Haemodynamic effects of carvedilol, a new beta-adrenoceptor blocker and precapillary vasodilator in essential hypertension.

Abstract:

:Carvedilol (BM 14190) is a new antihypertensive compound which combines beta-adrenoceptor blocking and precapillary vasodilating properties but is devoid of intrinsic sympathomimetic activity. The acute and long-term effects on blood pressure and regional haemodynamics (forearm plethysmography) were studied with carvedilol 25 mg b.i.d. or 50 mg b.i.d. Comparisons were made with propranolol 80 mg b.i.d. in a randomized double-blind placebo controlled trial comprised of 30 patients with essential hypertension. After a four-week placebo period active therapy was given for four weeks. Carvedilol administered acutely reduced blood pressure at both doses, delta 13/6 mmHg (P less than 0.001/P less than 0.01) and 17/10 mmHg (P less than 0.001/P less than 0.01). Resistance in the forearm fell significantly with the higher dose. This was in contrast to propranolol which only reduced heart rate acutely, and as expected caused a rise in forearm resistance. After four weeks both compounds had reduced blood pressure significantly and to the same extent. Blood flow was still significantly reduced with propranolol in contrast to the findings with carvedilol. We conclude that carvedilol given orally has a useful antihypertensive effect both acutely and during prolonged treatment. It is well tolerated and its haemodynamic profile is attractive.

journal_name

J Hypertens

journal_title

Journal of hypertension

authors

Eggertsen R,Sivertsson R,Andrén L,Hansson L

doi

10.1097/00004872-198410000-00013

subject

Has Abstract

pub_date

1984-10-01 00:00:00

pages

529-34

issue

5

eissn

0263-6352

issn

1473-5598

journal_volume

2

pub_type

临床试验,杂志文章,随机对照试验
  • Fasting inhibits natriuretic peptides clearance receptor expression in rat adipose tissue.

    abstract:OBJECTIVE AND DESIGN:The early phase of weight loss induced by fasting is associated with diuresis, natriuresis and reduction in blood pressure through unclear mechanisms. Atrial natriuretic peptide (ANP) is a cardiac hormone with potent natriuretic, diuretic and hypotensive effects mediated by 'biologically active' re...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199511000-00004

    authors: Sarzani R,Paci VM,Zingaretti CM,Pierleoni C,Cinti S,Cola G,Rappelli A,Dessì-Fulgheri P

    更新日期:1995-11-01 00:00:00

  • Carotid-femoral pulse wave velocity in the elderly.

    abstract::Predictive value of arterial stiffness in cardiovascular disease has been recognized for many decades. Carotid-femoral pulse wave velocity (cfPWV), as a noninvasive measurement, has been recommended as a gold standard of arterial stiffness, and we believe that this surrogate of arterial stiffness has been refined to t...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/HJH.0000000000000187

    authors: Zhang Y,Agnoletti D,Xu Y,Wang JG,Blacher J,Safar ME

    更新日期:2014-08-01 00:00:00

  • Influence of vitamin D receptor gene polymorphisms and 25-hydroxyvitamin D on blood pressure in apparently healthy subjects.

    abstract:BACKGROUND:There are no studies that relate BsmI polymorphism of the vitamin D receptor (VDR) gene and with vitamin D to blood pressure (BP). OBJECTIVE:To analyze if this polymorphism and 25-hydroxyvitamin D levels (25OHD3) influence BP in a population of healthy subjects. DESIGN:Transversal study on healthy populati...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/01.hjh.0000098139.70956.21

    authors: Muray S,Parisi E,Cardús A,Craver L,Fernández E

    更新日期:2003-11-01 00:00:00

  • Cardiac steroidogenesis and glucocorticoid in the development of cardiac hypertrophy during the progression to heart failure.

