. They comprised irregularly distributed glands and cysts lined by tall, mucin-rich epithelial cells exhibiting focal villoglandular architecture and low grade cytological atypia. The immunophenotype of the teratoma-associated tumours and those secondary to appendiceal neoplasia was identical: there was strong and diffuse expression of CK20, CEA, CDX-2, MUC2 and MUC5AC with no reactivity for the other antisera tested. CONCLUSIONS:PMP associated with primary ovarian neoplasia is rare, and probably restricted to mucinous tumours arising in mature cystic teratomas. The immunohistological findings in this study further support the view that such tumours exhibit a lower gastrointestinal and, more specifically, appendiceal phenotype. Careful examination and sampling of the ovaries may be required to demonstrate the teratomatous component of these tumours.
journal_name
Pathologyjournal_title
Pathologyauthors
Stewart CJ,Tsukamoto T,Cooke B,Leung YC,Hammond IGdoi
10.1080/00313020601024078subject
Has Abstractpub_date
2006-12-01 00:00:00pages
534-8issue
6eissn
0031-3025issn
1465-3931journal_volume
38pub_type
杂志文章相关文献
PATHOLOGY文献大全abstract::Iron tablets are widely used in the community. Severe, sometimes lethal, damage to the gastrointestinal tract following overdose is well known, but there is less appreciation of the damage that can be caused by therapeutic dosage. In this histological study of three esophageal lesions and six gastric lesions (includin...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029600169763
更新日期:1996-05-01 00:00:00
abstract:AIMS:To assess the production of a liver-specific protein, albumin, and of a master transcriptional factor, hepatocyte nuclear factor (HNF)-4alpha, in hepatoid adenocarcinoma tissue. METHODS:Standard and quantitative RT-PCR, using five cases of hepatoid and three cases of non-hepatoid gastric adenocarcinoma. RESULTS:...
journal_title:Pathology
pub_type: 杂志文章
doi:
更新日期:2003-02-01 00:00:00
abstract::The aim of this study was to subcategorise large cell carcinoma (LCC) with null immunophenotype according to the World Health Organization (WHO) Classification of 2015 into the existing groups of adenocarcinoma and squamous cell carcinoma by further molecular genetic analysis. Lineage-specific molecular alterations of...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2018.03.005
更新日期:2018-08-01 00:00:00
abstract::From August 1976 to July 1977, all faecal specimens (3298) sent to the Enteric Department of the Institute of Medical and Veterinary Science, Adelaide were selectively cultured for Yersinia enterocolitica. Yersinia enterocolitica was isolated from three patients with diarrhoea, one of whom acquired her infection overs...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313027909063540
更新日期:1979-01-01 00:00:00
abstract::This retrospective study evaluated 15,377 sets of BacT/Alert blood cultures to determine incubation time for blood cultures. Ninety-six per cent (1476) of total isolates signalled positive within five days and 56 isolates turned positive in five to seven days. Of the 56 organisms recovered between five and seven days,...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029800169176
更新日期:1998-05-01 00:00:00
abstract:AIMS:BRAF mutation has been shown in a large meta-analysis to be an independent prognostic marker for papillary thyroid carcinoma (PTC) with poorer survival and higher recurrence rates. METHODS:We studied prevalence of BRAF mutation in 77 patients with PTC from an Australian cohort using competitive polymerase chain r...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0000000000000008
更新日期:2013-12-01 00:00:00
abstract::Partial regression is common in cutaneous melanoma; however, complete regression manifesting as tumoural melanosis is rare, conceptually challenging and under-reported. In this study we report on clinical, histological and molecular findings in four cases of completely regressed cutaneous melanoma with nodal or brain ...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1016/j.pathol.2019.01.008
更新日期:2019-06-01 00:00:00
abstract::Phospholipid preparations from the nematode Ascaris suum or cysts of Echinococcus granulosus (hydatid cysts) induced an eosinophilia when injected into the peritoneal cavity of rats. Peritoneal eosinophilia persisted throughout 21 days of daily injections of Ascaris lipid and was accompanied by blood eosinophilia, mas...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313027709085252
