beta-Arrestin 1 couples thrombin to the rapid activation of the Akt pathway.

abstract：:Results of therapeutic trials of transfer factor in a number of laboratories suggest clinical benefit and enhancement of immunological reactivity in patients with primary or secondary immunodeficiency diseases. Long term follow-up of 32 patients with the Wiskott-Aldrich syndrome suggested that transfer factor caused c...

journal_title：Annals of the New York Academy of Sciences

authors： Spitler LE

更新日期：1979-01-01 00:00:00

abstract：:The human organism is in a state of dynamic equilibrium, homeostasis. The stress system is activated when homeostasis is challenged by extrinsic or intrinsic forces, the stressors. This system, whose central component is the central nervous system (CNS) and includes corticotropin-releasing hormone (CRH) and noradrener...

journal_title：Annals of the New York Academy of Sciences

authors： Stratakis CA,Chrousos GP

更新日期：1995-12-29 00:00:00

abstract：:The trailblazing research on sleep mechanisms and petit mal epilepsy, conducted during the period from 1940 through 1970, illuminated the brain substrate for normal consciousness and attention, as well as their disorders. This research helped inform and structure our neuropsychologically based model of the "elements" ...

journal_title：Annals of the New York Academy of Sciences

authors： Mirsky AF,Duncan CC

更新日期：2001-06-01 00:00:00

abstract：:We study the linear coupling between the Marangoni and Cowley-Rosensweig instabilities for a thin layer of ferrofluid subjected to a temperature gradient and a magnetic field. Both are perpendicular to the reference horizontal boundaries, one of which is a rigid plate, while the other is a free surface remaining flat ...

journal_title：Annals of the New York Academy of Sciences

authors： Hennenberg M,Slavtchev S,Weyssow B

更新日期：2009-04-01 00:00:00

abstract：:In this paper, I describe the development of the Irie Classroom Toolbox, a school-based violence prevention, teacher training program for use with children aged 3-6 years. In-depth interviews were conducted with Jamaican preschool teachers, who had participated in a trial of a classroom behavior management program, at...

journal_title：Annals of the New York Academy of Sciences

authors： Baker-Henningham H

更新日期：2018-05-01 00:00:00

abstract：:We propose a model for signaling events induced by fluid shear stress that incorporates many of the features discussed in this paper (FIG. 4). First, heterotrimeric G-proteins, as well as a small G-proteins, are activated by flow. Indeed, a G protein appears to be required for ERK1/2 activation by flow because ERK1/2 ...

journal_title：Annals of the New York Academy of Sciences

authors： Ishida T,Takahashi M,Corson MA,Berk BC

更新日期：1997-04-15 00:00:00

abstract：:The gain of the angular vestibulo-ocular reflex (aVOR) was determined in monkeys by rotation about a spatial vertical axis while upright or statically tilted forward and backward. Horizontal, vertical, and roll gains were determined at each head orientation and plotted as a function of head tilt. Before canal plugging...

journal_title：Annals of the New York Academy of Sciences

authors： Yakushin SB,Dai M,Raphan T,Suzuki J,Arai Y,Cohen B

更新日期：2001-10-01 00:00:00

abstract：:The aim of this prospective study was to assess the prevalence of antiphospholipid antibodies (aPL) in women who had undergone in vitro fertilization (IVF) and the relationship between aPL and IVF outcome. A total of 101 infertile women with at least three unsuccessful IVF attempts were consecutively included in this ...

journal_title：Annals of the New York Academy of Sciences

authors： Sanmarco M,Bardin N,Camoin L,Beziane A,Dignat-George F,Gamerre M,Porcu G

更新日期：2007-06-01 00:00:00

abstract：:A previous review of alternative treatments (Tx) of ADHD--those other than psychoactive medication and behavioral/psychosocial Tx--was supplemented with an additional literature search focused on adults with ADHD. Twenty-four alternative Tx were identified, ranging in scientific documentation from discrediting control...

journal_title：Annals of the New York Academy of Sciences

authors： Arnold LE

更新日期：2001-06-01 00:00:00

abstract：:It is thought that neuronal activity in orbitofrontal cortex (OFC) represents the value of anticipated reward; however activity in many other brain areas also seems to reflect expected reward value. For example, we have shown that in monkeys performing a memory-guided saccade task for a reward of variable size, activi...

journal_title：Annals of the New York Academy of Sciences

authors： Roesch MR,Olson CR

更新日期：2007-12-01 00:00:00

abstract：:To identify factors regulating neurogenesis and programmed cell death in mouse olfactory epithelium (OE), and to determine the mechanisms by which these factors act, we have studied mouse OE using two major experimental paradigms: tissue culture of embryonic OE and cell types isolated from it; and ablation of the olfa...