    abstract:BACKGROUND:Elevated plasma glucocorticoid level is an independent predictor of increased mortality risk in chronic heart failure, but local biosynthesis and pathophysiological roles of glucocorticoids in the heart remain unclear. METHODS:Dahl salt-sensitive rats on high-salt diet and mice with transthoracic aortic ban...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e328326cb04

    authors: Ohtani T,Mano T,Hikoso S,Sakata Y,Nishio M,Takeda Y,Otsu K,Miwa T,Masuyama T,Hori M,Yamamoto K

    更新日期:2009-05-01 00:00:00

  • The effect of losartan on global and focal cerebral perfusion and on renal function in hypertensives in mild early ischaemic stroke.

    abstract:BACKGROUND:Secondary prevention of stroke with antihypertensive drugs is now standard practice, but it is unclear how soon after a cerebrovascular event antihypertensive therapy should be initiated or re-started. Due to impaired cerebral autoregulation, changes in systemic blood pressure may be reflected in cerebral pe...

    journal_title:Journal of hypertension

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00004872-200405000-00022

    authors: Nazir FS,Overell JR,Bolster A,Hilditch TE,Reid JL,Lees KR

    更新日期:2004-05-01 00:00:00

  • Orthostatic blood pressure recovery associates with physical performance, frailty and number of falls in geriatric outpatients.

    abstract:OBJECTIVE:Blood pressure (BP) recovery after orthostatic hypotension might be important to prevent cerebral hypoperfusion episodes in older adults, and be related to better clinical outcome. The objective was to study the relationship between BP recovery and clinical outcome, that is physical and cognitive performance,...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002617

    authors: Mol A,Slangen LRN,van Wezel RJA,Maier AB,Meskers CGM

    更新日期:2021-01-01 00:00:00

  • Dietary sodium and pulse pressure in normotensive and essential hypertensive subjects.

    abstract:OBJECTIVES:To assess the influence of sodium intake on the two components of arterial blood pressure [mean blood pressure (MBP) and pulse pressure] and left ventricular mass (LVM) in normotensive subjects and never-treated hypertensive patients. METHODS:Blood pressure, LVM (M-mode echocardiography) and sodium excretio...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200404000-00011

    authors: du Cailar G,Mimran A,Fesler P,Ribstein J,Blacher J,Safar ME

    更新日期:2004-04-01 00:00:00

  • Albuminuria, but not estimated glomerular filtration rate, is associated with maladaptive arterial remodeling: the Hoorn Study.

    abstract:OBJECTIVE:Arterial remodeling aims to maintain a constant circumferential wall stress (sigmac). A failing remodeling process is associated with stroke. Data on the relationship between chronic kidney disease and arterial remodeling are scarce. METHODS:We investigated the association between a lower glomerular filtrati...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3282f50066

    authors: Hermans MM,Henry RM,Dekker JM,Nijpels G,Heine RJ,Stehouwer CD

    更新日期:2008-04-01 00:00:00

  • The accuracy of central SBP determined from the second systolic peak of the peripheral pressure waveform.

    abstract:BACKGROUND:Recent evidence suggests that central aortic blood pressure may be a better predictor of cardiovascular risk than peripheral blood pressure. The central SBP (cSBP) can be estimated from the late systolic shoulder of the radial pulse waveform. We compared the second systolic peak of the radial waveform (pSBP(...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/hjh.0b013e32832e0b58

    authors: Hickson SS,Butlin M,Mir FA,Graggaber J,Cheriyan J,Khan F,Grace AA,Yasmin,Cockcroft JR,Wilkinson IB,McEniery CM,Anglo-Cardiff Collaboration Trial Investigators.

    更新日期:2009-09-01 00:00:00

  • Assessment of age-dependent changes in circadian blood pressure rhythm in patients with essential hypertension.

    abstract::The effects of age on the circadian blood pressure rhythm of patients with untreated essential hypertension (n = 133, World Health Organization stage I or II) were compared with those of normotensive subjects (n = 91). Subjects were classified into three groups by age: young (less than 40 years old), adult (40-59 year...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199105000-00004

    authors: Munakata M,Imai Y,Abe K,Sasaki S,Minami N,Hashimoto J,Sakuma H,Ichijo T,Yoshizawa M,Sekino H

