The hypernoradrenergic state in vasodilator drug-treated hypertensive patients: effect of clonidine.

abstract：:The in vivo effects of two unsurmountable angiotensin II type 1 (AT1) antagonists, irbesartan (150 mg) and candesartan (8 mg), were studied in a double-blind, randomized, crossover study in 18 healthy men. The drugs' direct vascular effects were assessed as the rightward shift (dose ratio - 1) of angiotensin dose-effe...

journal_title：Journal of cardiovascular pharmacology

authors： Belz GG,Butzer R,Kober S,Mutschler E

更新日期：2002-04-01 00:00:00

abstract：:To investigate the epidemiological relationship of dietary factors to blood pressure (BP) and major cardiovascular diseases, we carried out the International Cooperative Cardiovascular Diseases and Alimentary Comparison (CARDIAC) Study, which so far involves 45 centers in 20 countries. From each population, 100 men an...

journal_title：Journal of cardiovascular pharmacology

authors： Yamori Y,Nara Y,Mizushima S,Mano M,Sawamura M,Kihara M,Horie R

更新日期：1990-01-01 00:00:00

abstract：:To assess the cardiac functional reserve of elderly hypertensive patients with left ventricular hypertrophy (LVH) we studied cardiac function after isometric exercise and beta-adrenergic stimulation. Forty-five elderly hypertensive and 16 normotensive patients (NC group) were recruited for the study. The hypertensive ...

journal_title：Journal of cardiovascular pharmacology

authors： Suzuki Y,Kuwajima I,Hoshino S,Kanemaru A,Shimozawa T,Matsushita S,Kuramoto K

更新日期：1991-01-01 00:00:00

abstract：:The mechanisms of sustained ventricular tachycardia (VT) induced by large cumulative dose of cesium chloride (Cs) remains unclear. Seven anesthetized rabbits were intravenously injected with Cs (1 mmol/kg) 3 times at 20-min intervals. The surface ECG and monophasic action potential of the left ventricular endocardium ...

journal_title：Journal of cardiovascular pharmacology

authors： Takahashi N,Ito M,Fujino T,Iwao T,Nakagawa M,Yonemochi H,Saikawa T,Sakata T

更新日期：1998-05-01 00:00:00

abstract：:A contribution by active vasodilation to the hypotensive effect of medroxalol was investigated in anesthetized dogs and reserpinized pithed rats. In anesthetized dogs, intravenous doses of medroxalol, which decreased blood pressure and heart rate, also produced a dose-related vasodilation in the isolated perfused grac...

journal_title：Journal of cardiovascular pharmacology

authors： Dage RC,Hsieh CP,Spedding M

更新日期：1983-01-01 00:00:00

abstract：:In this study the effects of a new calcium entry blocking agent, 2,6-dimethyl-3-methoxycarbonyl-4-(2-nitrophenyl)-5-(2-furoyl)-1, 4-dihydropyridine (MDL 72567), were compared with those of nifedipine on blood pressure, heart rate, ECG, and cardiac contractility indices in conscious sinoaortic baroreceptor-denervated (...

journal_title：Journal of cardiovascular pharmacology

authors： Petty MA,Spedding M,Di Francesco GF

更新日期：1987-10-01 00:00:00

abstract：:The formation of bone occurs via a series of events that are regulated by various hormones and cytokines. We previously reported that endothelin (ET) inhibits the mineralization by osteoblastic cells and natriuretic peptide (NP) promotes osteoblastic differentiation. Therefore, we attempted to identify the genes induc...

journal_title：Journal of cardiovascular pharmacology

authors： Inoue A,Kamiya A,Ishiji A,Hiruma Y,Hirose S,Hagiwara H

更新日期：2000-11-01 00:00:00

abstract：:We studied the effects of orally administered ibutilide, a class III antiarrhythmic agent, in a model of reentrant atrial flutter in conscious dogs. After baseline determination of atrial effective refractory period (AERP) and demonstration of reproducible induction of atrial flutter by rapid atrial pacing, 8 dogs rec...

journal_title：Journal of cardiovascular pharmacology

authors： Buchanan LV,Turcotte UM,Kabell GG,Gibson JK

更新日期：1993-07-01 00:00:00

abstract：:We studied the influence of prostacyclin (PGI2) on the contractile performance of isolated mammalian ventricular muscle. PGI2 had no direct influence on myocardial contractility, as evidenced by experiments on single cardiac cells and papillary muscle. Moreover, PGI2 did not interfere with the inotropic action of isop...

journal_title：Journal of cardiovascular pharmacology

authors： Couttenye MM,De Clerck NM,Herman AG,Brutsaert DL

更新日期：1985-09-01 00:00:00

abstract：:Adenosine protects the ischemic myocardium by coronary vasodilation and the depression of heart rate and contractility, improving myocardial energy balance. Adenosine effects on the myocardium are mediated predominantly by the type A1 receptors. Atrial natriuretic peptide (ANP), a vasodilator and regulator of blood vo...