journal_title：Annals of the New York Academy of Sciences

authors： Calof AL,Rim PC,Askins KJ,Mumm JS,Gordon MK,Iannuzzelli P,Shou J

更新日期：1998-11-30 00:00:00

abstract：:A remarkable "steroid sparing" effect of Saiboku-to was noted within 6 to 12 months of treatment in steroid-dependent asthmatic patients. Saiboku-to spared the downregulation of glucocorticoid receptor of human lymphocytes, plasma ACTH, and cortisol levels. It also spared downregulation of beta 2 receptor by beta 2 ag...

journal_title：Annals of the New York Academy of Sciences

authors： Nakajima S,Tohda Y,Ohkawa K,Chihara J,Nagasaka Y

更新日期：1993-06-23 00:00:00

abstract：:Despite advances in technology and medicine, death itself remains an immutable certainty. Indeed, the acceptance and understanding of our mortality are among the enduring metaphysical challenges that have confronted human beings from the beginning of time. How have we sought to cope with the inevitability of our morta...

journal_title：Annals of the New York Academy of Sciences

authors： Paulson S,Kellehear A,Kripal JJ,Leary L

更新日期：2014-11-01 00:00:00

abstract：:Iddm4 is a dominant non-major histocompatibility complex (MHC) determinant of diabetes susceptibility in BBDR rats treated with poly I:C, plus depletion of regulatory T cells. In congenic MHC-identical normal WF rats, Iddm4(d) sensitively and specifically predicts induced diabetes. We report a new diabetes-susceptible...

journal_title：Annals of the New York Academy of Sciences

authors： Blankenhorn EP,Descipio C,Rodemich L,Cort L,Leif JH,Greiner DL,Mordes JP

更新日期：2007-04-01 00:00:00

abstract：:1 alpha,25-Dihydroxyvitamin D3, the active form of vitamin D3, induced maturation of circulating monocytes to form macrophage-epithelioid cells and multinucleated giant cells in vitro. Calcitriol not only promoted the differentiation of monocytes, as shown by the marked morphological changes and enhanced secretion of ...

journal_title：Annals of the New York Academy of Sciences

authors： Ohta M,Okabe T,Ozawa K,Urabe A,Takaku F

更新日期：1986-01-01 00:00:00

abstract：:The multiple actions of somatostatin are mediated by specific membrane-bound receptors present in all somatostatin target tissues, such as brain, pituitary, pancreas, gastrointestinal tract, and kidney. For instance, in the human gastrointestinal tract, three different types of tissue compartments express somatostatin...

journal_title：Annals of the New York Academy of Sciences

authors： Reubi JC,Laissue J,Waser B,Horisberger U,Schaer JC

更新日期：1994-09-15 00:00:00

abstract：:In this article, we have presented an overview of fundamental issues involved in mediphotonic imaging, and reviewed some of the emerging techniques for early-light transillumination imaging of body organs. The results on human breast tissues presented here, together with the data accumulated and advances made by resea...

journal_title：Annals of the New York Academy of Sciences

authors： Alfano RR,Demos SG,Gayen SK

更新日期：1997-05-30 00:00:00

abstract：:Chlorine (Cl2 ) and bromine (Br2 ) are produced in large quantities throughout the world and used in the industry and the sanitation of water. These halogens can pose a significant threat to public health when released into the atmosphere during transportation and industrial accidents, or as acts of terrorism. In this...

journal_title：Annals of the New York Academy of Sciences

authors： Lazrak A,Song W,Zhou T,Aggarwal S,Jilling T,Garantziotis S,Matalon S

更新日期：2020-11-01 00:00:00

abstract：:In plants, the photons of light are absorbed at the level of the photosystems in the chloroplasts. The functioning of the photosynthetic electron transfer chain linked to this process is required to generate NADPH and ATP. In addition, the light signal promotes a regulatory cascade, situated in the stroma, that involv...

journal_title：Annals of the New York Academy of Sciences

authors： Jacquot JP,Rouhier N,Gelhaye E

更新日期：2002-11-01 00:00:00

abstract：:Improved technology and medical advances have increased the lifespan for people with thalassemia. As thalassemia is no longer exclusively a pediatric blood disorder, consideration must now be given to transition planning from pediatric to adult care. The complexity of thalassemia disease, coupled with the changing fac...