    更新日期:1991-05-01 00:00:00

  • p38 MAPK contributes to angiotensin II-induced COX-2 expression in aortic fibroblasts from normotensive and hypertensive rats.

    abstract:OBJECTIVE:To investigate the effect of angiotensin II on cyclooxygenase-2 (COX-2) expression in aortic adventitial fibroblasts from normotensive [Wistar-Kyoto (WKY)] rats and spontaneously hypertensive rats (SHRs). METHODS:Protein expression was determined by western blot, mRNA levels by real-time PCR, transcriptional...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/hjh.0b013e328317a730

    authors: Beltrán AE,Briones AM,García-Redondo AB,Rodríguez C,Miguel M,Alvarez Y,Alonso MJ,Martínez-González J,Salaices M

    更新日期:2009-01-01 00:00:00

  • Central haemodynamics in normal pregnancy: a prospective longitudinal study.

    abstract:OBJECTIVE:To conduct a longitudinal evaluation of the central haemodynamic adaptations of normal pregnancy. METHODS:This was a prospective longitudinal study involving healthy, normotensive women who were having an uncomplicated, singleton pregnancy. Brachial and central SBP, DBP, mean arterial pressure (MAP), brachia...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001768

    authors: O' Callaghan KM,Hennessy Á,Malvisi L,Kiely M

    更新日期:2018-10-01 00:00:00

  • Angiotensin II-induced apoptosis in rat cardiomyocyte culture: a possible role of AT1 and AT2 receptors.

    abstract:OBJECTIVES:To investigate the mechanism of angiotensin II-induced apoptosis in cultured cardiomyocytes by determining which receptor subtype is involved, and what is the relationship between intracellular Ca2+ changes and apoptosis. DESIGN AND METHODS:Neonatal rat cardiomyocytes were pretreated with either the AT1 ant...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200109000-00022

    authors: Goldenberg I,Grossman E,Jacobson KA,Shneyvays V,Shainberg A

    更新日期:2001-09-01 00:00:00

  • Characteristics of the 24-h ambulatory blood pressure monitoring in patients with Parkinson's disease - the SFC BP multicentre study in China.

    abstract:OBJECTIVES:Cardiovascular dysautonomia can be present at early, late and even prodromal stages of Parkinson's disease. This study aimed to describe the characteristics of 24-h ambulatory blood pressure (BP) monitoring and investigate the frequency of cardiovascular dysautonomia in Parkinson's disease without an abnorma...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002536

    authors: Chen SW,Wang YK,Dou RH,Xie XY,Hu YB,Ding N,Zhang GH,Jing HF,Zhao WD,Xue Y,Li Y,Wang G

    更新日期:2020-11-01 00:00:00

  • Vascular albumin permeability and hypertrophy in a rat model combining streptozotocin-induced diabetes and genetic hypertension.

    abstract:OBJECTIVE:To investigate the effects of hypertension and diabetes mellitus on vascular albumin permeability and hypertrophy in 11-week-old Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) with and without 3 weeks of streptozotocin-induced diabetes. METHODS:Vascular albumin permeability was measured as...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199505000-00008

    authors: Hulthén UL,Rumble J,Cooper ME,Johnston CI

    更新日期:1995-05-01 00:00:00

  • Family history of hypertension and cardiovascular reactivity to mental stress--effects of stimulus intensity and environment.

    abstract::Normotensives with hypertensive parents have been reported to exhibit enhanced cardiovascular reactions to mental stress. We have examined the question of why this result was not confirmed in all studies. In addition we have investigated whether appropriate tests can be performed under clinical rather than laboratory ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198502000-00006

    authors: Neus H,Gödderz W,Otten H,Rüddel H,von Eiff AW

    更新日期:1985-02-01 00:00:00

  • Contribution of systemic blood flow to untreated or inadequately controlled systolic--diastolic or isolated systolic hypertension in a community sample of African ancestry.

