Vaccines against Francisella tularensis.

Abstract:

:Francisella tularensis is one of the most pathogenic pathogens known, especially when disseminated as a small particle aerosol. Because of this, it was developed into a biological warfare agent by several states during the 20th century. Nowadays, concerns remain about the potential of this pathogen to cause widespread disease, tularemia, in the hands of terrorists. This has resurrected interest in methods to combat it. This article reviews the current status of vaccine development efforts against tularemia. To date most of our understanding of tularemia vaccine efficacy has been derived from the clinical and experimental use of a pragmatically attenuated live vaccine strain of F. tularensis subspecies holarctica. However, this vaccine which has been in existence for more than 50 years is still beset by regulatory issues that continue to hamper its licensure. These issues and possible solutions are highlighted, along with more modern molecular approaches to vaccine development against this highly virulent pathogen.

journal_name

Ann N Y Acad Sci

authors

Wayne Conlan J,Oyston PC

doi

10.1196/annals.1409.012

subject

Has Abstract

pub_date

2007-06-01 00:00:00

pages

325-50

eissn

0077-8923

issn

1749-6632

pii

annals.1409.012

journal_volume

1105

pub_type

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