更新日期:1977-04-01 00:00:00
abstract:AIMS:Activation of β-catenin has been identified as a possible mechanism for the development of nephroblastomas. In our study we investigated whether this activation occurs already in precursor lesions of nephroblastomas, called nephrogenic rests (NRs). Inactivation of the adenomatous polyposis coli (APC) protein is an...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0b013e32834bf65c
更新日期:2011-12-01 00:00:00
abstract::Solitary fibrous tumour (SFT) is well-described in the urinary tract, but malignant examples are rare. We studied our experience with high grade malignant SFT of the prostate to address the degree of histological and immunophenotypical overlap with sarcomatoid carcinoma and prostatic stromal sarcoma. Four cases were i...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2020.06.004
更新日期:2020-10-01 00:00:00
abstract::A glossary of terms commonly used in molecular genetics and cytogenetics has been prepared to assist pathologists. The emphasis is on clinically relevant examples. ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029109063573
更新日期:1991-07-01 00:00:00
abstract::Epithelial ovarian neoplasms can be divided into three distinct clinicopathological groups: benign, malignant and borderline tumours. Borderline tumours are less aggressive than epithelial carcinomas, with an indolent clinical course and delayed recurrence. However, a subset of these cases can progress to malignancy a...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2020.07.010
更新日期:2021-02-01 00:00:00
abstract::Review of problematic melanocytic consultation cases has enabled identification of the most common variants of benign melanocytic proliferations which can be confused with melanoma. Apart from Spitz naevus, the most common in this group of lesions are pigmented spindle cell naevus and atypical dermal nodule. Potential...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1080/00313020412331283842
更新日期:2004-10-01 00:00:00
abstract:AIMS:Nuclear factor-kappa B (NF-kappaB) activation has been recognised as an important mechanism in the development of cancers. However, expression status of NF-kappaB-related proteins in oesophageal squamous cell carcinoma (ESCC) tissues is largely unknown. In this study, we analysed expressions of NF-kappaB members (...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313020903257756
更新日期:2009-01-01 00:00:00
abstract::Recently, both the World Health Organization/International Agency for Research on Cancer (WHO/IARC) and the American Joint Committee on Cancer (AJCC) have classified oropharyngeal squamous cell carcinoma (OPSCC) on the basis of HPV status. For this purpose, the WHO/IARC recommended direct molecular HPV testing. In pra...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2019.02.002
更新日期:2019-06-01 00:00:00
abstract::The sections in the following review cover six main neurodegenerative diseases. The first article on Alzheimer's disease (AD) outlines the major evidence available to date that links Aβ-amyloid peptide as a proximal cause of AD. The article also highlights how an initial finding of the protein content of the amyloid p...
journal_title:Pathology
pub_type: 杂志文章,多中心研究,评审
doi:10.1097/PAT.0b013e3283426eee
更新日期:2011-02-01 00:00:00
abstract::One hundred and two cases of benign nerve sheath tumors (NSTs) were studied with a combined approach using routine light microscopy (LM), immunohistochemistry (IH) for myelin basic protein (MBP) and S-100 protein as well as transmission electron microscopy (TEM) with the aim of obtaining greater insight into the true ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313029009086659
更新日期:1990-10-01 00:00:00
abstract:AIM:To demonstrate that Flinders Island spotted fever (FISF), a spotted fever group rickettsial infection caused by Rickettsia honei, is found not only on Flinders Island (Bass Strait), Tasmania, but elsewhere in south-east Australia. METHODS:Cases of FISF were identified by rickettsial serology, culture and the detec...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020500099247
更新日期:2005-06-01 00:00:00
abstract::The most significant task of the pathologist examining a fetal death is, if possible, the provision of an explanation for the event, which will allow the clinical attendants to counsel the family in an informed and relevant manner. In some cases, no adequate explanation will be possible, though many conditions will be...