    abstract:AIMS:Age-related increases in systemic blood flow [stroke volume (SV), cardiac output (CO), and aortic flow (Q)] contribute substantially to untreated or inadequately controlled (uncontrolled) blood pressure (BP) in Africa. We aimed to identify the haemodynamic determinants of uncontrolled systolic--diastolic (Syst--di...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000002635

    authors: Mmopi KN,Norton GR,Bello H,Libhaber CD,Peters F,Sareli P,Peterson VR,Woodiwiss AJ

    更新日期:2020-08-29 00:00:00

  • Interpretation of renal angiography by radiologists.

    abstract:OBJECTIVE:Different radiologists may show considerable variation in their interpretation of renal angiograms. We therefore wished to establish the reliability of their interpretation. DESIGN:Assessment of the intra- and inter-observer agreement of the interpretation of renal angiograms. SETTING:Tertiary referral univ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199917120-00011

    authors: Schreij G,de Haan MW,Oei TK,Koster D,de Leeuw PW

    更新日期:1999-12-01 00:00:00

  • Carotid plaques, but not common carotid intima-media thickness, are independently associated with aortic stiffness.

    abstract:OBJECTIVE:It has been suggested that non-invasive aortic stiffness measurements can be used as an indicator of atherosclerosis. The relationships of arterial stiffness with arterial wall hypertrophy and atherosclerosis however, have rarely been investigated in large-scale studies. The present study reports the associat...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-200201000-00013

    authors: Zureik M,Temmar M,Adamopoulos C,Bureau JM,Courbon D,Thomas F,Bean K,Touboul PJ,Ducimetière P,Benetos A

    更新日期:2002-01-01 00:00:00

  • Selective chloride loading is pressor in the stroke-prone spontaneously hypertensive rat despite hydrochlorothiazide-induced natriuresis.

    abstract:OBJECTIVE:To test the hypothesis that in the stroke-prone spontaneously hypertensive rat (SHRSP), the pressor effect of selective dietary chloride loading depends on a positive external sodium balance. METHODS:In 43 male SHRSP fed a Japanese style diet containing a low normal amount of NaCl (0.4%), we compared the eff...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0b013e3283316cfc

    authors: Schmidlin O,Tanaka M,Sebastian A,Morris RC Jr

    更新日期:2010-01-01 00:00:00

  • Altered myogenic responsiveness of the renal microvasculature in experimental hypertension.

    abstract::Recent investigations have delineated the renal microvascular responsiveness to pressure, by using isolated afferent arterioles, juxtamedullary nephrons, and isolated perfused hydronephrotic kidneys. Both afferent arterioles and interlobular arteries (ILA) manifest pressure-dependent vasoconstrictor responses to eleva...

    journal_title:Journal of hypertension

    pub_type: 杂志文章,评审

    doi:10.1097/00004872-199612000-00002

    authors: Hayashi K,Epstein M,Saruta T

    更新日期:1996-12-01 00:00:00

  • Association of change in left ventricular mass with prognosis during long-term antihypertensive treatment.

    abstract:OBJECTIVE:The aim of the present study was to assess the prognostic value of changes in left ventricular hypertrophy in hypertensive patients with time. DESIGN:Two hundred and fifteen uncomplicated hypertensive patients underwent a high-quality baseline echocardiogram for left ventricular anatomy evaluation and in 151...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199510000-00003

    authors: Muiesan ML,Salvetti M,Rizzoni D,Castellano M,Donato F,Agabiti-Rosei E

    更新日期:1995-10-01 00:00:00

  • Blood pressure and endogenous testosterone in men: an inverse relationship.

    abstract::Exogenous sex hormone use, including oral contraceptives, post-menopausal hormonal therapy and anabolic steroids, has been associated with blood pressure changes in both sexes, but little is known about the relationship between blood pressure and endogenous sex hormones. We examined this relationship in men in the Ran...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Khaw KT,Barrett-Connor E

    更新日期:1988-04-01 00:00:00

  • The paradoxical role of left ventricular hypertrophy in wall stress-related arrhythmia.

