Thymosin beta4 is cardioprotective after myocardial infarction.

abstract：:Monitoring of wildlife diseases started in Scandinavia as sporadic postmortem examinations in the early 20th century. In 1945 a monitoring program for wildlife health was initiated. The program is today an integrated part of the National Environmental Monitoring programs in Sweden. The total material today comprises m...

journal_title：Annals of the New York Academy of Sciences

authors： Morner T

更新日期：2002-10-01 00:00:00

abstract：:Release of the amyloid precursor protein (APP) of Alzheimer's disease from Swiss 3T3 fibroblasts was stimulated in a concentration-dependent manner by phorbol 12-myristate 13-acetate. In fibroblasts overexpressing protein kinase C alpha (PKC alpha), the EC50 for this response was 7 nM, while in control cells the EC50 ...

journal_title：Annals of the New York Academy of Sciences

authors： Slack BE,Nitsch RM,Livneh E,Kunz GM Jr,Eldar H,Wurtman RJ

更新日期：1993-09-24 00:00:00

abstract：:Sensorineural hearing loss results from the degeneration of hair cells and/or auditory neurons in the cochlea of the inner ear. BDNF and NT-3 were shown to support survival of auditory neurons both in vitro and in vivo. Cochlea from P3-P4 rats were cultured as floating explants and hair cells in the organ of Corti wer...

journal_title：Annals of the New York Academy of Sciences

authors： Kuang R,Hever G,Zajic G,Yan Q,Collins F,Louis JC,Keithley E,Magal E

更新日期：1999-11-28 00:00:00

abstract：:Specific probes (alpha-bungarotoxin for acetylcholine receptor (AChR), staphylococcal protein A for IgG, monospecific antibodies against C3 and C9) labelled with peroxidase were applied to study of the ultrastructure of the MG end plate. In each case of MG there was postsynaptic AChR deficiency, usually greatest at en...

journal_title：Annals of the New York Academy of Sciences

authors： Engel AG,Sahashi K,Fumagalli G

更新日期：1981-01-01 00:00:00

abstract：:The molecular archaeology of the mutation spectra of tumor suppressor genes generates hypotheses concerning the etiology and molecular pathogenesis of human cancer. The spectrum of somatic mutations in the p53 gene implicates environmental carcinogens and both endogenous agents and processes in the etiology of human c...

journal_title：Annals of the New York Academy of Sciences

authors： Hussain SP,Hollstein MH,Harris CC

更新日期：2000-01-01 00:00:00

abstract：:Carbon nanotubes are considered to be one of the novel most attractive materials in nanotechnology. Because of their multiple industrial and biomedical applications, thorough studies on their toxicity and biocompatibility become a priority in order to prevent possible health risks. In this study the effects of multiwa...

journal_title：Annals of the New York Academy of Sciences

authors： De Nicola M,Nuccitelli S,Gattia DM,Traversa E,Magrini A,Bergamaschi A,Ghibelli L

更新日期：2009-08-01 00:00:00

abstract：:This paper explores aspects of the role that laboratory instruments have played in establishing psychology as a science. Comparisons of earlier instruments with their more modern counterparts indicate that many problems and methods still of interest today were explored in the laboratories of psychology's pioneers. Suc...

journal_title：Annals of the New York Academy of Sciences

authors： Caudle FM

更新日期：1983-01-01 00:00:00

abstract：:Hybrid liver systems are being developed as temporary extracorporeal liver support therapy. The overview given here emphasizes the development of both hepatocyte culture models for bioreactors and of systems for clinical therapy. In vitro studies demonstrate long term external metabolic function in isolated primary he...

journal_title：Annals of the New York Academy of Sciences

authors： Sauer IM,Obermeyer N,Kardassis D,Theruvath T,Gerlach JC

更新日期：2001-11-01 00:00:00

abstract：:In humans any effects of dietary saturated fats or omega-6 polyunsaturates on blood pressure appear to be mediated by changes in caloric intake and long-term weight changes. In contrast, omega-3 fatty acids have a mild antihypertensive effect which is seen most clearly in untreated subjects with higher blood pressures...

journal_title：Annals of the New York Academy of Sciences

authors： Beilin LJ

更新日期：1993-06-14 00:00:00

abstract：:By virtue of the progress in proteomics, the involvement of posttranslational modifications in aging has been more clearly demonstrated in recent years. We describe here that (1) carbonylation, a hallmark of protein oxidation in general, is paradoxically decreased in histone with aging and increased by calorie restric...

journal_title：Annals of the New York Academy of Sciences

authors： Nakamura A,Kawakami K,Kametani F,Nakamoto H,Goto S

更新日期：2010-06-01 00:00:00

abstract：:During their development, mononuclear phagocytes express a changing profile of proteinases that may participate in the degradation of elastin and other extracellular matrix components. Neutrophil elastase is produced and stored in azurophil-like granules in immature mononuclear phagocytes. Monocytes contain small amou...