journal_title：Annals of the New York Academy of Sciences

authors： Levine L,Levine M

更新日期：2010-08-01 00:00:00

abstract：:Bioelectrical impedance analysis (BIA) has been proposed for measuring fat-free mass, total body water, percent fat, body cell mass, intracellular water, and extracellular water: a veritable laboratory in a box. Although it is unlikely that BIA is quite this versatile, correlations have been demonstrated between BIA a...

journal_title：Annals of the New York Academy of Sciences

authors： Schoeller DA

更新日期：2000-05-01 00:00:00

abstract：:The Na,K-ATPase gamma subunit is present primarily in kidney as two splice variants, gammaa and gammab, which differ only at their extracellular N-termini. Two distinct effects of gamma are seen in biochemical Na,K-ATPase assays of mammalian (HeLa) cells transfected with gammaa or gammab, namely, (i) a decrease in K'(...

journal_title：Annals of the New York Academy of Sciences

authors： Blostein R,Pu HX,Scanzano R,Zouzoulas A

更新日期：2003-04-01 00:00:00

abstract：:Valproic acid (VA), a histone deacetylase inhibitor (HDACI), in vitro induces differentiation of promyelocyte leukemia cell (HL-60) and proliferation arrest and apoptosis of various leukemia cell lines. In MOLT-4 cells (human T lymphocyte leukemia) the cell cycle arrest is caused by 2 mM VA, while 4 mM VA induces main...

journal_title：Annals of the New York Academy of Sciences

authors： Záskodová D,Rezácová M,Vávrová J,Vokurková D,Tichy A

更新日期：2006-12-01 00:00:00

abstract：:Our recent studies in non-human primates have identified and characterized cerebro-ponto-cerebellar pathways involved in the control of vergence eye movements. Specifically, within the deep cerebellar nuclei and nucleus reticularis tegmenti pontis, we have identified neurons that are related to either the near respons...

journal_title：Annals of the New York Academy of Sciences

authors： Gamlin PD

更新日期：2002-04-01 00:00:00

abstract：:The liver is morphologically and functionally modulated by sex hormones. Long-term use of oral contraceptives (OCs) and anabolic androgenic steroids (AASs) can induce both benign (hemangioma, adenoma, and focal nodular hyperplasia [FNH]) and malignant (hepatocellular carcinoma [HCC]) hepatocellular tumors. Hepatic ade...

journal_title：Annals of the New York Academy of Sciences

authors： Giannitrapani L,Soresi M,La Spada E,Cervello M,D'Alessandro N,Montalto G

更新日期：2006-11-01 00:00:00

abstract：:TGF beta is a cytokine which is involved with the regulation of different aspects of host defense responses to injury. Overexpression of TGF beta can lead to the conversion of its protective functions to pathogenetic manifestations. TGF beta is a potent factor in promoting anabolic aspects in connective tissue metabol...

journal_title：Annals of the New York Academy of Sciences

authors： Lotz M,Seth P

更新日期：1993-06-23 00:00:00

abstract：:Metastasis is the main cause of human cancer deaths, and cell motility is one key component of the process of metastasis. The ERK mitogen-activated protein kinase (MAPK) signaling pathway is probably one of the most commonly activated in malignant human cancers. We describe the molecular mechanisms by which ERK MAPK s...

journal_title：Annals of the New York Academy of Sciences

authors： Viala E,Pouysségur J

更新日期：2004-12-01 00:00:00

abstract：:We have demonstrated a far more widespread and selective ischemic cell damage than previously thought. In area CA3, a distinct subpopulation of interneurons, characterized by their spiny dendrites and their calretinin content, was selectively vulnerable in the absence of any other CA3 involvement. In the dentate hilus...

journal_title：Annals of the New York Academy of Sciences

authors： Hsu M,Sik A,Gallyas F,Horváth Z,Buzsáki G

更新日期：1994-11-14 00:00:00

abstract：:Human immunodeficiency virus-type 1 (HIV-1) infection is characterized by increased immune cell apoptosis. Apoptosis can be triggered by signals that arise from within the cell, or by signals that are elicited by binding of extracellular "death ligands" to their "death receptors," most of which belong to the tumor nec...

journal_title：Annals of the New York Academy of Sciences

authors： Pinti M,Nasi M,Moretti L,Mussini C,Petrusca D,Esposito R,Cossarizza A

更新日期：2000-01-01 00:00:00

abstract：:The paper describes a comprehensive and objective evaluation of 2358 persons arrested in Philadelphia for driving while intoxicated. It was demonstrated that 63.8% of this population was involved with alcohol to an extent that a diagnosis of alcoholism was evident, and it is suggested that these persons are in need of...

journal_title：Annals of the New York Academy of Sciences

authors： Fine EW,Scoles P

更新日期：1976-01-01 00:00:00