    abstract:OBJECTIVE:To investigate the interrelationship between arrhythmias provoked by acute pressure changes, and the presence of left ventricular hypertrophy and electrolyte imbalances. DESIGN:An isolated working rat heart model was used in a prospective comparison of the effects of acute pressure changes in hypertensive an...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-199202000-00010

    authors: James MA,Jones JV

    更新日期:1992-02-01 00:00:00

  • Hepatic angiotensin II nuclear receptors and transcription of growth-related factors.

    abstract:OBJECTIVES:To investigate the influence of angiotensin II (All) receptors in isolated hepatic nuclei on other genes regulated by All and to determine whether the function of these intracellular receptors is influenced by alterations in the endocrine renin system. METHODS:Nuclei were isolated from hepatic tissue of nor...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Eggena P,Zhu JH,Sereevinyayut S,Giordani M,Clegg K,Andersen PC,Hyun P,Barrett JD

    更新日期:1996-08-01 00:00:00

  • Angiotensin converting enzyme inhibition prevents proto-oncogene expression in the vascular wall after injury.

    abstract:OBJECTIVES:Angiotensin converting enzyme (ACE) inhibitors reduce neointimal hyperplasia after balloon denudation, but the mechanisms are not completely understood. It has been demonstrated that nuclear oncogenes are induced in the vascular wall in the hours immediately after injury, and that the same genes are induced ...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:

    authors: Van Belle E,Bauters C,Wernert N,Delcayre C,McFadden EP,Dupuis B,Lablanche JM,Bertrand ME,Swynghedauw B

    更新日期:1995-01-01 00:00:00

  • Rapid increases in infant adiposity and overweight/obesity in childhood are associated with higher central and brachial blood pressure in early adulthood.

    abstract:BACKGROUND:Small size at birth and greater BMI in childhood are associated with greater brachial blood pressure (BP) in later life. Aortic (central) BP differs from brachial BP and is more predictive of organ damage and cardiovascular events; the relationship between BMI in childhood and central BP is not known. METHO...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000000269

    authors: Howe LD,Chaturvedi N,Lawlor DA,Ferreira DL,Fraser A,Davey Smith G,Tilling K,Hughes AD

    更新日期:2014-09-01 00:00:00

  • Aortic arch mechanics measured with two-dimensional speckle tracking echocardiography.

    abstract:PURPOSE:To study the feasibility of vascular mechanics at the aortic arch with two-dimensional speckle tracking echocardiography, as well as to define normal values and to compare results between hypertensive patients and healthy patients. METHODS:We included 107 patients (61 healthy patients and 46 hypertensive patie...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001336

    authors: Teixeira R,Monteiro R,Baptista R,Pereira T,Ribeiro MA,Gonçalves A,Cardim N,Gonçalves L

    更新日期:2017-07-01 00:00:00

  • Pulse rate reactivity in childhood as a risk factor for adult hypertension: the 1970 British cohort study.

    abstract:PURPOSE:Cardiovascular reactivity to mental stress has been used as a tool to predict short-term hypertension risk in adults but the impact of cardiovascular reactivity in childhood on hypertension in adulthood is unknown. Using the 1970 British Cohort study, we examined the association between pulse rate reactivity in...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/HJH.0000000000001023

    authors: Hamer M,Kivimäki M,Batty GD

    更新日期:2016-09-01 00:00:00

  • The measurement of central noradrenergic activity in spontaneously hypertensive rats: a comparison of free 3,4-dihydroxyphenylethyleneglycol levels with FLA-63 induced noradrenaline depletion.

    abstract::Noradrenergic activity was measured in the brainstem, hypothalamus and thoracic spinal cord of male and female spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats at 6 and 28-36 weeks of age. Two techniques were used, measurement of a major noradrenaline (NA) metabolite, free 3,4-dihydroxyphenylethyleneglycol...

    journal_title:Journal of hypertension

    pub_type: 杂志文章

    doi:10.1097/00004872-198506000-00007

    authors: Howes LG,Summers RJ,Rowe PR,Louis WJ

    更新日期:1985-06-01 00:00:00