journal_title：Annals of the New York Academy of Sciences

authors： Shapiro SD,Campbell EJ,Welgus HG,Senior RM

更新日期：1991-01-01 00:00:00

abstract：:In the light of results of clinical trials with immunoisolated human parathyroid tissue Ba2+-alginate capsules were developed that meet the requirements for long-term immunoisolated transplantation of (allogeneic and xenogeneic) cells and tissue fragments. Biocompatibility of the capsules was achieved by subjecting hi...

journal_title：Annals of the New York Academy of Sciences

authors： Zimmermann U,Thürmer F,Jork A,Weber M,Mimietz S,Hillgärtner M,Brunnenmeier F,Zimmermann H,Westphal I,Fuhr G,Nöth U,Haase A,Steinert A,Hendrich C

更新日期：2001-11-01 00:00:00

abstract：:Obesity and Type 2 diabetes are now major public health issues in developed nations and have reached epidemic proportions in many developing nations, as well as disadvantaged groups in developed countries, e.g., Mexican-Americans, African-Americans, and Australian Aborigines. These groups all show hyperinsulinemia and...

journal_title：Annals of the New York Academy of Sciences

authors： Zimmet P,Boyko EJ,Collier GR,de Courten M

更新日期：1999-11-18 00:00:00

abstract：:This paper presents a system dynamics policy model of nutritional food market transformation, tracing over-time interactions between the nutritional quality of supply, consumer food choice, population health, and governmental policy. Applied to the Canadian context and with body mass index as the primary outcome, we e...

journal_title：Annals of the New York Academy of Sciences

authors： Struben J,Chan D,Dubé L

更新日期：2014-12-01 00:00:00

abstract：:Evidence gathered to date from topographic data, geophysical data, well logs, and drill-core samples indicates that the buried Chicxulub basin, the source crater for the approximately 65 Ma Cretaceous-Tertiary (K/T) boundary deposits, is approximately 300 km in diameter. A prominent topographic ridge and a ring of gra...

journal_title：Annals of the New York Academy of Sciences

authors： Sharpton VL,Marin LE

更新日期：1997-05-30 00:00:00

abstract：:In two experiments, musically trained and untrained adults were tested on their ability to match spoken utterances with their tonal analogues (tone sequences that retained the pitch and temporal patterns of the utterances). In both cases, musical training was associated with superior performance, indicating an enhance...

journal_title：Annals of the New York Academy of Sciences

authors： Thompson WF,Schellenberg EG,Husain G

更新日期：2003-11-01 00:00:00

abstract：:This work summarizes new and emerging metrics and tools in esophageal function testing and their potential clinical impact. Because the diagnostic sensitivity and reliability of conventional impedance-pH variables are suboptimal, several novel impedance parameters, such as the postreflux swallow-induced peristaltic wa...

journal_title：Annals of the New York Academy of Sciences

authors： Akiyama J,Sumida J,Nakagawa K,Masamune A,Issariyakulkarn N,Patcharatrakul T,Shetler K,Kuribayashi S,Uraoka T,Triadafilopoulos G

更新日期：2020-12-01 00:00:00

abstract：:CYP21A2 genotyping remains an important element in the diagnosis and management of congenital adrenal hyperplasia, and establishing accurate genotype-phenotype correlations has facillitated adequate genetic counseling and prenatal management for at-risk families. Despite extensive efforts to establish a clear genotype...

journal_title：Annals of the New York Academy of Sciences

authors： Elmougy F,Sharaf S,Hafez M,Khattab A,Abou-Yousef H,Elsharkawy M,Baz H,Ekladious S,Sherif B,Musa N,Elshiwy Y,Afif A,Abdullatif M,Thabet G,Rady N,Ibrahim A,Soliman H

更新日期：2018-03-01 00:00:00

abstract：:A range of imidazoline derivatives are known to be effective stimulators of insulin secretion, and this response correlates with closure of ATP-sensitive potassium channels in the pancreatic beta-cell. However, mounting evidence indicates that potassium channel blockade may form only part of the mechanism by which imi...

journal_title：Annals of the New York Academy of Sciences

authors： Morgan NG,Chan SL,Mourtada M,Monks LK,Ramsden CA

更新日期：1999-06-21 00:00:00

abstract：:We created a toolbox of recombinant, microbial lipases, which allows us in combination with a lipase database to choose among the overexpressed lipases the most appropriate for a specific application and to improve it further via mutagenesis. By systematic comparison of geometry and properties of the scissile fatty ac...