journal_title:Pathology
pub_type: 杂志文章,评审
doi:10.1080/003130200104330
更新日期:2000-05-01 00:00:00
abstract::The monitoring of infliximab drug levels aids in the management of several autoimmune diseases, notably inflammatory bowel disease. Several commercial kits are now available and approved by the Therapeutic Goods Administration (TGA) for the measurement of infliximab levels, but there have been limited verification or ...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2016.07.001
更新日期:2016-10-01 00:00:00
abstract:AIMS:We assessed the expression of ALDH1 and EZH2, cancer stem cell (CSC) related markers, in triple negative and basal-like breast cancers, investigating their association with clinicopathological features and outcome. METHODS:Clinicopathological data were obtained from 140 cases of triple negative breast cancer. A t...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0b013e3283534bcb
更新日期:2012-06-01 00:00:00
abstract::The values of a number of biochemical variables have been studied before and after a 50-gram load of glucose orally. Reductions which were statistically significant were found for sodium, potassium, urea, total protein, albumin, calcium, phosphorus, urate, bilirubin, alkaline phosphatase, but not for bicarbonate, crea...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313027709085234
更新日期:1977-01-01 00:00:00
abstract:AIMS:CD151 belongs to the group of tetraspanins and is aberrantly expressed in different tumours and differential expression has been associated with prognosis. The aim of this study was to clarify the relationship of CD151 expression with tumour phenotype and clinical outcome in bladder cancer. METHODS:A bladder canc...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1097/PAT.0b013e32835576ee
更新日期:2012-08-01 00:00:00
abstract:AIMS:To investigate KAI1 and survivin expression in infiltrating ductal carcinomas, and to evaluate the relationship between clinicopathological factors and KAI1 and survivin expression levels in breast cancers. METHODS AND RESULTS:KAI and survivin expression levels were measured in 62 patients, using immunohistochemi...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020500058144
更新日期:2005-04-01 00:00:00
abstract::In the peritoneal cavity of the adult rat mast cells at the four stages of progressive maturation (and corresponding increase of sulphation of granules) are best demonstrated in free peritoneal fluid. Of the 0.1-0.2x10(6) cells in the free fluid, 26% are at stage 1 of maturation (all granules are stained by Alcian blu...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313027509081687
更新日期:1975-10-01 00:00:00
abstract::The in vitro activity of azthreonam, a novel monocyclic beta-lactam antibiotic, was investigated for Gram negative urinary pathogens by determining the susceptibilities of 105 consecutive isolates from specimens submitted to the Auckland Hospital microbiology laboratory. All were sensitive or of intermediate sensitivi...
journal_title:Pathology
pub_type: 杂志文章
doi:10.3109/00313028309084704
更新日期:1983-04-01 00:00:00
abstract::Distinction between melanocytic naevi and melanoma occasionally poses a diagnostic challenge in ambiguous cases showing overlapping histological features. Melanomas are characterised by the presence of multiple genomic copy number variants (CNVs), while this is not a feature of naevi. We assessed the feasibility and u...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2016.11.008
更新日期:2017-04-01 00:00:00
abstract:AIMS:Mixed type liposarcomas are rare. Here, we analysed the characteristics of an unusual case of mixed type liposarcoma, which consisted of a well-differentiated liposarcoma (WDL) and a pleomorphic liposarcoma (PL), with a special emphasis on molecular alterations. METHODS:Microscopic and immunohistochemical approac...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313020600557078
更新日期:2006-04-01 00:00:00
abstract:AIM:1) To determine the prevalence of hepatitis B in Sydney autopsies and 2) to determine the relationship between seroprevalence, hepatitis B risk factors and histological changes in the liver. METHODS:One hundred autopsy subjects were studied for evidence of past or present hepatitis B infection, using RIA to detect...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1080/00313029500169442
更新日期:1995-01-01 00:00:00
abstract::Investigating fever in the returned traveller can be difficult and costly. Dengue is one of the most frequently reported aetiologies. NS1 is a non-structural dengue virus protein detectable during acute infection. The aim of this report is to describe the utility of the Platelia Dengue NS1 antigen enzyme immunoassay (...
journal_title:Pathology
pub_type: 杂志文章
doi:10.1016/j.pathol.2020.01.438
更新日期:2020-04-01 00:00:00