journal_title：Journal of cardiovascular pharmacology

authors： Salman H,Bergman M,Schlesinger H,Zahavi I,Kessler-Icekson G

更新日期：1999-07-01 00:00:00

abstract：:Gangliosides, sialic acid-containing glycosphigolipids, are localized mostly to the outer leaflet of the lipid bilayer in the plasma membrane, particularly in brain. Gangliosides reduce edema formation, restore glucose metabolism, and increase cerebral blood flow after focal ischemia in the rat brain. We wished to det...

journal_title：Journal of cardiovascular pharmacology

authors： Maulik N,Das DK,Gogineni M,Cordis GA,Avrova N,Denisova N

更新日期：1993-07-01 00:00:00

abstract：:Left ventricular (LV) function and end-diastolic dimensions were determined during antegrade and retrograde perfusions, respectively. Isolated hearts from spontaneously hypertensive rats (SHRs) and renal hypertensive rats and SHRs to which either feldopine, nifedipine, alpha-methyldopa, or a combination of felodipine ...

journal_title：Journal of cardiovascular pharmacology

authors： Nordlander M,Wåhlander H,Friberg P

更新日期：1987-01-01 00:00:00

abstract：:The force generators in myocardial cells of rats and rabbits can exist in three different states: relaxed and calcium unresponsive; relaxed and calcium responsive; and contracted. The transition between the two calcium responsive states is produced by the abrupt rise in the concentration of calcium ions during activat...

journal_title：Journal of cardiovascular pharmacology

authors： Winegrad S,McClellan G,Weisberg A,Lin LE,Weindling S

更新日期：1986-01-01 00:00:00

abstract：:Using selective endothelin (ET) receptor antagonists, we investigated which ET receptor subtypes mediate the changes in blood pressure and hematocrit produced by intraarterial injection of ET-1 in the anesthetized rabbit. In addition, the receptor through which ET-1 stimulates the release of prostacyclin (PGI2) and, h...

journal_title：Journal of cardiovascular pharmacology

authors： McMurdo L,Lidbury PS,Corder R,Thiemermann C,Vane JR

更新日期：1993-01-01 00:00:00

abstract：:The concentrations of lactate, pyruvate, and adenosine, together with some of their derivatives, were determined in microdialysates from 12 pig hearts, 6 of which were subjected to preconditioning and 40 min of ischemia (index ischemia) and 6 of which were subjected to only 40 min of index ischemia. Two microdialysis ...

journal_title：Journal of cardiovascular pharmacology

authors： Wikström BG,Ronquist G,Waldenström A

更新日期：1996-05-01 00:00:00

abstract：:In an initial double-blind randomized study with three parallel groups, 48 patients, mean age 49.6 years (32-65 years), with hypertension WHO I-II, were given bisoprolol in doses of 5, 10, and 20 mg. Bisoprolol is a new beta 1-selective beta-blocking agent with a plasma half-life of 10-12 h and without intrinsic sympa...

journal_title：Journal of cardiovascular pharmacology

authors： Weiner L,Frithz G

更新日期：1986-01-01 00:00:00

abstract：:The combination of a beta-adrenoceptor-blocking drug with the dihydropyridine calcium channel antagonist, nitrendipine, has particular therapeutic advantages in the management of hypertension. The beta-blocker reduces any reflex increases in sympathetic nervous system and renin-angiotensin system activity that result ...

journal_title：Journal of cardiovascular pharmacology

authors： Mac Carthy EP

更新日期：1988-01-01 00:00:00

abstract：:In isolated rat tail arteries perfused with Krebs-Henseleit solution, ouabain, in concentrations of less than 10(-5) M, caused a concentration-dependent, noncompetitive inhibition of the vasoconstrictor response to phenylephrine. Concentrations of 10(-8) and 10(-6) M caused 30 and 61% inhibition, respectively. The inh...

journal_title：Journal of cardiovascular pharmacology

authors： Armsworth SJ,Marwood JF,Stokes GS

更新日期：1985-07-01 00:00:00

abstract：:The effects of prenylamine (PNL) and AQ-A 39 on sustained ventricular tachycardia (SVT) were studied by programmed stimulation in conscious dogs 4-10 days after ligation of the left anterior descending (LAD) coronary artery. In 8 of 16 dogs developing SVT in the control, PNL (3 mg/kg intravenously, i.v.) suppressed in...

journal_title：Journal of cardiovascular pharmacology

authors： Aidonidis I,Egel E,Hilbel T,Kuebler W,Brachmann J

更新日期：1993-09-01 00:00:00

abstract：:This study was designed to examine whether physiologically tolerable insulin, which maintains lower blood glucose, can protect the myocardium against ischemia/reperfusion (I/R) injury in a preclinical large animal model. Adult dogs were subjected to 50 minutes of myocardial ischemia (80% reduction in coronary blood fl...

journal_title：Journal of cardiovascular pharmacology

authors： Zhang HX,Zang YM,Huo JH,Liang SJ,Zhang HF,Wang YM,Fan Q,Guo WY,Wang HC,Gao F