journal_title：Annals of the New York Academy of Sciences

authors： Schmidt-Dannert C,Pleiss J,Schmid RD

更新日期：1998-12-13 00:00:00

abstract：:Learning to play a musical instrument requires complex multimodal skills involving simultaneous perception of several sensory modalities: auditory, visual, and somatosensory as well as the motor system. Musical training thus provides an adequate neuroscientific model to study multimodal integration and plasticity in m...

journal_title：Annals of the New York Academy of Sciences

authors： Pantev C,Lappe C,Herholz SC,Trainor L

更新日期：2009-07-01 00:00:00

abstract：:Spinal cord injury remains with limited natural recovery and only a few general ineffective treatment options. Recent publications have reported enhanced neurologic recovery with the use of methylprednisolone and GM-1 ganglioside. The results of the Maryland GM-1 Ganglioside Study reported a significant drug effect wi...

journal_title：Annals of the New York Academy of Sciences

authors： Geisler FH

更新日期：1998-06-19 00:00:00

abstract：:Stationary-phase mutation (a subset of which was previously called adaptive mutation) occurs in apparently nondividing, stationary-phase cells exposed to a nonlethal genetic selection. In one experimental system, stationary-phase reversion of an Escherichia coli F'-borne lac frameshift mutation occurs by a novel molec...

journal_title：Annals of the New York Academy of Sciences

authors： Lombardo MJ,Torkelson J,Bull HJ,McKenzie GJ,Rosenberg SM

更新日期：1999-05-18 00:00:00

abstract：:Uteroglobin (UG) is a multifunctional, secreted protein with anti-inflammatory and antichemotactic properties. While its anti-inflammatory effects, in part, stem from the inhibition of soluble phospholipase A2 (sPLA2) activity, the mechanism(s) of its antichemotactic effects is not clearly understood. Although specifi...

journal_title：Annals of the New York Academy of Sciences

authors： Kundu GC,Zhang Z,Mantile-Selvaggi G,Mandal A,Yuan CJ,Mukherjee AB

更新日期：2000-01-01 00:00:00

abstract：:In a variety of cell types including chinese hamster embryonic fibroblasts (IIC9 cells), alpha-thrombin is a potent mitogen. Thrombin irreversibly activates Par 1, a member of the seven membrane-spanning superfamily of G protein-coupled receptors (GPCRs). This, in turn, activates several heterotrimeric G proteins and ...

journal_title：Annals of the New York Academy of Sciences

authors： Goel R,Baldassare JJ

更新日期：2002-11-01 00:00:00

abstract：:The concentration of materials and energy within cities is an inevitable consequence of dense populations and their per capita requirements for food, fiber, and fuel. As the world population becomes increasingly urban over the coming decades, urban areas will dramatically affect the distribution of nutrients across th...

journal_title：Annals of the New York Academy of Sciences

authors： Bernhardt ES,Band LE,Walsh CJ,Berke PE

更新日期：2008-01-01 00:00:00

abstract：:Acanthamoeba castellanii (A. castellanii) is a common soil- or water-borne protozoon that feeds on bacteria by phagocytosis. A. castellanii can grow between 4 and 32 degrees C and has to adapt quickly to chilling in order to survive. We have identified a Delta12-fatty acid desaturase as key to low temperature adaptati...

journal_title：Annals of the New York Academy of Sciences

authors： Harwood JL

更新日期：2007-10-01 00:00:00

abstract：:Music-supported therapy (MST) has been developed recently to improve the use of the affected upper extremity after stroke. MST uses musical instruments, an electronic piano and an electronic drum set emitting piano sounds, to retrain fine and gross movements of the paretic upper extremity. In this paper, we first desc...

journal_title：Annals of the New York Academy of Sciences

authors： Rodriguez-Fornells A,Rojo N,Amengual JL,Ripollés P,Altenmüller E,Münte TF

更新日期：2012-04-01 00:00:00

abstract：:Autophagy is a phylogenetically conserved process that plays a critical role in the degradation of oxidatively damaged proteins and organelle turnover. The role of oxidative stress and apoptosis in methamphetamine (METH)-induced neurotoxicity is well known; however, the potential contribution of autophagy to METH-indu...

journal_title：Annals of the New York Academy of Sciences

authors： Kanthasamy A,Anantharam V,Ali SF,Kanthasamy AG

更新日期：2006-08-01 00:00:00

abstract：:Ovarian failure is heterogeneous, both in cause and in phenotype. Women whose menses cease prior to age 40 years and have menopausal FSH levels are traditionally considered by clinicians to have the diagnosis of "premature ovarian failure" (POF). In fact, however, the ovarian function in this disorder is in reality a ...

journal_title：Annals of the New York Academy of Sciences

authors： Simpson JL

更新日期：2008-01-01 00:00:00