更新日期：2006-12-01 00:00:00

abstract：:The relation between insulin resistance/ hyperinsulinemia and cardiovascular disease may be related to one of the cardiovascular effects of insulin. In acute experiments in humans, systemic euglycemic hyperinsulinemia induced vasodilation in skeletal muscle. Furthermore, the sympathetic nervous system is activated, al...

journal_title：Journal of cardiovascular pharmacology

authors： Tack CJ,Heeremans M,Thien T,Lutterman JA,Smits P

更新日期：1996-08-01 00:00:00

abstract：:The area of vulnerability (AOV) to ventricular fibrillation (VF) induction by high-voltage shocks has been proposed as a measure of vulnerability to VF. Biphasic shocks spanning the T wave and ranging between 50 V and the upper limit of vulnerability (ULV) to VF were delivered before and after terikalant (1 mg/kg) and...

journal_title：Journal of cardiovascular pharmacology

authors： Qi X,Varma P,Newman D,Mamalias N,Dorian P

更新日期：2002-02-01 00:00:00

abstract：:Endothelin (ET)-related peptides robustly stimulated [3H]-inositol phosphate (IP) formation in cultured cerebellar granule cells, astrocytes, and C6 glioma cells. Their agonist selectivities were ET-1 = ET-2 greater than or equal to sarafotoxin S6b greater than ET-3 greater than big ET-1 for granule cells and ET-1 gre...

journal_title：Journal of cardiovascular pharmacology

authors： Chuang DM,Lin WW,Lee CY

更新日期：1991-01-01 00:00:00

abstract：:We investigated the influence of the Ca(2+)-ATPase inhibitor thapsigargin (TG) on the vasorelaxant response to different endothelium-dependent and endothelium-independent relaxing agents in an isolated thoracic aorta preparation of the rabbit, precontracted by norepinephrine (NE). Pretreatment with 100 microM L-argini...

journal_title：Journal of cardiovascular pharmacology

authors： Amerini S,Filippi S,Parenti A,Ziche M,Ledda F

更新日期：1996-07-01 00:00:00

abstract：:Platelet-derived growth factor (PDGF) is a potent stimulator of growth of vascular smooth muscle cells (VSMCs). VSMCs from spontaneously hypertensive rats (SHRs) show exaggerated growth and increasingly express PDGF A-chain messenger RNA (mRNA). To examine adenovirus-mediated transfer of a ribozyme targeting the PDGF ...

journal_title：Journal of cardiovascular pharmacology

authors： Hu WY,Fukuda N,Kotani M,Kanmatsuse K

更新日期：2002-06-01 00:00:00

abstract：:MDL 19205 4-ethyl-1-,3-dihydro-5-(4-pyridinylcarbonyl)-2H-imidazol-2-one, a new cardioactive agent, has been shown to increase myocardial contractile force in animals. It is effective by both oral and intravenous routes. We studied 11 patients with congestive heart failure--in 10 cases owing to coronary artery disease...

journal_title：Journal of cardiovascular pharmacology

authors： Cottier C,Follath F,Kiowski W,Pfisterer M,Emmenegger H,Burkart F

更新日期：1987-02-01 00:00:00

abstract：INTRODUCTION:Newly emerging evidence showed that glucocorticoids could potentiate natriuretic peptides' action by increasing the density of natriuretic peptide receptor A, leading to a potent diuresis and a renal function improvement in patients with acute decompensated heart failure (ADHF). Therefore, glucocorticoid t...

journal_title：Journal of cardiovascular pharmacology

authors： Liu C,Liu K,COPE-ADHF Study Group.

更新日期：2014-04-01 00:00:00

abstract：:Currently, the effects of the thrombolytic drugs are tested in vivo in dog or rabbit models that require a relatively large amount of the drug. The goal of the present study was to describe a new model that would allow one to test the in vivo thrombolytic effect of drugs with a limited amount of compound. For this pur...

journal_title：Journal of cardiovascular pharmacology

authors： Clozel JP,Holvoet P,Tschopp T

更新日期：1988-01-01 00:00:00

abstract：:Glycogen synthase kinase (GSK)-3beta inhibitors play an anti-inflammatory role in several inflammatory diseases. Recent studies have demonstrated that GSK-3beta inhibitors protect against myocardial ischemia-reperfusion injury. However, the precise mechanisms remain unclear. We aimed to investigate the roles of inflam...

journal_title：Journal of cardiovascular pharmacology

authors： Gao HK,Yin Z,Zhou N,Feng XY,Gao F,Wang HC

更新日期：2008-09-01 00:00:00

abstract：:We previously showed that preoperative nicorandil, a hybrid potassium channel opener and nitrate compound, conferred cardioprotective effects in a hypoxia/reoxygenation model of isolated human atrial muscle by using functional recovery as an end point, and that ischaemic preconditioning surprisingly abolished the prot...

journal_title：Journal of cardiovascular pharmacology

authors： Imagawa J,Baxter GF,Yellon DM

更新日期：1998-01-01 00:00:00